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公开(公告)号：US08466288B2
公开(公告)日：2013-06-18
申请号：US13349868
申请日：2012-01-13
申请人： Alex Aronov , Jon H. Come , Robert J. Davies , Albert Charles Pierce , Philip N. Collier , Ronald Lee Grey, Jr. , Hardwin O'Dowd , James A. Henderson , Elaine B. Krueger , Arnaud Le Tiran , Yusheng Liao , David Messersmith , Jian Wang , Suganthini S. Nanthakumar , Jingrong Cao , Upul Keerthi Bandarage , Anne-Laure Grillot
发明人： Alex Aronov , Jon H. Come , Robert J. Davies , Albert Charles Pierce , Philip N. Collier , Ronald Lee Grey, Jr. , Hardwin O'Dowd , James A. Henderson , Elaine B. Krueger , Arnaud Le Tiran , Yusheng Liao , David Messersmith , Jian Wang , Suganthini S. Nanthakumar , Jingrong Cao , Upul Keerthi Bandarage , Anne-Laure Grillot
IPC分类号： C07D471/02 , C07D213/04 , C07D401/00 , C07D401/02 , C12N9/99 , A61K31/437
CPC分类号： C07D409/14 , C07D401/04 , C07D401/14 , C07D405/14 , C07D417/14 , C07D471/04 , C07D471/20 , C07D491/20
摘要： The present invention relates to compounds useful as inhibitors of PI3K, particularly of PI3Kγ. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用作PI3K抑制剂，特别是PI3Kgamma的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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公开(公告)号：US20120202784A1
公开(公告)日：2012-08-09
申请号：US13349868
申请日：2012-01-13
申请人： Alex Aronov , Jon H. Come , Robert J. Davies , Albert Charles Pierce , Philip N. Collier , Ronald Lee Grey, JR. , Hardwin O'Dowd , James A. Henderson , Elaine B. Krueger , Arnaud Le Tiran , Yusheng Liao , David Messersmith , Jian Wang , Suganthini S. Nanthakumar , Jingrong Cao , Upul Keerthi Bandarage , Anne-Laure Grillot
发明人： Alex Aronov , Jon H. Come , Robert J. Davies , Albert Charles Pierce , Philip N. Collier , Ronald Lee Grey, JR. , Hardwin O'Dowd , James A. Henderson , Elaine B. Krueger , Arnaud Le Tiran , Yusheng Liao , David Messersmith , Jian Wang , Suganthini S. Nanthakumar , Jingrong Cao , Upul Keerthi Bandarage , Anne-Laure Grillot
IPC分类号： A61K31/437 , A61K31/5377 , C12N9/99 , A61K31/496 , A61K31/551 , C07D471/20 , C07D471/04 , C07D491/20
CPC分类号： C07D409/14 , C07D401/04 , C07D401/14 , C07D405/14 , C07D417/14 , C07D471/04 , C07D471/20 , C07D491/20
摘要： The present invention relates to compounds useful as inhibitors of PI3K, particularly of PI3Kγ. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用作PI3K抑制剂，特别是PI3Kγ的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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公开(公告)号：US20120040950A1
公开(公告)日：2012-02-16
申请号：US12974388
申请日：2010-12-21
申请人： Alex Aronov , Jon H. Come , Robert J. Davies , Albert Charles Pierce , Philip N. Collier , Ronald Lee Grey, JR. , Hardwin O'Dowd , James A. Henderson , Elaine B. Krueger , Arnaud Le Tiran , Yusheng Liao , David Messersmith , Jian Wang , Suganthini S. Nanthakumar , Jingrong Cao , Upul Keerthi Bandarage , Anne-Laure Grillot
发明人： Alex Aronov , Jon H. Come , Robert J. Davies , Albert Charles Pierce , Philip N. Collier , Ronald Lee Grey, JR. , Hardwin O'Dowd , James A. Henderson , Elaine B. Krueger , Arnaud Le Tiran , Yusheng Liao , David Messersmith , Jian Wang , Suganthini S. Nanthakumar , Jingrong Cao , Upul Keerthi Bandarage , Anne-Laure Grillot
IPC分类号： A61K31/4439 , C07D401/14 , A61K31/444 , C07D471/04 , A61K31/437 , C07D403/14 , A61K31/506 , C07D413/14 , A61K31/5377 , A61P37/00 , A61P29/00 , A61P25/00 , A61P25/08 , A61P25/16 , A61P25/28 , A61P25/14 , C12N9/99 , C07D401/10
CPC分类号： C07D409/14 , C07D401/04 , C07D401/14 , C07D405/14 , C07D417/14 , C07D471/04 , C07D471/20 , C07D491/20
摘要： The present invention relates to compounds useful as inhibitors of PI3K, particularly of PI3Kγ. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
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4.发明授权公开(公告)号：US08524906B2
公开(公告)日：2013-09-03
申请号：US13211502
申请日：2011-08-17
申请人： Alex Aronov , Upul Keerthi Bandarage , Kevin Michael Cottrell , Robert J. Davies , Elaine B. Krueger , Mark Willem Ledeboer , Brian Ledford , Arnaud Le Tiran , David Messersmith , Tiansheng Wang , Jinwang Xu , Yusheng Liao
发明人： Alex Aronov , Upul Keerthi Bandarage , Kevin Michael Cottrell , Robert J. Davies , Elaine B. Krueger , Mark Willem Ledeboer , Brian Ledford , Arnaud Le Tiran , David Messersmith , Tiansheng Wang , Jinwang Xu , Yusheng Liao
IPC分类号： A61K31/4365 , C07D513/04
CPC分类号： C07D513/04
摘要： The present invention relates to compounds useful as inhibitors of PI3K, particularly of PI3Kγ. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用作PI3K抑制剂，特别是PI3Kgamma的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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5.发明申请公开(公告)号：US20120039849A1
