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公开(公告)号：US20070190079A1
公开(公告)日：2007-08-16
申请号：US11687949
申请日：2007-03-19
申请人： Andrew Shiau , Mark Massari , Guy Oshiro , Ayman Kabakibi , James Malecha , Stewart Noble
发明人： Andrew Shiau , Mark Massari , Guy Oshiro , Ayman Kabakibi , James Malecha , Stewart Noble
IPC分类号： A61K31/495
CPC分类号： A61K31/495
摘要： The present invention relates to methods of selective modulation of peroxisome proliferator activated receptors (PPARs) over G-protein coupled receptor 40 (GPR40), and the use of therapeutically effective amounts of compounds and pharmaceutical compositions which selectively modulate PPAR over GPR40 for the treatment of diseases in patients in need thereof. The methods disclosed herein are exceptionally useful in treating metabolic diseases whilst avoiding certain side effects common to modulators of PPAR previously disclosed in the art.
摘要翻译： 本发明涉及在G蛋白偶联受体40（GPR40）上选择性调节过氧化物酶体增殖物激活受体（PPAR）的方法，以及使用治疗有效量的化合物和药物组合物，其选择性调节PPR在GPR40上的治疗 有需要的患者的疾病。 本文公开的方法在治疗代谢疾病方面特别有用，同时避免了本领域先前公开的PPAR调节剂的常见副作用。
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公开(公告)号：US20060205736A1
公开(公告)日：2006-09-14
申请号：US11435082
申请日：2006-05-16
申请人： Stewart Noble , Guy Oshiro , James Malecha , Cunxiang Zhao , Sergio Duron , Andrew Lindstrom , Andrew Shiau , Boliang Lou , Steven Govek , David Thomas
发明人： Stewart Noble , Guy Oshiro , James Malecha , Cunxiang Zhao , Sergio Duron , Andrew Lindstrom , Andrew Shiau , Boliang Lou , Steven Govek , David Thomas
IPC分类号： A61K31/495 , C07D241/04
CPC分类号： C07D209/08 , C07D209/26 , C07D211/96 , C07D213/74 , C07D241/04 , C07D257/04 , C07D295/26 , C07D317/66 , C07D333/60 , C07D401/04 , C07D401/12 , C07D405/04 , C07D409/12 , C07D487/08
摘要： Compounds as modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.
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公开(公告)号：US20060167012A1
公开(公告)日：2006-07-27
申请号：US11258463
申请日：2005-10-25
申请人： Stewart Noble , Guy Oshiro , James Malecha , Cunxiang Zhao , Carmen Robinson , Sergio Duron , Michael Sertic , Andrew Lindstrom , Andrew Shiau , Christopher Bayne , Mehmet Kahraman , Boliang Lou , Steven Govek
发明人： Stewart Noble , Guy Oshiro , James Malecha , Cunxiang Zhao , Carmen Robinson , Sergio Duron , Michael Sertic , Andrew Lindstrom , Andrew Shiau , Christopher Bayne , Mehmet Kahraman , Boliang Lou , Steven Govek
IPC分类号： A61K31/495 , A61K31/4439 , A61K31/44 , C07D403/02
CPC分类号： C07D213/74 , C07D209/08 , C07D211/96 , C07D257/04 , C07D295/26 , C07D333/60 , C07D401/04 , C07D401/12 , C07D405/04 , C07D409/12 , C07D487/08
摘要： Compounds as modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.
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公开(公告)号：US07834004B2
公开(公告)日：2010-11-16
申请号：US12204489
申请日：2008-09-04
申请人： Stewart A. Noble , Guy Oshiro , James W. Malecha , Cunxiang Zhao , Carmen Robinson , Sergio G. Duron , Michael Sertic , Andrew K. Lindstrom , Andrew K. Shiau , Christopher D Bayne , Mehmet Kahraman , Boliang Lou , Steven P. Govek
发明人： Stewart A. Noble , Guy Oshiro , James W. Malecha , Cunxiang Zhao , Carmen Robinson , Sergio G. Duron , Michael Sertic , Andrew K. Lindstrom , Andrew K. Shiau , Christopher D Bayne , Mehmet Kahraman , Boliang Lou , Steven P. Govek
IPC分类号： A61K31/496 , A61K31/343 , A61K31/404 , A61K31/551 , A61K31/495 , C07D333/52 , C07D403/02 , C07D209/04 , C07D405/02 , C07D307/78
CPC分类号： C07D213/74 , C07D209/08 , C07D211/96 , C07D257/04 , C07D295/26 , C07D333/60 , C07D401/04 , C07D401/12 , C07D405/04 , C07D409/12 , C07D487/08
摘要： Compounds as modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.
