公开(公告)号：US20240226252A1

公开(公告)日：2024-07-11

申请号：US18235530

申请日：2023-08-18

Applicant: Allergan, Inc.

Inventor： Terrence J. Hunt

IPC: A61K38/48 ,  A61K9/00 ,  A61K47/10 ,  A61K47/26 ,  A61K47/32

CPC classification number: A61K38/4893 ,  A61K9/0019 ,  A61K47/10 ,  A61K47/26 ,  A61K47/32

Abstract: A Clostridial toxin pharmaceutical composition comprising a Clostridial toxin, such as a botulinum toxin, wherein the Clostridial toxin present in the pharmaceutical composition is stabilized by a non-protein excipient such as a polyvinylpyrrolidone, a disaccharide, a trisaccharide, a polysaccharide, an alcohol, a metal, an amino acid, a surfactant and/or a polyethylene glycol.

公开(公告)号：US20220370614A1

公开(公告)日：2022-11-24

申请号：US17879674

申请日：2022-08-02

Applicant: Allergan, Inc.

Inventor： Terrence J. Hunt

IPC: A61K47/10 ,  A61K38/48 ,  A61K9/19 ,  A61K9/00 ,  A61K47/32 ,  A61K47/26

Abstract: Animal protein-free, solid-form Clostridial toxin pharmaceutical compositions comprising a Clostridial toxin active ingredient and at least two excipients.

公开(公告)号：US20210268109A1

公开(公告)日：2021-09-02

申请号：US17322283

申请日：2021-05-17

Applicant: Allergan, Inc.

Inventor： Terrence J. Hunt

IPC: A61K47/10 ,  A61K38/48 ,  A61K9/19 ,  A61K9/00 ,  A61K47/32 ,  A61K47/26

Abstract: Animal protein-free, solid-form Clostridial toxin pharmaceutical compositions comprising a Clostridial toxin active ingredient and at least two excipients.

公开(公告)号：US11147878B2

公开(公告)日：2021-10-19

申请号：US17322283

申请日：2021-05-17

Applicant: Allergan, Inc.

Inventor： Terrence J. Hunt

IPC: A61K47/32 ,  A61K47/10 ,  A61K38/48 ,  A61K9/19 ,  A61K9/00 ,  A61K47/26

Abstract: Animal protein-free, solid-form Clostridial toxin pharmaceutical compositions comprising a Clostridial toxin active ingredient and at least two excipients.

公开(公告)号：US11033625B2

公开(公告)日：2021-06-15

申请号：US17071239

申请日：2020-10-15

Applicant: Allergan, Inc.

Inventor： Terrence J. Hunt

IPC: A61K38/48 ,  A61K9/19 ,  A61K47/32 ,  A61K47/10 ,  A61K9/00 ,  A61K47/26

Abstract: Animal protein-free, solid-form Clostridial toxin pharmaceutical compositions comprising a Clostridial toxin active ingredient and at least two excipients.

公开(公告)号：US20210038720A1

公开(公告)日：2021-02-11

申请号：US17071239

申请日：2020-10-15

Applicant: Allergan, Inc.

Inventor： Terrence J. Hunt

IPC: A61K47/10 ,  A61K38/48 ,  A61K9/19 ,  A61K9/00 ,  A61K47/32 ,  A61K47/26

Abstract: Animal protein-free, solid-form Clostridial toxin pharmaceutical compositions comprising a Clostridial toxin active ingredient and at least two excipients.

公开(公告)号：US20200330564A1

公开(公告)日：2020-10-22

申请号：US16918769

申请日：2020-07-01

Applicant: Allergan, Inc.

Inventor： Terrence J. Hunt

IPC: A61K38/48 ,  A61K9/00 ,  A61K47/26 ,  A61K47/32 ,  A61K47/10

Abstract: A Clostridial toxin pharmaceutical composition comprising a Clostridial toxin, such as a botulinum toxin, wherein the Clostridial toxin present in the pharmaceutical composition is stabilized by a non-protein excipient such as a polyvinylpyrrolidone, a disaccharide, a trisaccharide, a polysaccharide, an alcohol, a metal, an amino acid, a surfactant and/or a polyethylene glycol.