公开(公告)日：2012-02-16
申请号：US13211502
申请日：2011-08-17
申请人： Alex Aronov , Upul Keerthi Bandarage , Kevin Michael Cottrell , Robert J. Davies , Elaine B. Krueger , Mark Willem Ledeboer , Brian Ledford , Arnaud Le Tiran , David Messersmith , Tiansheng Wang , Jinwang Xu , Yusheng Liao
发明人： Alex Aronov , Upul Keerthi Bandarage , Kevin Michael Cottrell , Robert J. Davies , Elaine B. Krueger , Mark Willem Ledeboer , Brian Ledford , Arnaud Le Tiran , David Messersmith , Tiansheng Wang , Jinwang Xu , Yusheng Liao
IPC分类号： A61K31/437 , A61K31/497 , A61P25/00 , A61P29/00 , C12N9/99 , A61P37/06 , A61K38/21 , A61K38/07 , A61K39/395 , C07D471/04 , A61P37/02
CPC分类号： C07D513/04
摘要： The present invention relates to compounds useful as inhibitors of PI3K, particularly of PI3Kγ. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用作PI3K抑制剂，特别是PI3Kγ的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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公开(公告)号：US08344153B2
公开(公告)日：2013-01-01
申请号：US12796825
申请日：2010-06-09
申请人： Kevin Michael Cottrell , Alex Aronov , Robert J. Davies , Jon H. Come , David Messersmith , Jinwang Xu , Upul Keerthi Bandarage , Jingrong Cao
发明人： Kevin Michael Cottrell , Alex Aronov , Robert J. Davies , Jon H. Come , David Messersmith , Jinwang Xu , Upul Keerthi Bandarage , Jingrong Cao
IPC分类号： A61K31/425 , C07D277/00
CPC分类号： C07D417/06
摘要： The present invention relates to compounds useful as inhibitors of PI3K, particularly of PI3Kγ. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用作PI3K抑制剂，特别是PI3Kγ的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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公开(公告)号：US20120053187A1
公开(公告)日：2012-03-01
申请号：US13216606
申请日：2011-08-24
申请人： Alex Aronov , Jon H. Come , Kevin Michael Cottrell , Arnaud Le Tiran , Valerie Marone , Gabriel Martinez Botella , David Messersmith , Emilie Porter Huck , Ronald Lee Grey, JR.
发明人： Alex Aronov , Jon H. Come , Kevin Michael Cottrell , Arnaud Le Tiran , Valerie Marone , Gabriel Martinez Botella , David Messersmith , Emilie Porter Huck , Ronald Lee Grey, JR.
IPC分类号： A61K31/444 , A61K31/497 , C07D417/14 , C12N9/99 , A61P25/00 , A61P29/00 , A61P37/02 , A61P37/06 , C07D401/14 , A61K31/4439
CPC分类号： C07D417/14 , C07D417/04 , C07D513/04
摘要： The present invention relates to compounds useful as inhibitors of PI3K, particularly of PI3Kγ. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用作PI3K抑制剂，特别是PI3Kγ的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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公开(公告)号：US08268999B2
公开(公告)日：2012-09-18
申请号：US13216606
申请日：2011-08-24
申请人： Alex Aronov , Jon H. Come , Kevin Michael Cottrell , Arnaud Le Tiran , Valerie Marone , Gabriel Martinez Botella , David Messersmith , Emilie Porter Huck , Ronald Lee Grey, Jr.
发明人： Alex Aronov , Jon H. Come , Kevin Michael Cottrell , Arnaud Le Tiran , Valerie Marone , Gabriel Martinez Botella , David Messersmith , Emilie Porter Huck , Ronald Lee Grey, Jr.
IPC分类号： C07D401/10 , A61K31/497
CPC分类号： C07D417/14 , C07D417/04 , C07D513/04
摘要： The present invention relates to compounds useful as inhibitors of PI3K, particularly of PI3Kγ. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用作PI3K抑制剂，特别是PI3Kγ的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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公开(公告)号：US20110081316A1
公开(公告)日：2011-04-07
申请号：US12896042
申请日：2010-10-01
IPC分类号： A61K31/4439 , C07D401/06 , C07D401/14 , C07D403/10 , A61K31/498 , A61K31/4709 , A61P37/00 , A61P29/00 , A61P25/00 , A61K38/21 , A61K39/395 , C12N9/99
CPC分类号： C07D401/08 , C07D401/14 , C07D403/08
摘要： The present invention relates to compounds useful as inhibitors of PI3K, particularly of PI3Kγ. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用作PI3K抑制剂，特别是PI3Kγ的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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公开(公告)号：US20100316605A1
公开(公告)日：2010-12-16
申请号：US12796825
申请日：2010-06-09
IPC分类号： A61K38/21 , C07D417/14 , A61K31/4439 , C07D401/14 , A61K31/444 , C07D277/44 , A61K31/426 , A61K31/397 , A61K31/4545 , C07D241/42 , A61K31/498 , C07D215/12 , A61K31/4709 , C07D471/04 , A61K31/4375 , C07D413/14 , A61K31/5377 , A61K39/395 , A61P9/10 , A61P25/00 , A61P29/00 , A61P37/02 , C12N9/99
CPC分类号： C07D417/06
摘要： The present invention relates to compounds useful as inhibitors of PI3K, particularly of PI3Kγ. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用作PI3K抑制剂，特别是PI3Kγ的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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