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    DEVICE AND METHOD FOR FILTERING ONE OR MORE PARTICLES TO BE DETECTED FROM A FLUID
    1.
    发明申请
    DEVICE AND METHOD FOR FILTERING ONE OR MORE PARTICLES TO BE DETECTED FROM A FLUID 审中-公开
    用于过滤一种或多种待从流体中检测的颗粒的装置和方法

    公开(公告)号：US20110076754A1

    公开(公告)日：2011-03-31

    申请号：US12893122

    申请日：2010-09-29

    申请人： Alexander Frey ,  Karsten Hiltawsky ,  Daniel Sickert

    发明人： Alexander Frey ,  Karsten Hiltawsky ,  Daniel Sickert

    IPC分类号： C12M1/00 ,  B01D21/26 ,  B81B1/00 ,  B81B7/04

    CPC分类号： B01D45/12 ,  B01D21/0087 ,  B01D21/265 ,  B01D2221/10 ,  B01L3/502753 ,  B01L2300/0816 ,  B01L2300/0883 ,  B01L2400/0409 ,  G01N1/4077 ,  G01N33/54366

    摘要： A device is disclosed for filtering a particle to be detected from a fluid. In at least one embodiment, the device includes a substrate and, applied above it, a protective layer, a channel being disposed between them for the purpose of receiving a fluid containing different particles. In at least one embodiment, the channel extends at least partially in a spiral shape between its inlet and outlet and on its internal wall contains a coating for attracting a particle type to be filtered, which coating is applied at least on the radially outside subsection of the internal wall of the channel. Owing to the laminar longitudinal movement of the fluid inside the channel a radially outward directed centrifugal force acts on the particles, with the result that per time unit more particles come into contact with the radially outside subsection of the internal wall of the channel than the radially inside subsection of the internal wall of the channel. The filter effect is reinforced as a result.

    摘要翻译： 公开了一种用于从流体过滤待检测的颗粒的装置。 在至少一个实施例中，该装置包括衬底，并且在其上施加保护层，通道设置在它们之间，以便接收含有不同颗粒的流体。 在至少一个实施例中，通道至少部分地在其入口和出口之间以螺旋形状延伸，并且在其内壁上包含用于吸引要过滤的颗粒类型的涂层，该涂层至少施加在径向外侧的子部分 通道的内壁。 由于流体在通道内的层流纵向移动，径向向外定向的离心力作用在颗粒上，结果是每个时间单位更多的颗粒与通道的内壁的径向外部子部分接触，而不是径向 通道内壁的内部子部分。 因此，过滤效果得到加强。

    Method for Functionalizing Biosensor Chips
    5.
    发明申请
    Method for Functionalizing Biosensor Chips 有权
    功能化生物传感器芯片的方法

    公开(公告)号：US20080199974A1

    公开(公告)日：2008-08-21

    申请号：US11587058

    申请日：2005-03-18

    申请人： Alexander Frey ,  Franz Hofmann ,  Petra Schindler-Bauer

    发明人： Alexander Frey ,  Franz Hofmann ,  Petra Schindler-Bauer

    IPC分类号： H01L21/027

    CPC分类号： G01N33/54366 ,  G01N27/3277

    摘要： A met4hod is disclosed for functionalizing biosensors. The biosensors are based on semiconductor chips mounted on a finished processed wafer. They are provided with sensor fields placed thereupon, which are arranged in any array, and, to be precise, for carrying out a functionalization, for example, with organic molecules such as nucleic acids like DNA, RNA and PNA or with their derivatives, proteins, sugar molecules, or antibodies.

    摘要翻译： 公开了用于功能化生物传感器的met4hod。 生物传感器基于安装在成品加工晶片上的半导体芯片。 它们设置有放置在其上的传感器场，其被布置成任何阵列，并且准确地，用于进行功能化，例如用有机分子例如核酸如DNA，RNA和PNA或其衍生物，蛋白质 ，糖分子或抗体。

    Switching Circuit Arrangement
    6.
    发明申请
    Switching Circuit Arrangement 审中-公开
    开关电路布置

    公开(公告)号：US20080151088A1

    公开(公告)日：2008-06-26

    申请号：US11596005

    申请日：2005-05-12

    申请人： Alexander Frey ,  Meinrad Schienle ,  Roland Thewes

    发明人： Alexander Frey ,  Meinrad Schienle ,  Roland Thewes

    IPC分类号： H04N5/335 ,  H04N3/14

    CPC分类号： G01N27/3275 ,  G01N33/4836 ,  G09G2310/0297

    摘要： A switching circuit arrangement is disclosed. The arrangement includes a substrate, a plurality of functional units arranged on the substrate, a plurality of selection line groups including selection lines, a plurality of signal line groups including signal lines, a buffer unit for each signal line group, a selection unit which is coupled to the selection line groups, and a signal unit which is coupled to the signal lines.

