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公开(公告)号：US08945626B2
公开(公告)日：2015-02-03
申请号：US12309344
申请日：2007-07-13
申请人： Andrew James Elphick , John Staniforth , Dong Wang , David John Duncalf , Steven Paul Rannard , James Long , Alison Jayne Foster
发明人： Andrew James Elphick , John Staniforth , Dong Wang , David John Duncalf , Steven Paul Rannard , James Long , Alison Jayne Foster
CPC分类号： A61K9/1617 , A01N25/04 , A61K9/10 , A61K9/1635 , A61K9/1641 , A61K9/1652 , A61K9/19 , A61K31/167 , Y02A50/411 , A01N43/54 , A01N53/00 , A01N31/16 , A01N37/18
摘要： A process for the production of a composition comprising a water-insoluble paracetamol or NSAID which comprises the steps of: a) providing a mixture comprising: i) a water-insoluble paracetamol or NSAID, ii) a water soluble carrier, and iii) a solvent for each of the paracetamol or NSAID and the carrier, and b) spray-drying the mixture to remove the or each solvent and obtain a substantially solvent-free nano-dispersion of the paracetamol or NSAID in the carrier.
摘要翻译： 一种制备包含水不溶性对乙酰氨基酚或NSAID的组合物的方法，其包括以下步骤：a）提供混合物，其包括：i）水不溶性对乙酰氨基酚或NSAID，ii）水溶性载体，和iii） 溶剂，并且b）喷雾干燥该混合物以除去该溶剂或每种溶剂，并获得载体中对乙酰氨基酚或NSAID的基本上无溶剂的纳米分散体。
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公开(公告)号：US20090325995A1
公开(公告)日：2009-12-31
申请号：US12309341
申请日：2007-07-13
申请人： David John Duncalf , Steven Paul Rannard , James Long , Dong Wang , Andrew James Elphick , John Staniforth , Daniele Chauvin , Alison Jayne Foster
发明人： David John Duncalf , Steven Paul Rannard , James Long , Dong Wang , Andrew James Elphick , John Staniforth , Daniele Chauvin , Alison Jayne Foster
IPC分类号： A61K31/439 , A61P29/00 , A61P1/00
CPC分类号： A61K9/1617 , A01N25/04 , A61K9/10 , A61K9/1635 , A61K9/1641 , A61K9/1652 , A61K9/19 , A61K31/167 , Y02A50/411 , A01N43/54 , A01N53/00 , A01N31/16 , A01N37/18
摘要： A process for the production of a composition comprising a water-insoluble opioid which comprises the steps of: a) providing a mixture comprising: i) a water-insoluble opioid, ii) a water soluble carrier, and iii) a solvent for each of the opioid and the carrier, and b) spray-drying the mixture to remove the or each solvent and obtain a substantially solvent-free nano-dispersion of the opioid in the carrier
摘要翻译： 一种制备包含水不溶性阿片样物质的组合物的方法，其包括以下步骤：a）提供混合物，其包括：i）水不溶性阿片样物质，ii）水溶性载体，和iii） 阿片样物质和载体，以及b）喷雾干燥混合物以除去或溶剂，并获得载体中阿片样物质的基本上无溶剂的纳米分散体
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公开(公告)号：US07691873B2
公开(公告)日：2010-04-06
申请号：US12309341
申请日：2007-07-13
申请人： David John Duncalf , Steven Paul Rannard , James Long , Dong Wang , Andrew James Elphick , John Staniforth , Daniele Chauvin , Alison Jayne Foster
发明人： David John Duncalf , Steven Paul Rannard , James Long , Dong Wang , Andrew James Elphick , John Staniforth , Daniele Chauvin , Alison Jayne Foster
IPC分类号： A61K31/44 , A61K31/445
CPC分类号： A61K9/1617 , A01N25/04 , A61K9/10 , A61K9/1635 , A61K9/1641 , A61K9/1652 , A61K9/19 , A61K31/167 , Y02A50/411 , A01N43/54 , A01N53/00 , A01N31/16 , A01N37/18
摘要： A process for the production of a composition comprising a water-insoluble opioid which comprises the steps of: a) providing a mixture comprising: i) a water-insoluble opioid, ii) a water soluble carrier, and iii) a solvent for each of the opioid and the carrier, and b) spray-drying the mixture to remove the or each solvent and obtain a substantially solvent-free nano-dispersion of the opioid in the carrier.
