公开(公告)号：US20070069120A1

公开(公告)日：2007-03-29

申请号：US11237523

申请日：2005-09-28

申请人： Alexandre Shvartsburg ,  Richard Smith ,  Gordon Anderson

发明人： Alexandre Shvartsburg ,  Richard Smith ,  Gordon Anderson

IPC分类号： H01J49/40

CPC分类号： G01N27/624

摘要： The present invention relates generally to separation of ions based on their transport properties. More particularly, the invention relates to separation of ionic mixtures and characterization of ions in gases using higher-order differential ion mobility spectrometry (HODIMS) enabled by asymmetric waveforms of fundamentally new types. The invention discloses a method and apparatus for separation of ionic mixtures and characterization, identification, or quantification of ions in a gas based substantially on the terms of third or higher order in a series expansion of ion mobility as a function of electric field intensity. This is achieved using a periodic, time-dependent electric field with novel waveform profiles that cancel or substantially reduce the contributions to time-averaged ion motion of the leading n (where n≧2) terms of that expansion, thereby achieving ion separations based substantially on the (n+1)th term. Separations using HODIMS with different n are expected to be highly orthogonal, enabling multidimensional separations employing HODIMS analyzers of different orders. The expected high orthogonality between HODIMS and mass spectrometry or ion mobility spectrometry would make HODIMS/MS and HODIMS/IMS combinations powerful analytical tools of broad utility.

摘要翻译： 本发明一般涉及基于它们的运输特性分离离子。 更具体地，本发明涉及离子混合物的分离和使用通过基本上新型的不对称波形实现的高阶差分离子迁移谱（HODIMS）的气体中的离子表征。 本发明公开了一种用于分离离子混合物的方法和装置，并且基于离子迁移率的串联扩展作为电场强度的函数，基本上以三阶或更高阶的项为基础来表征，鉴定或定量气体中的离子。 这是使用具有新颖波形分布的周期性，时间依赖性电场来实现的，其消除或基本上减少对该扩展的前导n（其中n≥2）项的时间平均离子运动的贡献，由此实现基于离子分离 基本上在第（n + 1）项。 使用具有不同n的HODIMS的分离预计将具有高度正交性，可以使用具有不同阶数的HODIMS分析仪进行多维分离。 HODIMS和质谱法或离子迁移光谱法之间预期的高正交性将使HODIMS / MS和HODIMS / IMS组合成为强大的广泛应用的分析工具。

公开(公告)号：US20060219889A1

公开(公告)日：2006-10-05

申请号：US11097855

申请日：2005-03-31

申请人： Alexandre Shvartsburg ,  Keqi Tang ,  Richard Smith

发明人： Alexandre Shvartsburg ,  Keqi Tang ,  Richard Smith

IPC分类号： B01D59/44

CPC分类号： G01N27/624 ,  H01J49/004 ,  H01J49/40

摘要： Techniques and instrumentation are described for analyses of substances, including complex samples/mixtures that require separation prior to characterization of individual components. A method is disclosed for separation of ion mixtures and identification of ions, including protein and other macromolecular ions and their different structural isomers. Analyte ions are not free to rotate during the separation, but are substantially oriented with respect to the drift direction. Alignment is achieved by applying, at a particular angle to the drift field, a much stronger alternating electric field that “locks” the ion dipoles with moments exceeding a certain value. That value depends on the buffer gas composition, pressure, and temperature, but may be as low as ˜3 Debye under certain conditions. The presently disclosed method measures the direction-specific cross-sections that provide the structural information complementing that obtained from known methods, and, when coupled to those methods, increases the total peak capacity and specificity of gas-phase separations. Simultaneous 2-D separations by direction-specific cross sections along and orthogonally to the ion dipole direction are also possible.

