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    Optical detection arrangement for small volume chemical analysis of fluid samples
    1.
    发明授权
    Optical detection arrangement for small volume chemical analysis of fluid samples 失效
    流体样品小体积化学分析光学检测装置

    公开(公告)号：US5636017A

    公开(公告)日：1997-06-03

    申请号：US212521

    申请日：1994-03-11

    Applicant: Alfredo E. Bruno ,  Beat Krattiger ,  Carlo S. Effenhauser ,  Francois Maystre ,  Philippe Nussbaum

    Inventor： Alfredo E. Bruno ,  Beat Krattiger ,  Carlo S. Effenhauser ,  Francois Maystre ,  Philippe Nussbaum

    IPC: G01N21/45 ,  G01N21/05 ,  G01N21/64 ,  G01N27/447 ,  G01N30/74

    CPC classification number: G01N30/74 ,  G01N21/05 ,  G01N27/44721 ,  G01N2021/0346

    Abstract: An optical detection arrangement for small volume chemical analysis comprises a light source (22), a capillary tube (23) and a photoelectric detector (24). The arrangement of the light source (22) relative to the capillary tube (23) is such, that probing light (P) emitted from the light source (22) strikes a sample (S) to be analyzed, which is flowing through the capillary tube (23), whereas the photoelectric detector (24) is arranged relative to the capillary tube (23) such, that it is capable of detecting light comming from the capillary tube. The photoelectric detector (24) is connected with an evaluation electronics. Between the light source (22) and the capillary tube (23)the probing light (P) is guided essentially in a guiding means (26) which is made of a material having a refractive index gradient about perpendicular to the direction of propagation of the probing light (P), and which is connected to the capillary tube (23) such that probing light (P) exiting the guiding material (26) strikes the capillary tube (23). Preferably light emitting diodes (LEDs) or laser diodes are used as light source (22).

    Abstract translation: 用于小容量化学分析的光学检测装置包括光源（22），毛细管（23）和光电检测器（24）。 光源（22）相对于毛细管（23）的布置是这样的，即从光源（22）发射的探测光（P）撞击待分析的样品（S），该​​样品（S）流过毛细管 管（23），而光电检测器（24）相对于毛细管（23）布置，使得其能够检测来自毛细管的光。 光电检测器（24）与评估电路连接。 在光源（22）和毛细管（23）之间，探测光（P）基本上在引导装置（26）中引导，该引导装置（26）由具有垂直于 探测光（P），并且其连接到毛细管（23），使得离开引导材料（26）的探测光（P）撞击毛细管（23）。 优选使用发光二极管（LED）或激光二极管作为光源（22）。

    Analytic separation arrangement and method for the analysis of chemical samples
    2.
    发明授权
    Analytic separation arrangement and method for the analysis of chemical samples 失效
    分析分析方法和化学样品分析方法

    公开(公告)号：US5290520A

    公开(公告)日：1994-03-01

    申请号：US990213

    申请日：1992-12-14

    Applicant: Francois Maystre ,  Alfredo E. Bruno

    Inventor： Francois Maystre ,  Alfredo E. Bruno

    IPC: G02F1/13 ,  C09K19/30 ,  C09K19/46 ,  C09K19/54 ,  G01N30/02 ,  G01N30/34 ,  G01N30/62 ,  G01N30/74 ,  G01N30/78 ,  G01N30/84 ,  G01N21/01

    CPC classification number: G01N30/34 ,  G01N30/74 ,  C09K2219/17 ,  G01N2030/027 ,  G01N2030/625 ,  G01N2030/8435 ,  G01N30/78

    Abstract: An analytic separation arrangement includes a system of tubes including a separation zone, preferably a separation column, which tubes upstream the separation zone are connected with reservoirs for a carrier and a chemical sample to be seperated and analyzed, and downstream the separation zone are connected with a waste container for the carrier containing the sample and also are connected with transporting means for the carrier and the sample. The tube system is associated with an optical detector for monitoring changes in the absorption, in the fluorescence or in the optical activity of the carrier when it is transported through the tube system and past the optical detector, which is arranged in the path of the carrier behind the separation zone but in front of the waste container. Between the separation zone and the optical detector there is arranged in the path of the carrier a refractive index equalizing unit. Prior to being transported past the optical detector the carrier, which is comming from the separation zone, is directed through the refractive index equalizing unit, where its refractive index is preferably constantly monitored and where upon detection of changes of the refractive index of the carrier the deviation is compensated by adding to the carrier a compensating agent.

    Abstract translation: 分析分离装置包括管系统，其包括分离区，优选分离塔，分离区上游的管与用于载体和待分离和分析的化学样品的储存器连接，分离区的下游与 用于包含样品的载体的废物容器，并且还与用于载体和样品的输送装置连接。 管系统与光学检测器相关联，用于监测载体在其被传送通过管系统并经过光学检测器的荧光或荧光光学活性时的变化，光检测器布置在载体的路径中 在分离区后面，但在废物容器前面。 在分离区域和光学检测器之间，在载体的路径中布置折射率均衡单元。 在被传送通过光学检测器之前，从分离区转移的载体被引导通过折射率均衡单元，其折射率优选地被不断地监测，并且在检测到载体的折射率变化的地方 通过向载体添加补偿剂来补偿偏差。

    Flow cell for calorimetric measurements
    4.
    发明授权
    Flow cell for calorimetric measurements 失效
    用于量热测量的流动池