摘要翻译： 一种制备包含水不溶性阿片样物质的组合物的方法，其包括以下步骤：a）提供混合物，其包括：i）水不溶性阿片样物质，ii）水溶性载体，和iii） 阿片样物质和载体，以及b）喷雾干燥混合物以除去或溶解各种溶剂，并获得载体中阿片样物质的基本上无溶剂的纳米分散体。
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公开(公告)号：US09060937B2
公开(公告)日：2015-06-23
申请号：US12309292
申请日：2007-06-29
申请人： David John Duncalf , Andrew James Elphick , Alison Jayne Foster , James Long , Steven Paul Rannard , Dong Wang
发明人： David John Duncalf , Andrew James Elphick , Alison Jayne Foster , James Long , Steven Paul Rannard , Dong Wang
CPC分类号： A61K9/1617 , A01N25/04 , A61K9/10 , A61K9/1635 , A61K9/1641 , A61K9/1652 , A61K9/19 , A61K31/167 , Y02A50/411 , A01N43/54 , A01N53/00 , A01N31/16 , A01N37/18
摘要： A process for the production of a composition comprising a water-insoluble sartan which comprises the steps of: a) providing a mixture comprising: i) a water-insoluble sartan, ii) a water soluble carrier, iii) a solvent for each of the sartan and the carrier, and b) spray-drying the mixture to remove the or each solvent and obtain a substantially solvent-free nano-dispersion of the sartan in the carrier.
摘要翻译： 一种制备包含水不溶性沙丁胺的组合物的方法，其包括以下步骤：a）提供混合物，其包括：i）不溶于水的沙坦，ii）水溶性载体，iii） 沙坦和载体，以及b）喷雾干燥该混合物以除去或各种溶剂，并获得载体中沙丁烷的基本上无溶剂的纳米分散体。
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公开(公告)号：US20090304806A1
公开(公告)日：2009-12-10
申请号：US12309292
申请日：2007-06-29
申请人： David John Duncalf , Andrew James Elphick , Alison Jayne Foster , James Long , Steven Paul Rannard , Dong Wang
发明人： David John Duncalf , Andrew James Elphick , Alison Jayne Foster , James Long , Steven Paul Rannard , Dong Wang
CPC分类号： A61K9/1617 , A01N25/04 , A61K9/10 , A61K9/1635 , A61K9/1641 , A61K9/1652 , A61K9/19 , A61K31/167 , Y02A50/411 , A01N43/54 , A01N53/00 , A01N31/16 , A01N37/18
摘要： A process for the production of a composition comprising a water-insoluble sartan which comprises the steps of: a) providing a mixture comprising: i) a water-insoluble sartan, ii) a water soluble carrier, iii) a solvent for each of the sartan and the carrier, and b) spray-drying the mixture to remove the or each solvent and obtain a substantially solvent-free nano-dispersion of the sartan in the carrier.
摘要翻译： 一种制备包含水不溶性沙丁胺的组合物的方法，其包括以下步骤：a）提供混合物，其包含：i）不溶于水的沙坦，ii）水溶性载体，iii） 沙坦和载体，以及b）喷雾干燥该混合物以除去或各种溶剂，并获得载体中沙丁烷的基本上无溶剂的纳米分散体。
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公开(公告)号：US20120135058A1
公开(公告)日：2012-05-31
申请号：US13365830
申请日：2012-02-03
申请人： Doris Angus , David John Duncalf , Andrew James Elphick , Alison Jayne Foster , James Long , Steven Paul Rannard , Dong Wang
发明人： Doris Angus , David John Duncalf , Andrew James Elphick , Alison Jayne Foster , James Long , Steven Paul Rannard , Dong Wang
IPC分类号： C08L39/06 , A61K8/81 , A01P3/00 , C09B67/38 , A01N25/10 , A61Q5/00 , B82Y40/00 , B82Y30/00 , B82Y5/00
CPC分类号： A61K9/1617 , A01N25/04 , A61K9/10 , A61K9/1635 , A61K9/1641 , A61K9/1652 , A61K9/19 , A61K31/167 , Y02A50/411 , A01N43/54 , A01N53/00 , A01N31/16 , A01N37/18
摘要： The invention provides process for making contra-soluble nano-dispersions of at most sparingly-soluble materials in a soluble carrier material comprising the steps of: (i) providing a single phase mixture of: (a) a solvent or a mixture of miscible solvents wherein at least one of the solvents is an aqueous solvent and at least another solvent is a non-aqueous solvent, (b) at least one carrier material soluble in solvent (a), said carrier material being also contra-soluble to payload material (c) and solid at ambient temperature, (c) at least one a payload material which is soluble in solvent (a), and, (ii) freeze-drying the mixture to remove solvent (a) and thereby obtain the carrier material (b) in solid form with payload (c) dispersed therein as nanoparticles.