摘要翻译： 公开了作为过氧化物酶体增殖物激活受体的调节剂的化合物，包含其的药物组合物和使用其的治疗疾病的方法。
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公开(公告)号：US20090264417A1
公开(公告)日：2009-10-22
申请号：US12204489
申请日：2008-09-04
申请人： Stewart A. Noble , Guy Oshiro , James W. Malecha , Cunxiang Zhao , Carmen Robinson , Sergio G. Duron , Michael Sertic , Andrew K. Lindstrom , Andrew K. Shiau , Christopher D. Bayne , Mehmet Kahraman , Boliang Lou , Steven P. Govek
发明人： Stewart A. Noble , Guy Oshiro , James W. Malecha , Cunxiang Zhao , Carmen Robinson , Sergio G. Duron , Michael Sertic , Andrew K. Lindstrom , Andrew K. Shiau , Christopher D. Bayne , Mehmet Kahraman , Boliang Lou , Steven P. Govek
IPC分类号： A61K31/551 , C07D295/26 , A61K31/495 , A61K31/496 , C07K1/107 , C07D401/04 , C07D403/12
CPC分类号： C07D213/74 , C07D209/08 , C07D211/96 , C07D257/04 , C07D295/26 , C07D333/60 , C07D401/04 , C07D401/12 , C07D405/04 , C07D409/12 , C07D487/08
摘要： Compounds as modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.
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公开(公告)号：US20090029971A1
公开(公告)日：2009-01-29
申请号：US12204459
申请日：2008-09-04
申请人： Stewart A. Noble , Guy Oshiro , James W. Malecha , Cunxiang Zhao , Carmen Robinson , Sergio G. Duron , Michael Sertic , Andrew K. Lindstrom , Andrew K. Shiau , Christopher D. Bayne , Mehmet Kahraman , Boliang Lou , Steve P. Govek
发明人： Stewart A. Noble , Guy Oshiro , James W. Malecha , Cunxiang Zhao , Carmen Robinson , Sergio G. Duron , Michael Sertic , Andrew K. Lindstrom , Andrew K. Shiau , Christopher D. Bayne , Mehmet Kahraman , Boliang Lou , Steve P. Govek
IPC分类号： A61K31/496 , C07D241/04 , C07D401/04 , C07D211/70 , A61K31/4418 , A61K31/551 , A61K31/495 , C07D401/12 , C07D409/14
CPC分类号： C07D213/74 , C07D209/08 , C07D211/96 , C07D257/04 , C07D295/26 , C07D333/60 , C07D401/04 , C07D401/12 , C07D405/04 , C07D409/12 , C07D487/08
摘要： Compounds as modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.
摘要翻译： 公开了作为过氧化物酶体增殖物激活受体的调节剂的化合物，包含其的药物组合物和使用其的治疗疾病的方法。
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公开(公告)号：US07915253B2
公开(公告)日：2011-03-29
申请号：US12204459
申请日：2008-09-04
申请人： Stewart A. Noble , Guy Oshiro , James W. Malecha , Cunxiang Zhao , Carmen K. Robinson , Sergio G. Duron , Michael Sertic , Andrew K. Lindstrom , Andrew K. Shiau , Christopher D. Bayne , Mehmet Kahraman , Boliang Lou , Steve P. Govek
发明人： Stewart A. Noble , Guy Oshiro , James W. Malecha , Cunxiang Zhao , Carmen K. Robinson , Sergio G. Duron , Michael Sertic , Andrew K. Lindstrom , Andrew K. Shiau , Christopher D. Bayne , Mehmet Kahraman , Boliang Lou , Steve P. Govek
IPC分类号： A61K31/496 , A61K31/4418 , A61K31/551 , A61K31/495 , C07D241/04 , C07D401/04 , C07D211/70 , C07D401/12 , C07D409/14
CPC分类号： C07D213/74 , C07D209/08 , C07D211/96 , C07D257/04 , C07D295/26 , C07D333/60 , C07D401/04 , C07D401/12 , C07D405/04 , C07D409/12 , C07D487/08
摘要： Compounds as modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.
