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公开(公告)号:US07871642B2
公开(公告)日:2011-01-18
申请号:US11446844
申请日:2006-06-05
CPC分类号: A61K9/1075 , A61K9/4858 , A61K9/4866 , Y10S514/846 , Y10S514/937 , Y10S514/938 , Y10S514/941 , Y10S514/947
摘要: A nanodispersion comprises (a) a membrane-forming molecule, (b) a coemulsifier and (c) a lipophilic component, in pharmaceutical end formulations, the nanodispersion being obtainable by (α) mixing the components (a), (b) and (c) until a homogeneous clear liquid is obtained, and (β) adding the liquid obtained in step (α) to the water phase of the pharmaceutical end formulations, where steps (α) and (β) may be carried out without high energy mixing or homogenization. The nanodispersions prepared according to this invention are suitable as transport vehicles for pharmaceutical active agents.
摘要翻译: 纳米分散体包含(a)在药物末端制剂中的成膜分子(b)共乳化剂和(c)亲脂性组分,所述纳米分散体可通过(α)混合组分(a),(b)和( c)直到获得均匀的透明液体,并且将(步骤(α)中获得的液体)添加到药物末端制剂的水相中,其中步骤(α)和(&bgr)可以在不高的情况下进行 能量混合或均质化。 根据本发明制备的纳米分散体适合用作药物活性剂的运输工具。
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公开(公告)号:US07008638B2
公开(公告)日:2006-03-07
申请号:US10016903
申请日:2001-12-14
CPC分类号: A61K8/04 , A61K8/553 , A61K8/68 , A61K2800/21 , A61Q1/02 , A61Q17/00 , A61Q17/04 , A61Q19/00 , A61Q19/10 , B82Y5/00
摘要: A description is given of the use of a nanodispersion, which comprises (a) a membrane-forming molecule, (b) a coemulsifier and (c) a lipophilic component, in cosmetic end formulation, which nanodispersion is obtainable by (α) mixing the components (a), (b) and (c) until a homogeneous clear liquid is obtained, and (β) adding the liquid obtained in step (α) to the water phase of the cosmetic end formulations, steps (α) and (β) being carried out without any additional supply of energy. The nanodispersions used according to this invention can be easily prepared and are suitable as carrier systems for a very wide range of cosmetic active agents and oil-soluble dyes.
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公开(公告)号:US07381423B2
公开(公告)日:2008-06-03
申请号:US11103208
申请日:2005-04-11
CPC分类号: A61K8/553 , A61K8/04 , A61K2800/413 , A61Q1/02 , A61Q17/00 , A61Q17/04 , A61Q19/00 , A61Q19/10 , B82Y5/00 , Y10S514/937 , Y10S514/938
摘要: A description is given of the use of a nanodispersion, which comprises (a) a membrane-forming molecule, (b) a coemulsifier and (c) a lipophilic component, in cosmetic end formulation, which nanodispersion is obtainable by (α) mixing the components (a), (b) and (c) until a homogeneous clear liquid is obtained, and (β) adding the liquid obtained in, step (α) to the water phase of the cosmetic end formulations, steps (α) and (β) being carried out without any additional supply of energy. The nanodispersions used according to this invention can be easily prepared and are suitable as carrier systems for a very wide range of cosmetic active agents and oil-soluble dyes.
摘要翻译: 描述了纳米分散体的使用,其包括(a)成膜分子,(b)化妆品末端制剂中的共乳化剂和(c)亲脂性组分,所述纳米分散体可通过(α)将 组分(a),(b)和(c),直到获得均匀的透明液体,和(β)将在步骤(α)中获得的液体加入到化妆品末端制剂的水相中,步骤(α)和 beta)在没有任何额外的能量供应的情况下进行。 根据本发明使用的纳米分散体可以容易地制备并且适合作为用于非常宽范围的美容活性剂和油溶性染料的载体体系。
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公开(公告)号:US07081253B2
公开(公告)日:2006-07-25
申请号:US09306006
申请日:1999-05-06
CPC分类号: A61K9/1075 , A61K9/4858 , A61K9/4866 , Y10S514/846 , Y10S514/937 , Y10S514/938 , Y10S514/941 , Y10S514/947
摘要: A description is given of the use of a nanodispersion, which comprises (a) a membrane-forming molecule, (b) a coemulsifier and (c) a lipophilic component, in pharmaceutical end formulations, the nanodispersion being obtainable by (α) mixing the components (a), (b) and (c) until a homogeneous clear liquid is obtained, and (β) adding the liquid obtained in step (α) to the water phase of the pharmaceutical end formulations, steps (α) and (β) being carried out without any additional supply of energy. The nanodispersions used according to this invention are suitable as transport vehicles for pharmaceutical active agents.