摘要翻译： 描述了用于分析物质的技术和仪器，包括在表征单个组分之前需要分离的复杂样品/混合物。 公开了用于分离离子混合物和鉴定离子的方法，包括蛋白质和其它大分子离子及其不同的结构异构体。 分离离子在分离期间不能自由旋转，而是基本上相对于漂移方向取向。 通过以特定的角度对漂移场施加更强的交变电场来实现对准，所述交变电场通过超过一定值的力矩“锁定”离子偶极子。 该值取决于缓冲气体组成，压力和温度，但在某些条件下可能低至〜3德拜。 目前公开的方法测量提供与已知方法获得的结构信息互补的方向特异性横截面，并且当与这些方法耦合时，增加气相分离的总峰容量和特异性。 沿垂直于离子偶极方向的方向特定横截面同时进行2-D分离也是可能的。

公开(公告)号：US20070200059A1

公开(公告)日：2007-08-30

申请号：US11361264

申请日：2006-02-24

申请人： Keqi Tang ,  Alexandre Shvartsburg ,  Richard Smith

发明人： Keqi Tang ,  Alexandre Shvartsburg ,  Richard Smith

IPC分类号： H01J49/06

CPC分类号： H01J49/067

摘要： The invention discloses a new interface with non-circular conductance limit aperture(s) useful for effective transmission of non-circular ion beams between stages with different gas pressure. In particular, the invention provides an improved coupling of field asymmetric waveform ion mobility spectrometry (FAIMS) analyzers of planar or side-to-side geometry to downstream stages such as mass spectrometry or ion mobility spectrometry. In this case, the non-circular aperture is rectangular; other geometries may be optimum in other applications. In the preferred embodiment, the non-circular aperture interface is followed by an electrodynamic ion funnel that may focus wide ion beams of any shape into tight circular beams with virtually no losses. The jet disrupter element of the funnel may also have a non-circular geometry, matching the shape of arriving ion beam. The improved sensitivity of planar FAIMS/MS has been demonstrated in experiments using a non-contiguous elongated aperture but other embodiments (e.g., with a contiguous slit aperture) may be preferable, especially in conjunction with an ion funnel operated at high pressures.

摘要翻译： 本发明公开了一种具有非圆形电导限制孔径的新界面，其可用于在具有不同气体压力的级之间有效地传输非圆形离子束。 特别地，本发明提供了平面或侧对面几何的场非对称波形离子淌度光谱（FAIMS）分析仪与诸如质谱或离子淌度光谱法的下游阶段的改进的耦合。 在这种情况下，非圆形孔是矩形的; 其他几何形状在其他应用中可能是最佳的。 在优选实施例中，非圆形孔径界面之后是电动离子漏斗，其可将任何形状的宽离子束聚焦成紧密的圆形梁，实际上没有损失。 漏斗的喷射破坏器元件也可以具有与到达的离子束的形状匹配的非圆形几何形状。 已经在使用不连续的细长孔的实验中证明了平面FAIMS / MS的改进的灵敏度，但是其它实施例（例如，具有连续的狭缝孔）可能是优选的，特别是与在高压下操作的离子漏斗相结合。

公开(公告)号：US20060226353A1

公开(公告)日：2006-10-12

申请号：US11103984

申请日：2005-04-11

申请人： Keqi Tang ,  Alexandre Shvartsburg ,  Richard Smith

发明人： Keqi Tang ,  Alexandre Shvartsburg ,  Richard Smith

IPC分类号： H01J49/40

CPC分类号： G01N27/624 ,  H01J49/004

摘要： The present invention relates to a device for separation and characterization of gas-phase ions. The device incorporates an ion source, a field asymmetric waveform ion mobility spectrometry (FAIMS) analyzer, an ion mobility spectrometry (IMS) drift tube, and an ion detector. In one aspect of the invention, FAIMS operating voltages are electrically floated on top of the IMS drift voltage. In the other aspect, the FAIMS/IMS interface is implemented employing an electrodynamic ion funnel, including in particular an hourglass ion funnel. The present invention improves the efficiency (peak capacity) and sensitivity of gas-phase separations; the online FAIMS/IMS coupling creates a fundamentally novel two-dimensional gas-phase separation technology with high peak capacity, specificity, and exceptional throughput.

