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公开(公告)号：US08945509B2
公开(公告)日：2015-02-03
申请号：US13215157
申请日：2011-08-22
申请人： Aldrich Lau , Robert Eason , Maxim Brevnov , Handong Li , Kevin Hacker
发明人： Aldrich Lau , Robert Eason , Maxim Brevnov , Handong Li , Kevin Hacker
CPC分类号： G01N33/54326 , C12N1/02 , C12N13/00 , C12Q1/689 , G01N33/54353 , G01N33/56911
摘要： Magnetic beads that include polyvalent ligands comprising various carbohydrates are described. Methods for fabricating such magnetic beads are also provided as well as methods of their use to capture and enrich pathogen cell population for subsequent culture, lysis and identification.
摘要翻译： 描述包括包含各种碳水化合物的多价配体的磁珠。 还提供了制备这种磁珠的方法以及它们用于捕获和富集病原体细胞群以用于随后的培养，裂解和鉴定的方法。
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公开(公告)号：US20120045767A1
公开(公告)日：2012-02-23
申请号：US13215157
申请日：2011-08-22
申请人： Aldrich LAU , Robert Eason , Maxim Brevnov , Handong Li , Kevin Hacker
发明人： Aldrich LAU , Robert Eason , Maxim Brevnov , Handong Li , Kevin Hacker
CPC分类号： G01N33/54326 , C12N1/02 , C12N13/00 , C12Q1/689 , G01N33/54353 , G01N33/56911
摘要： Magnetic beads that include polyvalent ligands comprising various carbohydrates are described. Methods for fabricating such magnetic beads are also provided as well as methods of their use to capture and enrich pathogen cell population for subsequent culture, lysis and identification.
摘要翻译： 描述包括包含各种碳水化合物的多价配体的磁珠。 还提供了制备这种磁珠的方法以及它们用于捕获和富集病原体细胞群以用于随后的培养，裂解和鉴定的方法。
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公开(公告)号：US20130157277A1
公开(公告)日：2013-06-20
申请号：US13819240
申请日：2011-09-01
申请人： Kevin Hacker , Gregory Govoni , Nikolay Sergeev , Elena Bolchacova , Maxim Brevnov , Manohar Furtado , Johnie Young , Jim Nurse , Mareila Cuadras
发明人： Kevin Hacker , Gregory Govoni , Nikolay Sergeev , Elena Bolchacova , Maxim Brevnov , Manohar Furtado , Johnie Young , Jim Nurse , Mareila Cuadras
CPC分类号： C12N15/1003 , B01D29/13 , C12N1/066 , C12Q1/68 , C12Q1/689 , C12Q1/6895 , G01N21/75
摘要： Devices and methods for detecting microbial contaminants, such as bacteria and fungi, in fluids such as drinking water, pharmaceutical solutions and tissue culture media are provided. More particularly, provided are filtration devices for capture and processing of microorganisms from fluids, and improved methods for recovery, lysis and detection of microorganisms based on a combination of physical disruption with small beads and lysis solutions.
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公开(公告)号：US09044694B2
公开(公告)日：2015-06-02
申请号：US13819240
申请日：2011-09-01
申请人： Kevin Hacker , Gregory Govoni , Nikolay Sergeev , Elena Bolchacova , Maxim Brevnov , Manohar Furtado , Johnie Young , Jim Nurse , Mariela Cuadras
发明人： Kevin Hacker , Gregory Govoni , Nikolay Sergeev , Elena Bolchacova , Maxim Brevnov , Manohar Furtado , Johnie Young , Jim Nurse , Mariela Cuadras
CPC分类号： C12N15/1003 , B01D29/13 , C12N1/066 , C12Q1/68 , C12Q1/689 , C12Q1/6895 , G01N21/75
摘要： Devices and methods for detecting microbial contaminants, such as bacteria and fungi, in fluids such as drinking water, pharmaceutical solutions and tissue culture media are provided. More particularly, provided are filtration devices for capture and processing of microorganisms from fluids, and improved methods for recovery, lysis and detection of microorganisms based on a combination of physical disruption with small beads and lysis solutions.
摘要翻译： 提供了用于检测诸如饮用水，药物溶液和组织培养基的流体中的微生物污染物如细菌和真菌的装置和方法。 更具体地，提供了用于捕获和处理来自流体的微生物的过滤装置，以及基于物理破坏与小珠和裂解溶液的组合的微生物的回收，裂解和检测的改进方法。
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公开(公告)号：US09447409B2
公开(公告)日：2016-09-20
申请号：US12882194
申请日：2010-09-14
CPC分类号： C12N15/1003 , C12N1/06 , C12N15/1006 , C12N15/1013 , C12Q1/6806
摘要： The present teachings relate to the extraction of nucleic acid from solid materials. Provided are useful compositions, methods and kits for obtaining nucleic acids from a solid biological sample or an adhesive material having a biological material adherent or embedded within the adhesive substrate. The extracted nucleic acid can be used in downstream applications such as genotyping, detection, quantification, and identification of the source of the biological material.
