公开(公告)号：US5047502A

公开(公告)日：1991-09-10

申请号：US389093

申请日：1989-08-03

申请人： Allen I. Oliff ,  David C. Heimbrook ,  Mark W. Riemen ,  Victor M. Garsky

发明人： Allen I. Oliff ,  David C. Heimbrook ,  Mark W. Riemen ,  Victor M. Garsky

IPC分类号： A61K38/00 ,  C07K14/575

CPC分类号： C07K14/57572 ,  A61K38/00

摘要： Small cell lung carcinoma cells (SCLC) contain gastrin releasing peptide (GRP) receptors. The response of the cells to GRP is rapid growth. We have found a group of heptapeptides that act as GRP antagonists by blocking the binding of GRP to its receptor thereby inhibiting the growth of cells that are sensitive to the growth promoting acitivity of GRP.

摘要翻译： 小细胞肺癌细胞（SCLC）含有胃泌素释放肽（GRP）受体。 细胞对GRP的反应是快速增长。 我们已经发现一组作为GRP拮抗剂的七肽通过阻断GRP与其受体的结合，从而抑制对促进GRP活性的生长敏感的细胞的生长。

公开(公告)号：US5019647A

公开(公告)日：1991-05-28

申请号：US197872

申请日：1988-05-24

申请人： Mark W. Riemen ,  Allen I. Oliff ,  Walfred S. Saari ,  David C. Heimbrook

发明人： Mark W. Riemen ,  Allen I. Oliff ,  Walfred S. Saari ,  David C. Heimbrook

IPC分类号： A61K38/00 ,  C07K14/575

CPC分类号： C07K14/575 ,  A61K38/00

摘要： Small cell lung carcinoma cells (SCLC) contain gastrin releasing peptide (GRP) receptors. The response of the cells to GRP is rapid growth. We have found a group of peptide derivatives that act as GRP antagonists by blocking the binding of GRP to its receptor thereby inhibiting the growth of cells that are sensitive to the growth promoting activity of GRP.

公开(公告)号：US4943561A

公开(公告)日：1990-07-24

申请号：US276985

申请日：1988-11-28

申请人： David C. Heimbrook ,  Mark W. Riemen ,  Allen Oliff ,  Walfred S. Saari

发明人： David C. Heimbrook ,  Mark W. Riemen ,  Allen Oliff ,  Walfred S. Saari

IPC分类号： A61K38/22 ,  A61K38/00 ,  A61P35/00 ,  C07K1/02 ,  C07K7/06 ,  C07K14/575

CPC分类号： C07K14/57572 ,  A61K38/00

摘要： Small cell lung carcinoma (SCLC) cells contain gastrin releasing peptide (GRP) receptors. The response of the cells to GRP is rapid growth. We have found a group of peptide derivatives that act as GRP antagonists by blocking the binding of GRP to its receptor thereby inhibiting the growth of cells that are sensitive to the growth promoting activity of GRP.

公开(公告)号：US5912322A

公开(公告)日：1999-06-15

申请号：US839425

申请日：1997-04-14

申请人： Mark W. Riemen ,  Steven M. Stirdivant

发明人： Mark W. Riemen ,  Steven M. Stirdivant

IPC分类号： A61K47/48 ,  C07K14/21 ,  C07K14/485 ,  C07K14/495 ,  C07K14/00 ,  C12N15/00

CPC分类号： B82Y5/00 ,  A61K47/48353 ,  A61K47/48484 ,  C07K14/21 ,  C07K14/485 ,  C07K14/495 ,  C07K2319/00

摘要： Psuedomonas exotoxin 40 is modified by deleting or substituting one or more cysteine residues. Such a modified protein may be incorporated into a fusion protein with TGF.alpha.. The resulting fusion protein exhibits altered biological activities from unmodified TGF.alpha.-PE.sub.40, including decreased cell killing activity and increase receptor-binding activity.

