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1.发明申请INHIBITORS OF HEPATITIS C VIRUS RNA-DEPENDENT RNA POLYMERASE, AND COMPOSITIONS AND TREATMENTS USING THE SAME 失效HEPATITIS C病毒RNA依赖RNA聚合酶的抑制剂及其组合物和治疗公开(公告)号：US20060189681A1
公开(公告)日：2006-08-24
申请号：US11382154
申请日：2006-05-08
申请人： Allen Borchardt , Javier Gonzalez , Hui Li , Maria Linton , John Tatlock
发明人： Allen Borchardt , Javier Gonzalez , Hui Li , Maria Linton , John Tatlock
IPC分类号： A61K31/366 , C07D309/30
CPC分类号： C07D285/06 , C07D263/58 , C07D309/32 , C07D405/06 , C07D405/10 , C07D405/12 , C07D405/14 , C07D407/06 , C07D407/10 , C07D407/12 , C07D409/06 , C07D409/10 , C07D413/06 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/10 , C07D417/12 , C07D471/04 , C07D473/30 , C07D473/36 , C07D487/04 , C07D495/04 , C07D513/04
摘要： The invention relates to compounds of the formula 1 and to pharmaceutically acceptable salts, solvates, prodrugs and metabolites thereof, wherein W, Z, R1 and R2, are as defined herein. The invention also relates to methods of treating Hepatitis C virus in mammals by administering the compounds of formula 1, and to pharmaceutical compositions for treating such disorders, which contain the compounds of formula 1. The invention also relates to methods of preparing the compounds of formula 1.
摘要翻译： 本发明涉及式1的化合物及其药学上可接受的盐，溶剂合物，前药和代谢物，其中W，Z，R 1和R 2定义同上 这里。 本发明还涉及通过给予式1化合物治疗哺乳动物中的丙型肝炎病毒的方法以及含有式1化合物的用于治疗这种病症的药物组合物。本发明还涉及制备式 1。
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2.发明申请Inhibitors of hepatitis C virus RNA-dependent RNA polymerase, and compositions and treatments using the same 失效丙型肝炎病毒RNA依赖性RNA聚合酶的抑制剂，以及使用其的组合物和治疗公开(公告)号：US20050176701A1
公开(公告)日：2005-08-11
申请号：US10718337
申请日：2003-11-19
申请人： Allen Borchardt , Javier Gonzalez , Hui Li , Maria Linton , John Tatlock
发明人： Allen Borchardt , Javier Gonzalez , Hui Li , Maria Linton , John Tatlock
IPC分类号： A61K31/4025 , A61K31/452 , A61K31/496 , A61K31/519 , A61K31/5377 , A61K31/541 , A61P31/14 , C07D263/58 , C07D285/06 , C07D309/32 , C07D405/06 , C07D405/10 , C07D405/12 , C07D405/14 , C07D407/06 , C07D407/10 , C07D407/12 , C07D409/06 , C07D409/10 , C07D413/02 , C07D413/06 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/02 , C07D417/06 , C07D417/10 , C07D417/12 , C07D471/04 , C07D473/30 , C07D473/36 , C07D487/04 , C07D495/04 , C07D513/04 , C07D45/02
CPC分类号： C07D285/06 , C07D263/58 , C07D309/32 , C07D405/06 , C07D405/10 , C07D405/12 , C07D405/14 , C07D407/06 , C07D407/10 , C07D407/12 , C07D409/06 , C07D409/10 , C07D413/06 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/10 , C07D417/12 , C07D471/04 , C07D473/30 , C07D473/36 , C07D487/04 , C07D495/04 , C07D513/04
摘要： The invention relates to compounds of the formula 1 and to pharmaceutically acceptable salts, solvates, prodrugs and metabolites thereof, wherein W, Z, R1 and R2, are as defined herein. The invention also relates to methods of treating Hepatitis C virus in mammals by administering the compounds of formula 1, and to pharmaceutical compositions for treating such disorders, which contain the compounds of formula 1. The invention also relates to methods of preparing the compounds of formula 1.
