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1.发明申请METHODS AND REAGENTS FOR VACCINATION WHICH GENERATE A CD8 T CELL IMMUNE RESPONSE 审中-公开产生CD8细胞免疫应答的疫苗的方法和试剂公开(公告)号：US20110159034A1
公开(公告)日：2011-06-30
申请号：US12940627
申请日：2010-11-05
申请人： Andrew McMICHAEL , Adrian V.S. Hill , Sarah C. Gilbert , Jörg Schneider , Magdalena Plebanski , Tomas Hanke , Geoffrey L. Smith , Tom Blanchard
发明人： Andrew McMICHAEL , Adrian V.S. Hill , Sarah C. Gilbert , Jörg Schneider , Magdalena Plebanski , Tomas Hanke , Geoffrey L. Smith , Tom Blanchard
IPC分类号： A61K39/295 , A61K39/235 , A61P37/04 , A61P31/20
CPC分类号： C12N15/86 , A61K38/1709 , A61K39/0011 , A61K39/015 , A61K39/12 , A61K39/145 , A61K39/21 , A61K39/39 , A61K2039/51 , A61K2039/5256 , A61K2039/5258 , A61K2039/53 , A61K2039/54 , A61K2039/545 , A61K2039/55522 , A61K2039/57 , C07K14/005 , C07K14/445 , C12N2710/10343 , C12N2710/24043 , C12N2710/24143 , C12N2740/15034 , C12N2740/16134 , C12N2740/16234 , C12N2760/16122 , C12N2760/16134 , Y02A50/386 , Y02A50/412
摘要： New methods and reagents for vaccination are described which generate a CD8 T cell immune response against malarial and other antigens such as viral and tumour antigens. Novel vaccination regimes are described which employ a priming composition and a boosting composition, the boosting composition comprising a non-replicating or replication-impaired pox virus vector carrying at least one CD8 T cell epitope which is also present in the priming composition.
摘要翻译： 描述了用于疫苗接种的新方法和试剂，其产生针对疟疾和其他抗原如病毒和肿瘤抗原的CD8T细胞免疫应答。 描述了采用引发组合物和增强组合物的新型接种方案，该促进组合物包含携带至少一种CD8T细胞表位的非复制或复制受损的痘病毒载体，其也存在于引发组合物中。
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2.发明申请Methods and reagents for vaccination which generate a CD8 T cell immune response 审中-公开产生CD8 T细胞免疫应答的疫苗接种方法和试剂公开(公告)号：US20100119551A1
公开(公告)日：2010-05-13
申请号：US12456699
申请日：2009-06-19
申请人： Andrew McMichael , Adrian V.S. Hill , Sarah C. Gilbert , Jorg Schneider , Magdalena Plebanski , Tomas Hanke , Geoffrey L. Smith , Tom Blanchard
发明人： Andrew McMichael , Adrian V.S. Hill , Sarah C. Gilbert , Jorg Schneider , Magdalena Plebanski , Tomas Hanke , Geoffrey L. Smith , Tom Blanchard
IPC分类号： A61K39/285 , A61P31/12
CPC分类号： C12N15/86 , A61K38/1709 , A61K39/0011 , A61K39/015 , A61K39/12 , A61K39/145 , A61K39/21 , A61K39/39 , A61K2039/51 , A61K2039/5256 , A61K2039/5258 , A61K2039/53 , A61K2039/54 , A61K2039/545 , A61K2039/55522 , A61K2039/57 , C07K14/005 , C07K14/445 , C12N2710/10343 , C12N2710/24043 , C12N2710/24143 , C12N2740/15034 , C12N2740/16134 , C12N2740/16234 , C12N2760/16122 , C12N2760/16134 , Y02A50/386 , Y02A50/412
摘要： New methods and reagents for vaccination are described which generate a CD8 T cell immune response against malarial and other antigens such as viral and tumour antigens. Novel vaccination regimes are described which employ a priming composition and a boosting composition, the boosting composition comprising a non-replicating or replication-impaired pox virus vector carrying at least one CD8 T cell epitope which is also present in the priming composition.
