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公开(公告)号：US09458152B2
公开(公告)日：2016-10-04
申请号：US14920833
申请日：2015-10-22
Applicant: AMGEN INC.
Inventor： Matthew Weiss , Alessandro Boezio , Christiane Boezio , John R. Butler , Margaret Yuhua Chu-Moyer , Erin F. Dimauro , Thomas Dineen , Russell Graceffa , Angel Guzman-Perez , Hongbing Huang , Charles Kreiman , Daniel La , Isaac E. Marx , Benjamin Charles Milgram , Hanh Nho Nguyen , Emily Anne Peterson , Karina R. Vaida , Brian Sparling
IPC: A61K31/00 , C07D417/14 , C07D471/04 , C07D413/12 , C07D401/12 , C07D413/14 , C07D417/12 , C07C53/18 , C07D215/227 , C07D403/12 , C07D215/36 , C07D241/44 , C07D401/14
CPC classification number: C07D417/14 , C07C53/18 , C07D215/227 , C07D215/36 , C07D241/44 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04
Abstract: The present invention provides compounds of Formula I, and pharmaceutically acceptable salts thereof, that are inhibitors of voltage-gated sodium channels, in particular Nav1.7. The compounds are useful for the treatment of diseases associated with the activity of sodium channels such as pain disorders and itch. Also provided are pharmaceutical compositions containing compounds of the present invention.
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2.发明申请公开(公告)号：US20150057271A1
公开(公告)日：2015-02-26
申请号：US14377478
申请日：2013-02-12
Applicant: AMGEN INC.
Inventor： Christiane Boezio , Alessandro Boezio , Howard Bregman , Nagasree Chakka , James R. Coats , Katrina Woodin Copeland , Erin F. Dimauro , Thomas Dineen , Hua Gao , Daniel La , Isaac E. Marx , Hanh Nho Nguyen , Emily Anne Peterson , Matthew Weiss
IPC: C07D417/14 , C07D471/04 , C07D413/14 , C07D417/12 , C07D413/12
CPC classification number: C07D417/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04
Abstract: The present invention provides compounds of Formula I, or pharmaceutically acceptable salts thereof, that are inhibitors of voltage-gated sodium channels, in particular Nav 1.7. The compounds are useful for the treatment of diseases treatable by inhibition of sodium channels such as pain disorders. Also provided are pharmaceutical compositions containing compounds of the present invention.
Abstract translation: 本发明提供式I化合物或其药学上可接受的盐，其是电压门控钠通道的抑制剂，特别是Nav 1.7。 该化合物可用于治疗可通过抑制钠通道（例如疼痛障碍）治疗的疾病。 还提供含有本发明化合物的药物组合物。
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公开(公告)号：US09663508B2
公开(公告)日：2017-05-30
申请号：US15026740
申请日：2014-10-01
Applicant: AMGEN INC.
Inventor： Howard Bregman , Nagasree Chakka , Erin F. Dimauro , Hua Gao , Hakan Gunaydin , Hongbing Huang , Philip R. Olivieri , Laurie Schenkel , Matthew Weiss
IPC: C07D417/12 , C07D213/64 , C07D213/26 , C07D213/643 , C07D213/70 , C07D401/04 , C07D405/12
CPC classification number: C07D417/12 , C07D213/26 , C07D213/64 , C07D213/643 , C07D213/70 , C07D401/04 , C07D405/12
Abstract: The present invention provides compounds of Formula (Ia), and pharmaceutically acceptable salts thereof. The compounds are useful as inhibitors of voltage-gated sodium channels, in particular Nav 1.7. as described in the specification. The compounds are useful for the treatment of diseases treatable by inhibition of sodium channels such as pain disorders. Also provided are pharmaceutical compositions containing compounds of the present invention, as well as intermediates and processes useful for making the compounds.
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公开(公告)号：US09340549B2
公开(公告)日：2016-05-17
申请号：US14383432
申请日：2013-03-01
Applicant: AMGEN INC.
