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21 条记录 (耗时 0.036 秒)

    Peptide-containing liposomes, immunogenic liposomes and methods of preparation and use
    5.
    发明授权
    Peptide-containing liposomes, immunogenic liposomes and methods of preparation and use 失效
    含肽的脂质体，免疫原性脂质体及其制备和使用方法

    公开(公告)号：US5916588A

    公开(公告)日：1999-06-29

    申请号：US452549

    申请日：1995-05-25

    申请人： Mircea C. Popescu ,  Alan L. Weiner ,  Marie S. Recine ,  Andrew S. Janoff ,  Leonard Estis ,  Lynn D. Keyes ,  Carl R. Alving

    发明人： Mircea C. Popescu ,  Alan L. Weiner ,  Marie S. Recine ,  Andrew S. Janoff ,  Leonard Estis ,  Lynn D. Keyes ,  Carl R. Alving

    IPC分类号： A61K9/00 ,  A61K9/127 ,  A61K39/39 ,  A61K39/00

    CPC分类号： A61K39/39 ,  A61K9/1271 ,  A61K2039/55555

    摘要： A high integrity liposome comprising at least one stabile lipid and at least one peptide-like therapeutic agent associated with the liposome, adapted for parenteral administration to an animal, including a human, and method according to manufacture and use.Immunizing dosage forms comprising a liposome and an immunogen, wherein the liposome and immunogen are present in an immunization dose. Additionally, a dosage form, including such form particularly adapted to producing an immune response, comprising a salt according to an organic acid derivative of a sterol and an immunogen are present in an immunization dose, and method according to uses is disclosed. Further, a dosage form, including such form particularly adapted to producing an immune response, comprising dimyristolyphosphatidylcholine (DMPC)/cholesterol liposomes, optionally in an aluminum hydroxide gel, and an immunogen wherein the DMPC/cholesterol and immunogen are present in an immunization dose, and method according to use.

    摘要翻译： 包含至少一种稳定脂质和至少一种与脂质体相关的肽样治疗剂的高完整性脂质体，其适于肠胃外给予动物，包括人类，以及根据制造和使用的方法。 包含脂质体和免疫原的免疫剂型，其中所述脂质体和免疫原以免疫剂量存在。 此外，包含特定适于产生免疫应答的形式的剂型，其包含根据固醇和免疫原的有机酸衍生物的盐，其以免疫剂量存在，并且公开了根据用途的方法。 此外，包括特别适于产生免疫应答的剂型，包括任选在氢氧化铝凝胶中的二肉豆蔻基磷脂酰胆碱（DMPC）/胆固醇脂质体和免疫原，其中DMPC /胆固醇和免疫原以免疫剂量存在， 和方法根据用途。

    Potentiation of immune responses with liposomal adjuvants
    7.
    发明授权
    Potentiation of immune responses with liposomal adjuvants 失效
    用脂质体佐剂增强免疫反应

    公开(公告)号：US6090406A

    公开(公告)日：2000-07-18

    申请号：US485388

    申请日：1990-02-26

    申请人： Mircea C. Popescu ,  Alan L. Weiner ,  Marie S. Recine ,  Andrew S. Janoff ,  Leonard Estis ,  Lynn D. Keyes ,  Carl R. Alving

    发明人： Mircea C. Popescu ,  Alan L. Weiner ,  Marie S. Recine ,  Andrew S. Janoff ,  Leonard Estis ,  Lynn D. Keyes ,  Carl R. Alving

    IPC分类号： A61K9/00 ,  A61K9/127 ,  A61K39/12 ,  A61K39/385 ,  B01J13/02

    CPC分类号： A61K9/1271 ,  A61K9/1272 ,  A61K2039/55555 ,  Y10S424/812

    摘要： A high integrity liposome comprising at least one stabile lipid and at least one peptide-like therapeutic agent associated with said liposome, adapted for parenteral administration to an animal, including a human, and method according to manufacture and use. Immunizing dosage forms comprising a liposome and an immunogen, wherein said liposome and immunogen are present in an immunization dose. Additionally, a dosage form, including such form particularly adapted to producing an immune response, comprising a salt according to an organic acid derivative of a sterol and an immunogen wherein said organic acid derivative of a sterol and immunogen are present in an immunization dose, and method according to use is disclosed. Further, a dosage form, including such form particularly adapted to producing an immune response, comprising dimyristoylphosphatidylcholine (DMPC)/cholesterol liposomes, optionally in an aluminum hydroxide gel, and an immunogen wherein said DMPC/cholesterol and immunogen are present in an immunization dose, and method according to use.

