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    DEVICE AND METHOD FOR FILTERING ONE OR MORE PARTICLES TO BE DETECTED FROM A FLUID
    3.
    发明申请
    DEVICE AND METHOD FOR FILTERING ONE OR MORE PARTICLES TO BE DETECTED FROM A FLUID 审中-公开
    用于过滤一种或多种待从流体中检测的颗粒的装置和方法

    公开(公告)号：US20110076754A1

    公开(公告)日：2011-03-31

    申请号：US12893122

    申请日：2010-09-29

    申请人： Alexander Frey ,  Karsten Hiltawsky ,  Daniel Sickert

    发明人： Alexander Frey ,  Karsten Hiltawsky ,  Daniel Sickert

    IPC分类号： C12M1/00 ,  B01D21/26 ,  B81B1/00 ,  B81B7/04

    CPC分类号： B01D45/12 ,  B01D21/0087 ,  B01D21/265 ,  B01D2221/10 ,  B01L3/502753 ,  B01L2300/0816 ,  B01L2300/0883 ,  B01L2400/0409 ,  G01N1/4077 ,  G01N33/54366

    摘要： A device is disclosed for filtering a particle to be detected from a fluid. In at least one embodiment, the device includes a substrate and, applied above it, a protective layer, a channel being disposed between them for the purpose of receiving a fluid containing different particles. In at least one embodiment, the channel extends at least partially in a spiral shape between its inlet and outlet and on its internal wall contains a coating for attracting a particle type to be filtered, which coating is applied at least on the radially outside subsection of the internal wall of the channel. Owing to the laminar longitudinal movement of the fluid inside the channel a radially outward directed centrifugal force acts on the particles, with the result that per time unit more particles come into contact with the radially outside subsection of the internal wall of the channel than the radially inside subsection of the internal wall of the channel. The filter effect is reinforced as a result.

    摘要翻译： 公开了一种用于从流体过滤待检测的颗粒的装置。 在至少一个实施例中，该装置包括衬底，并且在其上施加保护层，通道设置在它们之间，以便接收含有不同颗粒的流体。 在至少一个实施例中，通道至少部分地在其入口和出口之间以螺旋形状延伸，并且在其内壁上包含用于吸引要过滤的颗粒类型的涂层，该涂层至少施加在径向外侧的子部分 通道的内壁。 由于流体在通道内的层流纵向移动，径向向外定向的离心力作用在颗粒上，结果是每个时间单位更多的颗粒与通道的内壁的径向外部子部分接触，而不是径向 通道内壁的内部子部分。 因此，过滤效果得到加强。

    APPARATUS AND METHOD FOR ACQUIRING, DETECTING, AND ANALYZING CELLS IN A MICROFLUIDIC SYSTEM
    4.
    发明申请
    APPARATUS AND METHOD FOR ACQUIRING, DETECTING, AND ANALYZING CELLS IN A MICROFLUIDIC SYSTEM 审中-公开
    在微流感系统中获取，检测和分析细胞的装置和方法

    公开(公告)号：US20110076684A1

    公开(公告)日：2011-03-31

    申请号：US12880379

    申请日：2010-09-13

    申请人： Alexander FREY ,  Karsten Hiltawsky ,  Daniel Sickert

    发明人： Alexander FREY ,  Karsten Hiltawsky ,  Daniel Sickert

    IPC分类号： C12Q1/68 ,  C12M1/34 ,  G01N33/53 ,  G01N33/574 ,  C12Q1/02

    CPC分类号： G01N33/57492 ,  B01L3/502761 ,  B01L2200/0647 ,  B01L2200/10 ,  B01L2300/0809 ,  B01L2300/0877 ,  B01L2400/0487 ,  G01N33/56966

    摘要： An apparatus is disclosed for acquiring, detecting, and, optionally, analyzing cells in a biological liquid, which apparatus has a microfluidic system. In at least one embodiment, the apparatus includes at least one microfluidic channel having a small cross-section which is completely or partially coated with cell-specific binding molecules and which has no flow obstacles dividing the fluid flow; at least one apparatus for generating a steady and alterable liquid flow through the microfluidic channel, and optionally at least one apparatus for analyzing the genetic information of the cell. In at least one embodiment, the method includes a sample of a biological liquid being conducted through an apparatus defined above at a defined velocity V1 so that cells possibly present in the sample are bound to the cell-specific binding molecules; the sample of the biological liquid and/or a suitable liquid being conducted one or more times through the apparatus at a (different) defined velocity V2 so that nonspecifically bound constituents of the sample are removed; the cells bound to the cell-specific binding molecules being appropriately detected; and optionally the cells bound in the channel being released and the genetic information of the cells being optionally analyzed, with the ratio of the velocities, V1:V2, being in the range from 1:5 to 1:10.