摘要翻译： 本发明提供了在可溶性载体材料中制备至多微溶性材料的可溶性纳米分散体的方法，其包括以下步骤：（i）提供单相混合物：（a）溶剂或可混溶溶剂的混合物 其中所述溶剂中的至少一种是水性溶剂，并且至少另一种溶剂是非水溶剂，（b）至少一种可溶于溶剂（a）的载体材料，所述载体材料也与所述载体材料 c）和环境温度下的固体，（c）至少一种可溶于溶剂（a）的有效载荷材料，和（ii）冷冻干燥该混合物以除去溶剂（a），从而获得载体材料 ），其中有效载荷（c）作为纳米颗粒分散在其中。
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公开(公告)号：US20120134940A1
公开(公告)日：2012-05-31
申请号：US13365826
申请日：2012-02-03
申请人： Doris Angus , David John Duncalf , Andrew James Elphick , Alison Jayne Foster , James Long , Steven Paul Rannard , Dong Wang
发明人： Doris Angus , David John Duncalf , Andrew James Elphick , Alison Jayne Foster , James Long , Steven Paul Rannard , Dong Wang
IPC分类号： C08L29/04 , C08L39/04 , A61K47/32 , A01N25/04 , A61K8/81 , A61Q5/12 , C11D3/37 , A61Q17/04 , D06P5/00 , C11D3/395 , A61Q13/00 , A23L1/22 , A61Q19/00 , A01P7/04 , A01P1/00 , A61P31/00 , C08L39/06 , B82Y5/00 , B82Y99/00
CPC分类号： A61K9/1617 , A01N25/04 , A61K9/10 , A61K9/1635 , A61K9/1641 , A61K9/1652 , A61K9/19 , A61K31/167 , Y02A50/411 , A01N43/54 , A01N53/00 , A01N31/16 , A01N37/18
摘要： The invention provides process for making water-soluble nano-dispersions of water-insoluble materials in a water-soluble carrier material comprising the steps of: (i) providing a single phase mixture of: (a) a non-aqueous solvent or a mixture of miscible non-aqueous solvents, (b) at least one carrier material soluble in non-aqueous solvent (a), said carrier material being also soluble in water and solid at ambient temperature, (c) at least one water-insoluble payload material which is soluble in non-solvent (a), and, (ii) drying the mixture to remove solvent (a) and thereby obtain the carrier material (b) in solid form with payload (c) dispersed therein as nanoparticles, wherein the product of the drying step is water dispersible to give an aqueous solution of (b) and an aqueous nano-dispersion of (c).
摘要翻译： 本发明提供在水溶性载体材料中制备水不溶性材料的水溶性纳米分散体的方法，其包括以下步骤：（i）提供单相混合物：（a）非水溶剂或混合物 的混溶性非水溶剂，（b）至少一种可溶于非水溶剂（a）的载体材料，所述载体材料在环境温度下也可溶于水和固体，（c）至少一种不溶于水的有效载荷材料 其可溶于非溶剂（a），和（ii）干燥混合物以除去溶剂（a），从而获得固体形式的载体材料（b），其中有效载荷（c）分散在其中作为纳米颗粒，其中产物 的干燥步骤是水分散，得到（b）的水溶液和（c）的水性纳米分散体。
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公开(公告)号：US20090175953A1
公开(公告)日：2009-07-09
申请号：US12309306
申请日：2007-06-29
申请人： Doris Angus , David John Duncalf , Andrew James Elphick , Alison Jayne Foster , James Long , Steven Paul Rannard , Dong Wang
发明人： Doris Angus , David John Duncalf , Andrew James Elphick , Alison Jayne Foster , James Long , Steven Paul Rannard , Dong Wang
IPC分类号： A61K9/16 , C09K3/00 , B01J13/00 , C09B67/08 , A01N43/653 , A01N37/50 , A01N31/16 , A01N53/00 , A01P1/00 , A01P3/00
CPC分类号： A61K9/1617 , A01N25/04 , A61K9/10 , A61K9/1635 , A61K9/1641 , A61K9/1652 , A61K9/19 , A61K31/167 , Y02A50/411 , A01N43/54 , A01N53/00 , A01N31/16 , A01N37/18
摘要： The invention provides process for making contra-soluble nano-dispersions of at most sparingly-soluble materials in a soluble carrier material comprising the steps of: (i) providing a single phase mixture of: a) a solvent or a mixture of miscible solvents, b) at least one carrier material soluble in solvent (a), said carrier material being also contra-soluble to payload material (c) and solid at ambient temperature, c) at least one a payload material which is soluble in solvent (a), and, (ii) drying the mixture to remove solvent (a) and thereby obtain the carrier material (b) in solid form with payload (c) dispersed therein as nanoparticles.
