公开(公告)号：US20100104843A1

公开(公告)日：2010-04-29

申请号：US12575090

申请日：2009-10-07

申请人： Aleksander J. Pyzik ,  Robert A. Newman ,  Mark A. Chartier ,  Amy Wetzel ,  Christopher N. Haney

发明人： Aleksander J. Pyzik ,  Robert A. Newman ,  Mark A. Chartier ,  Amy Wetzel ,  Christopher N. Haney

IPC分类号： B32B5/16 ,  C09K3/00

CPC分类号： C04B35/563 ,  C04B2235/3821 ,  C04B2235/402 ,  C04B2235/5436 ,  C04B2235/661

摘要： An improved aluminum-boron carbide (ABC) composite has been discovered that is comprised of a continuous network of AlB24C4 and boron carbide grains having therein other isolated aluminum-boron carbide reactive phases and at most 2% by volume of isolated metal. The improved ABC composite may be formed by forming boron carbide particulates into a porous body that has a porosity of at most about 35%, where the boron particulates have been heat treated to a temperature of 1200° C. to 1800° C., infiltrating the porous body with aluminum or aluminum alloy until an infiltrated aluminum-boron carbide body is formed that has at most about 1% porosity, heat treating the infiltrated body for at least 25 hours at 1000° C. to 1100° C. to form an aluminum boron carbide composite having a continuous network of AlB24C4 and boron carbide, and subsequently heat-treating to 700° C. to 900° C. to form the improved aluminum boron carbide composite.

摘要翻译： 已经发现了一种改进的碳化铝 - 碳化硼（ABC）复合材料，其由AlB24C4和碳化硼晶粒的连续网络组成，其中具有其它隔离的铝 - 碳化硼反应相和至多2体积％的隔离金属。 改进的ABC复合材料可以通过将碳化硼颗粒形成多孔体而形成，所述多孔体具有至多约35％的孔隙率，其中硼微粒被热处理至1200℃至1800℃，渗透 具有铝或铝合金的多孔体，直到形成渗透的铝 - 碳化硼体，其具有至多约1％的孔隙率，在1000℃至1100℃下将渗透体热处理至少25小时以形成 铝碳化硼复合材料，其具有AlB24C4和碳化硼的连续网络，并随后热处理至700℃至900℃以形成改进的碳化硼复合材料。

公开(公告)号：US20110312484A1

公开(公告)日：2011-12-22

申请号：US13223337

申请日：2011-09-01

申请人： Aleksander J. Pyzik ,  Robert A. Newman ,  Mark A. Chartier ,  Amy Wetzel ,  Christopher N. Haney

发明人： Aleksander J. Pyzik ,  Robert A. Newman ,  Mark A. Chartier ,  Amy Wetzel ,  Christopher N. Haney

IPC分类号： C04B35/563

CPC分类号： C04B35/563 ,  C04B2235/3821 ,  C04B2235/402 ,  C04B2235/5436 ,  C04B2235/661

摘要： An improved aluminum-boron carbide (ABC) composite has been discovered that is comprised of a continuous network of AlB24C4 and boron carbide grains having therein other isolated aluminum-boron carbide reactive phases and at most 2% by volume of isolated metal. The improved ABC composite may be formed by forming boron carbide particulates into a porous body that has a porosity of at most about 35%, where the boron particulates have been heat treated to a temperature of 1200° C. to 1800° C., infiltrating the porous body with aluminum or aluminum alloy until an infiltrated aluminum-boron carbide body is formed that has at most about 1% porosity, heat treating the infiltrated body for at least 25 hours at 1000° C. to 1100° C. to form an aluminum boron carbide composite having a continuous network of AlB24C4 and boron carbide, and subsequently heat-treating to 700° C. to 900° C. to form the improved aluminum boron carbide composite.

