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1.发明授权DNA encoding immunogenic gpIII glycoprotein of varicella-zoster virus 失效编码水痘带状疱疹病毒的免疫原性gpIII糖蛋白的DNA
公开(公告)号：US5306635A
公开(公告)日：1994-04-26
申请号：US896038
申请日：1992-06-09
IPC分类号： C07K14/03 , A61K39/00 , A61K39/25 , A61P31/12 , C07H21/04 , C07K14/00 , C07K14/04 , C12N1/15 , C12N1/21 , C12N5/00 , C12N5/10 , C12N15/00 , C12N15/09 , C12N15/38 , C12P21/02 , C12R1/91 , C12R1/92 , C12N1/19
CPC分类号： C07K14/005 , A61K39/00 , C12N2710/16722
摘要： A gene of varicella-zoster virus (VZV) which encodes immunogenic outer surface viral proteins has been identified by DNA sequence analysis. Antibodies directed against peptides imputed from the DNA sequence can react with the glycoprotein, which itself is reactive with neutralizing antibodies. The amino-terminal sequence of the purified glycoprotein is identical to a portion of the amino acid sequence imputed from the DNA sequence. This glycoprotein is useful for the preparation of a vaccine against VZV.
摘要翻译： 通过DNA序列分析鉴定了编码免疫原性外表面病毒蛋白的水痘带状疱疹病毒（VZV）基因。 针对从DNA序列估计的肽的抗体可以与糖蛋白反应，糖蛋白本身与中和抗体反应。 纯化的糖蛋白的氨基末端序列与从DNA序列估计的氨基酸序列的一部分相同。 该糖蛋白可用于制备针对VZV的疫苗。
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公开(公告)号：US4952674A
公开(公告)日：1990-08-28
申请号：US859159
申请日：1986-05-02
IPC分类号： C07K14/03 , A61K39/00 , A61K39/25 , A61P31/12 , C07H21/04 , C07K14/00 , C07K14/04 , C12N1/15 , C12N1/21 , C12N5/00 , C12N5/10 , C12N15/00 , C12N15/09 , C12N15/38 , C12P21/02 , C12R1/91 , C12R1/92
CPC分类号： C07K14/005 , A61K39/00 , C12N2710/16722
摘要： A gene of varicella-zoster virus (VZV) which encodes immunogenic outer surface viral proteins has been identified by DNA sequence analysis. Antibodies directed against peptides imputed from the DNA sequence can react with the glycoprotein, which itself is reactive with neutralizing antibodies. The amino-terminal sequence of the purified glycoprotein is identical to a portion of the amino acid sequence imputed from the DNA sequence. This glycoprotein is useful for the preparation of a vaccine against VZV.
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公开(公告)号：US4812559A
公开(公告)日：1989-03-14
申请号：US28826
申请日：1987-03-23
IPC分类号： C12N15/09 , A61K39/00 , A61K39/25 , C07H21/04 , C07K14/00 , C07K14/04 , C12N1/00 , C12N5/00 , C12N5/10 , C12N15/00 , C12N15/38 , C12P21/02 , C12R1/125 , C12R1/19 , C12R1/865 , C12R1/91 , C07H15/12
CPC分类号： A61K39/25 , A61K39/12 , C07K14/005 , A61K39/00 , C12N2710/16722 , C12N2710/16734 , Y10S930/224
摘要： A gene of varicella-zoster virus (VZV) which encodes immunogenic outer surface viral proteins has been identified by DNA sequence analysis. This gene can hybrid select messenger RNA which encodes and expresses a protein which reacts with human convalescent zoster sera and with polyclonal monospecific antisera which neutralize viral infectivity. These proteins are useful for the preparation of a vaccine for VZV.
摘要翻译： 通过DNA序列分析鉴定了编码免疫原性外表面病毒蛋白的水痘带状疱疹病毒（VZV）基因。 该基因可以杂交选择信使RNA，其编码和表达与人类恢复带状疱疹血清反应的蛋白质，以及中和病毒感染性的多克隆单特异性抗血清。 这些蛋白质可用于制备VZV疫苗。
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公开(公告)号：US4686101A
公开(公告)日：1987-08-11
申请号：US762001
申请日：1985-08-02
IPC分类号： C12N15/09 , A61K39/00 , A61K39/25 , C07H21/04 , C07K14/00 , C07K14/04 , C12N1/00 , C12N5/00 , C12N5/10 , C12N15/00 , C12N15/38 , C12P21/02 , C12R1/125 , C12R1/19 , C12R1/865 , C12R1/91 , C07K13/00
CPC分类号： A61K39/25 , A61K39/12 , C07K14/005 , A61K39/00 , C12N2710/16722 , C12N2710/16734 , Y10S930/224
摘要： A gene of varicella-zoster virus (VZV) which encodes immunogenic outer surface viral proteins has been identified by DNA sequence analysis. This gene can hybrid select messenger RNA which encodes and expresses a protein which reacts with human canvalescent zoster sera and with polyclonal monospecific antisera which neutralize viral infectivity. These proteins are useful for the preparation of a vaccine for VZV.