Inventor： Howard Bregman , John L. Buchanan , Nagasree Chakka , Erin F. Dimauro , Hakan Gunaydin , Angel Guzman-Perez , Zihao Hua , Hongbing Huang , Xin Huang , Matthew W. Martin , Vinod F. Patel
IPC: C07D413/14 , C07D487/04 , C07D413/08 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D473/00 , C07D263/34 , C07D519/00 , C07D413/10
CPC classification number: C07D487/04 , C07D263/34 , C07D413/08 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D473/00 , C07D519/00
Abstract: Compounds of Formula (I) and Formula (II) are useful inhibitors of tankyrase. Compounds of Formula (I) and Formula (II) have the following structure: where the definitions of the variables are provided herein.
Abstract translation: 式（I）和式（II）的化合物是阻聚酶的有用抑制剂。 式（I）和式（II）的化合物具有以下结构：其中在此提供变量的定义。
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公开(公告)号：US20150045368A1
公开(公告)日：2015-02-12
申请号：US14383432
申请日：2013-03-01
Applicant: AMGEN INC.
Inventor： Howard Bregman , John L. Buchanan , Nagasree Chakka , Erin F. Dimauro , Hakan Gunaydin , Angel Guzman-Perez , Zihao Hua , Hongbing Huang , Xin Huang , Matthew W. Martin , Vinod F. Patel
IPC: C07D487/04 , C07D519/00 , C07D413/14 , C07D413/10 , C07D471/04 , C07D413/12
CPC classification number: C07D487/04 , C07D263/34 , C07D413/08 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D473/00 , C07D519/00
Abstract: Compounds of Formula (I) and Formula (II) are useful inhibitors of tankyrase. Compounds of Formula (I) and Formula (II) have the following structure: where the definitions of the variables are provided herein.
Abstract translation: 式（I）和式（II）的化合物是阻聚酶的有用抑制剂。 式（I）和式（II）的化合物具有以下结构：其中在此提供变量的定义。
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Patent Agency Ranking
公开(公告)号：US09505749B2
公开(公告)日：2016-11-29
申请号：US14423078
申请日：2013-08-27
Applicant: AMGEN INC.
Inventor： Howard Bregman , John L. Buchanan , Nagasree Chakka , Erin F. Dimauro , Hakan Gunaydin , Angel Guzman-Perez , Zihao Hua , Xin Huang
IPC: C07D471/02 , C07D403/12 , C07D401/14 , C07D413/14 , C07D401/12 , C07D239/90 , C07D239/95 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04
CPC classification number: C07D471/02 , C07D239/90 , C07D239/95 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04
Abstract: Compounds of Formula I are useful inhibitors of tankyrase. Compounds of Formula I have the following structure: where the definitions of the variables are provided herein.
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7.发明授权公开(公告)号：US09346798B2
公开(公告)日：2016-05-24
申请号：US14377478
申请日：2013-02-12
Applicant: AMGEN INC.
Inventor： Christiane Boezio , Alessandro Boezio , Howard Bregman , Nagasree Chakka , James R. Coats , Katrina Woodin Copeland , Erin F. Dimauro , Thomas Dineen , Hua Gao , Daniel La , Isaac E. Marx , Hanh Nho Nguyen , Emily Anne Peterson , Matthew Weiss
IPC: C07D413/12 , C07D417/12 , C07D413/14 , C07D471/04 , C07D417/14
CPC classification number: C07D417/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04
Abstract: The present invention provides compounds of Formula I, or pharmaceutically acceptable salts thereof, that are inhibitors of voltage-gated sodium channels, in particular Nav 1.7. The compounds are useful for the treatment of diseases treatable by inhibition of sodium channels such as pain disorders. Also provided are pharmaceutical compositions containing compounds of the present invention.
Abstract translation: 本发明提供式I化合物或其药学上可接受的盐，其是电压门控钠通道的抑制剂，特别是Nav 1.7。 该化合物可用于治疗可通过抑制钠通道（例如疼痛障碍）治疗的疾病。 还提供含有本发明化合物的药物组合物。
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公开(公告)号：US09212182B2
公开(公告)日：2015-12-15
申请号：US14302337
申请日：2014-06-11
Applicant: AMGEN INC.
