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公开(公告)号：US09944649B2
公开(公告)日：2018-04-17
申请号：US15307510
申请日：2015-04-29
申请人： Alex Cortez , Timothy Hoffman , Yongkai Li , Tom Yao-Hsiang Wu , Xiaoyue Zhang
发明人： Alex Cortez , Timothy Hoffman , Yongkai Li , Tom Yao-Hsiang Wu , Xiaoyue Zhang
IPC分类号： C07D487/04 , A61K31/519 , A61P31/18 , A61P31/20 , A61P35/00 , A61P29/00 , A61P19/10 , A61P37/00
CPC分类号： C07D487/04
摘要： The invention provides a compounds, immunogenic compositions and pharmaceutical compositions comprising such compounds and methods of using such compounds to treat diseases or disorders associated with Toll-Like Receptor 7 activity.
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公开(公告)号：US20110053893A1
公开(公告)日：2011-03-03
申请号：US12874153
申请日：2010-09-01
申请人： Tom Yao Hsiang Wu , Yongkai Li , Alex Cortez , Kathy Yue , Xiaoyue Zhang , Manmohan Singh , David Skibinski
发明人： Tom Yao Hsiang Wu , Yongkai Li , Alex Cortez , Kathy Yue , Xiaoyue Zhang , Manmohan Singh , David Skibinski
IPC分类号： A61K31/675 , C07F9/38 , C07F9/42 , A61P31/00 , A61P11/00 , A61P17/00 , A61P19/02 , A61P29/00 , A61P31/18 , A61P35/00
CPC分类号： C07F9/6561 , C07D471/04
摘要： The invention provides a novel class of compounds, immunogenic compositions and pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with Toll-Like Receptors 7. In one aspect, the compounds are useful as adjuvants for enhancing the effectiveness of a vaccine.
摘要翻译： 本发明提供了一类新颖的化合物，免疫原性组合物和包含这些化合物的药物组合物以及使用这些化合物治疗或预防与Toll样受体7相关的疾病或病症的方法。一方面，该化合物可用作增强的佐剂 疫苗的有效性。
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公开(公告)号：US09315530B2
公开(公告)日：2016-04-19
申请号：US13820370
申请日：2011-09-01
申请人： Manmohan Singh , David A. G. Skibinski , Tom Yao-Hsiang Wu , Yongkai Li , Alex Cortez , Xiaoyue Zhang , Yefen Zou , Timothy Z. Hoffman , Jianfeng Pan , Kathy Yue
发明人： Manmohan Singh , David A. G. Skibinski , Tom Yao-Hsiang Wu , Yongkai Li , Alex Cortez , Xiaoyue Zhang , Yefen Zou , Timothy Z. Hoffman , Jianfeng Pan , Kathy Yue
IPC分类号： A61K39/39 , C07F9/6561 , A61K31/661 , A61K31/6615 , A61K31/662 , A61K39/095 , C07D471/04 , C07D487/04 , C07F9/645 , C07F9/6512 , C07F9/6558 , A61K39/00
CPC分类号： A61K39/39 , A61K31/661 , A61K31/6615 , A61K31/662 , A61K39/02 , A61K39/05 , A61K39/08 , A61K39/092 , A61K39/095 , A61K39/13 , A61K39/145 , A61K39/292 , A61K2039/55505 , A61K2039/55511 , C07D471/04 , C07D487/04 , C07F9/645 , C07F9/6512 , C07F9/65583 , C07F9/6561 , C07F9/65616 , Y02A50/466
摘要： Immunopotentiators can be adsorbed to insoluble metal salts, such as aluminum salts, to modify their pharmacokinetics, pharmacodynamics, intramuscular retention time, and/or immunostimulatory effect. Immunopotentiators are modified to introduce a moiety, such as a phosphonate group, which can mediate adsorption. These modified compounds can retain or improve their in vivo immunological activity even when delivered in an adsorbed form.
摘要翻译： 可以将免疫增强剂吸附到不溶性金属盐如铝盐上，以改变其药代动力学，药效学，肌内留置时间和/或免疫刺激作用。 修饰免疫增强剂以引入可介导吸附的部分，例如膦酸酯基团。 即使以吸附形式递送，这些改性化合物也可以保留或改善其体内免疫活性。
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公开(公告)号：US20110081365A1
公开(公告)日：2011-04-07
申请号：US12921129
申请日：2009-02-27
申请人： Alex Cortez , Yongkai Li , Pranab Mishra , Manmohan Singh , David Skibinski , Nicholas Valiante , Tom Yao-Hsiang Wu , Xiaoyue Zhang , Yefen Zou
发明人： Alex Cortez , Yongkai Li , Pranab Mishra , Manmohan Singh , David Skibinski , Nicholas Valiante , Tom Yao-Hsiang Wu , Xiaoyue Zhang , Yefen Zou
IPC分类号： A61K39/00 , C07D471/04 , C07D495/04 , C07D413/14 , C07D239/70 , A61K31/438 , A61K31/4985 , A61K31/5377 , A61K31/519 , A61P37/02 , A61P11/06 , A61P37/04
CPC分类号： C07D471/04 , C07D221/12 , C07D471/14 , C07D491/056 , C07D495/04
摘要： The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with Toll-Like Receptors, including TLR7 and TLR8. In one aspect, the compounds are useful as adjuvants for enhancing the effectiveness of a vaccine (formula I) wherein: X3 is N; X4 is N Or CR3; X5 is —CR4═CR5.
