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公开(公告)号：US20130100456A1
公开(公告)日：2013-04-25
申请号：US13444410
申请日：2012-04-11
IPC分类号： G01B9/02
CPC分类号： G01B9/02091 , A61B3/102 , G01B9/02004 , G01B9/02011 , G01B9/02014 , G01B9/02082 , G01B2290/70 , H01S3/07 , H01S3/08054 , H01S3/0809 , H01S3/0823 , H01S3/105 , H01S5/141
摘要： Systems and methods for increasing the duty cycle and/or producing interleaved pulses of alternating polarization states in swept-source optical coherence tomography (OCT) systems are considered. Embodiments including improved buffering, frequency selecting filter sharing among multiple SOAs, intracavity switching, and multiple wavelength bands are described. The unique polarization properties of the source configurations have advantages in speckle reduction, polarization-sensitive measurements, polarization state dependent phase shifts, spatial shifts, and temporal shifts in OCT measurements.
摘要翻译： 考虑在扫描光源相干断层摄影（OCT）系统中用于增加占空比和/或产生交替偏振状态的交错脉冲的系统和方法。 描述了包括改进的缓冲，多个SOA中的频率选择滤波器共享，腔内切换和多个波长带的实施例。 源结构的独特偏振特性在斑点减少，偏振敏感测量，极化状态相关相移，空间位移和OCT测量中的时间偏移方面具有优势。
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公开(公告)号：US20130010260A1
公开(公告)日：2013-01-10
申请号：US13542516
申请日：2012-07-05
摘要： Systems and methods for applying the concept of lightfield sensors to fundus photography are presented. In one embodiment, the ability to isolate specific regions of the collected lightfield are used to reduce the effects of glare in a fundus image. Additional embodiments in which aberrations can be characterized and removed, an image from a particular plane in the collected light field is used to aid in instrument alignment, and dynamic optimization of collection pupil diameter is accomplished are also presented.
摘要翻译： 介绍了将光场传感器应用于眼底摄影的系统和方法。 在一个实施例中，使用分离所收集的光场的特定区域的能力来减少眼底图像中眩光的影响。 其中可以表征和去除像差的其他实施例，来自收集的光场中的特定平面的图像用于帮助仪器对准，并且还呈现收集光瞳直径的动态优化。
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3.发明授权Systems and methods for improved balanced detection in optical coherence tomography imaging 有权用于改善光学相干层析成像中平衡检测的系统和方法公开(公告)号：US08913248B2
公开(公告)日：2014-12-16
申请号：US13489368
申请日：2012-06-05
CPC分类号： A61B5/0066 , A61B3/102 , G01B9/02004 , G01B9/02058 , G01B9/0207 , G01B9/02091
摘要： Systems and methods for reducing noise in balanced detection based optical coherence tomography (OCT) systems are described. Embodiments including both optical hardware and electronic based solutions to spectrally filter and attenuate the source reference light in optical coherence tomography in an effort to reduce RIN and FPN noise in OCT systems are presented. A novel application to electronic balanced detection schemes in which a single source of reference detection is balanced against the interferometric signals from multiple interferometers is also presented.
摘要翻译： 描述了基于平衡检测的光学相干断层扫描（OCT）系统中降低噪声的系统和方法。 提出了包括光学硬件和基于电子的解决方案的实施例，以在光学相干断层摄影中频谱滤波和衰减源参考光，以努力降低OCT系统中的RIN和FPN噪声。 还提出了一种电子平衡检测方案的新颖应用，其中单个参考检测源与来自多个干涉仪的干涉信号平衡。
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4.发明申请SYSTEMS AND METHODS FOR IMPROVED BALANCED DETECTION IN OPTICAL COHERENCE TOMOGRAPHY IMAGING 有权用于光学相干图像成像中改进的平衡检测的系统和方法公开(公告)号：US20130010302A1
公开(公告)日：2013-01-10
申请号：US13489368
申请日：2012-06-05
IPC分类号： G01B9/02
CPC分类号： A61B5/0066 , A61B3/102 , G01B9/02004 , G01B9/02058 , G01B9/0207 , G01B9/02091
摘要： Systems and methods for reducing noise in balanced detection based optical coherence tomography (OCT) systems are described. Embodiments including both optical hardware and electronic based solutions to spectrally filter and attenuate the source reference light in optical coherence tomography in an effort to reduce RIN and FPN noise in OCT systems are presented. A novel application to electronic balanced detection schemes in which a single source of reference detection is balanced against the interferometric signals from multiple interferometers is also presented.
