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    Hydrophilic polymer biomaterial having a specific magnetic resonance imaging signal and process for the preparation of said biomaterial
    7.
    发明授权
    Hydrophilic polymer biomaterial having a specific magnetic resonance imaging signal and process for the preparation of said biomaterial 有权
    具有特定磁共振成像信号的亲水性聚合物生物材料和用于制备所述生物材料的方法

    公开(公告)号：US07407646B2

    公开(公告)日：2008-08-05

    申请号：US10278256

    申请日：2002-10-23

    Applicant: Alexandre Laurent ,  Denis Labarre

    Inventor： Alexandre Laurent ,  Denis Labarre

    IPC: A61B5/055

    CPC classification number: C08K9/08

    Abstract: A charged biomaterial including at least one first hydrophilic polymer, and superparamagnetic iron oxide particles complexed with a second hydrophilic polymer substantially identical to or different from the first hydrophilic polymer, wherein the superparamagnetic iron oxide particles complexed with the second hydrophilic polymer are distributed substantially homogeneously and substantially without aggregates in the first hydrophilic polymer. A process for preparing a charged biomaterial including forming an aqueous solution of hydrophilic monomers and superparamagnetic iron oxide particles complexed with a hydrophilic polymer including monomers substantially identical to or different from the hydrophilic monomers, polymerizing the solution and forming a polymer hydrogel in which are distributed substantially homogeneously and substantially without aggregates the superparamagnetic iron oxide particles complexed with the hydrophilic polymer.

    Abstract translation: 包含与第一亲水性聚合物基本相同或不同的第二亲水性聚合物复合的至少一种第一亲水聚合物和超顺磁性氧化铁颗粒的带电生物材料，其中与第二亲水性聚合物复合的超顺磁性氧化铁颗粒基本均匀地分布， 基本上没有第一亲水性聚合物中的聚集体。 一种制备带电生物材料的方法，包括形成与亲水性聚合物复合的亲水性单体和超顺磁性氧化铁颗粒的水溶液，所述亲水性聚合物包括与亲水性单体基本上相同或不同的单体，使溶液聚合并形成聚合物水凝胶，其中基本上分布 均匀且基本上没有聚集与亲水性聚合物络合的超顺磁性氧化铁颗粒。

    Implantable swellable bio-resorbable polymer
    8.
    发明授权
    Implantable swellable bio-resorbable polymer 有权
    可植入的可溶胀生物可吸收聚合物

    公开(公告)号：US09320806B2

    公开(公告)日：2016-04-26

    申请号：US14003514

    申请日：2012-03-09

    Applicant: Laurence Moine ,  Alexandre Laurent ,  Michel Wassef ,  Laurent Bedouet ,  Stephanie Louguet ,  Valentin Verret ,  Emeline Servais

    Inventor： Laurence Moine ,  Alexandre Laurent ,  Michel Wassef ,  Laurent Bedouet ,  Stephanie Louguet ,  Valentin Verret ,  Emeline Servais

    IPC: A61K47/48 ,  A61K47/34 ,  C08F220/18 ,  C08F222/10 ,  C08F224/00

    CPC classification number: A61K47/48176 ,  A61K47/34 ,  A61K47/58 ,  A61K47/59 ,  C08F220/18 ,  C08F222/1006 ,  C08F224/00 ,  Y10T428/2982

    Abstract: The present invention relates to a polymer obtained from the polymerization of: (i) at least one monomer of formula (I) (CH2═CR1)CO—K (1) wherein: —K represents O—Z or N H—Z, Z representing (CR2R3)m-CH3, (CH2—CH2—O)m-H, (CH2—CH2—O)m-CH3, (CH2)m-NR4R5 with m representing an integer from 1 to 30; —R1, R2, R3, R4 and R5 independently represent H or a C1-C6 alkyl; (ii) at least between 0.1 and 50% mol, advantageously between 1 and 30% mol, more advantageously between 1 and 20 mol % of a cyclic monomer having a exomethylene group of formula (II) wherein: — R6, R7, R8 and R9 represent independently H or a C5-C7 aryl group or R6 and R9 are absent and R7 and R8 form together with the carbon atom on which they are bonded a C5-C7 aryl group; —i and j represent independently an integer chosen between 0 and 2; —X represents either O or X is not present and in this latter case, CR6R7 and CR8R9 are linked via a single bond C—C and (iii) at least one bio-resorbable block copolymer cross-linker.