公开(公告)号：US20180271959A1

公开(公告)日：2018-09-27

申请号：US15989742

申请日：2018-05-25

Applicant: Allergan, Inc.

Inventor： Terrence J. Hunt

IPC: A61K38/48 ,  A61K9/00 ,  A61K9/06 ,  A61K41/00 ,  A61K47/60 ,  A61K47/64 ,  A61K47/69 ,  A61K8/66 ,  A61K8/04 ,  A61K8/64 ,  A61K8/90 ,  A61Q19/08 ,  A61K47/34

CPC classification number: A61K38/4893 ,  A61K8/042 ,  A61K8/64 ,  A61K8/66 ,  A61K8/90 ,  A61K9/0019 ,  A61K9/0024 ,  A61K9/06 ,  A61K41/00 ,  A61K41/0052 ,  A61K47/34 ,  A61K47/60 ,  A61K47/643 ,  A61K47/6903 ,  A61K2800/52 ,  A61K2800/56 ,  A61K2800/594 ,  A61K2800/91 ,  A61K2800/95 ,  A61Q19/08 ,  C12Y304/24069 ,  Y02A50/469

Abstract: A thermo-reversible thermoplastic pharmaceutical composition, comprising a botulinum toxin and a biocompatible poloxamer which provides thermoreversibility to the composition and additionally stabilizes the botulinum toxin, is described. The pharmaceutical composition can be administered to a patient as a liquid, and gels after administration into a sustained release drug delivery system from which the biologically active botulinum toxin is released over a multi-day period thereby localizing the drug as a depot and controlling release to enhance the therapeutic effect per dose.

公开(公告)号：US20140112908A1

公开(公告)日：2014-04-24

申请号：US14139519

申请日：2013-12-23

Applicant: ALLERGAN, INC.

Inventor： Terrence J. Hunt

IPC: A61K38/48

CPC classification number: A61K38/4893 ,  A61K9/0019 ,  A61K47/10 ,  A61K47/26 ,  A61K47/32

Abstract: A Clostridial toxin pharmaceutical composition comprising a Clostridial toxin, such as a botulinum toxin, wherein the Clostridial toxin present in the pharmaceutical composition is stabilized by a non-protein excipient such as a polyvinylpyrrolidone, a disaccharides, a trisaccharide, a polysaccharide, an alcohol, a metal, an amino acid, a surfactant and/or a polyethylene glycol.

Abstract translation: 一种梭菌毒素药物组合物，其包含梭菌毒素，例如肉毒杆菌毒素，其中所述药物组合物中存在的梭菌毒素通过非蛋白质赋形剂如聚乙烯吡咯烷酮，二糖，三糖，多糖，醇， 金属，氨基酸，表面活性剂和/或聚乙二醇。

公开(公告)号：US20130296259A1

公开(公告)日：2013-11-07

申请号：US13933723

申请日：2013-07-02

Applicant: Allergan, Inc.

Inventor： Terrence J. Hunt

IPC: A61K38/16 ,  A61K47/42 ,  B65D85/00 ,  A61K47/36

CPC classification number: A61K47/22 ,  A61K8/02 ,  A61K8/44 ,  A61K8/64 ,  A61K8/65 ,  A61K8/66 ,  A61K8/732 ,  A61K8/99 ,  A61K9/0019 ,  A61K9/19 ,  A61K31/715 ,  A61K38/164 ,  A61K38/39 ,  A61K38/4893 ,  A61K39/08 ,  A61K47/183 ,  A61K47/36 ,  A61K47/42 ,  A61K2800/91 ,  A61Q19/08 ,  B65D85/70 ,  C07K14/33 ,  A61K2300/00

Abstract: This invention relates to the use of a composition comprising a polysaccharide and a botulinum toxin for reducing a skin wrinkle. In some embodiments, the polysaccharide comprises disaccharides. In some embodiments, the average molecular weight of a disaccharide unit of the polysaccharide is between about 345 D and about 1,000 D.

Abstract translation: 本发明涉及包含多糖和肉毒杆菌毒素的组合物用于减少皮肤皱纹的用途。 在一些实施方案中，多糖包含二糖。 在一些实施方案中，多糖的二糖单元的平均分子量在约345D和约1,000D之间。