摘要翻译： 描述了基于平衡检测的光学相干断层扫描（OCT）系统中降低噪声的系统和方法。 提出了包括光学硬件和基于电子的解决方案的实施例，以在光学相干断层摄影中频谱滤波和衰减源参考光，以努力降低OCT系统中的RIN和FPN噪声。 还提出了一种电子平衡检测方案的新颖应用，其中单个参考检测源与来自多个干涉仪的干涉信号平衡。
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公开(公告)号：US08998411B2
公开(公告)日：2015-04-07
申请号：US13542516
申请日：2012-07-05
摘要： Systems and methods for applying the concept of lightfield sensors to fundus photography are presented. In one embodiment, the ability to isolate specific regions of the collected lightfield are used to reduce the effects of glare in a fundus image. Additional embodiments in which aberrations can be characterized and removed, an image from a particular plane in the collected light field is used to aid in instrument alignment, and dynamic optimization of collection pupil diameter is accomplished are also presented.
摘要翻译： 介绍了将光场传感器应用于眼底摄影的系统和方法。 在一个实施例中，使用分离所收集的光场的特定区域的能力来减少眼底图像中眩光的影响。 其中可以表征和去除像差的其他实施例，来自收集的光场中的特定平面的图像用于帮助仪器对准，并且还呈现收集光瞳直径的动态优化。
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6.发明申请公开(公告)号：US20120249956A1
公开(公告)日：2012-10-04
申请号：US13433127
申请日：2012-03-28
IPC分类号： A61B3/14
CPC分类号： A61B3/102 , A61B3/0025 , A61B3/0033 , A61B3/113 , A61B3/12 , A61B3/145 , A61B5/0066 , G06T7/246 , G06T2207/10101 , G06T2207/20081 , G06T2207/30041 , G06T2210/41
摘要： Systems and methods for efficiently obtaining optical coherence tomography (OCT) measurement data with reduced effects of motion are presented. One embodiment involves determining the amount of motion present during the collection of an OCT data set based on images of the eye collected at the same time as the OCT data, and recollecting select portions of the OCT data set when the amount of eye motion is determined to exceed a predetermined threshold. Another embodiment includes enabling or disabling a tracking feature based on the quality of the images available for tracking. Another embodiment includes reducing the effect of motion in the axial direction based on a comparison to a model of the eye constructed from OCT data. The method can also be used to reduce the presence of mirror image artifacts in an OCT image.
摘要翻译： 提出了有效获得具有减少的运动影响的光学相干断层扫描（OCT）测量数据的系统和方法。 一个实施例涉及基于与OCT数据同时收集的眼睛的图像来确定OCT收集OCT数据集期间的运动量，以及当确定眼睛运动量时，重新收集OCT数据集的选择部分 超过预定阈值。 另一个实施例包括基于可用于跟踪的图像的质量启用或禁用跟踪特征。 另一实施例包括基于与由OCT数据构造的眼睛模型的比较来减小轴向运动的影响。 该方法还可用于减少OCT图像中镜像伪影的存在。
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7.发明授权Method and apparatus for measuring motion of a subject using a series of partial images from an imaging system 有权用于使用来自成像系统的一系列部分图像来测量对象的运动的方法和装置公开(公告)号：US08050504B2
公开(公告)日：2011-11-01
申请号：US12861672
申请日：2010-08-23
申请人： Matthew J. Everett , Claus Flachenecker , Martin Hacker , Scott A. Meyer , Keith E. O'Hara , Rick A. Williams
发明人： Matthew J. Everett , Claus Flachenecker , Martin Hacker , Scott A. Meyer , Keith E. O'Hara , Rick A. Williams
摘要： A line scan imager is used to determine the motion of a subject. Each line of image data from the line scan imager is compared with a reference image. The location of a matching line in the reference image reveals the displacement of the subject. The current subject displacement can be determined based on each line of image data. The resulting displacement information can be used to correctly place other optical beams on the subject. The method can be applied to tracking the human eye to facilitate measurement, imaging, or treatment with a beam of optical radiation.
摘要翻译： 行扫描成像器用于确定被摄体的运动。 将来自行扫描成像器的每行图像数据与参考图像进行比较。 参考图像中匹配线的位置显示了被摄体的位移。 可以基于每行图像数据来确定当前被摄体位移。 所得到的位移信息可用于将其他光束正确地放置在被摄体上。 该方法可以应用于跟踪人眼以便于用光束辐射进行测量，成像或处理。
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8.发明授权Method and apparatus for measuring motion of a subject using a series of partial images from an imaging system 有权用于使用来自成像系统的一系列部分图像来测量对象的运动的方法和装置公开(公告)号：US07805009B2
公开(公告)日：2010-09-28
申请号：US11389351
申请日：2006-03-24
申请人： Matthew J. Everett , Claus Flachenecker , Martin Hacker , Scott A. Meyer , Keith E. O'Hara , Rick A. Williams
发明人： Matthew J. Everett , Claus Flachenecker , Martin Hacker , Scott A. Meyer , Keith E. O'Hara , Rick A. Williams
摘要： A line scan imager is used to determine the motion of a subject. Each line of image data from the line scan imager is compared with a reference image. The location of a matching line in the reference image reveals the displacement of the subject. The current subject displacement can be determined based on each line of image data. The resulting displacement information can be used to correctly place other optical beams on the subject. The method can be applied to tracking the human eye to facilitate measurement, imaging, or treatment with a beam of optical radiation.