    摘要翻译： 包含至少一种稳定脂质和与所述脂质体相关联的至少一种肽样治疗剂的高完整性脂质体，适于肠胃外给予动物（包括人），以及根据制造和使用的方法。 包含脂质体和免疫原的免疫剂型，其中所述脂质体和免疫原以免疫剂量存在。 另外，包括特别适于产生免疫应答的剂型，其包含根据固醇和免疫原的有机酸衍生物的盐，其中所述固醇和免疫原的所述有机酸衍生物以免疫剂量存在，以及 公开了根据使用的方法。 此外，包括特别适于产生免疫应答的形式的剂型，包括二肉豆蔻酰磷脂酰胆碱（DMPC）/胆固醇脂质体，任选地在氢氧化铝凝胶中，以及免疫原，其中所述DMPC /胆固醇和免疫原以免疫剂量存在， 和方法根据用途。

    Steroidal liposomes exhibiting enhanced stability
    10.
    发明授权
    Steroidal liposomes exhibiting enhanced stability 失效
    具有增强的稳定性的类固醇脂质体

    公开(公告)号：US5100662A

    公开(公告)日：1992-03-31

    申请号：US422047

    申请日：1989-10-16

    申请人： Lois E. Bolcsak ,  Lawrence Boni ,  Mircea C. Popescu ,  Paul A. Tremblay

    发明人： Lois E. Bolcsak ,  Lawrence Boni ,  Mircea C. Popescu ,  Paul A. Tremblay

    IPC分类号： A61K9/127 ,  A61K39/145

    CPC分类号： A61K9/1271 ,  A61K39/12 ,  A61K39/145 ,  A61K9/1272 ,  A61K2039/55555 ,  C12N2760/16134 ,  Y10T428/2984

    摘要： The present invention relates to novel liposomes and liposome-like structures (vesicles) comprising an amount of a derivatized sterol either alone or in combination with additional liposome-forming lipids.Sterols such as cholesterol or other lipids, to which numerous charged or neutral groups are attached, may be used to prepare liposomes and liposome-like structures such as micelles, reverse micelles and hexagonal phases, suspensions of multilamellar vesicles or small unilamellar vesicles. The novel liposomes of the present invention may be prepared with or without the use of organic solvents. These vesicles may entrap compounds varying in polarity and solubility in water and other solvents. The vesicles of the present invention may function as vaccines after entrapment or association of an immunogen, as adjuvants, either alone or in combination with additional adjuvants, including, for example, Freund's adjuvant (and other oil emulsions), Bortedella Pertussis, aluminum salts and other metal salts and Mycobacterial products (including muramyldipeptides), among others. The present invention relates to novel liposomes and liposome-like structures (vesicles) comprising an amount of a derivatized sterol either alone or in combination with additional liposome-forming lipids.

    摘要翻译： 本发明涉及包含一定量的衍生化甾醇的新型脂质体和脂质体样结构（囊泡），其单独或与另外的形成脂质体的脂质组合。 许多带电荷或中性基团连接的胆固醇或其他脂质的甾醇可用于制备脂质体和脂质体样结构如胶束，反胶束和六方相，多层囊泡或小单层囊泡的悬浮液。 本发明的新型脂质体可以在使用或不使用有机溶剂的情况下制备。 这些囊泡可能会捕获在水和其他溶剂中极性和溶解度变化的化合物。 本发明的囊泡可以在作为佐剂截留或结合后单独或与另外的佐剂组合（例如弗氏佐剂（和其它油乳剂），百日咳百日咳杆菌，铝盐和 其他金属盐和分枝杆菌产品（包括胞壁酰二肽）等。 本发明涉及包含一定量的衍生化甾醇的新型脂质体和脂质体样结构（囊泡），其单独或与另外的形成脂质体的脂质组合。