摘要翻译： 描述了用于疫苗接种的新方法和试剂，其产生针对疟疾和其他抗原如病毒和肿瘤抗原的CD8T细胞免疫应答。 描述了采用引发组合物和增强组合物的新型接种方案，该促进组合物包含携带至少一种CD8T细胞表位的非复制或复制受损的痘病毒载体，其也存在于引发组合物中。
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3.发明申请Methods and reagents for vaccination which generate a CD8 T cell immune response 审中-公开产生CD8 T细胞免疫应答的疫苗接种方法和试剂公开(公告)号：US20090324632A1
公开(公告)日：2009-12-31
申请号：US12454385
申请日：2009-05-15
申请人： Andrew McMichael , Adrian V.S. Hill , Sarah C. Gilbert , Jorg Schneider , Magdalena Plebanski , Tomas Hanke , Geoffrey L. Smith , Tom Blanchard
发明人： Andrew McMichael , Adrian V.S. Hill , Sarah C. Gilbert , Jorg Schneider , Magdalena Plebanski , Tomas Hanke , Geoffrey L. Smith , Tom Blanchard
IPC分类号： A61K39/21
CPC分类号： C12N15/86 , A61K38/1709 , A61K39/0011 , A61K39/015 , A61K39/12 , A61K39/145 , A61K39/21 , A61K39/39 , A61K2039/51 , A61K2039/5256 , A61K2039/5258 , A61K2039/53 , A61K2039/54 , A61K2039/545 , A61K2039/55522 , A61K2039/57 , C07K14/005 , C07K14/445 , C12N2710/10343 , C12N2710/24043 , C12N2710/24143 , C12N2740/15034 , C12N2740/16134 , C12N2740/16234 , C12N2760/16122 , C12N2760/16134 , Y02A50/386 , Y02A50/412
摘要： New methods and reagents for vaccination are described which generate a CD8 T cell immune response against malarial and other antigens such as viral and tumour antigens. Novel vaccination regimes are described which employ a priming composition and a boosting composition, the boosting composition comprising a non-replicating or replication-impaired pox virus vector carrying at least one CD8 T cell epitope which is also present in the priming composition.
摘要翻译： 描述了用于疫苗接种的新方法和试剂，其产生针对疟疾和其他抗原如病毒和肿瘤抗原的CD8T细胞免疫应答。 描述了采用引发组合物和增强组合物的新型接种方案，该促进组合物包含携带至少一种CD8T细胞表位的非复制或复制受损的痘病毒载体，其也存在于引发组合物中。
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4.发明申请Methods and reagents for vaccination which generate A CD8 T cell immune response 审中-公开产生A CD8 T细胞免疫应答的接种疫苗的方法和试剂公开(公告)号：US20090191237A1
公开(公告)日：2009-07-30
申请号：US12221498
申请日：2008-08-04
申请人： Andrew McMichael , Adrian V.S. Hill , Sarah C. Gilbert , Jorg Schneider , Magdalena Plebanski , Tomas Hanke , Geoffrey L. Smith , Tom Blanchard
发明人： Andrew McMichael , Adrian V.S. Hill , Sarah C. Gilbert , Jorg Schneider , Magdalena Plebanski , Tomas Hanke , Geoffrey L. Smith , Tom Blanchard
IPC分类号： A61K39/00
CPC分类号： C12N15/86 , A61K38/1709 , A61K39/0011 , A61K39/015 , A61K39/12 , A61K39/145 , A61K39/21 , A61K39/39 , A61K2039/51 , A61K2039/5256 , A61K2039/5258 , A61K2039/53 , A61K2039/54 , A61K2039/545 , A61K2039/55522 , A61K2039/57 , C07K14/005 , C07K14/445 , C12N2710/10343 , C12N2710/24043 , C12N2710/24143 , C12N2740/15034 , C12N2740/16134 , C12N2740/16234 , C12N2760/16122 , C12N2760/16134 , Y02A50/386 , Y02A50/412
摘要： New methods and reagents for vaccination are described which generate a CD8 T cell immune response against malarial and other antigens such as viral and tumour antigens. Novel vaccination regimes are described which employ a priming composition and a boosting composition, the boosting composition comprising a non-replicating or replication-impaired pox virus vector carrying at least one CD8 T cell epitope which is also present in the priming composition.
