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    Hydrophilic polymer biomaterial having a specific magnetic resonance imaging signal and process for the preparation of said biomaterial
    2.
    发明授权
    Hydrophilic polymer biomaterial having a specific magnetic resonance imaging signal and process for the preparation of said biomaterial 有权
    具有特定磁共振成像信号的亲水性聚合物生物材料和用于制备所述生物材料的方法

    公开(公告)号：US07407646B2

    公开(公告)日：2008-08-05

    申请号：US10278256

    申请日：2002-10-23

    Applicant: Alexandre Laurent ,  Denis Labarre

    Inventor： Alexandre Laurent ,  Denis Labarre

    IPC: A61B5/055

    CPC classification number: C08K9/08

    Abstract: A charged biomaterial including at least one first hydrophilic polymer, and superparamagnetic iron oxide particles complexed with a second hydrophilic polymer substantially identical to or different from the first hydrophilic polymer, wherein the superparamagnetic iron oxide particles complexed with the second hydrophilic polymer are distributed substantially homogeneously and substantially without aggregates in the first hydrophilic polymer. A process for preparing a charged biomaterial including forming an aqueous solution of hydrophilic monomers and superparamagnetic iron oxide particles complexed with a hydrophilic polymer including monomers substantially identical to or different from the hydrophilic monomers, polymerizing the solution and forming a polymer hydrogel in which are distributed substantially homogeneously and substantially without aggregates the superparamagnetic iron oxide particles complexed with the hydrophilic polymer.

    Abstract translation: 包含与第一亲水性聚合物基本相同或不同的第二亲水性聚合物复合的至少一种第一亲水聚合物和超顺磁性氧化铁颗粒的带电生物材料，其中与第二亲水性聚合物复合的超顺磁性氧化铁颗粒基本均匀地分布， 基本上没有第一亲水性聚合物中的聚集体。 一种制备带电生物材料的方法，包括形成与亲水性聚合物复合的亲水性单体和超顺磁性氧化铁颗粒的水溶液，所述亲水性聚合物包括与亲水性单体基本上相同或不同的单体，使溶液聚合并形成聚合物水凝胶，其中基本上分布 均匀且基本上没有聚集与亲水性聚合物络合的超顺磁性氧化铁颗粒。

    Copolymer and hemoprotein based novel compounds and uses thereof
    10.
    发明申请
    Copolymer and hemoprotein based novel compounds and uses thereof 审中-公开
    基于共聚物和血液蛋白的新型化合物及其用途

    公开(公告)号：US20060182807A1

    公开(公告)日：2006-08-17

    申请号：US10533084

    申请日：2003-06-10

    Applicant: Christine Vauthier ,  Cedric Chauvierre ,  Patrick Couvreur ,  Denis Labarre ,  Liliane Leclerc ,  Michael Marden

    Inventor： Christine Vauthier ,  Cedric Chauvierre ,  Patrick Couvreur ,  Denis Labarre ,  Liliane Leclerc ,  Michael Marden

    IPC: A61K9/14 ,  A61K38/42 ,  C07K14/80

    CPC classification number: A61K9/0026 ,  A61K9/5138 ,  A61K9/5161 ,  A61K38/42 ,  A61K47/62 ,  A61K47/6905 ,  A61K47/6935 ,  A61K47/6939

    Abstract: The invention relates to novel compounds, characterized in that they comprise a hemoprotein which is associated with a sequenced block copolymer, comprising an hydrophilic segment which is an oligo or polysaccharide linked to at least one hydrophobic segment of formula (1) wherein x represents H or an radical which is alkyl, CN or CONHR, Y represents a COOR′, CONHR″ or C6H5 radical, wherein R, R′ and R″ represent, independently from each other, a hydrogen atom, a C1-C20 linear ou branched alkyl group, a C1-C20 linear or branched alcoxy group, an amino acid radical, a mono- or poly-hydroxyl acid radical or an aryl ou heteroaryl C5-C12 radical, and forms associated with a gas. The invention can be used as blood substitutes and depolluting agents.

    Abstract translation: 本发明涉及新化合物，其特征在于它们包含与序列嵌段共聚物相关的血蛋白，其包含与至少一个式（1）的疏水链连接的寡糖或多糖的亲水链段，其中x表示H或 作为烷基，CN或CONHR的基团，Y表示COOR'，CONHR“或C 6 H 5基团，其中R，R'和R”表示 独立地为氢原子，C 1 -C 20直链支链烷基，C 1 -C 3亚烷基 > 20个直链或支链烷氧基，氨基酸基团，单羟基或多羟基酸基或芳基杂芳基C 5 -C 12烷基， 激进和与气体相关的形式。 本发明可用作血液代用品和去污剂。

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