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    IMPLANT HAVING A PACLITAXEL-RELEASING COATING
    2.
    发明申请
    IMPLANT HAVING A PACLITAXEL-RELEASING COATING 审中-公开
    具有PACLITAXEL-RELEASING涂层的植入物

    公开(公告)号：US20120150282A1

    公开(公告)日：2012-06-14

    申请号：US13182786

    申请日：2011-07-14

    申请人： Nina Adden ,  Mark Steckel

    发明人： Nina Adden ,  Mark Steckel

    IPC分类号： A61F2/82

    CPC分类号： A61L27/047 ,  A61L27/18 ,  A61L27/54 ,  A61L27/58 ,  A61L31/022 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  C08L67/04

    摘要： An implant having a coating or a cavity filling comprising a PLGA polymer and taxane embedded therein, the release rate of the taxane after day two after implantation being ≦400 ng/day for a period of more than 10 consecutive days, characterized in that the PLGA polymer has a ratio of monomer units to each other of 60-99% lactic acid units to 40-1% glycolic acid units.

    摘要翻译： 具有包含PLGA聚合物和紫杉烷的紫外线涂层或腔体填充物的植入物，植入后第二天后紫杉烷的释放速率为400ng /天，连续10天以上，其特征在于， PLGA聚合物的单体单元相对于60-99％的乳酸单元相对于40-1％的乙醇酸单元。

    Needle assembly and method for passing suture
    4.
    发明授权
    Needle assembly and method for passing suture 失效
    针组装及缝合方法

    公开(公告)号：US5904692A

    公开(公告)日：1999-05-18

    申请号：US834639

    申请日：1997-04-14

    申请人： Mark Steckel ,  Pamela Jacob ,  Robert Morettin

    发明人： Mark Steckel ,  Pamela Jacob ,  Robert Morettin

    IPC分类号： A61B17/00 ,  A61B17/04 ,  A61B17/06 ,  A61F2/00

    CPC分类号： A61B17/06109 ,  A61B17/0469 ,  A61B17/0485 ,  A61B17/0493 ,  A61B2017/00349 ,  A61B2017/00805 ,  A61B2017/06042 ,  A61F2/0036

    摘要： A needle assembly for passing suture within the body includes a rigid needle having a proximal end and a pointed distal end, and an opening in the distal end extending through the needle for retaining a suture therein; a stop element positioned on the needle proximate to, and spaced from, the proximal end of the needle; a sheath having a lengthwise bore therethrough for slidably retaining the needle; and a lock member engageable with the needle stop element to prevent distal movement of the needle in the sheath bore. The needle distal end is movable to an exposed position for passing the assembly through tissue, and is movable to a shielded position within the sheath for passing the assembly safely past the tissue which is not to be penetrated. There is further contemplated a method for passing suture within the body, using the needle assembly.

    摘要翻译： 用于使缝合线在体内通过的针组件包括具有近端和尖端远端的刚性针，以及在远端延伸穿过针头的开口，用于将缝合线保持在其中; 位于所述针上的止动元件，其靠近所述针的近端并与所述针的近端隔开; 护套，其具有穿过其中的纵向孔，用于可滑动地保持针; 以及与所述针止动元件接合的锁定构件，以防止所述针在所述护套孔中的远端移动。 针头末端可移动到暴露位置，以使组件穿过组织，并且可移动到护套内的屏蔽位置，以使组件安全地穿过不被穿透的组织。 进一步考虑了使用针组件将缝合线传递到体内的方法。

    Magnesium-Based Absorbable Implants
    5.
    发明申请
    Magnesium-Based Absorbable Implants 有权
    镁基吸收植入物

    公开(公告)号：US20120143227A1

    公开(公告)日：2012-06-07

    申请号：US13309271

    申请日：2011-12-01

    申请人： Mark Steckel ,  Ioannis Pandelidis

    发明人： Mark Steckel ,  Ioannis Pandelidis

    IPC分类号： A61B17/03

    CPC分类号： A61F2/86 ,  A61B17/122 ,  A61B17/80 ,  A61B17/866 ,  A61B2017/00004 ,  A61B2017/0417 ,  A61F2210/0004 ,  A61F2210/0076 ,  A61L27/04 ,  A61L27/58 ,  A61L31/022 ,  A61L31/148 ,  C25F3/18 ,  C25F3/24

    摘要： A bioabsorbable implant including an elongated metallic element comprising an alloy of more than about 70% by weight magnesium and about 2-20% by weight lithium, substantially free of rare earth metals. An implantable tissue filler includes a particulate material suspended in a carrier, comprising more than about 70% by weight magnesium and about 2-20% by weight lithium, substantially free of rare earth metals. A bioabsorbable implant includes an elongated metallic element having a core and at least two layers of alternating compositions of magnesium, iron, and alloys thereof. A bioabsorbable implant includes at least three wires including magnesium and defining a cylindrical sheath surrounding at least one core wire including iron. A bioabsorbable implant includes a plurality of intertwined magnesium alloy wires defining a strand, with an Fe-rich layer formed by vapor, chemical and/or electro-deposition defined on a surface of at least one of the wires.