摘要翻译： 本发明涉及式1的化合物及其药学上可接受的盐，溶剂合物，前药和代谢物，其中W，Z，R 1和R 2定义同上 这里。 本发明还涉及通过给予式1化合物治疗哺乳动物中的丙型肝炎病毒的方法以及含有式1化合物的用于治疗这种病症的药物组合物。本发明还涉及制备式 1。
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3.发明授权Inhibitors of hepatitis C virus RNA-dependent RNA polymerase, and compositions and treatments using the same 失效丙型肝炎病毒RNA依赖性RNA聚合酶的抑制剂，以及使用其的组合物和治疗公开(公告)号：US07473790B2
公开(公告)日：2009-01-06
申请号：US11382154
申请日：2006-05-08
IPC分类号： C07D309/30 , C07D305/00 , C07D309/00
CPC分类号： C07D285/06 , C07D263/58 , C07D309/32 , C07D405/06 , C07D405/10 , C07D405/12 , C07D405/14 , C07D407/06 , C07D407/10 , C07D407/12 , C07D409/06 , C07D409/10 , C07D413/06 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/10 , C07D417/12 , C07D471/04 , C07D473/30 , C07D473/36 , C07D487/04 , C07D495/04 , C07D513/04
摘要： The invention relates to compounds of the formula 1 and to pharmaceutically acceptable salts, solvates, prodrugs and metabolites thereof, wherein W, Z, R1 and R2, are as defined herein. The invention also relates to methods of treating Hepatitis C virus in mammals by administering the compounds of formula 1, and to pharmaceutical compositions for treating such disorders, which contain the compounds of formula 1. The invention also relates to methods of preparing the compounds of formula 1.
摘要翻译： 本发明涉及式1的化合物及其药学上可接受的盐，溶剂合物，前药和代谢物，其中W，Z，R 1和R 2如本文所定义。 本发明还涉及通过给予式1化合物治疗哺乳动物中的丙型肝炎病毒的方法以及含有式1化合物的用于治疗这种病症的药物组合物。本发明还涉及制备式 1。
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4.发明授权Inhibitors of hepatitis C virus RNA-dependent RNA polymerase, and compositions and treatments using the same 失效丙型肝炎病毒RNA依赖性RNA聚合酶的抑制剂，以及使用其的组合物和治疗公开(公告)号：US07148226B2
公开(公告)日：2006-12-12
申请号：US10718337
申请日：2003-11-19
IPC分类号： A61K31/519
CPC分类号： C07D285/06 , C07D263/58 , C07D309/32 , C07D405/06 , C07D405/10 , C07D405/12 , C07D405/14 , C07D407/06 , C07D407/10 , C07D407/12 , C07D409/06 , C07D409/10 , C07D413/06 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/10 , C07D417/12 , C07D471/04 , C07D473/30 , C07D473/36 , C07D487/04 , C07D495/04 , C07D513/04
摘要： The invention relates to compounds of the formula 1 and to pharmaceutically acceptable salts, solvates, prodrugs and metabolites thereof, wherein W, Z, R1 and R2, are as defined herein. The invention also relates to methods of treating Hepatitis C virus in mammals by administering the compounds of formula 1, and to pharmaceutical compositions for treating such disorders, which contain the compounds of formula 1. The invention also relates to methods of preparing the compounds of formula 1.
摘要翻译： 本发明涉及式1的化合物及其药学上可接受的盐，溶剂合物，前药和代谢物，其中W，Z，R 1和R 2定义同上 这里。 本发明还涉及通过给予式1化合物治疗哺乳动物中的丙型肝炎病毒的方法以及含有式1化合物的用于治疗这种病症的药物组合物。本发明还涉及制备式 1。
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5.发明申请INHIBITORS OF HEPATITIS C VIRUS RNA-DEPENDENT RNA POLYMERASE, AND COMPOSITIONS AND TREATMENTS USING THE SAME 失效HEPATITIS C病毒RNA依赖RNA聚合酶的抑制剂及其组合物和治疗公开(公告)号：US20070015764A1
公开(公告)日：2007-01-18
申请号：US11470540
申请日：2006-09-06
申请人： Javier Gonzalez , Tanya Jewell , Hui Li , Angelica Linton , John Tatlock
发明人： Javier Gonzalez , Tanya Jewell , Hui Li , Angelica Linton , John Tatlock
IPC分类号： A61K31/519 , A61K31/506 , A61K31/497 , A61K31/501 , A61K31/4433 , A61K31/416 , A61K31/4178 , A61K31/427 , A61K31/422 , C07D487/02 , C07D405/02
CPC分类号： C07D309/32 , C07D405/06 , C07D405/14 , C07D471/04 , C07D487/04
摘要： The present invention provides compounds of formula (4), and their pharmaceutically acceptable salts and solvates, which are useful as inhibitors of the Hepatitis C virus (HCV) polymerase enzyme and are also useful for the treatment of HCV infections in HCV-infected mammals. The present invention also provides pharmaceutical compositions comprising compounds of formula (4), their pharmaceutically acceptable salts and solvates. Furthermore, the present invention provides intermediate compounds and methods useful in the preparation of compounds of formula (4).