摘要翻译： 描述了用于疫苗接种的新方法和试剂，其产生针对疟疾和其他抗原如病毒和肿瘤抗原的CD8T细胞免疫应答。 描述了采用引发组合物和增强组合物的新型接种方案，该促进组合物包含携带至少一种CD8T细胞表位的非复制或复制受损的痘病毒载体，其也存在于引发组合物中。
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5.发明授权Methods and reagents for immunization which generate a CD8 T cell immune response 有权产生CD8 T细胞免疫应答的疫苗接种方法和试剂公开(公告)号：US07514087B2
公开(公告)日：2009-04-07
申请号：US10833439
申请日：2004-04-28
申请人： Andrew McMichael , Adrian V. S. Hill , Sarah C. Gilbert , Jörg Schneider , Magdalena Plebanski , Tomas Hanke , Geoffrey L. Smith , Tom Blanchard
发明人： Andrew McMichael , Adrian V. S. Hill , Sarah C. Gilbert , Jörg Schneider , Magdalena Plebanski , Tomas Hanke , Geoffrey L. Smith , Tom Blanchard
IPC分类号： A61K39/275 , A61K39/12 , A61K31/70 , C07H21/02 , A01N43/04
CPC分类号： C12N15/86 , A61K38/1709 , A61K39/0011 , A61K39/015 , A61K39/12 , A61K39/145 , A61K39/21 , A61K39/39 , A61K2039/51 , A61K2039/5256 , A61K2039/5258 , A61K2039/53 , A61K2039/54 , A61K2039/545 , A61K2039/55522 , A61K2039/57 , C07K14/005 , C07K14/445 , C12N2710/10343 , C12N2710/24043 , C12N2710/24143 , C12N2740/15034 , C12N2740/16134 , C12N2740/16234 , C12N2760/16122 , C12N2760/16134 , Y02A50/386 , Y02A50/412
摘要： New methods and reagents for vaccination are described which generate a CD8 T cell immune response against malarial and other antigens such as viral and tumor antigens. Novel vaccination regimes are described which employ a priming composition and a boosting composition, the boosting composition comprising a non-replicating or replication-impaired pox virus vector carrying at least one CD8 T cell epitope which is also present in the priming composition.
摘要翻译： 描述了用于疫苗接种的新方法和试剂，其产生针对疟疾和其他抗原如病毒和肿瘤抗原的CD8T细胞免疫应答。 描述了采用引发组合物和增强组合物的新型接种方案，该促进组合物包含携带至少一种CD8T细胞表位的非复制或复制受损的痘病毒载体，其也存在于引发组合物中。
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公开(公告)号：US07407661B2
公开(公告)日：2008-08-05
申请号：US10833744
申请日：2004-04-28
申请人： Andrew McMichael , Adrian V. S. Hill , Sarah C. Gilbert , Jörg Schneider , Magdalena Plebanski , Tomas Hanke , Geoffrey L. Smith , Tom Blanchard
发明人： Andrew McMichael , Adrian V. S. Hill , Sarah C. Gilbert , Jörg Schneider , Magdalena Plebanski , Tomas Hanke , Geoffrey L. Smith , Tom Blanchard
CPC分类号： C12N15/86 , A61K38/1709 , A61K39/0011 , A61K39/015 , A61K39/12 , A61K39/145 , A61K39/21 , A61K39/39 , A61K2039/51 , A61K2039/5256 , A61K2039/5258 , A61K2039/53 , A61K2039/54 , A61K2039/545 , A61K2039/55522 , A61K2039/57 , C07K14/005 , C07K14/445 , C12N2710/10343 , C12N2710/24043 , C12N2710/24143 , C12N2740/15034 , C12N2740/16134 , C12N2740/16234 , C12N2760/16122 , C12N2760/16134 , Y02A50/386 , Y02A50/412
摘要： New methods and reagents for vaccination are described which generate a CD8 T cell immune response against malarial and other antigens such as viral and tumour antigens. Novel vaccination regimes are described which employ a priming composition and a boosting composition, the boosting composition comprising a non-replicating or replication-impaired pox virus vector carrying at least one CD8 T cell epitope which is also present in the priming composition.