    摘要翻译： 一种生物可吸收植入物，其包括细长的金属元素，其包含大于约70重量％的镁和约2-20重量％的锂的合金，基本上不含稀土金属。 可植入组织填料包括悬浮在载体中的颗粒材料，其包含大于约70重量％的镁和约2-20重量％的锂，基本上不含稀土金属。 生物可吸收植入物包括细长的金属元件，其具有芯和至少两层交替组成的镁，铁及其合金。 生物可吸收植入物包括至少三根包括镁的线，并限定围绕包括铁的至少一根芯线的圆柱形护套。 生物可吸收植入物包括限定线的多个交织的镁合金线，其中​​富铁层由限定在至少一根导线的表面上的蒸气，化学和/或电沉积形成。

    Sheath With Radio-Opaque Markers For Identifying Split Propagation
    6.
    发明申请
    Sheath With Radio-Opaque Markers For Identifying Split Propagation 审中-公开
    带有无线电透明标记的护套用于识别分裂传播

    公开(公告)号：US20090259286A1

    公开(公告)日：2009-10-15

    申请号：US12102162

    申请日：2008-04-14

    申请人： Rachit Ohri ,  Mark Steckel

    发明人： Rachit Ohri ,  Mark Steckel

    IPC分类号： A61F2/06

    CPC分类号： A61F2/97 ,  A61F2/958 ,  A61F2002/821 ,  A61F2002/9583 ,  A61F2250/0098

    摘要： A medical device delivery system includes a self-expanding medical device mounted on a balloon portion of a catheter. A sheath is provided around the medical device to hold the device in place with the device staying in a compressed state. The balloon portion is inflated to cause the sheath to rupture and release the self-expanding medical device. A number of radio-opaque markers in a pattern that will aid in determining whether or not the sheath has properly ruptured upon inflation of the balloon portion are provided on the sheath. The radio-opaque markers are positioned with respect to an expected sheath rupture propagation path along which the sheath is expected to rupture. The pattern of the markers changes as the sheath ruptures and this change is detected by an operator of the system.

    摘要翻译： 医疗装置输送系统包括安装在导管的球囊部分上的自扩张医疗装置。 在医疗装置周围设置护套，以将装置保持在处于压缩状态的装置的适当位置。 气囊部分被充气以使皮肤破裂并释放自膨胀的医疗装置。 许多不透射线的标记物将有助于确定在球囊部分膨胀时护套是否适当地破裂。 射线不透明标记物相对于期望的鞘破裂传播路径定位，预期护套穿过其将破裂。 标记的图案随着鞘破裂而变化，并且该变化由系统的操作者检测到。

    DEVICE DELIVERY SYSTEM WITH BALLOON-RELATIVE SHEATH POSITIONING
    7.
    发明申请
    DEVICE DELIVERY SYSTEM WITH BALLOON-RELATIVE SHEATH POSITIONING 审中-公开
    具有气球相对湿度定位的装置输送系统

    公开(公告)号：US20080319388A1

    公开(公告)日：2008-12-25

    申请号：US11766198

    申请日：2007-06-21

    申请人： David Slattery ,  Damian Kelly ,  Michael Gilmore ,  Mark Steckel

    发明人： David Slattery ,  Damian Kelly ,  Michael Gilmore ,  Mark Steckel

    IPC分类号： A61M25/10

    CPC分类号： A61F2/958 ,  A61F2/97 ,  A61M2025/1004

    摘要： A medical device delivery system includes a self-expanding medical device mounted on a balloon portion of a catheter. A sheath is provided around the medical device to hold the device in place with the device staying in a compressed state. A series of perforations or an initial cut is provided in the sheath at a predetermined location, or within a predetermined range of locations, on the circumference of the sheath. The predetermined location or range of locations are determined with respect to the folds of the balloon portion.

    摘要翻译： 医疗装置输送系统包括安装在导管的球囊部分上的自扩张医疗装置。 在医疗装置周围设置护套，以将装置保持在处于压缩状态的装置的适当位置。 一套穿孔或初始切口在套管的一个预定位置处或在一个预定的位置范围内设置在护套的圆周上。 相对于球囊部分的折痕确定位置的预定位置或范围。

    MEDICAL DEVICES HAVING BIOERODABLE LAYERS FOR THE RELEASE OF THERAPEUTIC AGENTS
    9.
    发明申请
    MEDICAL DEVICES HAVING BIOERODABLE LAYERS FOR THE RELEASE OF THERAPEUTIC AGENTS 审中-公开
    具有生物可降解层的医疗器械用于治疗药物释放

    公开(公告)号：US20090074838A1

    公开(公告)日：2009-03-19

    申请号：US12056689

    申请日：2008-03-27

    申请人： Courtney Sikes ,  Mark Steckel

    发明人： Courtney Sikes ,  Mark Steckel

    IPC分类号： A61F2/04

    CPC分类号： A61K9/0024 ,  A61L27/34 ,  A61L27/54 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/604 ,  C08L67/04

    摘要： According to an aspect of the present invention, medical devices are provided which comprise: (a) a substrate, (b) an inner bioerodable polymeric layer over the substrate that comprises (i) 80 wt % or more of an amorphous biodegradable polymeric component and (ii) 20 wt % or less of a therapeutic agent component, and (c) an outer bioerodable polymeric layer over the inner bioerodable polymeric layer that comprises (i) 80 wt % or more of an amorphous biodegradable polymeric component and (ii) 20 wt % or less of a therapeutic agent component. The compositions of the inner and outer layers differ such that the outer layer has a bioerosion rate that is faster than that of the inner layer.

    摘要翻译： 根据本发明的一个方面，提供了医疗装置，其包括：（a）基底，（b）在基底上的内生物可蚀解聚合物层，其包含（i）80重量％或更多的无定形可生物降解的聚合物组分和 （ii）20重量％或更少的治疗剂组分，和（c）内部生物可蚀解聚合物层上的外生物可蚀解聚合物层，其包含（i）80重量％或更多的无定形可生物降解聚合物组分和（ii）20 重量％以下的治疗剂成分。 内层和外层的组成不同，使得外层具有比内层更快的生物腐蚀速率。