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    HIGHLY SELECTIVE COATED-ELECTRODE NANOGAP TRANSDUCERS FOR THE DETECTION OF REDOX MOLECULES
    3.
    发明申请
    HIGHLY SELECTIVE COATED-ELECTRODE NANOGAP TRANSDUCERS FOR THE DETECTION OF REDOX MOLECULES 审中-公开
    用于检测氧化还原分子的高选择性涂覆电极纳米粒子转移体

    公开(公告)号：US20160245774A1

    公开(公告)日：2016-08-25

    申请号：US15144591

    申请日：2016-05-02

    申请人： Noureddine Tayebi ,  Xing Su ,  Handong Li

    发明人： Noureddine Tayebi ,  Xing Su ,  Handong Li

    IPC分类号： G01N27/327 ,  C23C16/00

    CPC分类号： G01N27/3278 ,  C23C16/00

    摘要： Highly selective coated-electrode nanogap transducers for the detection of redox molecules are described. In an example, an analyte detection system includes one or more transducer electrodes having a surface for analyte detection. The surface includes a coating to inhibit direct contact of analyte with the surface of the one or more transducer electrodes.

    摘要翻译： 描述了用于检测氧化还原分子的高选择性涂层电极纳米胶片转换器。 在一个示例中，分析物检测系统包括具有用于分析物检测的表面的一个或多个换能器电极。 表面包括抑制分析物与一个或多个换能器电极的表面的直接接触的涂层。

    Method of making a semiconductor radiation detector
    4.
    发明授权
    Method of making a semiconductor radiation detector 有权
    制造半导体辐射探测器的方法

    公开(公告)号：US08742522B2

    公开(公告)日：2014-06-03

    申请号：US13442957

    申请日：2012-04-10

    申请人： Handong Li ,  Michael Prokesch ,  John F. Eger

    发明人： Handong Li ,  Michael Prokesch ,  John F. Eger

    IPC分类号： H01L27/14

    CPC分类号： H01L31/022408 ,  H01L27/14676 ,  H01L27/14696 ,  H01L31/085 ,  H01L31/1828 ,  Y02E10/543

    摘要： A method of making a semiconductor radiation detector wherein the metal layers which serve as the cathode and anode electrodes are recessed from the designated prospective dice lines which define the total upper and lower surface areas for each detector such that the dicing blade will not directly engage the metal during dicing and therefore prevent metal from intruding upon (smearing) the vertical side walls of the detector substrate.

    摘要翻译： 一种制造半导体辐射检测器的方法，其中用作阴极和阳极电极的金属层从指定的预期骰子线凹下，其限定每个检测器的总上表面积和下表面积，使得切割刀片不会直接接合 金属，因此防止金属侵入（污染）检测器基板的垂直侧壁。

    Lateral collection photovoltaics
    7.
    发明授权
    Lateral collection photovoltaics 有权
    横向收集光伏

    公开(公告)号：US08294025B2

    公开(公告)日：2012-10-23

    申请号：US11972491

    申请日：2008-01-10

    申请人： Stephen J. Fonash ,  Handong Li ,  David Stone

    发明人： Stephen J. Fonash ,  Handong Li ,  David Stone

    IPC分类号： H01L31/02224

    CPC分类号： H01L31/035281 ,  B82Y20/00 ,  H01L31/022425 ,  H01L31/022433 ,  H01L31/03529 ,  H01L31/18 ,  H01L51/445 ,  H01L51/447 ,  Y02E10/549 ,  Y10T428/24174

    摘要： Lateral collection photovoltaic (LCP) structures based on micro- and nano-collecting elements are used to collect photogenerated carriers. In one set of embodiments, the collecting elements are arrayed on a conducting substrate. In certain versions, the collecting elements are substantially perpendicular to the conductor. In another set of embodiments, the micro- or nano-scale collecting elements do not have direct physical and electrical contact to any conducting substrate. In one version, both anode and cathode electrodes are laterally arrayed. In another version, the collecting elements of one electrode are a composite wherein a conductor is separated by an insulator, which is part of each collector element, from the opposing electrode residing on the substrate. In still another version, the collection of one electrode structure is a composite containing both the anode and the cathode collecting elements for collection. An active material is positioned among the collector elements.

    摘要翻译： 使用基于微纳米收集元件的侧向收集光伏（LCP）结构来收集光生载流子。 在一组实施例中，集合元件排列在导电衬底上。 在某些形式中，收集元件基本上垂直于导体。 在另一组实施例中，微尺度或纳米级收集元件不具有与任何导电衬底的直接物理和电接触。 在一个版本中，阳极和阴极电极都是横向排列的。 在另一个版本中，一个电极的收集元件是复合材料，其中导体由驻留在基底上的相对电极的绝缘体分隔开，绝缘体是每个集电器元件的一部分。 在另一个版本中，一个电极结构的集合是包含阳极和阴极收集元件用于收集的复合物。 活性物质位于收集器元件之间。

    High Vacuum In-Situ Refining Method for High-Purity Materials and an Apparatus Thereof
    8.
    发明申请
    High Vacuum In-Situ Refining Method for High-Purity Materials and an Apparatus Thereof 失效
    高纯度材料的真空原位精炼方法及其设备

