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    OPTICAL TOMOGRAPHIC IMAGING APPARATUS AND IMAGING METHOD THEREFOR
    6.
    发明申请
    OPTICAL TOMOGRAPHIC IMAGING APPARATUS AND IMAGING METHOD THEREFOR 有权
    光学成像装置及其成像方法

    公开(公告)号：US20130107272A1

    公开(公告)日：2013-05-02

    申请号：US13808895

    申请日：2011-07-04

    申请人： Futoshi Hirose

    发明人： Futoshi Hirose

    IPC分类号： G01B9/02

    CPC分类号： G01B9/02011 ,  A61B3/102 ,  A61B5/0066 ,  G01B9/02027 ,  G01B9/02044 ,  G01B9/02091 ,  G01B2290/65 ,  G01B2290/70

    摘要： An imaging apparatus adjusts the polarization directions of irradiation beams (to a diffraction grating) corresponding to first and second beams respectively which have different polarization directions (for example, by adjusting a relative angle formed between light-emitting ends of respective polarization maintaining fibers) so that the spectral characteristics of the irradiation beams at the diffraction grating coincide with each other. Then, the imaging apparatus acquires a tomographic image indicating polarization information for a object based on beams (that come from the diffraction grating for splitting and diffracting a beam from the adjustment unit) corresponding to the first and second beams respectively which have different polarization directions.

    摘要翻译： 成像装置调整分别对应于具有不同偏振方向的第一和第二光束的照射光束（衍射光栅）的偏振方向（例如，通过调整形成在各偏振光纤的发光端之间的相对角度） 衍射光栅处的照射光束的光谱特性彼此一致。 然后，成像装置基于分别具有不同偏振方向的第一和第二光束的光束（来自用于分割和衍射来自调节单元的光束的衍射光栅）获得指示物体的偏振信息的断层图像。

    Systems and methods for phase measurements
    7.
    发明授权
    Systems and methods for phase measurements 有权
    相位测量的系统和方法

    公开(公告)号：US08334982B2

    公开(公告)日：2012-12-18

    申请号：US12494605

    申请日：2009-06-30

    申请人： Christopher Fang-Yen ,  Gabriel Popescu ,  Changhuei Yang ,  Adam Wax ,  Ramachandra Dasari ,  Michael Feld

    发明人： Christopher Fang-Yen ,  Gabriel Popescu ,  Changhuei Yang ,  Adam Wax ,  Ramachandra Dasari ,  Michael Feld

    IPC分类号： G01B11/02

    CPC分类号： G01B9/02091 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/7232 ,  G01B9/02002 ,  G01B9/02007 ,  G01B9/02011 ,  G01B9/02057 ,  G01B9/02063 ,  G01B9/02067 ,  G01B9/02069 ,  G01B9/02071 ,  G01B9/02072 ,  G01B9/02078 ,  G01B9/02083 ,  G01B9/0209 ,  G01B2290/45 ,  G01B2290/60 ,  G01B2290/70 ,  G01J9/04 ,  G01N21/45

    摘要： Preferred embodiments of the present invention are directed to systems for phase measurement which address the problem of phase noise using combinations of a number of strategies including, but not limited to, common-path interferometry, phase referencing, active stabilization and differential measurement. Embodiment are directed to optical devices for imaging small biological objects with light. These embodiments can be applied to the fields of, for example, cellular physiology and neuroscience. These preferred embodiments are based on principles of phase measurements and imaging technologies. The scientific motivation for using phase measurements and imaging technologies is derived from, for example, cellular biology at the sub-micron level which can include, without limitation, imaging origins of dysplasia, cellular communication, neuronal transmission and implementation of the genetic code. The structure and dynamics of sub-cellular constituents cannot be currently studied in their native state using the existing methods and technologies including, for example, x-ray and neutron scattering. In contrast, light based techniques with nanometer resolution enable the cellular machinery to be studied in its native state. Thus, preferred embodiments of the present invention include systems based on principles of interferometry and/or phase measurements and are used to study cellular physiology. These systems include principles of low coherence interferometry (LCI) using optical interferometers to measure phase, or light scattering spectroscopy (LSS) wherein interference within the cellular components themselves is used, or in the alternative the principles of LCI and LSS can be combined to result in systems of the present invention.

