公开(公告)号：US4888025A

公开(公告)日：1989-12-19

申请号：US742240

申请日：1985-06-07

Applicant: Andree Bugaut ,  Alain Genet

Inventor： Andree Bugaut ,  Alain Genet

IPC: A61K8/41 ,  A61Q5/10 ,  C07C233/00 ,  C07D207/40 ,  C07D207/404 ,  C07D303/22 ,  C07D303/36

CPC classification number: A61K8/418 ,  A61Q5/10 ,  C07D207/404 ,  C07D303/22

Abstract: The present invention relates to new 1-(substituted phenoxy)-3-aminopropan-2-ol compounds in which the extra-nuclear amine group may or may not be substituted, and to the process for their preparation. The invention also relates to hair-dyeing compositions containing these new compounds and to a dyeing process using the said compositions.

Abstract translation: 本发明涉及新的1-（取代的苯氧基）-3-氨基丙-2-醇化合物，其中核 - 外胺基团可以被取代，也可以是它们的制备方法。 本发明还涉及含有这些新化合物的染发组合物和使用所述组合物的染色方法。

公开(公告)号：US4736067A

公开(公告)日：1988-04-05

申请号：US647755

申请日：1984-09-06

Applicant: Andree Bugaut ,  Alain Genet ,  Jean Cotteret ,  Alex Junino

Inventor： Andree Bugaut ,  Alain Genet ,  Jean Cotteret ,  Alex Junino

IPC: A61K8/00 ,  A61K20060101 ,  A61K8/34 ,  A61K8/35 ,  A61K8/40 ,  A61K8/41 ,  A61Q5/06 ,  A61Q5/10 ,  C07C20060101 ,  C07C67/00 ,  C07C209/00 ,  C07C209/08 ,  C07C209/18 ,  C07C209/36 ,  C07C209/60 ,  C07C209/62 ,  C07C211/52 ,  C07C215/16 ,  C09B51/00 ,  C09B53/00 ,  C09B67/42 ,  D06P1/32 ,  D06P1/42 ,  D06P3/08 ,  C07C87/58 ,  A61K7/13 ,  C07C87/28

CPC classification number: A61K8/418 ,  A61Q5/065 ,  A61Q5/10

Abstract: New dimethyl derivatives of 3-nitro-4-aminoaniline, process for their preparation, and their use for dyeing keratinic fibres.The invention relates to dimethyl derivatives of 3-nitro-4-aminoaniline of formula: ##STR1## in which CH.sub.3 is in position 2 or 5 of the benzene ring and R.sub.1 and R.sub.2 denote independently of each other a hydrogen atom, a lower alkyl group, a lower mono- or polyhydroxyalkyl or a lower aminoalkyl group in which the amino group is optionally mono- or disubstituted by a lower alkyl radical or by a lower mono- or polyhydroxyalkyl radical, it being understood that the two symbols R.sub.1 and R.sub.2 can be simultaneously other than hydrogen only when the mobile CH.sub.3 radical is in position 5, or cosmetically acceptable salts of these compounds, as well as the process for preparing them and their use in dye compositions, in particular for hair, equally for direct coloring and for coloring by an oxidation route.

Abstract translation: 3-硝基-4-氨基苯胺的新二甲基衍生物，其制备方法及其用于染色角蛋白纤维的用途。 本发明涉及下列结构式的3-硝基-4-氨基苯胺的二甲基衍生物：其中CH 3位于苯环的2或5位，R 1和R 2彼此独立地表示氢原子，低级烷基 ，低级单羟基烷基或多羟基烷基或低级氨基烷基，其中氨基任选被低级烷基或低级单羟基或多羟基烷基单取代或二取代，应理解，两个符号R1和R2可以是 同时除了氢，只有当可移动的CH3基团在5位时，或这些化合物的美容上可接受的盐，以及它们的制备方法以及它们在染料组合物中的用途，特别是用于毛发，同样用于直接着色和着色 通过氧化路线。

公开(公告)号：US4601726A

公开(公告)日：1986-07-22

申请号：US673789

申请日：1984-11-21

Applicant: Jean-Francois Grollier ,  Jean Cotteret ,  Andree Bugaut ,  Alain Genet

Inventor： Jean-Francois Grollier ,  Jean Cotteret ,  Andree Bugaut ,  Alain Genet

IPC: C09B67/20 ,  A61K8/00 ,  A61K8/35 ,  A61K8/40 ,  A61K8/41 ,  A61Q5/06 ,  A61Q5/10 ,  C09B51/00 ,  C09B67/22 ,  D06P1/19 ,  D06P3/04 ,  D06P3/14 ,  A61K7/13

CPC classification number: A61K8/418 ,  A61Q5/065 ,  C09B51/00 ,  C09B67/0033

Abstract: The invention provides a composition and process for directly dyeing keratinic fibres. The combination of 1-N-methylamino-2-nitro-4-N'-methyl-N'-(2' ,3'-dihydroxypropyl)amino benzene with certain 2-nitroparaphenylenediamine direct nitro dyes produces a dye composition in which the dyes can be more concentrated (without crystallizing out) and hence produce darker shades.