    公开(公告)号：US20080257109A1

    公开(公告)日：2008-10-23

    申请号：US12067835

    申请日：2006-04-11

    申请人： Xiaolong Du ,  Zhaoquan Zeng ,  Hongtao Yuan ,  Handong Li ,  Qikun Xue ,  Jinfeng Jia

    发明人： Xiaolong Du ,  Zhaoquan Zeng ,  Hongtao Yuan ,  Handong Li ,  Qikun Xue ,  Jinfeng Jia

    IPC分类号： C21C5/30 ,  C21B7/24

    CPC分类号： C22B9/02 ,  C22B9/04 ,  C22B9/14 ,  C22B19/12 ,  C22B19/18 ,  F27B14/04 ,  F27B14/20 ,  Y02P10/234

    摘要： The present invention concerns a high vacuum in-situ refining method for high-purity and superhigh-purity materials and the apparatus thereof, characterized in heating the upper part and lower part of crucible separately using double-heating-wires diffusion furnace under vacuum, thereby forming the temperature profile which is high at upper part and low at lower part of crucible, or in reverse during different stages; then heating the crucible in two steps to remove impurities with high saturation vapor pressure and low saturation vapor pressure respectively in efficiency; and obtaining high-purity materials eventually. The whole procedure is isolated from atmosphere, reducing contamination upon stuff remarkably. The present invention could provide products with high-quality and high production capacity, which are stable in performance, therefore is reliable and free from contamination. The present invention is appropriate for manufacture of high-purity and superhigh-purity materials, particularly for manufacture of high-activity high-purity materials.

    摘要翻译： 本发明涉及一种用于高纯度和超高纯度材料的高真空原位精制方法及其装置，其特征在于使用双重加热丝扩散炉在真空下分别加热坩埚的上部和下部，由此 形成坩埚上部和下部较高的温度分布，或在不同阶段形成相反的温度分布; 然后分两步加热坩埚以分别以高饱和蒸气压和低饱和蒸气压去除杂质; 并最终获得高纯度材料。 整个过程与大气隔离，减少了污染物的显着。 本发明可以提供具有高质量和高生产能力的产品，性能稳定，因此可靠，无污染。 本发明适用于制造高纯度和超高纯度材料，特别是用于制造高活性高纯度材料。

    Label free analysis of nucleic acids
    9.
    发明授权
    Label free analysis of nucleic acids 有权
    无标签分析核酸

    公开(公告)号：US07354720B2

    公开(公告)日：2008-04-08

    申请号：US11313874

    申请日：2005-12-20

    申请人： Andrea Cuppoletti ,  Handong Li

    发明人： Andrea Cuppoletti ,  Handong Li

    IPC分类号： C12Q1/68 ,  C07H21/02 ,  C07H21/04

    CPC分类号： C12Q1/6816 ,  C12Q1/6834 ,  C12Q2565/107 ,  C12Q2563/107

    摘要： A method is provided for label free analysis of nucleic acid materials. In accordance with the present invention, a fluorescent material is provided having a certain fluorescence emission without nucleic acids attached thereto. The fluorescent material of the present invention, has a greater emission upon the binding of a single stranded nucleic acid and an even greater emission upon the binding of a double stranded nucleic acid allowing detection of double stranded binding without using a label attached to the DNA.

    摘要翻译： 提供了一种用于无标记分析核酸材料的方法。 根据本发明，提供具有一定荧光发射的荧光材料，而不附加核酸。 本发明的荧光材料在单链核酸结合时具有更大的发射，并且在双链核酸的结合时具有甚至更大的发射，从而允许检测双链结合而不使用与DNA连接的标记。

    Method for the selective enrichment and labeling of phosphorproteins
    10.
    发明申请
    Method for the selective enrichment and labeling of phosphorproteins 有权
    磷蛋白选择性富集和标记方法

    公开(公告)号：US20080081782A1

    公开(公告)日：2008-04-03

    申请号：US11529541

    申请日：2006-09-29

    申请人： Handong Li ,  Narayan Sundararajan

    发明人： Handong Li ,  Narayan Sundararajan

    IPC分类号： A61K38/16 ,  C07K14/475

    CPC分类号： C07K1/13 ,  C07K7/08

    摘要： The embodiments of the invention relate to a method for the introduction of a labeling structure such as a fluorescent molecules or a Raman tags to a compound. Imidazole functionalized resins or polymers are used to selectively immobilize phosphocompounds without protecting the carboxylic groups. Relying on the pKa difference between amines and hydrazides and carrying out the reaction in a slightly acidic buffer, all of the amines are protected by protonation while the hydrazides react with the phosphate imidazolide to form a phosphoramidate bond.

    摘要翻译： 本发明的实施方案涉及将化合物引入诸如荧光分子或拉曼标签的标记结构的方法。 咪唑官能化树脂或聚合物用于选择性地固定磷酸化合物而不保护羧基。 依赖于胺和酰肼之间的pKα差异并在微酸性缓冲液中进行反应，所有的胺都被质子化保护，而酰肼与磷酸咪唑化物反应形成氨基磷酸酯键。