摘要翻译： 本教导涉及从固体材料中提取核酸。 提供了用于从固体生物样品获得核酸的有用的组合物，方法和试剂盒或具有粘附或嵌入粘合剂基底内的生物材料的粘合剂材料。 提取的核酸可用于下游应用，例如生物材料来源的基因分型，检测，定量和鉴定。
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公开(公告)号：US20110159485A1
公开(公告)日：2011-06-30
申请号：US12882194
申请日：2010-09-14
CPC分类号： C12N15/1003 , C12N1/06 , C12N15/1006 , C12N15/1013 , C12Q1/6806
摘要： The present teachings relate to the extraction of nucleic acid from solid materials. Provided are useful compositions, methods and kits for obtaining nucleic acids from a solid biological sample or an adhesive material having a biological material adherent or embedded within the adhesive substrate. The extracted nucleic acid can be used in downstream applications such as genotyping, detection, quantification, and identification of the source of the biological material.
摘要翻译： 本教导涉及从固体材料中提取核酸。 提供了用于从固体生物样品获得核酸的有用的组合物，方法和试剂盒或具有粘附或嵌入粘合剂基底内的生物材料的粘合剂材料。 提取的核酸可用于下游应用，例如生物材料来源的基因分型，检测，定量和鉴定。
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7.发明授权Capillary electrophoresis apparatus having filling/refilling system and methods for use thereof 失效具有填充/再填充系统的毛细管电泳装置及其使用方法公开(公告)号：US06475361B1
公开(公告)日：2002-11-05
申请号：US09378561
申请日：1999-08-19
申请人： Irena N. Merenkova , Maxim Brevnov
发明人： Irena N. Merenkova , Maxim Brevnov
IPC分类号： G01N2726
CPC分类号： G01N27/44721 , G01N27/44704 , G01N27/44782
摘要： The present invention relates to an electrophoresis apparatus having a filling/refilling system and methods of using the same. The electrophoresis apparatus comprises a first buffer chamber comprising a solid portion, at least one inlet channel in said solid portion, and at least one outlet channel in said solid portion, wherein said at least one inlet channel is in fluid communication with at least one inlet port, said at least one outlet channel is in fluid communication with at least one outlet port and said at least one inlet channel is in fluid communication with said at least one outlet channel. The electrophoresis apparatus also comprises a plurality of capillaries having first ends, second ends, and intermediate portions disposed between said first ends and said second ends, wherein said first ends extend into said first buffer chamber and are in fluid communication with said at least one inlet channel and said at least one outlet channel.
摘要翻译： 本发明涉及具有填充/补充系统的电泳装置及其使用方法。 电泳装置包括第一缓冲室，其包括固体部分，所述固体部分中的至少一个入口通道和所述固体部分中的至少一个出口通道，其中所述至少一个入口通道与至少一个入口 所述至少一个出口通道与至少一个出口端口流体连通，并且所述至少一个入口通道与所述至少一个出口通道流体连通。 电泳装置还包括多个毛细管，其具有设置在所述第一端和所述第二端之间的第一端，第二端和中间部分，其中所述第一端延伸到所述第一缓冲室中并与所述至少一个入口流体连通 通道并且表示至少一个出口通道。
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公开(公告)号：US06103083A
公开(公告)日：2000-08-15
申请号：US27426
申请日：1998-02-20
申请人： Irena N. Merenkova , Maxim Brevnov
发明人： Irena N. Merenkova , Maxim Brevnov
IPC分类号： G01N27/447 , G01N27/00
CPC分类号： G01N27/44782 , G01N27/44721
摘要： The present invention relates to an electrophoresis apparatus having a plurality of capillaries arranged in a plane such that a curving contour is formed by the intersection points of each of the capillaries with the plane. The apparatus may be used to determine the sequence of nucleic acids. The present invention also relates to methods of using the electrophoresis apparatus and methods of making the electrophoresis apparatus.
摘要翻译： 电泳装置技术领域本发明涉及一种具有多个毛细管的电泳装置，其布置在平面中，使得每个毛细管与平面的交点形成弯曲轮廓。 该装置可用于确定核酸序列。 本发明还涉及使用电泳装置的方法和制作电泳装置的方法。
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