摘要翻译： 通过删除或取代一个或多个半胱氨酸残基来修饰Psuedomonas外毒素40。 这种修饰的蛋白质可以掺入到具有TGFα的融合蛋白中。 所得的融合蛋白表现出来自未修饰的TGFα-PE40的生物活性改变，包括降低的细胞杀伤活性和增加受体结合活性。

公开(公告)号：US5306635A

公开(公告)日：1994-04-26

申请号：US896038

申请日：1992-06-09

申请人： Paul M. Keller ,  Mark W. Riemen ,  Ronald W. Ellis ,  Andrew J. Davison ,  Robert S. Lowe

发明人： Paul M. Keller ,  Mark W. Riemen ,  Ronald W. Ellis ,  Andrew J. Davison ,  Robert S. Lowe

IPC分类号： C07K14/03 ,  A61K39/00 ,  A61K39/25 ,  A61P31/12 ,  C07H21/04 ,  C07K14/00 ,  C07K14/04 ,  C12N1/15 ,  C12N1/21 ,  C12N5/00 ,  C12N5/10 ,  C12N15/00 ,  C12N15/09 ,  C12N15/38 ,  C12P21/02 ,  C12R1/91 ,  C12R1/92 ,  C12N1/19

CPC分类号： C07K14/005 ,  A61K39/00 ,  C12N2710/16722

摘要： A gene of varicella-zoster virus (VZV) which encodes immunogenic outer surface viral proteins has been identified by DNA sequence analysis. Antibodies directed against peptides imputed from the DNA sequence can react with the glycoprotein, which itself is reactive with neutralizing antibodies. The amino-terminal sequence of the purified glycoprotein is identical to a portion of the amino acid sequence imputed from the DNA sequence. This glycoprotein is useful for the preparation of a vaccine against VZV.

摘要翻译： 通过DNA序列分析鉴定了编码免疫原性外表面病毒蛋白的水痘带状疱疹病毒（VZV）基因。 针对从DNA序列估计的肽的抗体可以与糖蛋白反应，糖蛋白本身与中和抗体反应。 纯化的糖蛋白的氨基末端序列与从DNA序列估计的氨基酸序列的一部分相同。 该糖蛋白可用于制备针对VZV的疫苗。

公开(公告)号：US4952674A

公开(公告)日：1990-08-28

申请号：US859159

申请日：1986-05-02

申请人： Paul M. Keller ,  Ronald W. Ellis ,  Robert S. Lowe ,  Mark W. Riemen ,  Andrew J. Davison

发明人： Paul M. Keller ,  Ronald W. Ellis ,  Robert S. Lowe ,  Mark W. Riemen ,  Andrew J. Davison

IPC分类号： C07K14/03 ,  A61K39/00 ,  A61K39/25 ,  A61P31/12 ,  C07H21/04 ,  C07K14/00 ,  C07K14/04 ,  C12N1/15 ,  C12N1/21 ,  C12N5/00 ,  C12N5/10 ,  C12N15/00 ,  C12N15/09 ,  C12N15/38 ,  C12P21/02 ,  C12R1/91 ,  C12R1/92

CPC分类号： C07K14/005 ,  A61K39/00 ,  C12N2710/16722

摘要： A gene of varicella-zoster virus (VZV) which encodes immunogenic outer surface viral proteins has been identified by DNA sequence analysis. Antibodies directed against peptides imputed from the DNA sequence can react with the glycoprotein, which itself is reactive with neutralizing antibodies. The amino-terminal sequence of the purified glycoprotein is identical to a portion of the amino acid sequence imputed from the DNA sequence. This glycoprotein is useful for the preparation of a vaccine against VZV.

公开(公告)号：US5621078A

公开(公告)日：1997-04-15

申请号：US391259

申请日：1995-02-21

申请人： Mark W. Riemen ,  Steven M. Stirdivant

发明人： Mark W. Riemen ,  Steven M. Stirdivant

IPC分类号： A61K47/48 ,  C07K14/21 ,  C07K14/485 ,  C07K14/495

CPC分类号： B82Y5/00 ,  A61K47/48353 ,  A61K47/48484 ,  C07K14/21 ,  C07K14/485 ,  C07K14/495 ,  C07K2319/00

摘要： Pseudomonas exotoxin 40 is modified by deleting or substituting one or more cysteine residues. Such a modified protein, when hybridized to TGF.alpha., exhibits altered biological activities from unmodified TGF.alpha. PE.sub.40, including decreased cell killing activity and increased receptor-binding activity.

摘要翻译： 通过缺失或取代一个或多个半胱氨酸残基来修饰假单胞菌外毒素40。 当与TGFα杂交时，这种修饰的蛋白质表现出来自未修饰的TGFαPE40的改变的生物活性，包括降低的细胞杀伤活性和增加的受体结合活性。