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公开(公告)号：US4769239A
公开(公告)日：1988-09-06
申请号：US642983
申请日：1984-08-21
申请人： Ronald W. Ellis , Paul M. Keller
发明人： Ronald W. Ellis , Paul M. Keller
IPC分类号： C12N15/09 , A61K39/00 , A61K39/25 , C07H21/04 , C07K1/22 , C07K14/00 , C07K14/03 , C07K14/04 , C07K16/00 , C12N1/00 , C12N1/20 , C12N15/00 , C12P21/02 , C12R1/19 , A61K39/12 , C12P21/00
CPC分类号： C07K14/005 , A61K39/00 , C12N2710/16722
摘要： A gene of varicella-zoster virus (VZV) which encodes immunogenic outer surface viral proteins has been identified through DNA sequence analysis. Fragments of the DNA have been cloned into a vector which, when placed into a host organism, expresses proteins which react with human convalescent zoster sera and with monoclonal antibodies which neutralize viral infectivity. These proteins are useful for preparation of a vaccine for VZV.
摘要翻译： 通过DNA序列分析鉴定了编码免疫原性外表面病毒蛋白的水痘带状疱疹病毒（VZV）基因。 DNA片段已被克隆到载体中，当被放置在宿主生物体中时，其表达与人类恢复性带状疱疹血清反应的蛋白质和中和病毒感染性的单克隆抗体。 这些蛋白质可用于制备VZV疫苗。
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公开(公告)号：US07157443B2
公开(公告)日：2007-01-02
申请号：US10498070
申请日：2002-12-06
申请人： Joseph G. Joyce , James C. Cook, III , Chitrananda Abeygunawardana , Karen M. Grimm , Craig T. Przysiecki , Robert W. Hepler , Charlotte C. Ip , Keith Roper , Qiuwei Xu , Kathrin U. Jansen , Paul M. Keller , Leslie D. Cope
发明人： Joseph G. Joyce , James C. Cook, III , Chitrananda Abeygunawardana , Karen M. Grimm , Craig T. Przysiecki , Robert W. Hepler , Charlotte C. Ip , Keith Roper , Qiuwei Xu , Kathrin U. Jansen , Paul M. Keller , Leslie D. Cope
IPC分类号： A61K31/715 , A61K39/02 , C07H1/00
CPC分类号： A61K39/085
摘要： A high molecular weight polysaccharide intracellular adhesin (SAE) antigen having the general structure of poly-1,6,β-2-amidoglucopyranoside, which is variable substituted with N-acetyl and O-succinyl substituents is described. Also, a method is given for isolating this antigen from Staphylococcus aureus. The SAE can be used in a vaccine, either alone, conjugated to an immunogenic protein, and/or with an immunogenic adjuvant.
摘要翻译： 描述了具有可被N-乙酰基和O-琥珀酰基取代基取代的聚-1,6，β-2-酰胺基吡喃糖苷的一般结构的高分子量多糖细胞内粘附素（SAE）抗原。 此外，给出了用于从金黄色葡萄球菌分离该抗原的方法。 SAE可以单独用于疫苗，与免疫原性蛋白质结合，和/或用免疫原性佐剂使用。
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公开(公告)号：US06372425B1
公开(公告)日：2002-04-16
申请号：US09140201
申请日：1998-08-21
申请人： Beth Arnold , Paul M. Keller , Anthony J. Conley , Alan R. Shaw , Jwu-Sheng Tung
发明人： Beth Arnold , Paul M. Keller , Anthony J. Conley , Alan R. Shaw , Jwu-Sheng Tung
IPC分类号： C12Q170
CPC分类号： C40B40/02 , C07K16/1063 , C07K2317/21 , C12N15/101 , C12N15/1037
摘要： A process of purifying target molecules is described that involves the selection of ligands based on identifying, in real time, association and dissociation constants with a given target molecule; using this information to select at least one ligand that exhibit predetermined association and dissociation constants with a given target molecule; anchoring a quantity of ligand to an activated solid support; contacting a quantity of target molecules with the anchored ligand(s); removing low affinity target molecules from anchored ligand and eluting particularly pure target molecules.