    摘要翻译： 公开了一种开关电路装置。 该布置包括基板，布置在基板上的多个功能单元，包括选择线的多个选择线组，包括信号线的多个信号线组，每个信号线组的缓冲单元，选择单元 耦合到选择线组，以及耦合到信号线的信号单元。

    Circuit arrangement, electrochemical sensor, sensor arrangement, and method for processing a current signal provided via a sensor electrode
    7.
    发明授权
    Circuit arrangement, electrochemical sensor, sensor arrangement, and method for processing a current signal provided via a sensor electrode 有权
    电路布置，电化学传感器，传感器布置和用于处理经由传感器电极提供的电流信号的方法

    公开(公告)号：US07123029B2

    公开(公告)日：2006-10-17

    申请号：US10913706

    申请日：2004-08-05

    申请人： Alexander Frey ,  Christian Paulus ,  Meinrad Schienle ,  Roland Thewes

    发明人： Alexander Frey ,  Christian Paulus ,  Meinrad Schienle ,  Roland Thewes

    IPC分类号： G01R27/26 ,  G01N27/26

    CPC分类号： G01N27/3276

    摘要： Circuit arrangement having a sensor electrode, a first circuit unit, which is electrically coupled to the sensor electrode, and a second circuit unit, which has a first capacitor. The first circuit unit holds an electrical potential of the sensor electrode in a predetermined first reference range around a predetermined electrical desired potential by coupling the first capacitor and the sensor electrode such that there is a matching of their electrical potentials. If the second circuit unit detects the electrical potential of the first capacitor being outside a second reference range, the second circuit unit brings the first capacitor to a first electrical reference potential.

    摘要翻译： 具有传感器电极，电耦合到传感器电极的第一电路单元和具有第一电容器的第二电路单元的电路装置。 第一电路单元通过将第一电容器和传感器电极耦合使得存在与它们的电位相匹配的方式，将传感器电极的电位保持在预定的电气期望电位周围的预定的第一参考范围内。 如果第二电路单元检测到第一电容器的电位在第二参考范围之外，则第二电路单元将第一电容器引入第一电参考电位。

    Biosensors array and method for operating a biosensor array
    8.
    发明申请
    Biosensors array and method for operating a biosensor array 有权
    用于操作生物传感器阵列的生物传感器阵列和方法

    公开(公告)号：US20050247559A1

    公开(公告)日：2005-11-10

    申请号：US11019948

    申请日：2004-12-21

    申请人： Alexander Frey ,  Franz Hofmann ,  Birgit Holzapfl ,  Christian Paulus ,  Meinrad Schienle ,  Roland Thewes

    发明人： Alexander Frey ,  Franz Hofmann ,  Birgit Holzapfl ,  Christian Paulus ,  Meinrad Schienle ,  Roland Thewes

    IPC分类号： G01N33/53 ,  G01N27/02 ,  G01N27/327 ,  G01N27/403 ,  G01N27/416 ,  G01N33/487 ,  G01N37/00 ,  G01N27/26

    CPC分类号： G01N27/3276

    摘要： A biosensor array having a substrate, a plurality of biosensor zones arranged on the substrate, each of which has a first terminal and a second terminal, at least one drive line and at least one detection line, the at least one drive line being electrically insulated from the at least one detection line. In each case the first terminal of each biosensor zone is coupled to precisely one of the at least one drive line and the second terminal of each biosensor zone is coupled to precisely one of the at least one detection line, and at least one of the at least one drive line and at least one of the at least one detection line is coupled to at least two of the biosensor zones. The biosensor array also has a drive unit for providing an electrical drive signal, a detection unit for detecting an electrical detection signal resulting from the electrical drive signal, and a selection unit that couples the drive unit to the drive line of a biosensor zone to be selected and the detection unit to the detection line of the biosensor zone to be selected, whereby the biosensor zone is selected.