摘要翻译： 描述了用于疫苗接种的新方法和试剂，其产生针对疟疾和其他抗原如病毒和肿瘤抗原的CD8T细胞免疫应答。 描述了采用引发组合物和增强组合物的新型接种方案，该促进组合物包含携带至少一种CD8T细胞表位的非复制或复制受损的痘病毒载体，其也存在于引发组合物中。
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公开(公告)号：US06663871B1
公开(公告)日：2003-12-16
申请号：US09454204
申请日：1999-12-09
申请人： Andrew McMichael , Adrian V. S. Hill , Sarah C. Gilbert , Jörg Schneider , Magdalena Plebanski , Tomas Hanke , Geoffrey L. Smith , Tom Blanchard
发明人： Andrew McMichael , Adrian V. S. Hill , Sarah C. Gilbert , Jörg Schneider , Magdalena Plebanski , Tomas Hanke , Geoffrey L. Smith , Tom Blanchard
IPC分类号： A61K3900
CPC分类号： C12N15/86 , A61K38/1709 , A61K39/0011 , A61K39/015 , A61K39/12 , A61K39/145 , A61K39/21 , A61K39/39 , A61K2039/51 , A61K2039/5256 , A61K2039/5258 , A61K2039/53 , A61K2039/54 , A61K2039/545 , A61K2039/55522 , A61K2039/57 , C07K14/005 , C07K14/445 , C12N2710/10343 , C12N2710/24043 , C12N2710/24143 , C12N2740/15034 , C12N2740/16134 , C12N2740/16234 , C12N2760/16122 , C12N2760/16134 , Y02A50/386 , Y02A50/412
摘要： New methods and reagents for vaccination are described which generate a CD8 T cell immune response against malarial and other antigens such as viral and tumour antigens. Novel vaccination regimes are described which employ a priming composition and a boosting composition, the boosting composition comprising a non-replicating or replication-impaired pox virus vector carrying at least one CD8 T cell epitope which is also present in the priming composition.
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8.发明授权公开(公告)号：US08771700B2
公开(公告)日：2014-07-08
申请号：US12310432
申请日：2007-08-23
CPC分类号： C07K14/005 , A61K38/00 , A61K38/162 , C07K16/081 , C12N7/00 , C12N2710/24033 , C12N2710/24122
摘要： Described are compositions and methods useful for modulating the immune system of a subject. Also included are diagnostic methods for monitoring an immunologic condition. In particular the invention relates to antagonists of interferon proteins and associated methods of use as well as methods to develop neutralizing antibodies against IFN antagonists to treat viral infections.