摘要翻译: 给出了使用纳米分散体的描述,该纳米分散体包含(a)在药物末端制剂中的成膜分子,(b)共乳化剂和(c)亲脂性组分,纳米分散体可通过(α)混合 组分(a),(b)和(c),直到获得均匀的透明液体,和(β)将步骤(α)中获得的液体加入到药物末端制剂的水相中,步骤(α)和 )在没有任何额外的能量供应的情况下进行。 根据本发明使用的纳米分散体适合用作药物活性剂的运输载体。
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公开(公告)号:US06369268B1
公开(公告)日:2002-04-09
申请号:US09530537
申请日:2000-05-01
申请人: Thomas Ehlis , Peter Frankhauser , Dietmar Hüglin
发明人: Thomas Ehlis , Peter Frankhauser , Dietmar Hüglin
IPC分类号: C07C22900
CPC分类号: D21C9/1042 , A23L29/035 , A61K8/44 , A61K2800/51 , A61Q5/02 , A61Q15/00 , A61Q17/00 , A61Q19/00 , C07C229/24 , C11D1/46 , C11D3/26 , D06M13/332 , D06M2200/50 , D06P1/645
摘要: Described are diester amine adducts of formula (1) wherein R1, R2, R3, R4 are each independently of one another C4-C22alkyl; C2-C22alkenyl; or C5-C7cycloalkyl; X1 and X2 are each independently of the other hydrogen, C1-C4alkyl; C2-C4hydroxyalkyl or C2-C4hydroxyhaloalkyl; Y is a radical of formula (1b); A1 is C2-C3alkylene or 2-hydroxy-n-propylene; X3 is hydrogen; C1-C4alkyl, C2-C4hydroxyalkyl; or C2-C4hydroxyhaloalkyl; (A) is an asymmetrical carbon atom in the R- or S-configuration, wherein, if C1=R, C2=R; C1=S, C2=S; and C1=R; C2=S; m1 is 1 or 2; and n is an integer from 1 to 4; p is 0 or 1; which adducts may be in the form of free bases or ammonium salts. Said compounds are precursors of compounds having good complex-forming properties and are thus able to effectively bind heavy metal ions such as iron, zinc, magnesium or copper ions and to prevent metal-initiated oxidations after enzymatic or chemical cleavage. They have a plurality of uses, for example in foods, beverages, derusting and decalcification baths, as additives in liquids for cooling-water circuits, in personal-care products, as bleaching stabilizers, in cleaning agents and detergents, in the textile industry and also as soft handle agents for organic fibre materials.
摘要翻译: 描述了式(1)的二酯加合物,其中R 1,R 2,R 3,R 4各自独立地为C 1 -C 22烷基; C 2 -C 22烯基; 或C 5 -C 7环烷基; X 1和X 2各自独立地为另一个氢,C 1 -C 4烷基; C 2 -C 4羟烷基或C 2 -C 4羟基卤代烷基; Y是式(1b)的基团; A1是C2-C3亚烷基或2-羟基 - 正丙烯; X3是氢; C 1 -C 4烷基,C 2 -C 4羟烷基; 或C 2 -C 4羟基卤代烷基; (A)是R-或S-构型中的不对称碳原子,其中如果C1 = R,则C2 = R; C1 = S,C2 = S; 和C1 = R; C2 = S; m1为1或2; n为1〜4的整数。 p为0或1; 哪些加成物可以是游离碱或铵盐的形式。 所述化合物是具有良好的络合物形成性质的化合物的前体,因此能够有效地结合重金属离子如铁,锌,镁或铜离子,并且在酶或化学裂解后防止金属引发的氧化。 它们具有多种用途,例如在食品,饮料,除锈和脱钙浴中,作为用于冷却水回路的液体,个人护理产品中的添加剂,漂白稳定剂,清洁剂和洗涤剂在纺织工业中的用途,以及 也作为有机纤维材料的软处理剂。
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6.
