公开(公告)号：US5636017A

公开(公告)日：1997-06-03

申请号：US212521

申请日：1994-03-11

申请人： Alfredo E. Bruno ,  Beat Krattiger ,  Carlo S. Effenhauser ,  Francois Maystre ,  Philippe Nussbaum

发明人： Alfredo E. Bruno ,  Beat Krattiger ,  Carlo S. Effenhauser ,  Francois Maystre ,  Philippe Nussbaum

IPC分类号： G01N21/45 ,  G01N21/05 ,  G01N21/64 ,  G01N27/447 ,  G01N30/74

CPC分类号： G01N30/74 ,  G01N21/05 ,  G01N27/44721 ,  G01N2021/0346

摘要： An optical detection arrangement for small volume chemical analysis comprises a light source (22), a capillary tube (23) and a photoelectric detector (24). The arrangement of the light source (22) relative to the capillary tube (23) is such, that probing light (P) emitted from the light source (22) strikes a sample (S) to be analyzed, which is flowing through the capillary tube (23), whereas the photoelectric detector (24) is arranged relative to the capillary tube (23) such, that it is capable of detecting light comming from the capillary tube. The photoelectric detector (24) is connected with an evaluation electronics. Between the light source (22) and the capillary tube (23)the probing light (P) is guided essentially in a guiding means (26) which is made of a material having a refractive index gradient about perpendicular to the direction of propagation of the probing light (P), and which is connected to the capillary tube (23) such that probing light (P) exiting the guiding material (26) strikes the capillary tube (23). Preferably light emitting diodes (LEDs) or laser diodes are used as light source (22).

摘要翻译： 用于小容量化学分析的光学检测装置包括光源（22），毛细管（23）和光电检测器（24）。 光源（22）相对于毛细管（23）的布置是这样的，即从光源（22）发射的探测光（P）撞击待分析的样品（S），该​​样品（S）流过毛细管 管（23），而光电检测器（24）相对于毛细管（23）布置，使得其能够检测来自毛细管的光。 光电检测器（24）与评估电路连接。 在光源（22）和毛细管（23）之间，探测光（P）基本上在引导装置（26）中引导，该引导装置（26）由具有垂直于 探测光（P），并且其连接到毛细管（23），使得离开引导材料（26）的探测光（P）撞击毛细管（23）。 优选使用发光二极管（LED）或激光二极管作为光源（22）。

公开(公告)号：US5290520A

公开(公告)日：1994-03-01

申请号：US990213

申请日：1992-12-14

申请人： Francois Maystre ,  Alfredo E. Bruno

发明人： Francois Maystre ,  Alfredo E. Bruno

IPC分类号： G02F1/13 ,  C09K19/30 ,  C09K19/46 ,  C09K19/54 ,  G01N30/02 ,  G01N30/34 ,  G01N30/62 ,  G01N30/74 ,  G01N30/78 ,  G01N30/84 ,  G01N21/01

CPC分类号： G01N30/34 ,  G01N30/74 ,  C09K2219/17 ,  G01N2030/027 ,  G01N2030/625 ,  G01N2030/8435 ,  G01N30/78

摘要： An analytic separation arrangement includes a system of tubes including a separation zone, preferably a separation column, which tubes upstream the separation zone are connected with reservoirs for a carrier and a chemical sample to be seperated and analyzed, and downstream the separation zone are connected with a waste container for the carrier containing the sample and also are connected with transporting means for the carrier and the sample. The tube system is associated with an optical detector for monitoring changes in the absorption, in the fluorescence or in the optical activity of the carrier when it is transported through the tube system and past the optical detector, which is arranged in the path of the carrier behind the separation zone but in front of the waste container. Between the separation zone and the optical detector there is arranged in the path of the carrier a refractive index equalizing unit. Prior to being transported past the optical detector the carrier, which is comming from the separation zone, is directed through the refractive index equalizing unit, where its refractive index is preferably constantly monitored and where upon detection of changes of the refractive index of the carrier the deviation is compensated by adding to the carrier a compensating agent.

摘要翻译： 分析分离装置包括管系统，其包括分离区，优选分离塔，分离区上游的管与用于载体和待分离和分析的化学样品的储存器连接，分离区的下游与 用于包含样品的载体的废物容器，并且还与用于载体和样品的输送装置连接。 管系统与光学检测器相关联，用于监测载体在其被传送通过管系统并经过光学检测器的荧光或荧光光学活性时的变化，光检测器布置在载体的路径中 在分离区后面，但在废物容器前面。 在分离区域和光学检测器之间，在载体的路径中布置折射率均衡单元。 在被传送通过光学检测器之前，从分离区转移的载体被引导通过折射率均衡单元，其折射率优选地被不断地监测，并且在检测到载体的折射率变化的地方 通过向载体添加补偿剂来补偿偏差。