摘要翻译： 本发明提供了在可溶性载体材料中制备至多微溶性材料的可溶性纳米分散体的方法，其包括以下步骤：（i）提供单相混合物：a）溶剂或可混溶溶剂的混合物， b）可溶于溶剂（a）的至少一种载体材料，所述载体材料在环境温度下也可溶于有效载荷材料（c）和固体，c）至少一种可溶于溶剂（a）的有效载荷材料， ，和（ii）干燥混合物以除去溶剂（a），从而获得固体形式的载体材料（b），其中有效载荷（c）作为纳米颗粒分散在其中。
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公开(公告)号：US20100008995A1
公开(公告)日：2010-01-14
申请号：US12309343
申请日：2007-07-13
申请人： David John Duncalf , Paul Rannard , James Long , Dong Wang , Andrew James Elphick , John Staniforth , Alison Jayne Foster
发明人： David John Duncalf , Paul Rannard , James Long , Dong Wang , Andrew James Elphick , John Staniforth , Alison Jayne Foster
IPC分类号： A61K31/454 , A61K31/404 , A61K31/4196 , A61K31/421 , A61K31/403 , A61P25/06 , A61K9/14
CPC分类号： A61K9/1617 , A01N25/04 , A61K9/10 , A61K9/1635 , A61K9/1641 , A61K9/1652 , A61K9/19 , A61K31/167 , Y02A50/411 , A01N43/54 , A01N53/00 , A01N31/16 , A01N37/18
摘要： A process for the production of a composition comprising a water-insoluble triptan which comprises the steps of: a) providing a mixture comprising: i) a water-insoluble triptan, ii) a water soluble carrier, and iii) a solvent for each of the triptan and the carrier, and b) spray-drying the mixture to remove the or each solvent and obtain a substantially solvent-free nano-dispersion of the triptan in the carrier.
摘要翻译： 一种制备包含水不溶性曲坦的组合物的方法，其包括以下步骤：a）提供混合物，其包括：i）不溶于水的曲坦，ii）水溶性载体，和iii） 曲坦和载体，以及b）喷雾干燥混合物以除去或溶解各种溶剂，并获得载体中曲坦的基本上无溶剂的纳米分散体。
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公开(公告)号：US08821932B2
公开(公告)日：2014-09-02
申请号：US12309294
申请日：2007-06-29
IPC分类号： A61K9/10 , A61K31/351 , A61K8/04 , A61K9/16
CPC分类号： A61K9/1617 , A01N25/04 , A61K9/10 , A61K9/1635 , A61K9/1641 , A61K9/1652 , A61K9/19 , A61K31/167 , Y02A50/411 , A01N43/54 , A01N53/00 , A01N31/16 , A01N37/18
摘要： A process for the production of a composition comprising a water-insoluble statin which comprises the steps of: a) providing a mixture comprising: i) a water-insoluble statin ii) a water soluble carrier, iii) a solvent for each of the statin and the carrier, and b) spray-drying the mixture to remove the or each solvent and obtain a substantially solvent-free nano-dispersion of the statin in the carrier.
摘要翻译： 一种制备包含水不溶性他汀类的组合物的方法，其包括以下步骤：a）提供混合物，其包括：i）不溶于水的他汀类，ii）水溶性载体，iii）每种他汀类的溶剂 和载体，以及b）喷雾干燥混合物以除去或溶解各种溶剂，并获得载体中他汀类药物基本上无溶剂的纳米分散体。
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