摘要翻译： 已经发现了一种改进的碳化铝 - 碳化硼（ABC）复合材料，其由AlB24C4和碳化硼晶粒的连续网络组成，其中具有其它隔离的铝 - 碳化硼反应相和至多2体积％的隔离金属。 改进的ABC复合材料可以通过将碳化硼颗粒形成多孔体而形成，所述多孔体具有至多约35％的孔隙率，其中硼微粒被热处理至1200℃至1800℃，渗透 具有铝或铝合金的多孔体，直到形成渗透的铝 - 碳化硼体，其具有至多约1％的孔隙率，在1000℃至1100℃下将渗透体热处理至少25小时，以形成 铝碳化硼复合材料，其具有AlB24C4和碳化硼的连续网络，并随后热处理至700℃至900℃以形成改进的碳化硼复合材料。

公开(公告)号：US20110104464A1

公开(公告)日：2011-05-05

申请号：US12994763

申请日：2009-06-03

申请人： Aleksander J. Pyzik ,  Robert A. Newman ,  Nicholas M. Shinkel ,  Clifford S. Todd ,  Amy Wetzel

发明人： Aleksander J. Pyzik ,  Robert A. Newman ,  Nicholas M. Shinkel ,  Clifford S. Todd ,  Amy Wetzel

IPC分类号： B05D3/12 ,  B32B15/20 ,  B32B3/26

CPC分类号： C04B35/5615 ,  C04B35/5618 ,  C04B35/71 ,  C04B41/009 ,  C04B41/5127 ,  C04B41/5155 ,  C04B41/88 ,  C04B2235/3843 ,  C04B2235/3891 ,  C04B2235/402 ,  C04B2235/405 ,  C04B2235/407 ,  C04B2235/608 ,  C04B2235/616 ,  C04B2235/6581 ,  C04B2235/6582 ,  C04B2235/75 ,  C04B2235/786 ,  C04B2235/788 ,  C04B2235/80 ,  C04B2235/85 ,  C04B2235/96 ,  C22C1/1036 ,  C22C29/06 ,  Y10T428/24992 ,  C04B41/4523

摘要： Densified composites of a metal such as copper or aluminum with a titanium-silicon-carbide or titanium-aluminum-carbide ceramic material are prepared by forming the ceramic material into a body, and infiltrating the body with the molten metal. The metal is able to rapidly penetrate into void spaces, between grain boundaries and even into the crystal structure of the ceramic grains to form a composite. The starting ceramic material may be previously densified, in which case various types of gradient structures can be produced easily. The process can be operated at low pressures, and so the hot pressing methods that normally must be used to densify these ceramic materials can be avoided.

摘要翻译： 通过将陶瓷材料形成体内并用熔融金属渗透身体，制备诸如铜或铝的金属与钛 - 碳化硅或钛 - 碳化铝陶瓷材料的致密复合材料。 该金属能够迅速地渗透到晶界之间的空隙，甚至陶瓷晶粒的晶体结构中，以形成复合材料。 起始陶瓷材料可以预先致密化，在这种情况下可以容易地生产各种类型的梯度结构。 该方法可以在低压下操作，因此可以避免通常必须用于致密化这些陶瓷材料的热压方法。

公开(公告)号：US08863816B2

公开(公告)日：2014-10-21

申请号：US12994763

申请日：2009-06-03

申请人： Aleksander J. Pyzik ,  Nicholas M. Shinkel ,  Robert A. Newman ,  Clifford S. Todd ,  Amy Wetzel

发明人： Aleksander J. Pyzik ,  Nicholas M. Shinkel ,  Robert A. Newman ,  Clifford S. Todd ,  Amy Wetzel