摘要翻译： 本发明提供了可用作丙型肝炎病毒（HCV）聚合酶的抑制剂的式（4）化合物及其药学上可接受的盐和溶剂合物，并且也可用于治疗HCV感染的哺乳动物中的HCV感染。 本发明还提供包含式（4）化合物，其药学上可接受的盐和溶剂合物的药物组合物。 此外，本发明提供了可用于制备式（4）化合物的中间体化合物和方法。
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6.发明授权Inhibitors of hepatitis C virus RNA-dependent RNA polymerase, and compositions and treatments using the same 失效丙型肝炎病毒RNA依赖性RNA聚合酶的抑制剂，以及使用其的组合物和治疗公开(公告)号：US08268835B2
公开(公告)日：2012-09-18
申请号：US12503286
申请日：2009-07-15
IPC分类号： A61K31/519 , C07D487/04 , A61P31/12
CPC分类号： C07D309/32 , C07D405/06 , C07D405/14 , C07D471/04 , C07D487/04
摘要： The present invention provides compounds of formula (4), and their pharmaceutically acceptable salts and solvates, which are useful as inhibitors of the Hepatitis C virus (HCV) polymerase enzyme and are also useful for the treatment of HCV infections in HCV-infected mammals. The present invention also provides pharmaceutical compositions comprising compounds of formula (4), their pharmaceutically acceptable salts and solvates. Furthermore, the present invention provides intermediate compounds and methods useful in the preparation of compounds of formula (4).
摘要翻译： 本发明提供了可用作丙型肝炎病毒（HCV）聚合酶的抑制剂的式（4）化合物及其药学上可接受的盐和溶剂合物，并且也可用于治疗HCV感染的哺乳动物中的HCV感染。 本发明还提供包含式（4）化合物，其药学上可接受的盐和溶剂合物的药物组合物。 此外，本发明提供了可用于制备式（4）化合物的中间体化合物和方法。
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7.发明申请Inhibitors of Hepatitis C Virus RNA-Dependent RNA Polymerase, and Compositions and Treatments Using the Same 失效丙型肝炎病毒RNA依赖性RNA聚合酶的抑制剂，以及使用其的组合物和治疗公开(公告)号：US20090281122A1
公开(公告)日：2009-11-12
申请号：US12503286
申请日：2009-07-15
IPC分类号： A61K31/519 , C07D487/04 , A61P31/12
CPC分类号： C07D309/32 , C07D405/06 , C07D405/14 , C07D471/04 , C07D487/04
摘要： The present invention provides compounds of formula (4), and their pharmaceutically acceptable salts and solvates, which are useful as inhibitors of the Hepatitis C virus (HCV) polymerase enzyme and are also useful for the treatment of HCV infections in HCV-infected mammals. The present invention also provides pharmaceutical compositions comprising compounds of formula (4), their pharmaceutically acceptable salts and solvates. Furthermore, the present invention provides intermediate compounds and methods useful in the preparation of compounds of formula (4).
