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    Microscope Illumination Method and Microscope
    1.
    发明申请
    Microscope Illumination Method and Microscope 有权
    显微镜照明方法和显微镜

    公开(公告)号：US20130027770A1

    公开(公告)日：2013-01-31

    申请号：US13559778

    申请日：2012-07-27

    申请人： Michael Ganser ,  Albrecht Weiss

    发明人： Michael Ganser ,  Albrecht Weiss

    IPC分类号： G02B21/06

    CPC分类号： G02B21/088 ,  G02B5/22 ,  G02B21/125 ,  G02B21/16

    摘要： The invention relates to a microscope illumination method, to a microscope illumination set, comprising a white light LED (4) and a correction filter (6), and to a corresponding microscope system (1) for analysing a sample (10) alternately or simultaneously in transmitted light bright field illumination and in incident light fluorescence illumination, wherein a white light LED (4) is used for the transmitted light bright field illumination, and a correction filter (6) is activated at a location in the illumination beam path of the transmitted light bright field illumination both during transmitted light bright field illumination and during incident light fluorescence illumination, wherein the correction filter (6) has a spectral transmission profile which has a minimum in the wavelength range of at least one maximum of the spectrum of the white light LED (4).

    摘要翻译： 本发明涉及一种显微照明方法，涉及一种包括白光LED（4）和校正滤光片（6）的显微照明组件，以及用于交替或同时分析样品（10）的相应显微系统（1） 在透射光明场照明和入射光荧光照明中，其中白光LED（4）用于透射光明场照明，校正滤光片（6）在照明光束路径中的位置被激活 在透射光明场照明期间和在入射光荧光照明期间的透射光明场照明，其中所述校正滤光片（6）具有光谱透射分布，所述光谱透射分布在白色光谱的至少一个最大值的波长范围内具有最小值 灯LED（4）。

    Process for the Production of Fatty Acid Alkyl Esters
    3.
    发明申请
    Process for the Production of Fatty Acid Alkyl Esters 失效
    脂肪酸烷基酯的制备方法

    公开(公告)号：US20100234458A1

    公开(公告)日：2010-09-16

    申请号：US12304078

    申请日：2007-05-16

    申请人： Eric Dubreucq ,  Albrecht Weiss ,  Bernhard Gutsche ,  Bernd Fabry ,  Guy Moulin

    发明人： Eric Dubreucq ,  Albrecht Weiss ,  Bernhard Gutsche ,  Bernd Fabry ,  Guy Moulin

    IPC分类号： A61K8/37 ,  C12P7/64 ,  A61Q90/00 ,  A23L1/28 ,  A23D9/00

    CPC分类号： C12P7/649 ,  A23K10/10 ,  C10L1/026 ,  C11C3/003 ,  Y02E50/13 ,  Y02E50/17

    摘要： Disclosed is an improved process for the production of fatty acid lower alkyl esters according to formula (I) R1CO—OR2   (I) in which R1CO represents a linear or branched acyl moiety having from about 6 to about_22 carbon atoms and 0 to 6 double bonds and wherein R2 is a linear or branched alkyl moiety having 1 to 6 carbon atoms, by transesterification of triglycerides or fatty acid esters using C1-C6 aliphatic alcohols, which includes the steps of (a) providing an aqueous mixture of aliphatic C1-C6 alcohol by fermenting in a first reactor a carbon_source comprising carbohydrates and/or glycerol produce a fermentation broth comprising said aliphatic C1-C6 alcohol, (b) providing in a second reactor a triglyceride and/or an ester of a fatty acid, together with a biocatalyst capable of effecting a transesterification reaction, (c) transferring said aqueous aliphatic C1-C6 alcohol mixture obtained from said first reactor into said_second reactor to provide_a two-phase system, and (d) effecting the transesterification reaction to produce said fatty acid lower alkyl ester and a glycerol- or alcohol-containing aqueous phase. The products thus obtained are particularly useful as components of the fuel known as biodiesel.