Abstract translation: 本发明提供了直接染色角蛋白纤维的组合物和方法。 1-N-甲基氨基-2-硝基-4-N'-甲基-N' - （2'，3'-二羟基丙基）氨基苯与某些2-硝基对苯二胺直接硝基染料的组合产生染料组合物，其中染料 可以更集中（不结晶），从而产生较暗的色调。

公开(公告)号：US5186717A

公开(公告)日：1993-02-16

申请号：US764958

申请日：1991-09-25

Applicant: Andree Bugaut ,  Alex Junino ,  Jean J. Vandenboosche

Inventor： Andree Bugaut ,  Alex Junino ,  Jean J. Vandenboosche

IPC: A61K8/41 ,  A61K9/12 ,  A61Q5/06 ,  A61Q5/10

CPC classification number: A61K8/418 ,  A61Q5/065 ,  A61Q5/10

Abstract: The invention provides dyeing compositions for keratin fibres, which contain at least one dyestuff corresponding to the formula: ##STR1## in which R.sub.1 and R.sub.2 independently of one another denote a hydrogen atom, an alkyl group, a monohydroxyalkyl or polyhydroxyalkyl group, an alkyl group substituted by an alkoxy group, or an aminoalkyl group of which the amino group can optionally be monosubstituted or disubstituted by an alkyl group, and the radical R.sub.2 can also denote a phenyl group or a phenyl group substituted by an alkyl, hydroxyl or amino group, and Z denotes a hydrogen atom or an alkyl group, or their cosmetically acceptable salts. Many of the dyestuffs are novel.

Abstract translation: 本发明提供了用于角蛋白纤维的染色组合物，其含有至少一种对应于下式的染料：其中R 1和R 2彼此独立地表示氢原子，烷基，单羟基烷基或多羟基烷基，烷基 被烷氧基取代，或氨基可以任选被烷基单取代或二取代的氨基烷基，基团R2也可以表示被烷基，羟基或氨基取代的苯基或苯基， Z表示氢原子或烷基，或其化学上可接受的盐。 许多染料是新颖的。

公开(公告)号：US4973757A

公开(公告)日：1990-11-27

申请号：US819636

申请日：1986-01-17

Applicant: Andree Bugaut ,  Alex Junino

Inventor： Andree Bugaut ,  Alex Junino

IPC: A61K8/00 ,  A61K8/40 ,  A61K8/41 ,  A61Q5/06 ,  A61Q5/10 ,  C07C20060101 ,  C07C209/00 ,  C07C211/00 ,  C07C211/49 ,  C07C213/00 ,  C07C213/02 ,  C07C215/76 ,  C07C217/20 ,  C07C217/76 ,  C09B51/00 ,  D06P1/19 ,  D06P3/04

CPC classification number: A61K8/418 ,  A61Q5/065 ,  A61Q5/10

Abstract: The invention relates to a process for the preparation of nitroanilines, which consists in reacting an amine RNH.sub.2, or ammonia, with 3,4-methylenedioxynitriobenzene to give the products of the formula: ##STR1## in which R denotes hydrogen, alkyl, monohydroxyalkyl or polyhydroxyalkyl, alkoxyalkyl or aminoalkyl of the formula: ##STR2## in which R.sub.1 and R.sub.2, which are identical or different, denote hydrogen, alkyl or monohydroxyalkyl or polyhydroxyalkyl and n denotes an integer from 2 to 4, or of the formula: ##STR3## in which A denotes OCH.sub.2 or ##STR4## and R.sub.1 denotes --CH.sub.2 CH.sub.2 OH or ##STR5## or their salts. The invention also relates to the dyeing compositions for keratin fibres, and in particular for hair, which contain a dyestuff of the above formula (I) in which R denotes alkyl, polyhydroxyalkyl, alkoxyalkyl or aminoalkyl of the abovementioned formula, and to the dyestuffs of the formula (I) in which R denotes alkoxyalkyl or aminoalkyl of the above formula, and of the formula (IIB), which are novel.

