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公开(公告)号：US20100113959A1
公开(公告)日：2010-05-06
申请号：US12224770
申请日：2007-03-07
IPC分类号： A61B5/0478 , A61N2/02
摘要： In one aspect, a portable transcranial magnetic stimulation (TMS) device for delivering a TMS procedure is provided. The portable TMS device comprises at least one coil that, when energized, generates electromagnetic energy, a helmet adapted to fit a user's head and configured to hold the at least one coil in a predetermined position with respect to the user's head, and a port having at least one power connection coupled to the at least one coil, the at least one power connection adapted to connect the at least one coil to a power source capable of energizing the at least one coil, the port further comprising at least one data connection adapted to exchange data with at least one external component, the port being located on the helmet. In another aspect a method of positioning a coil with respect to a person's head to target a desired region of the person's brain with transcranial magnetic stimulation (TMS) is provided. The method comprises obtaining a dielectric property map of a portion of the brain, the dielectric map indicating a spatial distribution of at least one dielectric property over the portion of the brain, determining a location for the coil based, at least in part, on the dielectric property map, the location being such that when the coil is positioned at the location, magnetic energy generated by the coil is focused on the desired region, and positioning the coil at the determined location.
摘要翻译： 在一个方面，提供了一种用于递送TMS程序的便携式经颅磁刺激（TMS）装置。 所述便携式TMS装置包括至少一个线圈，所述至少一个线圈当被激励时产生电磁能量，头盔适于装配使用者的头部并被配置为将所述至少一个线圈保持在相对于所述用户头部的预定位置，以及具有 耦合到所述至少一个线圈的至少一个电源连接器，所述至少一个电源连接器适于将所述至少一个线圈连接到能够激励所述至少一个线圈的电源，所述端口还包括适于 与至少一个外部组件交换数据，该端口位于头盔上。 在另一方面，提供了一种通过经颅磁刺激（TMS）将线圈相对于人的头部定位以靶向人的大脑的期望区域的方法。 该方法包括获得脑的一部分的介电特性图，电介质图表示脑部分上的至少一种介电性质的空间分布，至少部分地基于所述线圈的位置来确定线圈的位置 介电特性图，该位置使得当线圈位于该位置时，由线圈产生的磁能聚焦在期望的区域上，并将线圈定位在所确定的位置处。
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2.发明授权Systems and methods for applying signals, including contralesional signals, to neural populations 有权将信号（包括对数信号）应用于神经群体的系统和方法公开(公告)号：US08926676B2
公开(公告)日：2015-01-06
申请号：US11697696
申请日：2007-04-06
IPC分类号： A61N1/36
CPC分类号： A61N1/36171 , A61N1/36082 , A61N1/36103 , A61N1/3615
摘要： Systems and methods for applying signals, including contralesional electromagnetic signals, to neural populations, are disclosed. A particular method can be directed to treating a patient having a subject neural population in a first (e.g., ipsilesional) hemisphere of the brain, with the subject neural population having, or previously having, a functionality capable of being improved. The method can include directing an application of electromagnetic signals at least proximate to a target neural population at a second (e.g., contralesional) hemisphere of the brain to at least constrain a functionality of the target neural population, which has transcallosal communication with the first hemisphere.
摘要翻译： 公开了将信号（包括对数电磁信号）应用于神经群体的系统和方法。 具体方法可以涉及在脑的第一（例如ipsilesional）半球中治疗具有受试者神经群体的患者，其中受试者神经群体具有或预先具有能够改善的功能。 该方法可以包括将电磁信号的应用引导至少接近于大脑的第二（例如，对照）半球处的目标神经群体，以至少约束目标神经群体的功能，该目标神经群体与第一半球具有蜕皮通讯 。
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公开(公告)号：US20120179076A1
公开(公告)日：2012-07-12
申请号：US13200080
申请日：2011-09-16
CPC分类号： A61N1/0408 , A61H5/005 , A61H2201/10 , A61H2201/1604 , A61H2201/165 , A61H2201/5043 , A61N1/0472 , A63F2300/301 , A63F2300/6669 , A63F2300/6692 , G09G3/003
摘要： A system and method for treating amblyopic individuals through an engaging treatment modality which considers binocular function in adapting treatment. The present invention may be practiced by providing a dichoptic display having multiple sub-displays; providing a video game system and controller in communication with the dichoptic display; running a game program having a graphical presentation; using one sub-display to display a first view of the presentation and a second sub-display to display a second view of the presentation; and altering at least one of the first or second view of the presentation.
