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公开(公告)号：US20070015781A1
公开(公告)日：2007-01-18
申请号：US10574536
申请日：2004-10-04
IPC分类号： A61K31/4747 , A61K31/407 , C07D471/10
CPC分类号： C07D487/10
摘要： The present invention relates to novel 2-(6-oxo-1,7-diaza-spiro[4.4]non-7-yl)-propionamides of the formula wherein R1, R2, R3, R4, R5, R6, m and p are as defined in the specification, to their preparation, to their use as pharmaceuticals and to pharmaceutical compositions containing them.
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2.发明授权公开(公告)号：US07655686B2
公开(公告)日：2010-02-02
申请号：US11823311
申请日：2007-06-26
IPC分类号： A61K31/407 , C07D487/10
CPC分类号： C07D487/10
摘要： The present invention relates to novel 2-(6-oxo-1,7-diaza-spiro[4.4]non-7-yl)-propionamides of the formula wherein R1, R2, R3, R4, R5, R6, m and p are as defined in the specification, to their preparation, to their use as pharmaceuticals and to pharmaceutical compositions containing them.
摘要翻译： 本发明涉及下式的新的2-（6-氧代-1,7-二氮杂 - 螺[4.4]壬-7-基） - 丙酰胺其中R1，R2，R3，R4，R5，R6，m和p 在本说明书中对其制备，其用作药物和含有它们的药物组合物的用途。
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3.发明申请公开(公告)号：US20070265328A1
公开(公告)日：2007-11-15
申请号：US11823311
申请日：2007-06-26
IPC分类号： A61K31/40 , A61P25/00 , A61P9/00 , C07D491/00
CPC分类号： C07D487/10
摘要： The present invention relates to novel 2-(6-oxo-1,7-diaza-spiro[4.4]non-7-yl)-propionamides of the formula wherein R1, R2, R3, R4, R5, R6, m and p are as defined in the specification, to their preparation, to their use as pharmaceuticals and to pharmaceutical compositions containing them.
摘要翻译： 本发明涉及下式的新的2-（6-氧代-1,7-二氮杂 - 螺[4.4]壬-7-基） - 丙酰胺其中R 1，R 2 R 3，R 3，R 4，R 5，R 6，m和p分别为 在本说明书中定义，它们的制备，用作药物和含有它们的药物组合物。
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![Dibenzo[b,f]oxepine-10-carboxamides and pharmaceutical uses thereof](/abs-image/US/2009/11/03/US07612054B2/abs.jpg.150x150.jpg)
4.发明授权公开(公告)号：US07612054B2
公开(公告)日：2009-11-03
申请号：US10565456
申请日：2004-07-23
申请人： Yves Auberson , Claudia Betschart , Stefanie Flohr , Ralf Glatthar , Oliver Simic , Marina Tintelnot-Blomley , Thomas J. Troxler , Eric Vangrevelinghe , Siem Jacob Veenstra
发明人： Yves Auberson , Claudia Betschart , Stefanie Flohr , Ralf Glatthar , Oliver Simic , Marina Tintelnot-Blomley , Thomas J. Troxler , Eric Vangrevelinghe , Siem Jacob Veenstra
IPC分类号： A01N43/00 , A61K31/33 , C07D313/00
CPC分类号： C07D405/12 , C07C235/82 , C07C2603/32 , C07D313/14 , C07D407/12 , C07D413/12 , C07D453/02 , C07D491/04
摘要： The present invention pertains to novel dibenzo[b,f]oxepine-10-carboxamides compound to a process for the preparation of such compounds of formula I, their use as a pharmaceuticals, especially in the treatment of neurological and vascular disorders related to beta-amyloid generation and/or aggregation, and to pharmaceutical compositions and combinations comprising such compounds of formula I.