摘要翻译： 描述了可用于调节受试者的免疫系统的组合物和方法。 还包括用于监测免疫条件的诊断方法。 特别地，本发明涉及干扰素蛋白质的拮抗剂和相关使用方法以及开发针对IFN拮抗剂的中和抗体以治疗病毒感染的方法。
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9.发明授权Compositions containing recombinant poxviruses having foreign DNA expressed under the control of poxvirus regulatory sequences 失效含有在痘病毒调控序列控制下表达外源DNA的重组痘病毒的组合物公开(公告)号：US07015024B1
公开(公告)日：2006-03-21
申请号：US08470357
申请日：1995-06-06
申请人： Bernard Moss , Michael Mackett , Geoffrey L. Smith
发明人： Bernard Moss , Michael Mackett , Geoffrey L. Smith
IPC分类号： C12N7/01 , C12N5/10 , A61K39/275 , A61K39/285
CPC分类号： C12N15/86 , A61K39/00 , A61K39/12 , A61K39/275 , A61K39/285 , A61K2039/5256 , C07K14/005 , C12N7/00 , C12N9/1033 , C12N2710/16622 , C12N2710/24122 , C12N2710/24134 , C12N2710/24143 , C12N2730/10122 , C12N2760/20234 , Y02A50/403 , Y02A50/464 , Y02A50/466
摘要： Recombinant poxviruses, such as vaccinia, are provided that comprises a segment comprised of (A) a first DNA sequence encoding a polypeptide that is foreign to poxvirus and (B) a poxvirus transcriptional regulatory sequence, wherein (i) said transcriptional regulatory sequence is adjacent to and exerts transcriptional control over said first DNA sequence and (ii) said segment is positioned within a nonessential genomic region of said recombinant poxvirus. Vaccines, carriers, cells, and media comprising recombinant poxviruses, and methods of immunization with recombinant poxviruses, also are provided.
摘要翻译： 提供重组痘病毒，例如牛痘，其包含由（A）编码痘病毒异源的多肽的第一DNA序列和（B）痘病毒转录调节序列组成的片段，其中（i）所述转录调控序列相邻 对所述第一DNA序列进行转录控制，并且（ii）所述片段位于所述重组痘病毒的非必需基因组区域内。 还提供了疫苗，载体，细胞和包含重组痘病毒的培养基，以及用重组痘病毒免疫的方法。
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10.发明授权Methods of immunization using recombinant poxviruses having foreign DNA expressed under the control of poxvirus regulatory sequences 失效使用在痘病毒调控序列控制下表达外源DNA的重组痘病毒免疫方法公开(公告)号：US07045136B1
公开(公告)日：2006-05-16
申请号：US08470359
申请日：1995-06-06
申请人： Bernard Moss , Michael Mackett , Geoffrey L. Smith
发明人： Bernard Moss , Michael Mackett , Geoffrey L. Smith
IPC分类号： A61K39/275 , A61K39/285
CPC分类号： C12N15/86 , A61K39/00 , A61K39/12 , A61K39/275 , A61K39/285 , A61K2039/5256 , C07K14/005 , C12N7/00 , C12N9/1033 , C12N2710/16622 , C12N2710/24122 , C12N2710/24134 , C12N2710/24143 , C12N2730/10122 , C12N2760/20234 , Y02A50/403 , Y02A50/464 , Y02A50/466
摘要： Recombinant poxviruses, such as vaccinia, are provided that comprises a segment comprised of (A) a first DNA sequence encoding a polypeptide that is foreign to poxvirus and (B) a poxvirus transcriptional regulatory sequence, wherein (i) said transcriptional regulatory sequence is adjacent to and exerts transcriptional control over said first DNA sequence and (ii) said segment is positioned within a nonessential genomic region of said recombinant poxvirus. Vaccines, carriers, cells, and media comprising recombinant poxviruses, and methods of immunization with recombinant poxviruses also are provided.
摘要翻译： 提供重组痘病毒，例如牛痘，其包含由（A）编码痘病毒异源的多肽的第一DNA序列和（B）痘病毒转录调节序列组成的片段，其中（i）所述转录调控序列相邻 对所述第一DNA序列进行转录控制，并且（ii）所述片段位于所述重组痘病毒的非必需基因组区域内。 还提供了疫苗，载体，细胞和包含重组痘病毒的培养基，以及用重组痘病毒免疫的方法。
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