IPC分类号： B22D23/04 ,  C22C1/10 ,  C04B41/51 ,  C04B35/56 ,  C04B35/71 ,  C04B41/00 ,  C04B41/88 ,  C22C29/06

CPC分类号： C04B35/5615 ,  C04B35/5618 ,  C04B35/71 ,  C04B41/009 ,  C04B41/5127 ,  C04B41/5155 ,  C04B41/88 ,  C04B2235/3843 ,  C04B2235/3891 ,  C04B2235/402 ,  C04B2235/405 ,  C04B2235/407 ,  C04B2235/608 ,  C04B2235/616 ,  C04B2235/6581 ,  C04B2235/6582 ,  C04B2235/75 ,  C04B2235/786 ,  C04B2235/788 ,  C04B2235/80 ,  C04B2235/85 ,  C04B2235/96 ,  C22C1/1036 ,  C22C29/06 ,  Y10T428/24992 ,  C04B41/4523

摘要： Densified composites of a metal such as copper or aluminum with a titanium-silicon-carbide or titanium-aluminum-carbide ceramic material are prepared by forming the ceramic material into a body, and infiltrating the body with the molten metal. The metal is able to rapidly penetrate into void spaces, between grain boundaries and even into the crystal structure of the ceramic grains to form a composite. The starting ceramic material may be previously densified, in which case various types of gradient structures can be produced easily. The process can be operated at low pressures, and so the hot pressing methods that normally must be used to densify these ceramic materials can be avoided.

摘要翻译： 通过将陶瓷材料形成体内并用熔融金属渗透身体，制备诸如铜或铝的金属与钛 - 碳化硅或钛 - 碳化铝陶瓷材料的致密复合材料。 该金属能够迅速地渗透到晶界之间的空隙，甚至陶瓷晶粒的晶体结构中，以形成复合材料。 起始陶瓷材料可以预先致密化，在这种情况下可以容易地生产各种类型的梯度结构。 该方法可以在低压下操作，因此可以避免通常必须用于致密化这些陶瓷材料的热压方法。

公开(公告)号：US20060240500A1

公开(公告)日：2006-10-26

申请号：US10524237

申请日：2003-08-04

申请人： John Kopchick ,  Karen Coschigano ,  Amy Wetzel

发明人： John Kopchick ,  Karen Coschigano ,  Amy Wetzel

IPC分类号： A61K48/00 ,  A61K38/54 ,  C12Q1/62

CPC分类号： A01K67/0275 ,  A01K2217/05 ,  A01K2227/105 ,  A01K2267/03 ,  A61K38/00 ,  A61K38/177 ,  A61K38/465 ,  A61K38/53 ,  C07K14/47 ,  G01N2800/347

摘要： Various nucleic acids and proteins have been identified by differential hybridization methods as useful as markers for diagnosing kidney damage. The identified marker proteins include (I) androgen related protein, SON protein, FUSE binding Protein 1, claudin10, heat shock protein, phospho triesterase related protein, ubiquitin protein ligase Nedd-4, and Ac39/physophilin, and (II) disabled-2 p96, palmitylated serine/threonine kinase, tumor differentially expressed 1 protein, cytochrome oxidase III, TLH 39 protein precursor, hydroxysteroid dehydrogenase 4 delta -3 beta, and glutathione peroxidase III. The proteins of group (I), and antagonists of the proteins of group (II), are useful for protecting mammals against kidney damage.

摘要翻译： 已经通过差异杂交方法鉴定了各种核酸和蛋白质，作为用于诊断肾损伤的标记物。 鉴定的标记蛋白包括（I）雄激素相关蛋白，SON蛋白，FUSE结合蛋白1，claudin10，热休克蛋白，磷酸三酯酶相关蛋白，泛素蛋白连接酶Nedd-4和Ac39 / physophilin，和（II）残基-2 p96，棕榈酰丝氨酸/苏氨酸激酶，肿瘤差异表达1蛋白，细胞色素氧化酶III，TLH 39蛋白前体，羟基类固醇脱氢酶4Δ5β-3β和谷胱甘肽过氧化物酶III。 组（I）的蛋白质和组（II）的蛋白质的拮抗剂可用于保护哺乳动物免受肾损伤。