    摘要翻译： 一种具有衬底的生物传感器阵列，布置在所述衬底上的多个生物传感器区域，每个生物传感器区域具有第一端子和第二端子，至少一条驱动线路和至少一条检测线路，所述至少一条驱动线路电绝缘 从所述至少一个检测线。 在每种情况下，每个生物传感器区域的第一端子被精确地耦合到至少一条驱动线路中的一条，并且每个生物传感器区域的第二端口精确地耦合到至少一条检测线路中的至少一条， 至少一个驱动线和所述至少一个检测线中的至少一个耦合到所述生物传感器区域中的至少两个。 生物传感器阵列还具有用于提供电驱动信号的驱动单元，用于检测由电驱动信号产生的电检测信号的检测单元，以及将驱动单元与生物传感器区域的驱动线连接的选择单元， 将选择的检测单元和生物传感器区域的检测线进行选择，从而选择生物传感器区域。

    Sensor arrangement and method for operating a sensor arrangement
    9.
    发明申请
    Sensor arrangement and method for operating a sensor arrangement 有权
    用于操作传感器装置的传感器布置和方法

    公开(公告)号：US20050194250A1

    公开(公告)日：2005-09-08

    申请号：US11002736

    申请日：2004-12-02

    申请人： Alexander Frey ,  Christian Paulus ,  Meinrad Schienle ,  Roland Thewes

    发明人： Alexander Frey ,  Christian Paulus ,  Meinrad Schienle ,  Roland Thewes

    IPC分类号： C12M1/00 ,  C12Q1/68 ,  G01N1/00 ,  G01N27/02

    CPC分类号： C12M1/00 ,  C12Q1/6837 ,  G01N1/00 ,  G01N27/3276 ,  C12Q2565/607

    摘要： Sensor arrangement, set up as an integrated circuit, having a substrate, at least three sensor electrodes arranged on the substrate such that, in an operating state in which an electrically conductive substance is introduced into the sensor arrangement, the sensor electrodes are coupled to one another by means of the electrically conductive substance, capture molecules immobilized on at least a portion of the sensor electrodes, wherein molecules to be detected can hybridize with the capture molecules, a control circuit for applying a first electrical signal to a selected sensor electrode and simultaneously applying a second electrical signal to at least two of the other sensor electrodes, the first electrical signal being a first temporally variable electrical signal and/or the second electrical signal being a second temporally variable electrical signal, a detection device, which is set up such that, in a first operating state, in which a reference liquid is introduced into the sensor arrangement, a reference value of a third temporally variable electrical signal resulting from the first temporally variable electrical signal and/or from the second temporally variable electrical signal is detected at the selected sensor electrode, and in a second operating state, in which an analyte possibly having molecules to be detected is introduced into the sensor arrangement, a sensor value of the third temporally variable electrical signal resulting from the first temporally variable electrical signal and/or from the second temporally variable electrical signal is detected at the selected sensor electrode, and an evaluation circuit, which, on the basis of the reference value and the sensor value, determines whether a hybridization event has taken place at the selected sensor electrode.

    摘要翻译： 设置为集成电路的传感器布置，具有衬底，布置在衬底上的至少三个传感器电极，使得在将导电物质引入传感器装置的操作状态下，传感器电极耦合到一个 另一个通过导电物质捕获固定在传感器电极的至少一部分上的分子，其中待检测的分子可与捕获分子杂交;控制电路，用于将第一电信号施加到所选择的传感器电极，同时 将第二电信号施加到至少两个其它传感器电极，所述第一电信号是第一时间可变电信号和/或所述第二电信号是第二时间可变电信号，所述检测装置被设置为 在第一操作状态下，将参考液体引入到传感器中 在所选择的传感器电极处检测由第一时间可变电信号和/或来自第二时间可变电信号产生的第三时间可变电信号的参考值，并且在第二操作状态中，分析物可能 将要检测的分子引入传感器装置中，在所选择的传感器电极处检测由第一时间可变电信号和/或来自第二时间可变电信号产生的第三时间可变电信号的传感器值， 评估电路，其基于参考值和传感器值确定在所选择的传感器电极处是否发生杂交事件。