摘要翻译： 一种通过接合治疗方式治疗弱视个体的系统和方法，其在适应治疗中考虑双目功能。 本发明可以通过提供具有多个子显示器的双向显示来实现; 提供与双向显示器通信的视频游戏系统和控制器; 运行具有图形呈现的游戏程序; 使用一个子显示器来显示演示的第一视图和第二子显示器以显示演示的第二视图; 以及改变演示文稿的第一或第二视图中的至少一个。
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4.发明授权公开(公告)号：US06571123B2
公开(公告)日：2003-05-27
申请号：US09746055
申请日：2000-12-21
申请人： John R. Ives , Alvaro Pascual-Leone
发明人： John R. Ives , Alvaro Pascual-Leone
IPC分类号： A61B504
CPC分类号： A61N2/006 , A61B5/0476 , A61B5/0482 , A61B5/0484 , A61B5/4094 , A61N2/02
摘要： A system for monitoring an electroencephalogram of a patient during administration of transcranial magnetic stimulation including a transcranial magnetic stimulation (TMS) system, an electroencephalogram (EEG) monitoring system, and a control system, coupled between the EEG system and the TMS system, that responds to signals provided by the EEG system and controls the TMS system wherein timing of operation of the TMS system does not need to be synchronized to timing of operation of the EEG system. A conductive plastic electrode system for use with the EEG monitoring system is also provided.
摘要翻译： 一种用于在施用经颅磁刺激期间监测患者的脑电图的系统，包括耦合在EEG系统和TMS系统之间的经颅磁刺激（TMS）系统，脑电图（EEG）监测系统和控制系统，其响应 对于由EEG系统提供的信号并且控制TMS系统，其中TMS系统的操作定时不需要与EEG系统的操作定时同步。 还提供了一种用于EEG监测系统的导电塑料电极系统。
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5.发明授权Methods for treating and/or collecting information regarding neurological disorders, including language disorders 失效用于治疗和/或收集关于神经障碍（包括语言障碍）的信息的方法公开(公告)号：US07565199B2
公开(公告)日：2009-07-21
申请号：US10731892
申请日：2003-12-09
CPC分类号： A61N1/36082 , A61N1/08
摘要： Methods for treating and/or collecting information regarding neurological disorders, including language disorders. A method in accordance with one embodiment directing a patient to perform a language-based task, directing information to be collected, with the information corresponding to a level of neural activity in the patient's brain while the patient performs the language-based task, and, based at least in part on the information, selecting a stimulation site within the patient's skull for receiving an electrode coupleable to an electrical current. In further embodiments, at least one electrode can be placed at the stimulation site, and the patient's language disorder can be reduced by applying electrical stimulation directly to the stimulation site via the at least one electrode.
摘要翻译： 用于治疗和/或收集关于神经障碍（包括语言障碍）的信息的方法。 根据一个实施例的方法，指导患者执行基于语言的任务，指导要收集的信息，其中所述信息对应于患者执行基于语言的任务期间患者大脑中的神经活动水平，以及， 至少部分地基于信息，选择患者颅骨内的刺激部位以接收可耦合到电流的电极。 在另外的实施方案中，至少一个电极可以放置在刺激部位，并且可以通过经由至少一个电极直接施加电刺激到刺激部位来减少患者的语言障碍。
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6.发明申请Methods for Treating and/or Collecting Information Regarding Neurological Disorders, Including Language Disorders 有权治疗和/或收集关于神经障碍，包括语言障碍的信息的方法公开(公告)号：US20080146959A1
公开(公告)日：2008-06-19
申请号：US11935135
申请日：2007-11-05
IPC分类号： A61B5/0476
CPC分类号： A61N1/36082 , A61N1/08
摘要： Methods for treating and/or collecting information regarding neurological disorders, including language disorders, are disclosed. A method in accordance with one embodiment directing a patient to perform a language-based task, directing information to be collected, with the information corresponding to a level of neural activity in the patient's brain while the patient performs the language-based task, and, based at least in part on the information, selecting a stimulation site within the patient's skull for receiving an electrode coupleable to an electrical current. In further embodiments, at least one electrode can be placed at the stimulation site, and the patient's language disorder can be reduced by applying electrical stimulation directly to the stimulation site via the at least one electrode.