摘要翻译： 本发明提供了一类新颖的化合物，包含这些化合物的药物组合物和使用这些化合物治疗或预防与Toll样受体（包括TLR7和TLR8）相关的疾病或病症的方法。 一方面，所述化合物可用作增强疫苗（式I）有效性的佐剂，其中：X3为N; X4是N或CR3; X5是-CR4 = CR5。
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公开(公告)号：US08466167B2
公开(公告)日：2013-06-18
申请号：US12921129
申请日：2009-02-27
申请人： Tom Yao Hsiang Wu , Yongkai Li , Alex Cortez , Yefen Zou , Pranab Mishra , Xiaoyue Zhang , David Skibinski , Manmohan Singh , Nicholas Valiante
发明人： Tom Yao Hsiang Wu , Yongkai Li , Alex Cortez , Yefen Zou , Pranab Mishra , Xiaoyue Zhang , David Skibinski , Manmohan Singh , Nicholas Valiante
IPC分类号： A61K31/44 , C07D471/00
CPC分类号： C07D471/04 , C07D221/12 , C07D471/14 , C07D491/056 , C07D495/04
摘要： The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with Toll-Like Receptors, including TLR7 and TLR8. In one aspect, the compounds are useful as adjuvants for enhancing the effectiveness of a vaccine (formula I) wherein: X3 is N; X4 is N Or CR3; X5 is —CR4═CR5.
摘要翻译： 本发明提供了一类新颖的化合物，包含这些化合物的药物组合物和使用这些化合物治疗或预防与Toll样受体（包括TLR7和TLR8）相关的疾病或病症的方法。 一方面，所述化合物可用作增强疫苗（式I）有效性的佐剂，其中：X3为N; X4是N或CR3; X5是-CR4 = CR5。
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公开(公告)号：US09045470B2
公开(公告)日：2015-06-02
申请号：US12874153
申请日：2010-09-01
申请人： Tom Yao Hsiang Wu , Yongkai Li , Alex Cortez , Kathy Yue , Xiaoyue Zhang , Manmohan Singh , David Skibinski
发明人： Tom Yao Hsiang Wu , Yongkai Li , Alex Cortez , Kathy Yue , Xiaoyue Zhang , Manmohan Singh , David Skibinski
IPC分类号： A01N61/00 , A61K31/00 , A01N57/00 , A61K31/675 , C07D471/04
CPC分类号： C07F9/6561 , C07D471/04
摘要： The invention provides a novel class of compounds, immunogenic compositions and pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with Toll-Like Receptors 7. In one aspect, the compounds are useful as adjuvants for enhancing the effectiveness of a vaccine.
摘要翻译： 本发明提供了一类新颖的化合物，免疫原性组合物和包含这些化合物的药物组合物以及使用这些化合物治疗或预防与Toll样受体7相关的疾病或病症的方法。一方面，该化合物可用作增强的佐剂 疫苗的有效性。
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公开(公告)号：US20120177681A1
公开(公告)日：2012-07-12
申请号：US13223793
申请日：2011-09-01
申请人： Manmohan Singh , David A.G. Skibinski , Tom Yao-Hsiang Wu , Yongkai Li , Alex Cortez , Xiaoyue Zhang , Yefen Zou , Timothy Z. Hoffman , Jianfeng Pan , Kathy Yue
发明人： Manmohan Singh , David A.G. Skibinski , Tom Yao-Hsiang Wu , Yongkai Li , Alex Cortez , Xiaoyue Zhang , Yefen Zou , Timothy Z. Hoffman , Jianfeng Pan , Kathy Yue
IPC分类号： A61K39/39 , C07F9/6512 , A61K31/675 , A61P31/12 , C07F9/553 , C07F9/645 , A61P37/04 , A61P31/04 , C07F9/6561 , C07F9/38
CPC分类号： C07F9/6561 , A61K31/661 , A61K31/6615 , A61K31/662 , A61K39/02 , A61K39/05 , A61K39/08 , A61K39/092 , A61K39/095 , A61K39/13 , A61K39/145 , A61K39/292 , A61K39/39 , A61K2039/55505 , A61K2039/55511 , C07D471/04 , C07D487/04 , C07F9/645 , C07F9/6512 , C07F9/65583 , C07F9/65616 , Y02A50/466
摘要： Immunopotentiators can be adsorbed to insoluble metal salts, such as aluminium salts, to modify their pharmacokinetics, pharmacodynamics, intramuscular retention time, and/or immunostimulatory effect. Immunopotentiators are modified to introduce a moiety, such as a phosphonate group, which can mediate adsorption. These modified compounds can retain or improve their in vivo immunological activity even when delivered in an adsorbed form.