Abstract translation: 本发明涉及一种制备硝基苯胺的方法，该方法包括使胺RNH2或氨与3,4-亚甲二氧基三苯胺反应，得到下式的产物：其中R表示氢，烷基 ，单羟基烷基或多羟基烷基，烷氧基烷基或氨基烷基，其中R 1和R 2相同或不同，表示氢，烷基或单羟基烷基或多羟基烷基，n表示2至4的整数，或下式： （IIB）其中A表示OCH2或，R1表示-CH2CH2OH或者它们的盐。 本发明还涉及用于角蛋白纤维，特别是毛发的染色组合物，其含有上述式（I）的染料，其中R表示上述式的烷基，多羟基烷基，烷氧基烷基或氨基烷基，以及染料 其中R表示上式的烷氧基烷基或氨基烷基和式（IIB）的式（I），其为新颖的。

公开(公告)号：US4954131A

公开(公告)日：1990-09-04

申请号：US385496

申请日：1989-07-26

Applicant: Andree Bugaut ,  Alex Junino

Inventor： Andree Bugaut ,  Alex Junino

IPC: A61K8/00 ,  A61K8/22 ,  A61K8/33 ,  A61K8/35 ,  A61K8/40 ,  A61K8/41 ,  A61K8/49 ,  A61Q5/10 ,  C07C217/28 ,  C07C217/82 ,  C07C233/16 ,  C07C275/34 ,  C09B53/00

CPC classification number: A61Q5/10 ,  A61K8/415 ,  C07C275/34

Abstract: A new substituted metaaminophenol of formula (I): ##STR1## wherein Z represents a monohydroxylated or polyhydroxylated hydrocarbon radical of 1 to 6 carbon atoms or an aminoalkyl radical of the formula: ##STR2## wherein n is an integer from 1 to 6 and R.sub.1 and R.sub.2, which are identical or different, represent a hydrogen atom or an alkyl or hydroxyalkyl radical of 1 to 6 carbon atoms or an acyl radical of 1 to 4 carbon atoms, and R represents a hydrogen atom, an alkyl radical or monohydroxyalkyl or polyhydroxyalkyl, monocarbamylalkyl, dicarbamylalkyl, aminoalkyl, acyl, carbalkoxy, carbamyl or monoalkylcarbamyl radical, the abovementioned alkyl radicals containing 1 to 6 carbon atoms, or an acid salt thereof with the proviso that if R represents a hydrogen atom, Z cannot represent --CH.sub.2 CH.sub.2 OH is disclosed, together with a process for their preparation, hair-dyeing compositions containing them and a hair-dyeing process.

公开(公告)号：US4333730A

公开(公告)日：1982-06-08

申请号：US142572

申请日：1980-04-18

Applicant: Andree Bugaut ,  Majdi M. Shahin ,  Jean-Jacques H. Vandenbossche ,  Gregoire Kalopissis

Inventor： Andree Bugaut ,  Majdi M. Shahin ,  Jean-Jacques H. Vandenbossche ,  Gregoire Kalopissis

IPC: A61K8/00 ,  A61K8/22 ,  A61K8/23 ,  A61K8/25 ,  A61K8/33 ,  A61K8/34 ,  A61K8/35 ,  A61K8/36 ,  A61K8/365 ,  A61K8/37 ,  A61K8/39 ,  A61K8/40 ,  A61K8/41 ,  A61K8/42 ,  A61K8/46 ,  A61K8/49 ,  A61K8/73 ,  A61Q5/10 ,  C07C67/00 ,  C07C213/00 ,  C07C217/84 ,  C07C233/12 ,  C07D209/48 ,  C09B53/00 ,  A61K7/13

CPC classification number: C07D209/48 ,  A61K8/411 ,  A61Q5/10

Abstract: Novel meta-phenylenediamines are provided for use as couplers with dye bases in hair dye compositions. These meta-phenylenediamines have the formula: ##STR1## in which n is 2, 3 or 4. Their acid addition salts may also be used.

Abstract translation: 提供新的间苯二胺可用作染发剂组合物中染料基的成色剂。 这些间苯二胺具有以下分子式：其中n为2,3或4的。它们的酸加成盐也可以使用。

公开(公告)号：US4277244A

公开(公告)日：1981-07-07

申请号：US9943

申请日：1979-02-06

Applicant: Andree Bugaut ,  Patrick Andrillon

Inventor： Andree Bugaut ,  Patrick Andrillon

IPC: C09B53/00 ,  A61K20060101 ,  A61K8/00 ,  A61K8/33 ,  A61K8/40 ,  A61K8/41 ,  A61K8/42 ,  A61K8/49 ,  A61Q5/10 ,  C07C20060101 ,  C07C67/00 ,  C07C213/00 ,  C09B57/00 ,  C09B59/00 ,  D06P1/32 ,  D06P3/08 ,  D06P3/14 ,  C07C91/06 ,  A61K7/12

CPC classification number: A61Q5/10 ,  A61K8/411

Abstract: A dyeing composition for keratinic fibers, especially human hair, comprising an aqueous solution containing a dyeing amount of at least one dye compound having the formula: ##STR1## in which R.sub.1 is --(CH.sub.2).sub.n --OR, R is methyl or ethyl, n is 2 or 3, or one of the corresponding acid salts.