公开(公告)号:US07344706B2
公开(公告)日:2008-03-18
申请号:US10507295
申请日:2003-03-04
申请人: Jürg Haase , Thomas Ehlis , Elek Borsos , Dietmar Hüglin , Bernd Herzog
发明人: Jürg Haase , Thomas Ehlis , Elek Borsos , Dietmar Hüglin , Bernd Herzog
CPC分类号: A61K8/4966 , A61Q17/04
摘要: UV absorber compositions are described, comprising (a) from 1 to 99% by weight of a hydroxyphenyltriazine compound of formula (I) wherein R1, R2 and R3 are each independently of the others C1-C18alkyl; C2-C10,alkenyl; or phenyl-C1-C4 alkyl; R4 is hydrogen; or C1-C5alkyl; and (b) from 99 to 1% by weight of a further UV absorber selected from the group of (b) hydroxyphenyltriazines that are different from component (a), (b2) benzotriazoles, (b3) dibenzoylmethane derivatives and (b4) camphor derivatives. The compositions are suitable as UV filters in cosmetic compositions
摘要翻译: 描述了UV吸收剂组合物,其包含(a)1至99重量%的式(I)的羟基苯基三嗪化合物,其中R 1,R 2和R 2 > 3 SUB>各自独立地为C 1 -C 12烷基; C 2 -C 10,烯基; 或苯基-C 1 -C 4烷基; R 4是氢; 或C 1 -C 5烷基; (b)99〜1重量%的另外的紫外线吸收剂,其选自(b)不同于组分(a),(b-2)苯并三唑的(b)羟基苯基三嗪,(b < (3/4)二苯甲酰甲烷衍生物和(b 4 S)樟脑衍生物。 该组合物适用于化妆品组合物中的UV过滤器
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公开(公告)号:US06217856B1
公开(公告)日:2001-04-17
申请号:US09308094
申请日:1999-05-17
申请人: Thomas Ehlis , Dietmar Hüglin , Helmut Luther
发明人: Thomas Ehlis , Dietmar Hüglin , Helmut Luther
IPC分类号: A61K706
CPC分类号: C07D251/24 , A61K8/4966 , A61Q17/04
摘要: A description is given of symmetrical triazine derivatives of formula (1), wherein R1 and R2 are each independently of the other hydrogen; C1-C12alkyl, C1-C12alkoxy; and R3 is C1-C12alkyl; or C1-C12alkoxy. The easily accessible triazine derivatives are suitable for protecting ultraviolet-sensitive materials, in particular skin and hair of humans and animals, from the harmful effects of UV radiation.
摘要翻译: 给出式(1)的对称三嗪衍生物的描述,其中R 1和R 2各自独立于另一个氢; C 1 -C 12烷基,C 1 -C 12烷氧基; 且R 3为C 1 -C 12烷基; 或C 1 -C 12烷氧基。 容易获得的三嗪衍生物适用于防止紫外线辐射的有害影响的紫外线敏感材料,特别是人和动物的皮肤和毛发。
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8.
