EHV-1 vectors
    1.
    发明授权
    EHV-1 vectors 失效
    EHV-1载体

    公开(公告)号:US06706515B2

    公开(公告)日:2004-03-16

    申请号:US10100548

    申请日:2002-03-18

    IPC分类号: C12N701

    摘要: The invention relates to manipulation of equine herpes virus for use in gene therapy and in particular to modifications of the virus so that it can carry heterologous material and furthermore, preferably, be replication deficient so that the virus cannot replicate in the target tissue.

    摘要翻译: 本发明涉及用于基因治疗的马疱疹病毒的操作,特别是涉及病毒的修饰以使其能够携带异源物质,此外,优选为复制缺陷型,使得病毒不能在靶组织中复制。

    HIV vaccine
    2.
    发明授权
    HIV vaccine 失效
    艾滋病毒疫苗

    公开(公告)号:US06692955B1

    公开(公告)日:2004-02-17

    申请号:US09856652

    申请日:2001-07-16

    IPC分类号: C12N1574

    摘要: A herpesvirus saimiri (HVS) vector which has inserted therein at least a part of a gene encoding an envelope protein of HIV for use in delivering said protein to a specific cell population such as T cell lymphocytes and/or macrophages. The invention also provides a vaccine comprising the recombinant vector.

    摘要翻译: 已经插入其中的至少一部分编码HIV包膜蛋白的基因的疱疹病毒simiri(HVS)载体用于将所述蛋白质递送到特定细胞群体例如T细胞淋巴细胞和/或巨噬细胞。 本发明还提供了包含重组载体的疫苗。

    Herpesvirus saimiri as viral vector
    3.
    发明授权
    Herpesvirus saimiri as viral vector 失效
    疱疹病毒saimiri作为病毒载体

    公开(公告)号:US06379967B1

    公开(公告)日:2002-04-30

    申请号:US09254326

    申请日:1999-03-04

    IPC分类号: C12N15869

    摘要: The invention relates to herpesvirus saimiri viruses that are genetically modified by mutations and/or deleting specific essential and non-essential genes. The essential genes are required in replication of viral genes and are needed for viral proliferation. The non-essential genes can represent sites for the insertion of heterologous genetic material.

    摘要翻译: 本发明涉及通过突变和/或删除特定基本和非必需基因进行遗传修饰的疱疹病毒赛米里病毒。 病毒基因的复制需要基本的基因,是病毒增殖所必需的。 非必需基因可以代表用于插入异源遗传物质的位点。

    EHV-1 vectors
    4.
    发明授权
    EHV-1 vectors 失效
    EHV-1载体

    公开(公告)号:US06387685B1

    公开(公告)日:2002-05-14

    申请号:US09319976

    申请日:1999-09-07

    IPC分类号: C12N700

    摘要: The invention relates to manipulation of equine herpes virus for use in gene therapy and in particular to modifications of the virus so that it can carry heterologous material and furthermore, preferably, be replication deficient so that the virus cannot replicate in the target tissue.

    摘要翻译: 本发明涉及用于基因治疗的马疱疹病毒的操作,特别是涉及病毒的修饰以使其能够携带异源物质,此外,优选为复制缺陷型,使得病毒不能在靶组织中复制。