Abstract translation: 用于角质纤维，特别是人发的染色组合物，其包含含有染色量的至少一种下式的染料化合物的水溶液：其中R 1为 - （CH 2）n -OR，R为甲基或乙基， n为2或3，或相应的酸盐之一。

公开(公告)号：US4259261A

公开(公告)日：1981-03-31

申请号：US22615

申请日：1979-03-21

Applicant: Andree Bugaut ,  Jean-Jacques Vandenbossche

Inventor： Andree Bugaut ,  Jean-Jacques Vandenbossche

IPC: A61K8/00 ,  A61K20060101 ,  A61K8/22 ,  A61K8/23 ,  A61K8/25 ,  A61K8/33 ,  A61K8/34 ,  A61K8/35 ,  A61K8/39 ,  A61K8/40 ,  A61K8/41 ,  A61K8/42 ,  A61K8/46 ,  A61K8/49 ,  A61K8/73 ,  A61Q5/10 ,  C07C20060101 ,  C07C67/00 ,  C07C213/00 ,  C07C217/84 ,  C07C231/00 ,  C07C233/00 ,  C07C233/18 ,  C07C233/25 ,  C07C233/43 ,  C07C239/00 ,  C07C271/16 ,  C07C271/28 ,  C07C275/14 ,  C07C275/24 ,  C07C307/02 ,  C07C311/02 ,  C09B53/00 ,  C09B53/02 ,  C09B57/00 ,  C09B59/00 ,  D06P1/32 ,  D06P3/04 ,  D06P3/06 ,  F16L7/00 ,  F16L57/00 ,  C07C91/40 ,  C07C91/42 ,  C07C93/14

CPC classification number: A61Q5/10 ,  A61K8/411 ,  A61K8/42 ,  A61K8/466

Abstract: Couplers having the general formula (I): ##STR1## or the acid salts thereof in which formula R is either(a) hydrogen or(b) a C.sub.1 -C.sub.3 alkyl or(c) a C.sub.1 -C.sub.3 hydroxyalkyl, andZ is either(a) hydroxyalkyl, or(b) alkoxyalkyl in which the alkoxy group contains 1 to 2 carbon atoms, or(c) mesylaminoalkyl, or(d) acetylaminoalkyl, or(e) ureidoalkyl, or(f) carbethoxyaminoalkylthe alkyl groups in the radicals constituting Z comprising from 2 to 3 carbon atoms andZ is not hydroxyethyl when R is hydrogen.These couplers form dyeing compositions when mixed with an oxidation base consisting of a paraphenylenediamine having the general formula: ##STR2##

Abstract translation: 具有通式（I）的成色剂：其中式R为（a）氢或（b）C1-C3烷基或（c）C1-C3羟烷基，Z为或 （a）羟烷基或（b）烷氧基含有1至2个碳原子的烷氧基烷基，或（c）甲磺酰氨基烷基或（d）乙酰氨基烷基或（e）脲基烷基，或（f） 构成Z为2〜3个碳原子的基团，当R为氢时，Z不为羟乙基。 当与由具有以下通式的对苯二胺组成的氧化基团混合时，这些成色剂形成染色组合物：

公开(公告)号：US4185958A

公开(公告)日：1980-01-29

申请号：US935014

申请日：1978-08-18

Applicant: Andree Bugaut ,  Jean-Francois Grollier ,  Jean-Jacques Vandenboosche

Inventor： Andree Bugaut ,  Jean-Francois Grollier ,  Jean-Jacques Vandenboosche

IPC: A61K8/00 ,  A61K8/33 ,  A61K8/41 ,  A61Q5/10 ,  C07C45/46 ,  C07C59/52 ,  C07C59/68 ,  C07C65/05 ,  C07D295/194 ,  C07D307/83 ,  D06P3/14 ,  A61K7/13

CPC classification number: C07D295/194 ,  A61K8/365 ,  A61Q5/065 ,  C07C45/46 ,  C07C59/52 ,  C07C59/68 ,  C07C65/05 ,  C07D307/83

Abstract: A composition suitable for dyeing keratin fibres, especially human hair, is provided comprising a direct dyestuff and, as a levelling agent, a 2,5-dihydroxyphenylcarboxylic acid or a salt thereof.

Abstract translation: 提供适合于染色角蛋白纤维，特别是人发的组合物，其包含直接染料和作为流平剂的2,5-二羟基苯基羧酸或其盐。