摘要翻译： 行扫描成像器用于确定被摄体的运动。 将来自行扫描成像器的每行图像数据与参考图像进行比较。 参考图像中匹配线的位置显示了被摄体的位移。 可以基于每行图像数据来确定当前被摄体位移。 所得到的位移信息可用于将其他光束正确地放置在被摄体上。 该方法可以应用于跟踪人眼以便于用光束照射进行测量，成像或处理。
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9.发明申请METHOD OF BIOIMAGE DATA PROCESSING FOR REVEALING MORE MEANINGFUL ANATOMIC FEATURES OF DISEASED TISSUES 有权生物数据处理方法发布疾病组织的更多意义的解剖特征公开(公告)号：US20100226542A1
公开(公告)日：2010-09-09
申请号：US12709234
申请日：2010-02-19
申请人： Matthew J. Everett , Scott A. Meyer , Paul F. Stetson , Yan Zhou
发明人： Matthew J. Everett , Scott A. Meyer , Paul F. Stetson , Yan Zhou
IPC分类号： G06K9/00
CPC分类号： A61B5/0066 , G06T7/0014 , G06T19/00 , G06T2200/24 , G06T2207/10101 , G06T2207/30041 , G06T2210/41
摘要： The present invention discloses a method for generating elevation maps or images of a tissue layer/boundary with respect to a fitted reference surface, comprising the steps of finding and segmenting a desired tissue layer/boundary; fitting a smooth reference surface to the segmented tissue layer/boundary; calculating elevations of the same or other tissue layer/boundary relative to the fitted reference surface; and generating maps of elevation relative to the fitted surface. The elevation can be displayed in various ways including three-dimensional surface renderings, topographical contour maps, contour maps, en-face color maps, and en-face grayscale maps. The elevation can also be combined and simultaneously displayed with another tissue layer/boundary dependent set of image data to provide additional information for diagnostics.
摘要翻译： 本发明公开了一种用于产生相对于拟合的参考表面的组织层/边界的仰角图或图像的方法，包括以下步骤：找到并分割所需的组织层/边界; 将平滑的参考表面拟合到分段的组织层/边界; 计算相对于拟合参考表面的相同或其它组织层/边界的高度; 并产生相对于拟合表面的高程图。 高程可以以各种方式显示，包括三维表面效果图，地形轮廓图，轮廓图，面孔颜色图和面对灰度图。 也可以将高程组合并同时显示另一个组织层/边界依赖的图像数据集，以提供用于诊断的附加信息。
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公开(公告)号：US07755769B2
公开(公告)日：2010-07-13
申请号：US12075477
申请日：2008-03-11
IPC分类号： G01B11/02
CPC分类号： A61B3/102 , A61B3/0025 , A61B3/113 , A61B3/1233 , A61B5/0059 , A61B5/0066 , G01B9/02048 , G01B9/02077 , G01B9/02087 , G01B9/02091 , G01N21/4795 , G01N2021/1787
摘要： An image data set acquired by an optical coherence tomography (OCT) system is corrected for effects due to motion of the sample. A first set of A-scans is acquired within a time short enough to avoid any significant motion of the sample. A second more extensive set of A-scans is acquired over an overlapping region on the sample. Significant sample motion may occur during acquisition of the second set. A-scans from the first set are matched with A-scans from the second set, based on similarity between the longitudinal optical scattering profiles they contain. Such matched pairs of A-scans are likely to correspond to the same region in the sample. Comparison of the OCT scanner coordinates that produced each A-scan in a matching pair, in conjunction with any shift in the longitudinal scattering profiles between the pair of A-scans, reveals the displacement of the sample between acquisition of the first and second A-scans in the pair. Estimates of the sample displacement are used to correct the transverse and longitudinal coordinates of the A-scans in the second set, to form a motion-corrected OCT data set.
摘要翻译： 通过光学相干断层摄影（OCT）系统获得的图像数据集由于样品的运动而被校正。 在足够短的时间内获取第一组A扫描，以避免样品的任何显着运动。 在样本上的重叠区域获取第二组更广泛的A扫描。 在采集第二组时可能会发生显着的样品运动。 基于其包含的纵向光学散射曲线之间的相似性，来自第一组的A扫描与来自第二组的A扫描匹配。 这样匹配的A扫描对可能对应于样本中的相同区域。 在匹配对中产生每个A扫描的OCT扫描器坐标与一对A-扫描之间的纵向散射分布的任何变化相结合的比较显示样品在第一和第二A- 扫描成对。 使用样本位移的估计来校正第二组中的A扫描的横向和纵向坐标，以形成运动校正的OCT数据集。
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