摘要翻译： 本发明涉及新的二苯并[b，f]氧杂七环素-10-甲酰胺化合物，其用于制备式I化合物的方法，它们作为药物的用途，特别是用于治疗与β-谷氨酸相关的神经和血管疾病， 淀粉样蛋白生成和/或聚集，以及包含式I化合物的药物组合物和组合。
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![Novel dibenzo [b, f] oxepine-10-carboxamides and pharmaceutical uses thereof](/abs-image/US/2007/05/17/US20070111991A1/abs.jpg.150x150.jpg)
5.发明申请Novel dibenzo [b, f] oxepine-10-carboxamides and pharmaceutical uses thereof 失效新的二苯并[b，f]氧杂七环素-10-甲酰胺及其药物用途公开(公告)号：US20070111991A1
公开(公告)日：2007-05-17
申请号：US10565456
申请日：2004-07-23
申请人： Yves Auberson , Claudia Betschart , Stefanie Flohr , Ralf Glatthar , Oliver Simic , Marina Tintelnot-Blomley , Thomas Troxler , Eric Vangrevelinghe , Siem Veenstra
发明人： Yves Auberson , Claudia Betschart , Stefanie Flohr , Ralf Glatthar , Oliver Simic , Marina Tintelnot-Blomley , Thomas Troxler , Eric Vangrevelinghe , Siem Veenstra
IPC分类号： A61K31/55 , A61K31/5375 , A61K31/5377 , A61K31/495 , A61K31/496 , A61K31/445 , A61K31/452 , A61K31/4025
CPC分类号： C07D405/12 , C07C235/82 , C07C2603/32 , C07D313/14 , C07D407/12 , C07D413/12 , C07D453/02 , C07D491/04
摘要： The present invention pertains to novel dibenzo[b,f]oxepine-10-carboxamides compound to a process for the preparation of such compounds of formula I, their use as a pharmaceuticals, especially in the treatment of neurological and vascular disorders related to beta-amyloid generation and/or aggregation, and to pharmaceutical compositions and combinations comprising such compounds of formula I.
摘要翻译： 本发明涉及新的二苯并[b，f]氧杂七环素-10-甲酰胺化合物，其用于制备式I化合物的方法，它们作为药物的用途，特别是用于治疗与β-谷氨酸相关的神经和血管疾病， 淀粉样蛋白生成和/或聚集，以及包含式I化合物的药物组合物和组合。
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公开(公告)号：US20100022500A1
公开(公告)日：2010-01-28
申请号：US12566928
申请日：2009-09-25
申请人： Yves AUBERSON , Claudia Betschart , Ralf Glatthar , Kurt Laumen , Rainer MacHauer , Marina Tintelnot-Blomley , Thomas J. Troxler , Siem Jacob Veenstra
发明人： Yves AUBERSON , Claudia Betschart , Ralf Glatthar , Kurt Laumen , Rainer MacHauer , Marina Tintelnot-Blomley , Thomas J. Troxler , Siem Jacob Veenstra
IPC分类号： A61K31/395 , C07D245/02 , C07D291/02 , A61P25/00
CPC分类号： C07D245/02 , C07D255/00 , C07D273/00 , C07D281/00 , C07D471/08 , C07D513/08
摘要： The present invention relates to novel macrocyclic compounds of the formula wherein R1, R2, R3, U, V, W, X, Y, Z and n are as defined in the specification, the number of ring atoms included in the macrocyclic ring being 14, 15, 16 or 17, in free base form or in acid addition salt form, to their preparation, to their use as pharmaceuticals and to pharmaceutical compositions comprising them.
摘要翻译： 本发明涉及下式的新型大环化合物其中R1，R2，R3，U，V，W，X，Y，Z和n如说明书中所定义，大环中包括的环原子数为14 ，15,16或17，以游离碱形式或以酸加成盐形式，用于制备，用作药物和包含它们的药物组合物。
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公开(公告)号：US07612055B2
公开(公告)日：2009-11-03
申请号：US10577260
申请日：2004-11-04
申请人： Yves Auberson , Claudia Betschart , Ralf Glatthar , Kurt Laumen , Rainer Machauer , Marina Tintelnot-Blomley , Thomas J. Troxler , Siem Jacob Veenstra
发明人： Yves Auberson , Claudia Betschart , Ralf Glatthar , Kurt Laumen , Rainer Machauer , Marina Tintelnot-Blomley , Thomas J. Troxler , Siem Jacob Veenstra
IPC分类号： A01N43/00 , A61K31/33 , C07D245/00
CPC分类号： C07D245/02 , C07D255/00 , C07D273/00 , C07D281/00 , C07D471/08 , C07D513/08
摘要： The present invention relates to novel macrocyclic compounds of the formula wherein R1, R2, R3, U, V, W, X, Y, Z and n are as defined in the specification, the number of ring atoms included in the macrocyclic ring being 14, 15, 16 or 17, in free base form or in acid addition salt form, to their preparation, to their use as pharmaceuticals and to pharmaceutical compositions comprising them.
