摘要:
Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, especially Aβ amyloidosis, such as observed in Alzheimer's disease, IAPP amyloidosis, such as observed in type 2 diabetes, and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment.
摘要:
Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, especially Aβ amyloidosis, such as observed in Alzheimer's disease, IAPP amyloidosis, such as observed in type 2 diabetes, and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment.
摘要:
Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, especially Aβ amyloidosis, such as observed in Alzheimer's disease, IAPP amyloidosis, such as observed in type 2 diabetes, and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment.
摘要:
Compounds and their pharmaceutically acceptable salts, their synthesis and labeling, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, including Aβ amyloidosis, such as observed in Alzheimer's disease, IAPP amyloidosis, such as observed in type 2 diabetes, and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment are provided. Also provided is the use of the disclosed compounds as imaging agents and methods for in vivo imaging and detection of amyloid and synuclein.
摘要:
Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, especially Aβ amyloidosis, such as observed in Alzheimer's disease, IAPP amyloidosis, such as observed in type 2 diabetes, AA/SAA amyloidosis, such as observed in systemic AA amyloidosis and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment.
摘要:
A seed and plant growth medium module includes a seed embedded in plant growth medium which is encapsulated in a biodegradable moisture retaining shell. The shell has a bottom with an upper covering. A root opening is provided in the bottom to allow egress of roots as the seed germinates. A plant egress opening is provided in the upper covering to allow upward growth of a plant resulting when the seed germinates. At least one water entry opening is provided in the shell to allow entry of moisture into the shell to wet the plant growth medium.
摘要:
In a transaction-based verification environment for complex semiconductor devices, enhanced verification efficiency may be achieved by providing a transaction to machine code translator and an appropriate interface that enables access of the translated machine code instruction by a CPU under test. In this manner, transaction-based test environments may have a high degree of reusability and may be used for verification on block level and system level.
摘要:
The proportioner (10) has a variable speed controlled DC motor (12) having a gearbox (14) and crankshaft (16) at either end which are connected to reciprocating piston pumps (18). The outputs (18a) of the two pumps (18) are fed to a manifold (22) where the pressure of each output is measured. The user sets a setpoint pressure (e.g. 1000 psi) and the controller (26) then compares the pressures of the two components and controls the higher of the two relative to the setpoint. Ratio assurance is monitored by continuing to look at both output pressures. If one side falls below a predetermined percentage of the setpoint (50% in the preferred embodiment), an alarm may be raised or operation stopped.
摘要:
A method for obtaining visual feedback for vowel quality is disclosed. By filtering and decomposing audio signals in formants, one or more software modules and/or applications may determine the type of phoneme in an audio signal that corresponds to a vowel. First and second formants may be measured in their frequencies; subsequently frequencies values of first formant and second formant may be assigned as X and Y coordinates, respectively. These (X,Y) coordinates may be used for graphing points and trajectories of the points in a Cartesian coordinate system while the user is pronouncing a vowel. Thus, graphic feedback for vowel pronunciation may be obtained.
摘要:
A system and method for metered dosage illumination in a bioanalysis or other system includes an illumination system or subsystem that can provide optimized amounts of excitation light within the short exposure times necessary to measure fast biological activity. The amount of light can be precisely measured to provide quantitative results. The light flux can be precisely controlled to generate a prescribed minimum amount of light, in order to reduce adverse lighting effects on both fluors and samples. The system and method is particularly useful in any quality-control, analysis, or assessment-based environment. Typical research and development applications can include quality control, instrument calibration, and light output standardization; while clinical and diagnostics applications can include clinical monitoring, bioassay calibration and control for diagnostics, treatment and or therapeutic evaluation.