    摘要翻译： 本发明的优选实施例涉及用于相位测量的系统，其使用多种策略的组合来解决相位噪声问题，包括但不限于公共路径干涉测量，相位参考，主动稳定和差分测量。 实施例涉及用于用光成像小生物物体的光学装置。 这些实施方案可以应用于例如细胞生理学和神经科学领域。 这些优选实施例基于相位测量和成像技术的原理。 使用相位测量和成像技术的科学动机源于例如亚微米级别的细胞生物学，其可以包括但不限于成像发育异常起源，细胞通讯，神经元传播和遗传密码的实现。 亚细胞组分的结构和动力学目前不能使用现有的方法和技术（例如x射线和中子散射）在其天然状态下研究。 相比之下，具有纳米分辨率的基于光的技术使得能够以其天然状态研究细胞机械。 因此，本发明的优选实施例包括基于干涉测量和/或相位测量的原理的系统，并且用于研究细胞生理学。 这些系统包括使用光学干涉仪来测量相位的低相干干涉测量（LCI）原理，或使用其中使用细胞部件本身内部的干扰的光散射光谱（LSS），或者替代地，LCI和LSS的原理可以组合以产生 在本发明的系统中。

    Process, system and software arrangement for determining at least one location in a sample using an optical coherence tomography
    8.
    发明授权
    Process, system and software arrangement for determining at least one location in a sample using an optical coherence tomography 有权
    用于使用光学相干断层摄影确定样本中的至少一个位置的过程，系统和软件布置

    公开(公告)号：US08081316B2

    公开(公告)日：2011-12-20

    申请号：US11200228

    申请日：2005-08-08

    申请人： Johannes Fitzgerald de Boer ,  Boris Hyle Park

    发明人： Johannes Fitzgerald de Boer ,  Boris Hyle Park

    IPC分类号： G01B9/02

    CPC分类号： A61B3/1225 ,  A61B3/1005 ,  A61B3/102 ,  G01B9/02004 ,  G01B9/02011 ,  G01B9/02044 ,  G01B9/02067 ,  G01B9/02068 ,  G01B9/02069 ,  G01B9/02083 ,  G01B9/02091 ,  G01B2290/45 ,  G01B2290/70 ,  G01N21/4795

    摘要： A system, process and software arrangement are provided to determine at least one position of at least one portion of a sample. In particular, information associated with the portion of the sample is obtained. Such portion may be associated with an interference signal that includes a first electromagnetic radiation received from the sample and a second electro-magnetic radiation received from a reference. In addition, depth information and/or lateral information of the portion of the sample, may be obtained. At least one weight function can be applied to the depth information and/or the lateral information so as to generate resulting information. Further, a surface position, a lateral position and/or a depth position of the portion of the sample may be ascertained based on the resulting information.

    摘要翻译： 提供系统，过程和软件布置以确定样品的至少一部分的至少一个位置。 特别地，获得与样本部分相关联的信息。 这样的部分可以与包括从样本接收的第一电磁辐射和从参考接收的第二电磁辐射的干扰信号相关联。 此外，可以获得样本部分的深度信息和/或横向信息。 至少一个权重函数可以应用于深度信息和/或横向信息，以便生成结果信息。 此外，可以基于所得到的信息来确定样品的该部分的表面位置，横向位置和/或深度位置。

    Method and apparatus for polarization-sensitive optical coherence tomography
    9.
    发明授权
    Method and apparatus for polarization-sensitive optical coherence tomography 有权
    用于偏振敏感光学相干断层扫描的方法和装置