摘要翻译： 本发明涉及下式的新型大环化合物其中R1，R2，R3，U，V，W，X，Y，Z和n如说明书中所定义，大环中包括的环原子数为14 ，15,16或17，以游离碱形式或以酸加成盐形式，用于制备，用作药物和包含它们的药物组合物。
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公开(公告)号：US20070072792A1
公开(公告)日：2007-03-29
申请号：US10577260
申请日：2004-11-04
申请人： Yves Auberson , Claudia Betschart , Ralf Glatthar , Kurt Laumen , Rainer Machauer , Marina Tintelnot-Blomley , Thomas Troxler , Siem Veenstra
发明人： Yves Auberson , Claudia Betschart , Ralf Glatthar , Kurt Laumen , Rainer Machauer , Marina Tintelnot-Blomley , Thomas Troxler , Siem Veenstra
IPC分类号： A61K38/12 , A61K31/4745 , A61K31/4245 , A61K31/433 , A61K31/454 , A61K31/423 , C07D487/04 , C07K5/12
CPC分类号： C07D245/02 , C07D255/00 , C07D273/00 , C07D281/00 , C07D471/08 , C07D513/08
摘要： The present invention relates to novel macrocyclic compounds of the formula wherein R1, R2, R3, U, V, W, X, Y, Z and n are as defined in the specification, the number of ring atoms included in the macrocyclic ring being 14, 15, 16 or 17, in free base form or in acid addition salt form, to their preparation, to their use as pharmaceuticals and to pharmaceutical compositions comprising them.
摘要翻译： 本发明涉及下式的新的大环化合物：其中R 1，R 2，R 3，U，V，W，X， Y，Z和n如说明书中所定义，大环中包括的环原子数为14,15,16或17，以游离碱形式或以酸加成盐形式，其制备方式用于 药物和包含它们的药物组合物。
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公开(公告)号：US07696379B2
公开(公告)日：2010-04-13
申请号：US11912626
申请日：2006-04-24
IPC分类号： C07C231/00 , C07D263/02 , C07D261/02 , C07D249/08 , C07D233/00 , C07C237/00 , A61K31/33 , A61K31/16
CPC分类号： C07C235/54 , C07C233/22 , C07C233/23 , C07C233/74 , C07C235/14 , C07C235/36 , C07C235/78 , C07C237/38 , C07C317/44 , C07D233/90 , C07D249/08 , C07D249/10 , C07D307/68
摘要： The invention provides compounds of formula (I) wherein R1 represents hydrogen or alkyl; R2 represents an unsubstituted or substituted heterocycle or R2 represents an unsubstituted or substituted aryl; R3 represents alkyl or halogen; X represents a single bond or an alkandiyl-group, optionally interrupted by one or more oxygen atoms or carbonyl groups or carbonyloxy groups in free base or acid addition salt form, processes for their preparation and their use as pharmaceuticals.
摘要翻译： 本发明提供式（I）化合物，其中R 1表示氢或烷基; R2表示未取代或取代的杂环，或者R2表示未取代或取代的芳基; R3表示烷基或卤素; X代表单键或烷二基，任选地被一个或多个氧原子或游离碱或酸加成盐形式的羰基或羰基氧基中断，其制备及其用作药物。
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公开(公告)号：US20090105266A1
公开(公告)日：2009-04-23
申请号：US12148557
申请日：2008-04-18
申请人： Ralf Glatthar , David Carcache
发明人： Ralf Glatthar , David Carcache
IPC分类号： A61K31/498 , C07D235/02 , A61K31/4184 , A61K31/4439 , C07D401/02 , C07D401/14 , A61K31/444 , A61K31/4709
CPC分类号： C07D401/04 , C07D401/10 , C07D401/14 , C07D403/04 , C07D403/14 , C07D471/04 , C07D471/06
摘要： The present invention relates to novel benzimidazole derivatives, their preparation, their use as pharmaceuticals and pharmaceutical compositions containing them, wherein the compounds have the formula (I): in which the substitutents are as defined in claim 1 and salts, solvates, hydrates and N-oxides thereof.
摘要翻译： 本发明涉及新的苯并咪唑衍生物，其制备方法，它们作为药物的用途和含有它们的药物组合物，其中化合物具有式（I）：其中取代基如权利要求1所定义，其盐，溶剂合物，水合物和N - 氧化物。
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