    公开(公告)号：US5482372A

    公开(公告)日：1996-01-09

    申请号：US212668

    申请日：1994-03-11

    Applicant: Pierre Bataillard ,  Alfredo E. Bruno

    Inventor： Pierre Bataillard ,  Alfredo E. Bruno

    IPC: G01K17/00 ,  G01N25/42 ,  G01N25/48 ,  G01N25/20

    CPC classification number: G01N25/42 ,  G01N25/4846

    Abstract: A flow cell for calorimetric measurements comprises a body (2) with at least one flow channel (3), which extends between an inlet opening (4) and an outlet opening (5), and a thermoelectric detector (16) for monitoring temperature changes, which occur during chemical or biochemical processes in a measuring volume (17). The measuring volume (17) is arranged in close vicinity of the outlet opening (5). The body (2) of the flow cell (1) has a good thermal conductivity of a magnitude such, that a fluid flowing through the flow channel (3) is thermostatizised prior to entering the measuring volume (17) solely by flowing through the flow channel (3) and free of any external thermostatization means. Thus, a flow cell is provided, which is capable of self-thermostatizing a fluid flowing therethrough.

    Abstract translation: 用于量热测量的流动池包括具有在入口开口（4）和出口开口（5）之间延伸的至少一个流动通道（3）的主体（2）和用于监测温度变化的热电探测器（16） ，其在测量体积中的化学或生化过程中发生（17）。 测量体积（17）布置在靠近出口（5）处。 流动池（1）的主体（2）具有良好的热导率，其流量通过流动通道（3）的流体在进入测量体积（17）之前仅通过流过流量 通道（3），没有任何外部恒温装置。 因此，提供了能够使流过其中的流体自动恒温的流动池。

    Interferometric apparatus for monitoring changes of the refractive index of fluid samples in capillary tubes
    5.
    发明授权
    Interferometric apparatus for monitoring changes of the refractive index of fluid samples in capillary tubes 失效
    用于监测毛细管中流体样品的折射率变化的干涉仪

    公开(公告)号：US5426505A

    公开(公告)日：1995-06-20

    申请号：US154205

    申请日：1993-11-18

    Applicant: Martial Geiser ,  Hans P. Herzig ,  Beat Krattiger ,  Alfredo E. Bruno

    Inventor： Martial Geiser ,  Hans P. Herzig ,  Beat Krattiger ,  Alfredo E. Bruno

    IPC: G01N21/45 ,  G01N27/447 ,  G01N30/02 ,  G01N30/74 ,  G01B9/02

    CPC classification number: G01N30/74 ,  G01N21/45 ,  G01N27/44721 ,  G01N2030/027 ,  G01N2201/0612

    Abstract: An interferometric apparatus for monitoring changes of the refractive index of An interferometri1capillary tubes comprising a source of coherent light, which is arranged with respect to a capillary tube which is part of a capillary liquid chromatographic system or a capillary electrophoretic system, such that the coherent light beam strikes the capillary tube about perpendicular to its longitudinal extension. In the forward direction of the coherent light beam, behind the capillary tube, the apparatus comprises a photoelectric detector for monitoring a resulting interference fringe pattern and the shifts thereof, which is connected to an evaluation electronics. Between the light source and the capillary tube there is arranged a beam splitting optical element for generating a converging probe beam, which travels along a probe beam axis and strikes the capillary tube at its bore, and a converging reference beam, which travels along a reference beam axis, that extends generally parallel to the probe beam axis and is located in close vicinity to the probe beam axis, and which does not strike the capillary bore.

    Abstract translation: 一种用于监测包括相干光源的干涉式毛细管的折射率变化的干涉仪，其相对于作为毛细管液相色谱系统或毛细管电泳系统的一部分的毛细管布置，使得相干光 梁垂直于其纵向延伸部分撞击毛细管。 在相干光束的向前方向上，毛细管后面，该装置包括用于监测所得干涉条纹图案及其偏移的光电检测器，其连接到评估电子器件。 在光源和毛细管之间布置有分束光学元件，用于产生会聚的探针光束，其沿着探针光束轴线行进并在其孔处撞击毛细管，并且会聚参考光束沿着参考 射束轴线，其大致平行于探针光束轴线延伸并且位于探针光束轴线附近，并且不会撞击毛细管孔。

    Interferometric measuring arrangement for refractive index measurements in capillary tubes
    7.
    发明授权
    Interferometric measuring arrangement for refractive index measurements in capillary tubes 失效
    毛细管中折射率测量的干涉测量装置

    公开(公告)号：US5251009A

    公开(公告)日：1993-10-05

    申请号：US12610

    申请日：1993-02-02

    Applicant: Alfredo E. Bruno

    Inventor： Alfredo E. Bruno

    IPC: G01N21/03 ,  G01N21/45 ,  G01N30/74 ,  G01B9/02

    CPC classification number: G01N21/0332 ,  G01N21/45 ,  G01N2021/0346 ,  G01N21/6402

    Abstract: A detection cell (4) is part of an interferometer for measuring changes in the refractive index of a medium located in a capillary (2). In order to simplify the evaluation of an interference fringe pattern, the capillary (2) is arranged in a matching fluid (15), the refractive index of which corresponds to that of the material of the capillary. The matching fluid (15) acts at the same time as a temperature-control bath for the capillary, thereby substantially increasing the temperature stability.

    Abstract translation: 检测单元（4）是用于测量位于毛细管（2）中的介质的折射率变化的干涉仪的一部分。 为了简化干涉条纹图案的评估，毛细管（2）布置在匹配流体（15）中，其折射率对应于毛细管材料的折射率。 匹配流体（15）与用于毛细管的温度控制槽同时作用，从而大大提高了温度稳定性。

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