摘要翻译： 本发明涉及气相离子的分离和表征装置。 该装置包括离子源，场非对称波形离子迁移谱（FAIMS）分析仪，离子迁移谱（IMS）漂移管和离子检测器。 在本发明的一个方面，FAIMS工作电压在IMS漂移电压的顶部被浮动。 另一方面，使用电动离子漏斗实现FAIMS / IMS接口，特别包括沙漏离子漏斗。 本发明提高气相分离的效率（峰值容量）和灵敏度; 在线FAIMS / IMS耦合产生了具有高峰值容量，特异性和卓越吞吐量的基本上新颖的二维气相分离技术。

公开(公告)号：US20050092918A1

公开(公告)日：2005-05-05

申请号：US10933661

申请日：2004-09-02

申请人： Richard Smith ,  Keqi Tang ,  Alexandre Shvartsburg

发明人： Richard Smith ,  Keqi Tang ,  Alexandre Shvartsburg

IPC分类号： G01N27/64 ,  H01J49/02 ,  H01J49/04 ,  H01J49/06 ,  H01J49/16 ,  H01J49/40 ,  H01J49/42

CPC分类号： H01J49/066 ,  G01N27/622 ,  H01J49/40

摘要： A method and apparatus enabling increased sensitivity in ion mobility spectrometry/mass spectrometry instruments which substantially reduces or eliminates the loss of ions in ion mobility spectrometer drift tubes utilizing a device for transmitting ions from an ion source which allows the transmission of ions without significant delay to an hourglass electrodynamic ion funnel at the entrance to the drift tube and/or an internal ion funnel at the exit of the drift tube. An hourglass electrodynamic funnel is formed of at least an entry element, a center element, and an exit element, wherein the aperture of the center element is smaller than the aperture of the entry element and the aperture of the exit elements. Ions generated in a relatively high pressure region by an ion source at the exterior of the hourglass electrodynamic funnel are transmitted to a relatively low pressure region at the entrance of the hourglass funnel through a conductance limiting orifice. Alternating and direct electrical potentials are applied to the elements of the hourglass electrodynamic funnel thereby drawing ions into and through the hourglass electrodynamic funnel thereby introducing relatively large quantities of ions into the drift tube while maintaining the gas pressure and composition at the interior of the drift tube as distinct from those at the entrance of the electrodynamic funnel and allowing a positive gas pressure to be maintained within the drift tube, if desired. An internal ion funnel is provided within the drift tube and is positioned at the exit of said drift tube. The advantage of the internal ion funnel is that ions that are dispersed away from the exit aperture within the drift tube, such as those that are typically lost in conventional drift tubes to any subsequent analysis or measurement, are instead directed through the exit of the drift tube, vastly increasing the amount of ions exiting the drift tube.

公开(公告)号：US20050267688A1

公开(公告)日：2005-12-01

申请号：US10846188

申请日：2004-05-14

申请人： Konstantinos Petritis ,  Lars Kangas ,  Gordon Anderson ,  Richard Smith

发明人： Konstantinos Petritis ,  Lars Kangas ,  Gordon Anderson ,  Richard Smith

IPC分类号： G01N33/68 ,  G06F19/00 ,  G01N33/48 ,  G01N33/50

CPC分类号： C07K1/16 ,  G01N30/8693 ,  G01N33/6803 ,  G01N33/6806 ,  G01N2030/8831 ,  G16B40/00

摘要： A method for predicting the elution time of a peptide in chromatographic and electrophoretic separations by first providing a data set of known elution times of known peptides, then creating a plurality of vectors, each vector having a plurality of dimensions, and each dimension representing positional information about at least a portion of the amino acids present in the known peptides. A hypothetical vector is then created by assigning dimensional values for at least one hypothetical peptide, and a predicted elution time for the hypothetical vector is created by performing at least one multivariate regression fitting the hypothetical peptide to the plurality of vectors. Preferably, the multivariate regression is accomplished by the use of an artificial neural network and the elution times are first normalized using linear regression.