    摘要翻译： 公开了用于获取，检测和可选地分析生物液体中的细胞的装置，该装置具有微流体系统。 在至少一个实施方案中，该装置包括至少一个具有小截面的微流体通道，其完全或部分涂覆有细胞特异性结合分子，并且没有流动障碍物分流流体流动; 用于产生通过微流体通道的稳定和可变的液体流的至少一个装置，以及可选地用于分析细胞的遗传信息的至少一个装置。 在至少一个实施方案中，该方法包括以限定的速度V1通过上述设备传导的生物液体的样品，使得可能存在于样品中的细胞与细胞特异性结合分子结合; 生物液体样品和/或合适的液体以（不同的）限定速度V2进行一次或多次穿过设备，从而去除样品的非特异性结合的成分; 与细胞特异性结合分子结合的细胞被适当地检测; 并且可选地，在通道中结合的细胞被释放，并且可选地分析细胞的遗传信息，速度比V1：V2在1:5至1:10的范围内。

    DEVICE AND METHOD TO EXTRACT MATERIAL OF A MATERIAL RESERVOIR
    5.
    发明申请
    DEVICE AND METHOD TO EXTRACT MATERIAL OF A MATERIAL RESERVOIR 审中-公开
    提取材料储存材料的装置和方法

    公开(公告)号：US20100076340A1

    公开(公告)日：2010-03-25

    申请号：US12566009

    申请日：2009-09-24

    申请人： Gerald Eckstein ,  Karsten Hiltawsky ,  Heinz-Ingo Schneider ,  Daniel Sickert

    发明人： Gerald Eckstein ,  Karsten Hiltawsky ,  Heinz-Ingo Schneider ,  Daniel Sickert

    IPC分类号： A61B10/02 ,  A61B10/00

    CPC分类号： A61B10/0045 ,  A61B10/007 ,  A61B10/0233 ,  A61B2010/008 ,  A61B2017/00336

    摘要： A device to extract material of a material reservoir has at least one guide tube with internal space and with an inner wall surrounding the internal space; at least one sled that can implement a sled translation movement in the inner space along a longitudinal alignment of the guide tube; and at least one collection unit with collection surface to collect the material. The collection unit and the sled are coupled to one another such that the sled translation movement of the sled leads to a collection translation movement of the collection surface of the collection unit, and such that the collection surface can be inserted into the material reservoir and be withdrawn from the material reservoir. A rotation mechanism that is operated manually or automatically can be provided with which a wire, which acts as a collection device, can be displaced in vivo over a length of 1 mm to up to 2 cm within a venous cannula. The invention is used in medical technology, for example, to collect cells from a reservoir in the form of a bodily fluid.

    摘要翻译： 提取材料储存器材料的装置具有至少一个具有内部空间的引导管和围绕内部空间的内壁; 至少一个可以沿着导管的纵向排列在内部空间中实现滑动平移运动的滑板; 以及至少一个具有收集表面的收集​​单元以收集材料。 收集单元和滑雪板彼此联接，使得滑板的滑轨平移运动导致收集单元的收集表面的收集​​平移运动，并且使得收集表面可以插入材料储存器中并且被 从物料库撤出。 可以提供手动或自动操作的旋转机构，其中用作收集装置的线可以在静脉插管内在1mm至高达2cm的长度内在体内移位。 本发明用于医疗技术，例如以体液的形式从储存器收集细胞。

    Method for Integrating Functional Nanostructures Into Microelectric and Nanoelectric circuits
    9.
    发明申请
    Method for Integrating Functional Nanostructures Into Microelectric and Nanoelectric circuits 审中-公开
    将功能纳米结构纳入微电和纳米电路的方法

    公开(公告)号：US20090173527A1

    公开(公告)日：2009-07-09

    申请号：US11990265

    申请日：2006-07-27

    申请人： Annegret Benke ,  Gerald Eckstein ,  Oliver Jost ,  Michael Mertig ,  Daniel Sickert ,  Sebastian Taeger

    发明人： Annegret Benke ,  Gerald Eckstein ,  Oliver Jost ,  Michael Mertig ,  Daniel Sickert ,  Sebastian Taeger

    IPC分类号： H05K1/11 ,  C25B7/00

    CPC分类号： H01L51/102 ,  B82Y10/00 ,  B82Y30/00 ,  H01L51/0048

    摘要： A nanostructure is provided on a substrate by forming at least one multi-electrode arrangement on the substrate, wherein said electrodes comprise respective electrode areas projected with respect to the opposite electrode ends which extend along a line in such a way that the adjacent ends produce a respectively frequency time-variable potential difference. A suspension of nano-object such as nanotubes, nanowires and/or carbon nanotubes is produced and then transferred to the substrate between the adjacent ends. The assembly of respective individual nano-objects is dielectrophoreticly deposited on the line between said adjacent ends, and the assembly of respective nano-objects is fused in the area of the ends in such a way that the nanostructure is formed.

    摘要翻译： 通过在衬底上形成至少一个多电极布置在衬底上提供纳米结构，其中所述电极包括相对于相对电极端部突出的相应电极区域，所述相对电极端部沿着一条线延伸，使得相邻端部产生 分别为频率时变电位差。 产生纳米材料如纳米管，纳米线和/或碳纳米管的悬浮液，然后转移到相邻端之间的基底。 各个单独的纳米物体的组件被介电电泳沉积在所述相邻端之间的线上，并且各个纳米物体的组件以端部的区域融合，使得形成纳米结构。