摘要翻译： 描述了纯化靶分子的过程，其涉及通过用给定的靶分子实时鉴定缔合和解离常数来选择配体; 使用该信息选择至少一种与给定的靶分子呈现预定缔合和解离常数的配体; 将一定量的配体锚定到活化的固体支持物上; 使一定数量的靶分子与锚定的配体接触; 从锚定的配体去除低亲和性目标分子并洗脱出特别纯的靶分子。
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公开(公告)号：US5763574A
公开(公告)日：1998-06-09
申请号：US625691
申请日：1996-04-04
CPC分类号： C07K14/005 , C07K14/22 , C07K16/1063 , A61K39/00 , C07K2319/00 , C12N2740/16122
摘要： Immunological conjugates of HIV-specific selected principal neutralization epitopes are prepared. These epitopes bind 19b, a broadly neutralizing human monoclonal antibody specific for the HIV gp120. The epitopes are identified from oligopeptide epitope libraries. The conjugates are useful for vaccination against AIDS or ARC, as well as in the production of other HIV-specific broadly neutralizing antibodies for passive immunity against AIDS or ARC.
摘要翻译： 制备HIV特异性选择的主要中和表位的免疫缀合物。 这些表位结合了19b，一种广泛中和的针对HIV gp120的人单克隆抗体。 从寡肽表位库鉴定表位。 缀合物可用于针对AIDS或ARC的疫苗接种，以及用于产生针对AIDS或ARC的被动免疫的其他HIV特异性广泛中和抗体。
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9.发明授权Peptide conjugate compositions and methods for the prevention and treatment of alzheimer's disease 有权肽缀合物组合物和预防和治疗阿尔茨海默病的方法公开(公告)号：US07850973B2
公开(公告)日：2010-12-14
申请号：US11919897
申请日：2006-05-01
申请人： Victor M. Garsky , Joseph G. Joyce , Paul M. Keller , Gene Kinney , Xiaoping Liang , John W. Shiver
发明人： Victor M. Garsky , Joseph G. Joyce , Paul M. Keller , Gene Kinney , Xiaoping Liang , John W. Shiver
CPC分类号： A61K39/0007 , A61K2039/6068 , A61K2039/6087 , A61K2039/6093 , A61K2039/64
摘要： The invention provides compositions and methods for the treatment of diseases associated with amyloid deposits of Aβ in the brain of a patient, such as Alzheimer's disease. Such methods entail administering an immunogenic fragment of Aβ, lacking a T-cell epitope, capable of inducing a beneficial immune response in the form of antibodies to Aβ. In another aspect, the immunogenic fragment of Aβ is capable of elevating plasma Aβ levels. The immunogenic fragments comprise linear or multivalent peptides of Aβ. Pharmaceutical compositions comprise the immunogenic fragment chemically linked to a carrier molecule which may be administered with an adjuvant.
摘要翻译： 本发明提供了用于治疗与淀粉样蛋白沉积相关的疾病的组合物和方法。 在患者的脑中，如阿尔茨海默病。 这种方法需要施用能够以A和Bgr的抗体形式诱导有益的免疫应答的A＆bgr的免疫原性片段，缺少T细胞表位。 另一方面，A＆bgr的免疫原性片段 能够提升血浆A＆bgr; 水平。 免疫原性片段包含A和Bgr的线性或多价肽。 药物组合物包含与可与佐剂一起施用的载体分子化学连接的免疫原性片段。
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公开(公告)号：US5340726A
公开(公告)日：1994-08-23
申请号：US107411
申请日：1993-08-16
CPC分类号： C07K14/43531 , A61K38/00
摘要： A protein which inhibits collagen-stimulated platelet aggregation. The protein has a molecular weight of approximately 17,000. A method of isolating the protein from Ornithodoros moubata and using the protein to prevent or delay blood coagulation by blocking the stimulation of platelet aggregation by collagen is also described. The protein is useful in the prevention, prophylaxis, therapy and treatment of thrombotic diseases.
摘要翻译： 抑制胶原刺激的血小板聚集的蛋白质。 蛋白质的分子量约为17,000。 还描述了从Ornithodoros moubata中分离蛋白质并使用该蛋白质来阻止或延缓血液凝固的方法，该方法是阻止胶原对血小板聚集的刺激。 该蛋白质可用于预防，预防，治疗和治疗血栓性疾病。
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