    摘要翻译： 公开了一种改进的根据式（I）R1CO-OR2（I）的脂肪酸低级烷基酯的制备方法，其中R 1 CO表示具有约6至约22个碳原子和0至6个双键的直链或支链酰基部分 并且其中R 2是具有1至6个碳原子的直链或支链烷基部分，通过使用C 1 -C 6脂族醇进行甘油三酯或脂肪酸酯的酯交换反应，其包括以下步骤：（a）提供脂族C1-C6醇的水性混合物 通过在第一反应器中发酵包含碳水化合物和/或甘油的碳源产生包含所述脂族C 1 -C 6醇的发酵液，（b）在第二反应器中提供甘油三酯和/或脂肪酸酯以及生物催化剂 能够进行酯交换反应，（c）将从所述第一反应器获得的脂族C1-C6醇混合物混合物转移到所述第二反应器中以提供两相体系，和（d） 进行酯交换反应以产生所述脂肪酸低级烷基酯和含甘油或醇的水相。 这样得到的产物特别适用于称为生物柴油的燃料的组分。

    FLUORESCENCE MICROSCOPE HAVING AN ILLUMINATION DEVICE
    4.
    发明申请
    FLUORESCENCE MICROSCOPE HAVING AN ILLUMINATION DEVICE 有权
    具有照明装置的荧光显微镜

    公开(公告)号：US20080198448A1

    公开(公告)日：2008-08-21

    申请号：US12032435

    申请日：2008-02-15

    申请人： Michael Ganser ,  Albrecht Weiss

    发明人： Michael Ganser ,  Albrecht Weiss

    IPC分类号： G02B21/06

    CPC分类号： G02B21/16 ,  G02B21/06 ,  G02B27/1006

    摘要： An arrangement for fluorescence microscopic examination of specimens includes: a fluorescence microscope; an illumination device that includes: a housing including an interface configured to optically couple the housing and the fluorescence microscope; a plurality of light-emitting diodes disposed in the housing; a respective collector disposed downstream of each of the light emitting diodes and configured to generate a directed light flux; and at least one dichroic splitter disposed in the housing, the at least one splitter and the light-emitting diodes being spatially disposed with respect to one another so that the directed light fluxes are combinable via the at least one splitter into a common illumination beam path directed onto the interface; and a logical control device common to the fluorescence microscope and the illumination device.

    摘要翻译： 用于荧光显微镜检查的样品的布置包括：荧光显微镜; 一种照明装置，包括：壳体，包括被配置为光耦合所述壳体和所述荧光显微镜的接口; 设置在所述壳体中的多个发光二极管; 设置在每个所述发光二极管的下游并且被配置为产生有向光通量的相应集电极; 以及设置在所述壳体中的至少一个二向色分配器，所述至少一个分离器和所述发光二极管相对于彼此在空间上设置，使得所述定向光束可经由所述至少一个分离器组合成公共照明光束路径 指向界面; 以及荧光显微镜和照明装置通用的逻辑控制装置。

    Enzymes with lipase/acyltransferase activity, nucleic acids encoding the same and methods of use thereof
    6.
    发明授权
    Enzymes with lipase/acyltransferase activity, nucleic acids encoding the same and methods of use thereof 有权
    具有脂肪酶/酰基转移酶活性的酶，编码其的核酸及其使用方法

    公开(公告)号：US07247463B2

    公开(公告)日：2007-07-24

    申请号：US10681636

    申请日：2003-10-08

    申请人： Albrecht Weiss ,  Frederic Bigey ,  Eric Dubreucq ,  Guy Moulin

    发明人： Albrecht Weiss ,  Frederic Bigey ,  Eric Dubreucq ,  Guy Moulin

    IPC分类号： C12N9/10 ,  C12N9/20

    CPC分类号： C12N9/1025 ,  C12N9/20

    摘要： Polypeptides with lipase/acyltransferase activity are described with an amino acid sequence which has identity to the sequence reported in SEQ ID NO 2 of at least 49%, also polypeptides which display this activity, as well as nucleic acids (genes) which code for these polypeptides, vectors which contain nucleic acids which code for these polypeptides, transformed microorganisms which contain these nucleic acids, processes for production of these polypeptides and the application of nucleic acids for discovering new lipase/acyltransferases and the use of these lipase/acyltransferases as catalysts in chemical and biochemical processes.