摘要翻译： 通过首先提供已知肽的已知洗脱时间的数据集，然后产生多个向量，每个载体具有多个维度，并且每个维度表示位置信息，用于预测肽在色谱和电泳分离中的洗脱时间的方法 约至少一部分已知肽中存在的氨基酸。 然后通过为至少一个假想肽分配尺寸值来产生假想载体，并且通过对多个载体进行拟合假想肽的至少一个多变量回归而产生假设载体的预测洗脱时间。 优选地，通过使用人造神经网络实现多变量回归，并且首先使用线性回归归一化洗脱时间。

公开(公告)号：US20180265254A1

公开(公告)日：2018-09-20

申请号：US15923296

申请日：2018-03-16

申请人： Richard Smith

发明人： Richard Smith

IPC分类号： B65D25/02 ,  B65D25/20 ,  B65D25/22 ,  B65D21/02

CPC分类号： B65D25/02 ,  B25H3/06 ,  B25H5/00 ,  B65D21/0213 ,  B65D25/205 ,  B65D25/22

摘要： A fluid sample display for displaying actual vehicle fluid samples alongside comparisons of exemplary fluids has a tray with dimples to receive the fluid samples. The dimples are coverable by a movable cover. The tray can have an indicia panel for removably receiving indicia indicative of a vehicle and/or vehicle owner.

公开(公告)号：US20150377294A1

公开(公告)日：2015-12-31

申请号：US14675898

申请日：2015-04-01

申请人： Richard Smith ,  Asley Crowther ,  Jesse Harries Graeter ,  Scott Macindoe ,  Michael Ulfert Hornemann

发明人： Richard Smith ,  Asley Crowther ,  Jesse Harries Graeter ,  Scott Macindoe ,  Michael Ulfert Hornemann

IPC分类号： F16C33/66 ,  B08B3/10 ,  B01D35/02 ,  B08B3/02

CPC分类号： F16C33/6622 ,  B01D35/02 ,  B08B3/02 ,  B08B3/10 ,  B08B9/00 ,  F03D80/50 ,  F03D80/55 ,  F03D80/70 ,  F16C2360/31

摘要： A method is disclosed for replacing grease in a main bearing of a wind turbine, the main bearing located in a housing and the housing having least one cover plate. the bearing cover plate is removed from the housing, grease is manually removed from the main bearing, and a flushing cover is installed on the housing in place of the bearing cover plate. The flushing cover has at least two parts, the parts fitting around the main shaft, and each part having a seal so that when its attached to the bearing housing, the flushing cover forms a seal with the main shaft. The flushing cover has holes allowing access to the main bearing, and a solvent or oil is sprayed via one of the holes onto the main bearing to remove grease, the remaining holes being sealed by a removable plug. Solvent or oil is pumped out of the housing via a port at the bottom of the housing or flushing cover. The process is repeated for each hole, and the flushing cover removed, the main bearing packed with grease, and the bearing cover plate re-affixed. The spraying step involves pumping solvent or oil from a reservoir to the spray nozzle, and the step of pumping solvent or oil out of the bearing housing involves pumping solvent or oil to the reservoir via a return hose. This means that the solvent or oil is recycled during the replacing of the grease. An apparatus for flushing grease from a main bearing of a wind turbine is also described.