摘要翻译： 公开了治疗和/或收集关于神经障碍（包括语言障碍）的信息的方法。 根据一个实施例的方法，指导患者执行基于语言的任务，指导要收集的信息，其中所述信息对应于患者执行基于语言的任务期间患者大脑中的神经活动水平，以及， 至少部分地基于信息，选择患者颅骨内的刺激部位以接收可耦合到电流的电极。 在另外的实施方案中，至少一个电极可以放置在刺激部位，并且可以通过经由至少一个电极直接施加电刺激到刺激部位来减少患者的语言障碍。
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7.发明授权公开(公告)号：US06266556B1
公开(公告)日：2001-07-24
申请号：US09067111
申请日：1998-04-27
申请人： John R. Ives , Alvaro Pascual-Leone
发明人： John R. Ives , Alvaro Pascual-Leone
IPC分类号： A61B504
CPC分类号： A61N2/006 , A61B5/0476 , A61B5/0482 , A61B5/0484 , A61B5/4094 , A61N2/02
摘要： A system for monitoring an electroencephalogram of a patient during administration of transcranial magnetic stimulation including a transcranial magnetic stimulation (TMS) system, an electroencephalogram (EEG) monitoring system, and a control system, coupled between the EEG system and the TMS system, that responds to signals provided by the EEG system and controls the TMS system wherein timing of operation of the TMS system does not need to be synchronized to timing of operation of the EEG system. A conductive plastic electrode system for use with the EEG monitoring system is also provided.
摘要翻译： 一种用于在施用经颅磁刺激期间监测患者的脑电图的系统，包括耦合在EEG系统和TMS系统之间的经颅磁刺激（TMS）系统，脑电图（EEG）监测系统和控制系统，其响应 对于由EEG系统提供的信号并且控制TMS系统，其中TMS系统的操作定时不需要与EEG系统的操作定时同步。 还提供了一种用于EEG监测系统的导电塑料电极系统。
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公开(公告)号：US20110224571A1
公开(公告)日：2011-09-15
申请号：US12947491
申请日：2010-11-16
IPC分类号： A61B5/0484
CPC分类号： A61B5/0484 , A61B5/4076
摘要： Non-invasive and objective methods for evaluating neurological conditions that are associated with impaired cortical plasticity using, e.g., Transcranial Magnetic Stimulation (TMS) or Theta Burst Stimulation (TBS).
摘要翻译： 使用例如经颅磁刺激（TMS）或刺激刺激（TBS）评估与皮层可塑性受损相关的神经病学条件的非侵入性和客观方法。
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公开(公告)号：US20100210894A1
公开(公告)日：2010-08-19
申请号：US12312931
申请日：2007-12-01
IPC分类号： A61N2/04
CPC分类号： A61N2/006 , A61B5/0006 , A61B5/04001 , A61B5/0476 , A61B5/0482 , A61B5/4094 , A61B90/14 , A61N2/008 , A61N2/02
摘要： Method and devices are provided for treating subjects with Transcranial Magnetic Stimulation (TMS). According to some approaches, the methods and devices are configured for the treatment of ongoing seizures. Other approaches relate to the use of TMS as an antiepileptogenic or for use in determining preferential placement of intracranial probes.
摘要翻译： 提供了用经颅磁刺激（TMS）治疗受试者的方法和装置。 根据一些方法，方法和装置被配置用于治疗持续性发作。 其他方法涉及使用TMS作为抗癫痫发生或用于确定颅内探针的优先放置。
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10.发明申请SYSTEMS AND METHODS FOR APPLYING SIGNALS, INCLUDING CONTRALESIONAL SIGNALS, TO NEURAL POPULATIONS 有权适用信号的系统和方法，包括对比信号，神经人口公开(公告)号：US20070288072A1
公开(公告)日：2007-12-13
申请号：US11697696
申请日：2007-04-06
申请人： Alvaro Pascual-Leone , Bradford Gliner , David Himes , Leif Sloan
发明人： Alvaro Pascual-Leone , Bradford Gliner , David Himes , Leif Sloan
IPC分类号： A61N5/00
CPC分类号： A61N1/36171 , A61N1/36082 , A61N1/36103 , A61N1/3615
摘要： Systems and methods for applying signals, including contralesional electromagnetic signals, to neural populations, are disclosed. A particular method can be directed to treating a patient having a subject neural population in a first (e.g., ipsilesional) hemisphere of the brain, with the subject neural population having, or previously having, a functionality capable of being improved. The method can include directing an application of electromagnetic signals at least proximate to a target neural population at a second (e.g., contralesional) hemisphere of the brain to at least constrain a functionality of the target neural population, which has transcallosal communication with the first hemisphere.
摘要翻译： 公开了将信号（包括对数电磁信号）应用于神经群体的系统和方法。 具体方法可以涉及在脑的第一（例如ipsilesional）半球中治疗具有受试者神经群体的患者，其中受试者神经群体具有或预先具有能够改善的功能。 该方法可以包括将电磁信号的应用引导至少接近于大脑的第二（例如，对照）半球处的目标神经群体，以至少约束目标神经群体的功能，该目标神经群体与第一半球具有蜕皮通讯 。
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