摘要翻译： 本发明提供了可用作丙型肝炎病毒（HCV）聚合酶的抑制剂的式（4）化合物及其药学上可接受的盐和溶剂合物，并且也可用于治疗HCV感染的哺乳动物中的HCV感染。 本发明还提供包含式（4）化合物，其药学上可接受的盐和溶剂合物的药物组合物。 此外，本发明提供了可用于制备式（4）化合物的中间体化合物和方法。
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8.发明授权Inhibitors of Hepatitis C virus RNA-dependent RNA polymerase, and compositions and treatments using the same 失效丙型肝炎病毒RNA依赖性RNA聚合酶的抑制剂，以及使用其的组合物和治疗公开(公告)号：US07151105B2
公开(公告)日：2006-12-19
申请号：US11204269
申请日：2005-08-15
IPC分类号： A61K31/519 , A61K31/35 , A01N43/90 , A01N43/16 , C07D487/00
CPC分类号： C07D309/32 , C07D405/06 , C07D405/14 , C07D471/04 , C07D487/04
摘要： The present invention provides compounds of formula (4), and their pharmaceutically acceptable salts and solvates, which are useful as inhibitors of the Hepatitis C virus (HCV) polymerase enzyme and are also useful for the treatment of HCV infections in HCV-infected mammals. The present invention also provides pharmaceutical compositions comprising compounds of formula (4), their pharmaceutically acceptable salts and solvates. Furthermore, the present invention provides intermediate compounds and methods useful in the preparation of compounds of formula (4).
摘要翻译： 本发明提供了可用作丙型肝炎病毒（HCV）聚合酶的抑制剂的式（4）化合物及其药学上可接受的盐和溶剂合物，并且也可用于治疗HCV感染的哺乳动物中的HCV感染。 本发明还提供包含式（4）化合物，其药学上可接受的盐和溶剂合物的药物组合物。 此外，本发明提供了可用于制备式（4）化合物的中间体化合物和方法。
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公开(公告)号：US07115658B2
公开(公告)日：2006-10-03
申请号：US10434702
申请日：2003-05-09
申请人： Allen J. Borchardt , Peter Scott Dragovich , Javier Gonzalez , Tanya Michelle Jewell , Hui Li , Maria Angelica Linton , John Howard Tatlock , Ru Zhou , Thomas Jay Prins , Melwyn A. Abreo
发明人： Allen J. Borchardt , Peter Scott Dragovich , Javier Gonzalez , Tanya Michelle Jewell , Hui Li , Maria Angelica Linton , John Howard Tatlock , Ru Zhou , Thomas Jay Prins , Melwyn A. Abreo
IPC分类号： A61K31/351
CPC分类号： C07D405/06 , C07D309/32 , C07D405/12 , C07D407/06 , C07D413/12 , C07D417/06 , C07D487/04
摘要： Compounds of formula I are hepatitis C virus (HCV) RNA-dependent RNA polymerase (RdRp) inhibitors, and are useful in therapeutic and prophylactic treatment of persons infected with hepatitis C virus
摘要翻译： 式I化合物为丙型肝炎病毒（HCV）RNA依赖性RNA聚合酶（RdRp）抑制剂，可用于丙型肝炎病毒感染者的治疗和预防性治疗
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10.发明授权Inhibitors of hepatitis C virus RNA-dependent RNA polymerase, and compositions and treatments using the same 失效丙型肝炎病毒RNA依赖性RNA聚合酶的抑制剂，以及使用其的组合物和治疗公开(公告)号：US07622605B2
公开(公告)日：2009-11-24
申请号：US11470540
申请日：2006-09-06
CPC分类号： C07D309/32 , C07D405/06 , C07D405/14 , C07D471/04 , C07D487/04
摘要： The present invention provides compounds of formula (4), and their pharmaceutically acceptable salts and solvates, which are useful as inhibitors of the Hepatitis C virus (HCV) polymerase enzyme and are also useful for the treatment of HCV infections in HCV-infected mammals. The present invention also provides pharmaceutical compositions comprising compounds of formula (4), their pharmaceutically acceptable salts and solvates. Furthermore, the present invention provides intermediate compounds and methods useful in the preparation of compounds of formula (4).
摘要翻译： 本发明提供了可用作丙型肝炎病毒（HCV）聚合酶的抑制剂的式（4）化合物及其药学上可接受的盐和溶剂合物，并且也可用于治疗HCV感染的哺乳动物中的HCV感染。 本发明还提供包含式（4）化合物，其药学上可接受的盐和溶剂合物的药物组合物。 此外，本发明提供了可用于制备式（4）化合物的中间体化合物和方法。
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