    公开(公告)号：US07826059B2

    公开(公告)日：2010-11-02

    申请号：US10055282

    申请日：2002-01-22

    申请人： Jonathan E. Roth ,  Joseph A. Izatt ,  Andrew M. Rollins

    发明人： Jonathan E. Roth ,  Joseph A. Izatt ,  Andrew M. Rollins

    IPC分类号： G01B9/02

    CPC分类号： A61B5/0066 ,  A61B5/0073 ,  G01B9/02011 ,  G01B9/02072 ,  G01B9/02091 ,  G01B9/04 ,  G01B2290/70 ,  G01N21/4795 ,  Y10T29/49716

    摘要： A method and apparatus for extracting the vector optical properties of biological samples with micron-scale resolution in three dimensions, using polarization-sensitive optical coherence tomography (PS-OCT). The method measures net retardance, net fast axis, and reflectivity. Polarization sensing is accomplished by illuminating the sample with at least three separate polarization states, using consecutive acquisitions of the same pixel, A-scan, or B-scan. The method can be implemented using non-polarization-maintaining fiber and a single detector. This PS-OCT method reported measures fast axis explicitly. In a calibration test of the system, net retardance was measured with an average error of 7.5° (standard deviation 2.2°) over the retardance range 0° to 180°, and fast axis with average error of 4.8° over the range 0° to 180°.

    摘要翻译： 一种使用偏振光敏光学相干断层扫描（PS-OCT）三维提取微尺度分辨率的生物样品的矢量光学性质的方法和装置。 该方法测量净延迟，净快轴和反射率。 通过使用相同像素，A扫描或B扫描的连续采集，以至少三个单独的极化状态照射样本来实现极化感测。 该方法可以使用非偏振维持光纤和单个检测器来实现。 这种PS-OCT方法报道了快轴测量。 在系统的校准测试中，在0°至180°的延迟范围内测量平均误差为7.5°（标准偏差2.2°）的净延迟，平均误差为4.8°的快轴在0°至 180°。

    Method and device for optical determination of physical properties of features, not much larger than the optical wavelength used, on a test sample
    10.
    发明授权
    Method and device for optical determination of physical properties of features, not much larger than the optical wavelength used, on a test sample 有权
    用于在测试样品上光学确定特征物理性质的方法和装置，其比所使用的光波长不大

    公开(公告)号：US07808648B2

    公开(公告)日：2010-10-05

    申请号：US11742414

    申请日：2007-04-30

    申请人： Torbjorn Sandstrom

    发明人： Torbjorn Sandstrom

    IPC分类号： G01B9/02 ,  G01B11/02

    CPC分类号： G01N21/9501 ,  G01B9/02011 ,  G01B9/0209 ,  G01B2290/45 ,  G01B2290/70 ,  G01J4/04 ,  G01J9/02 ,  G01N21/21 ,  G01N2021/95676

    摘要： A method and device for optical determination of physical properties of features, not much larger than the optical wavelength used, on a test sample are described. A beam is split into reference and illuminating beams having known polarization. The test sample is exposed to the illuminating beam and recombined to form an image. The image is detected using at least one sensor, which may be cameras. A point-to-point map of polarization, phase and power is extracted from data representing the image. Optionally, the sensor may be a camera. The sensor may detect at least three optical parameters, such as a Stokes vector, a Jones vector, a Jones matrix, a Mueller matrix or a coherency matrix.

    摘要翻译： 描述了用于在测试样品上光学确定不同于所使用的光波长的特征的物理性质的方法和装置。 光束被分割成具有已知偏振的参考和照明光束。 将测试样品暴露于照明光束并重新组合以形成图像。 使用至少一个可以是相机的传感器来检测图像。 从表示图像的数据中提取极化，相位和功率的点对点图。 可选地，传感器可以是相机。 传感器可以检测至少三个光学参数，例如斯托克斯矢量，琼斯矢量，琼斯矩阵，米勒矩阵或相干矩阵。