Inventor： Matthew Weiss , Alessandro Boezio , Christiane Boezio , John R. Butler , Margaret Yuhua Chu-Moyer , Erin F. Dimauro , Thomas Dineen , Russell Graceffa , Angel Guzman-Perez , Hongbing Huang , Charles Kreiman , Daniel La , Isaac E. Marx , Benjamin Charles Milgrim , Hanh Nho Nguyen , Emily Peterson , Karina Romero , Brian Sparling
IPC: A61K31/00 , C07D215/00 , C07D471/04 , C07D413/12 , C07D401/12 , C07D413/14 , C07D417/12 , C07C53/18 , C07D215/227 , C07D403/12 , C07D215/36 , C07D241/44
CPC classification number: C07D417/14 , C07C53/18 , C07D215/227 , C07D215/36 , C07D241/44 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04
Abstract: The present invention provides compounds of Formula I, and pharmaceutically acceptable salts thereof, that are inhibitors of voltage-gated sodium channels, in particular Nav1.7. The compounds are useful for the treatment of diseases associated with the activity of sodium channels such as pain disorders and itch. Also provided are pharmaceutical compositions containing compounds of the present invention.
Abstract translation: 本发明提供式I化合物及其药学上可接受的盐，其是电压门控钠通道的抑制剂，特别是Nav1.7。 该化合物可用于治疗与钠通道活性相关的疾病，例如疼痛障碍和瘙痒。 还提供含有本发明化合物的药物组合物。
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公开(公告)号：US20150225396A1
公开(公告)日：2015-08-13
申请号：US14423078
申请日：2013-08-27
Applicant: AMGEN INC.
Inventor： Howard Bregman , John L. Buchanan , Nagasree Chakka , Erin F. Dimauro , Hakan Gunaydin , Angel Guzman-Perez , Zihao Hua , Xin Huang
IPC: C07D471/02 , C07D413/14 , C07D401/14 , C07D239/95 , C07D401/12 , C07D239/90 , C07D417/12 , C07D413/12 , C07D417/14
CPC classification number: C07D471/02 , C07D239/90 , C07D239/95 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04
Abstract: Compounds of Formula I are useful inhibitors of tankyrase. Compounds of Formula I have the following structure: where the definitions of the variables are provided herein.
Abstract translation: 式I化合物是阻聚酶的有用抑制剂。 式I的化合物具有以下结构：其中本文提供变量的定义。
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公开(公告)号：US09012443B2
公开(公告)日：2015-04-21
申请号：US13707096
申请日：2012-12-06
Applicant: Amgen Inc.
Inventor： Christiane Boezio , Howard Bregman , James R. Coats , Erin F. Dimauro , Thomas Dineen , Bingfan Du , Russell Graceffa , Charles Kreiman , Daniel La , Isaac E. Marx , Nagasree Chakka , Hanh Nho Nguyen , Emily Anne Peterson , Matthew Weiss , Katrina W. Copeland , Holly L. Deak , Alessandro Boezio
IPC: C07D498/04 , C07D417/12 , C07D417/14 , C07D401/14 , C07D471/04 , A61K31/433 , C07D403/12 , C07D413/14 , C07D401/12 , C07D403/14 , C07D239/42 , C07D409/14 , C07D413/12 , C07D277/52 , C07D285/08
CPC classification number: C07D498/04 , C07D239/42 , C07D277/52 , C07D285/08 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04
Abstract: The present invention provides compounds of Formula I, or pharmaceutically acceptable salts thereof, that are inhibitors of voltage-gated sodium channels, in particular Nav 1.7. The compounds are useful for the treatment of diseases treatable by inhibition of sodium channels such as pain disorders. Also provided are pharmaceutical compositions containing compounds of the present invention.
Abstract translation: 本发明提供式I化合物或其药学上可接受的盐，其是电压门控钠通道的抑制剂，特别是Nav 1.7。 该化合物可用于治疗可通过抑制钠通道（例如疼痛障碍）治疗的疾病。 还提供含有本发明化合物的药物组合物。
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