公开(公告)号:US08449868B2
公开(公告)日:2013-05-28
申请号:US12378567
申请日:2009-02-17
申请人: John Jennings , Dietmar Hüglin , Jianwen Mao , Andreas Mühlebach
发明人: John Jennings , Dietmar Hüglin , Jianwen Mao , Andreas Mühlebach
IPC分类号: A61K8/02 , A61Q19/00 , A61Q5/00 , A61Q11/00 , A61Q15/00 , A61Q9/02 , A61Q5/02 , A61Q5/04 , A61Q5/10 , A61Q5/08 , A61Q3/02 , A61Q1/06 , A61Q1/10 , A61Q17/04 , A01N25/00 , A01P1/00
CPC分类号: A61K8/8117 , A61K8/11 , A61K8/8129 , A61K2800/413 , A61Q5/02 , A61Q5/12 , A61Q17/005 , A61Q17/04 , A61Q19/04
摘要: The present invention is directed to cationic nanoparticles, methods to make them, and the use of compositions containing said nanoparticles in personal care compositions or formulations. The nanoparticles are useful in personal care applications and impart antimicrobial properties to home and personal care products containing them. These cationic nanoparticles also contribute useful conditioning properties to hair-care and skin-care products.
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公开(公告)号:US08404257B1
公开(公告)日:2013-03-26
申请号:US09830787
申请日:1999-10-21
IPC分类号: A61K8/00
CPC分类号: A61K8/347 , A61K8/37 , A61K8/42 , A61K8/46 , A61K8/466 , A61K8/4926 , A61K8/4966 , A61K8/4973 , A61K8/498 , A61K2800/522 , A61Q1/02 , A61Q1/06 , A61Q1/08 , A61Q1/10 , A61Q1/12 , A61Q5/02 , A61Q5/06 , A61Q9/02 , A61Q11/00 , A61Q13/00 , A61Q15/00 , A61Q17/04 , A61Q19/007 , A61Q19/10 , C11D3/0084 , C11D3/2034 , C11D3/28 , C11D3/30 , C11D3/32 , C11D3/349
摘要: A description is given of the use of phenolic antioxidants of formulae (1) and/or (2) and/or (3) for stabilizing body-care and household products.
摘要翻译: 给出了使用式(1)和/或(2)和/或(3)的酚类抗氧化剂来稳定身体护理和家用产品的描述。
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公开(公告)号:US07432400B2
公开(公告)日:2008-10-07
申请号:US10488452
申请日:2002-08-29
申请人: Barbara Wagner , Dietmar Hüglin
发明人: Barbara Wagner , Dietmar Hüglin
CPC分类号: C07D453/02 , A61K8/35 , A61Q17/04 , C07C45/74 , C07C49/683 , C07C49/755 , C07C49/796 , C07C49/813 , C07C67/343 , C07C69/738 , C07C317/44 , C07C2602/08 , C07D239/62
摘要: These are described biphenylene compounds of formula (I) wherein R1 is a C1-C18alkyl, C2-C18alkenyl, C6-C10aryl or C6-C10aryl or C6-C10heteroaryl radical each unsubstituted or mono- or poly-substituted by hydroxy, halogen, C1-C18alkyl, C1-C18alkoxy, amino, C1-C5monoalkyamino or by di-C1-C5alkylamino; C5-C7cycloalkyl or C5-C7cycloalkenyl each unsubstituted or substituted by C1-C5alkyl; —OR′; or NR′R″; R2 is a C1-C18alkyl, C2-C18alkenyl, C6-C10aryl or C6-C10heteroaryl radical each unsubstituted or mono- poly-substituted by hydroxy, hadroxy, C1-C18alkoxy, amino, C1-C5monoalkylamino or by di-C1-C5alkylamino; —OR′; —NR′R″; or R1 and R2 together form a 5- to 7- membered monocyclic carbocyclic or heterocyclic ring; R3 is hydrogen; C1-C6alkyl or C1-C6alkoxy; R′ and R″ are each independently of the other hydrogen; unsubstituted or mono- or poly-hydroxy-, halo-, C1-C18alkyl-, C1-C18alkoxy-, amino- or quaternary ammonium groupsubstituted C1-C18alkyl, C5-C7cycloalkyl or phenyl; and n is 0 or 1; wherein, when R2 is OR′ or NR′R″ and n=1, R1 is not simultaneously OR′; or NR′R″. The compounds according to the invention are suitable especially as sun protection agents in cosmetic, pharmaceutical and veterinary medicine preparations.
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