摘要翻译： 可以将免疫增强剂吸附到不溶性金属盐如铝盐上，以改变其药代动力学，药效学，肌内留置时间和/或免疫刺激作用。 修饰免疫增强剂以引入可介导吸附的部分，例如膦酸酯基团。 即使以吸附形式递送，这些改性化合物也可以保留或改善其体内免疫活性。
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公开(公告)号：US20150225432A1
公开(公告)日：2015-08-13
申请号：US14696165
申请日：2015-04-24
申请人： Alex Cortez , Yongkai Li , Manmohan Singh , David Skibinski , Kathy Yue , Tom Yao-Hsiang Wu , Xiaoyue Zhang
发明人： Alex Cortez , Yongkai Li , Manmohan Singh , David Skibinski , Kathy Yue , Tom Yao-Hsiang Wu , Xiaoyue Zhang
IPC分类号： C07F9/6561
CPC分类号： C07F9/6561 , C07D471/04
摘要： The invention provides a novel class of compounds, immunogenic compositions and pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with Toll-Like Receptors 7. In one aspect, the compounds are useful as adjuvants for enhancing the effectiveness of a vaccine.
摘要翻译： 本发明提供了一类新颖的化合物，免疫原性组合物和包含这些化合物的药物组合物以及使用这些化合物治疗或预防与Toll样受体7相关的疾病或病症的方法。一方面，该化合物可用作增强的佐剂 疫苗的有效性。
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公开(公告)号：US08895577B2
公开(公告)日：2014-11-25
申请号：US13867752
申请日：2013-04-22
申请人： Tom Yao-Hsiang Wu , Yongkai Li , Alex Cortez , Yefen Zou , Pranab Mishra , Xiaoyue Zhang , Nicholas Valiante
发明人： Tom Yao-Hsiang Wu , Yongkai Li , Alex Cortez , Yefen Zou , Pranab Mishra , Xiaoyue Zhang , Nicholas Valiante
IPC分类号： A61K31/44 , C07D491/056 , C07D495/04 , C07D221/12 , C07D471/04 , C07D471/14
CPC分类号： C07D471/04 , C07D221/12 , C07D471/14 , C07D491/056 , C07D495/04
摘要： The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with Toll-Like Receptors, including TLR7 and TLR8. In one aspect, the compounds are useful as adjuvants for enhancing the effectiveness of a vaccine (formula I) wherein: X3 is N; X4 is N Or CR3; X5 is —CR4═CR5.
摘要翻译： 本发明提供了一类新颖的化合物，包含这些化合物的药物组合物和使用这些化合物治疗或预防与Toll样受体（包括TLR7和TLR8）相关的疾病或病症的方法。 一方面，所述化合物可用作增强疫苗（式I）有效性的佐剂，其中：X3为N; X4是N或CR3; X5是-CR4 = CR5。
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公开(公告)号：US20130274465A1
公开(公告)日：2013-10-17
申请号：US13820370
申请日：2011-09-01
申请人： Manmohan Singh , David A.G. Skibinski , Tom Yao-Hsiang Wu , Yongkai Li , Alex Cortez , Xiaoyue Zhang , Yefen Zou , Timothy Z. Hoffman , Jianfeng Pan , Kathy Yue
发明人： Manmohan Singh , David A.G. Skibinski , Tom Yao-Hsiang Wu , Yongkai Li , Alex Cortez , Xiaoyue Zhang , Yefen Zou , Timothy Z. Hoffman , Jianfeng Pan , Kathy Yue
IPC分类号： C07F9/6561 , C07F9/645 , C07F9/6558 , C07F9/6512
CPC分类号： A61K39/39 , A61K31/661 , A61K31/6615 , A61K31/662 , A61K39/02 , A61K39/05 , A61K39/08 , A61K39/092 , A61K39/095 , A61K39/13 , A61K39/145 , A61K39/292 , A61K2039/55505 , A61K2039/55511 , C07D471/04 , C07D487/04 , C07F9/645 , C07F9/6512 , C07F9/65583 , C07F9/6561 , C07F9/65616 , Y02A50/466
摘要： Immunopotentiators can be adsorbed to insoluble metal salts, such as aluminium salts, to modify their pharmacokinetics, pharmacodynamics, intramuscular retention time, and/or immunostimulatory effect. Immunopotentiators are modified to introduce a moiety, such as a phosphonate group, which can mediate adsorption. These modified compounds can retain or improve their in vivo immunological activity even when delivered in an adsorbed form.
摘要翻译： 可以将免疫增强剂吸附到不溶性金属盐如铝盐上，以改变其药代动力学，药效学，肌内留置时间和/或免疫刺激作用。 修饰免疫增强剂以引入可介导吸附的部分，例如膦酸酯基团。 即使以吸附形式递送，这些改性化合物也可以保留或改善其体内免疫活性。
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