    Abstract translation: 本发明涉及聚合得到的聚合物：（i）至少一种式（I）单体（CH 2 = CR 1）CO-K（1）其中：-K表示O-Z或NH-Z，Z 代表（CR 2 R 3）m -CH 3，（CH 2 -CH 2 -O）m H，（CH 2 -CH 2 -O）m -CH 3，（CH 2）m -NR 4 R 5，m代表1至30的整数; -R1，R2，R3，R4和R5独立地表示H或C1-C6烷基; （ii）至少0.1至50摩尔％，有利地为1至30摩尔％，更有利地为1至20摩尔％的具有式（II）的外亚甲基的环状单体，其中：-R 6，R 7，R 8和 R9独立地表示H或C5-C7芳基或R6和R9不存在，R7和R8与它们所连接的碳原子一起形成C5-C7芳基; -i和j独立地表示选自0和2之间的整数; -X表示O或X不存在，并且在后一种情况下，CR 6 R 7和CR 8 R 9通过单键C-C和（iii）至少一种生物可吸收嵌段共聚物交联剂连接。

    IMPLANTABLE SWELLABLE BIO-RESORBABLE POLYMER
    10.
    发明申请
    IMPLANTABLE SWELLABLE BIO-RESORBABLE POLYMER 有权
    可植入式可剥离的生物可降解聚合物

    公开(公告)号：US20130344159A1

    公开(公告)日：2013-12-26

    申请号：US14003514

    申请日：2012-03-09

    Applicant: Laurence Moine ,  Alexandre Laurent ,  Michel Wassef ,  Laurent Bedouet ,  Stephanie Louguet ,  Valentin Verret ,  Emeline Servais

    Inventor： Laurence Moine ,  Alexandre Laurent ,  Michel Wassef ,  Laurent Bedouet ,  Stephanie Louguet ,  Valentin Verret ,  Emeline Servais

    IPC: A61K47/48 ,  A61K47/34

    CPC classification number: A61K47/48176 ,  A61K47/34 ,  A61K47/58 ,  A61K47/59 ,  C08F220/18 ,  C08F222/1006 ,  C08F224/00 ,  Y10T428/2982

    Abstract: The present invention relates to a polymer obtained from the polymerization of: (i) at least one monomer of formula (I) (CH2═CR1)CO—K (1) wherein: K represents O—Z or NH—Z, Z representing (CR2R3)m-CH3, (CH2—CH2—O)m-H, (CH2—CH2—O)m-CH3, (CH2)m-NR4R5 with m representing an integer from 1 to 30; R1, R2, R3, R4 and R5 independently represent H or a C1-C6 alkyl; (ii) at least between 0.1 and 50% mol, advantageously between 1 and 30% mol, more advantageously between 1 and 20 mol % of a cyclic monomer having a exomethylene group of formula (II) wherein: R6, R7, R8 and R9 represent independently H or a C5-C7 aryl group or R6 and R9 are absent and R7 and R8 form together with the carbon atom on which they are bonded a C5-C7 aryl group; i and j represent independently an integer chosen between 0 and 2; X represents either O or X is not present and in this latter case, CR6R7 and CR8R9 are linked via a single bond C—C and (iii) at least one bio-resorbable block copolymer cross-linker.

    Abstract translation: 本发明涉及由以下聚合得到的聚合物：（i）至少一种式（I）单体（CH2 = CR1）CO-K（1）其中：K代表OZ或NH-Z，Z代表（CR2R3） ）m-CH3，（CH2-CH2-O）mH，（CH2-CH2-O）m-CH3，（CH2）m-NR4R5，m代表1至30的整数; R1，R2，R3，R4和R5独立地表示H或C1-C6烷基; （ii）具有式（II）的外亚甲基的环状单体的至少0.1至50摩尔％，有利地为1至30摩尔％，更有利地为1至20摩尔％，其中：R6，R7，R8和R9 独立地表示H或C 5 -C 7芳基或R 6和R 9不存在，并且R 7和R 8与它们所连接的碳原子一起形成C 5 -C 7芳基; i和j独立地表示0和2之间的整数; X表示O或X不存在，在后一种情况下，CR6R7和CR8R9通过单键C-C和（iii）至少一种生物可吸收嵌段共聚物交联剂连接。

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