摘要翻译： 公开了一种用于更换风力涡轮机的主轴承中的润滑脂的方法，位于壳体中的主轴承和具有至少一个盖板的壳体。 将轴承盖板从壳体中取出，从主轴承上手动取出润滑脂，并且将外壳上的冲洗盖安装在轴承盖板上。 冲洗盖具有至少两个部件，部件围绕主轴安装，每个部件具有密封件，使得当其附接到轴承壳体时，冲洗盖与主轴形成密封。 冲洗盖具有允许进入主轴承的孔，并且通过一个孔将溶剂或油喷射到主轴承上以除去油脂，剩余的孔被可移除的塞子密封。 溶剂或油通过外壳或冲洗盖底部的端口从外壳中抽出。 每个孔重复该过程，拆下冲洗盖，装有油脂的主轴承和轴承盖板重新固定。 喷射步骤包括将溶剂或油从储存器泵送到喷嘴，并且将溶剂或油抽出轴承壳体的步骤包括通过返回软管将溶剂或油泵送到储存器。 这意味着溶剂或油在更换润滑脂期间被循环使用。 还描述了用于从风力涡轮机的主轴承冲洗润滑脂的装置。

公开(公告)号：US08522527B2

公开(公告)日：2013-09-03

申请号：US12690283

申请日：2010-01-20

申请人： Adnan Eroglu ,  Douglas Anthony Pennell ,  Johannes Buss ,  Richard Smith

发明人： Adnan Eroglu ,  Douglas Anthony Pennell ,  Johannes Buss ,  Richard Smith

IPC分类号： F02K3/10 ,  F02C1/06 ,  F02C1/00 ,  F02C7/22

CPC分类号： F23R3/286 ,  F23R3/34 ,  F23R2900/03341

摘要： A burner (1) for a gas turbine includes a duct (2) enclosing a plurality of vortex generators (3) and, downstream of them, a lance (5) provided with nozzles (6) for injecting a gaseous fuel. The burner (1) also includes a mixer (7) for diluting and mixing the gaseous fuel with air to form a mixture. The mixer (7) is connected to the nozzles (6) for feeding them with the mixture. A method includes feeding the gaseous fuel in the burner (1).

摘要翻译： 一种用于燃气轮机的燃烧器（1）包括封闭多个涡流发生器（3）的管道（2），并且在其下游设置有喷枪（5），喷枪（6）用于喷射气态燃料。 燃烧器（1）还包括用于将气体燃料稀释和混合以形成混合物的混合器（7）。 混合器（7）连接到喷嘴（6），用于将它们供给到混合物中。 一种方法包括将燃料（1）中的气态燃料进料。

公开(公告)号：US20130022238A1

公开(公告)日：2013-01-24

申请号：US13507320

申请日：2012-06-21

申请人： Stephen M. Wood ,  Richard Smith ,  David Bear ,  George Kechter ,  Conor O'Neill

发明人： Stephen M. Wood ,  Richard Smith ,  David Bear ,  George Kechter ,  Conor O'Neill

IPC分类号： G06K9/78 ,  G06K19/06

CPC分类号： G06K19/06056 ,  G06K5/00 ,  G06K9/00577 ,  G06K19/06 ,  G06Q30/0185 ,  G07D7/2033

摘要： Systems and methods for identifying, tracking, tracing and determining the authenticity of a good include an imaging system, a database, and an authentication center. The imaging system is configured to capture an image of a unique signature associated with a good. The unique signature can be, for example, a random structure or pattern unique to the particular good. The imaging system is configured to process the image to identify at least one metric that distinguishes the unique signature from unique signatures of other goods. The database is configured to receive information related to the good and its unique signature from the imaging system, and to store the information therein. The authentication center is configured to analyze the field image with respect to the information stored in the database to determine whether the unique signature in the field image is a match to the captured image stored in the database.

摘要翻译： 用于识别，跟踪，跟踪和确定商品的真实性的系统和方法包括成像系统，数据库和认证中心。 成像系统被配置为捕获与商品相关联的唯一签名的图像。 独特的签名可以是例如特定商品独特的随机结构或图案。 成像系统被配置为处理图像以识别将唯一签名与其他商品的唯一签名区分开的至少一个度量。 数据库被配置为从成像系统接收与该品牌及其唯一签名相关的信息，并且将该信息存储在其中。 认证中心被配置为相对于存储在数据库中的信息来分析场图像，以确定场图像中的唯一签名是否与存储在数据库中的捕获图像相匹配。