    摘要翻译： 具有脂肪酶/酰基转移酶活性的多肽用与SEQ ID NO 2中报道的序列具有至少49％的同一性的氨基酸序列以及显示该活性的多肽以及编码这些活性的核酸（基因）来描述 多肽，含有编码这些多肽的核酸的载体，含有这些核酸的转化微生物，这些多肽的生产方法和用于发现新的脂肪酶/酰基转移酶的核酸的应用以及这些脂肪酶/酰基转移酶作为催化剂的用途 化学和生化过程。

    Salicyl alcohol derivatives
    9.
    发明授权
    Salicyl alcohol derivatives 失效
    水杨醇衍生物

    公开(公告)号：US06750332B1

    公开(公告)日：2004-06-15

    申请号：US09856835

    申请日：2002-02-26

    申请人： Ralf Otto ,  Albrecht Weiss

    发明人： Ralf Otto ,  Albrecht Weiss

    IPC分类号： C07H1500

    CPC分类号： C07H15/04 ,  A61K8/602 ,  A61Q19/00 ,  C08B37/00 ,  C12P7/62 ,  C12P19/44

    摘要： Novel salicyl alcohol derivatives having valuable cosmetically and pharmaceutically useful properties, such as prostaglandin synthesis inhibition, corresponding to the formula (I): R1—OCH2—Ph—O—Z—(R2)n  (I), a method for producing the same and their utilization in cosmetics and pharmacy.

    摘要翻译： 新颖的水杨醇衍生物具有有价值的美容和药学上有用的性质，如前列腺素合成抑制，对应于式（I）：其制备方法及其在化妆品和药学中的应用。

    Holder for attaching a component with a dovetail slot
    10.
    发明授权
    Holder for attaching a component with a dovetail slot 失效
    用于连接带有燕尾槽的部件的支架

    公开(公告)号：US06384992B1

    公开(公告)日：2002-05-07

    申请号：US09633262

    申请日：2000-08-04

    申请人： Albrecht Weiss

    发明人： Albrecht Weiss

    IPC分类号： G02B2100

    CPC分类号： G02B21/248 ,  B25B1/2489 ,  G01B5/0002 ,  G02B7/16

    摘要： The application describes a holder for attaching a component with outside dovetail carriages to a bearing surface. A pin-like bolt and, next to it, a ssion spring, which is bent away from the bolt under preloading, are attached in front of the bearing surface as interacting holder components. The cross sections, the lengths and the distance between the bolt and the compression spring are adapted to the inner profile of the dovetail carriage. To attach the component, the dovetail carriage is pressed manually by means of the bolt and the compression spring, until it comes into contact with the bearing surface, and is latched in place. The bolt and the compression spring are pressed into the inner sides of the dovetail carriage on both sides by the preloading of the bent compression spring. Advantageously, the compression spring is additionally preloaded toward the bearing surface. The holder offers precise, tilt-resistant attachment of the component in any three-dimensional position while requiring very little space. Multiple holders having a plurality of holders on a displaceable longitudinal slide or a rotable cylinder are suitable for attaching a plurality of fluorescence filter blocks for optional use in a fluorescence microscope.

    摘要翻译： 本申请描述了一种用于将具有外部燕尾车架的部件附接到支承表面的保持器。 一个销状螺栓，并在其旁边，一个在预加载下从螺栓上弯曲的弹簧弹簧，作为相互作用的保持器部件被连接在支承表面的前面。 螺栓和压缩弹簧之间的横截面，长度和距离适合于燕尾形托架的内部轮廓。 为了安装该部件，通过螺栓和压缩弹簧手动地对燕尾托架进行压制，直到它与支承表面接触并被锁定就位。 螺栓和压缩弹簧通过弯曲的压缩弹簧的预加载被压入燕尾座两侧的内侧。 有利地，压缩弹簧另外被预载到轴承表面。 该夹具可以在任何三维位置提供精确，防倾斜的部件附件，同时要求极少的空间。 在可移动的纵向滑动件或可旋转的圆柱体上具有多个保持器的多个保持器适用于在荧光显微镜中附接多个荧光过滤器块以供任选使用。