摘要翻译： 公开了作为过氧化物酶体增殖物激活受体的调节剂的化合物，包含其的药物组合物和使用其的治疗疾病的方法。
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8.发明申请ARYL-SUBSTITUTED HETEROCYCLIC PDE4 INHIBITORS AS ANTI-INFLAMMATORY AGENTS 审中-公开ARYL取代的杂环化PDE4抑制剂作为抗炎剂公开(公告)号：US20100105729A1
公开(公告)日：2010-04-29
申请号：US12444533
申请日：2007-09-20
IPC分类号： A61K31/4155 , A61K31/4709 , C07D409/04 , C07D401/04 , C07D403/04 , A61P29/00
CPC分类号： A61K31/415 , A61K31/4155 , A61K31/4709
摘要： Disclosed herein are potent and selective aryl-substituted heterocyclic compounds, useful as inhibitors of phosphodiesterase 4 (PDE4), compositions comprising the same, and their application as pharmaceuticals for the treatment of disease. Methods of inhibition of PDE4 activity are also provided, as well as methods for the treatment of inflammatory diseases and other diseases in which PDE4 or one of its isoforms may play a role.
摘要翻译： 本文公开了有效和选择性的芳基取代的杂环化合物，其可用作磷酸二酯酶4（PDE4）的抑制剂，包含其的组合物及其作为用于治疗疾病的药物的应用。 还提供了抑制PDE4活性的方法，以及治疗炎性疾病和其中PDE4或其一种同工型可能发挥作用的其它疾病的方法。
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公开(公告)号：US20090275586A1
公开(公告)日：2009-11-05
申请号：US12444539
申请日：2007-09-20
IPC分类号： A61K31/5025 , C07D471/04 , A61P35/00
CPC分类号： A61K31/519 , A61K31/166 , A61K31/4015 , A61K31/4162 , A61K31/4192 , A61K31/428 , A61K31/4365 , A61K31/443 , A61K31/4741 , A61K31/498 , A61K31/4985 , A61K31/505 , A61K31/506 , A61K31/53 , A61K31/538
摘要： The present invention is directed to potent and selective heterocyclic compounds, useful as inhibitors of phosphodiesterase 4 (PDE4), compositions comprising the same, and their application as pharmaceuticals for the treatment of disease. Methods of inhibition of PDE4 activity are also provided, as well as methods for the treatment of inflammatory diseases and other diseases in which PDE4 or one of its isoforms may play a role.
摘要翻译： 本发明涉及有效和选择性的杂环化合物，其可用作磷酸二酯酶4（PDE4）的抑制剂，包含其的组合物及其作为用于治疗疾病的药物的应用。 还提供了抑制PDE4活性的方法，以及治疗炎性疾病和其中PDE4或其一种同工型可能发挥作用的其它疾病的方法。
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公开(公告)号：US20090227599A1
公开(公告)日：2009-09-10
申请号：US12396513
申请日：2009-03-03
申请人： Stewart A. Noble , Guy Oshiro , James W. Malecha , Cunxiang Zhao , Sergio G. Duron , Andrew K. Lindstrom , Andrew K. Shiau , Boliang Lou , Steven P. Govek , David J. Thomas
发明人： Stewart A. Noble , Guy Oshiro , James W. Malecha , Cunxiang Zhao , Sergio G. Duron , Andrew K. Lindstrom , Andrew K. Shiau , Boliang Lou , Steven P. Govek , David J. Thomas
IPC分类号： A61K31/495 , C07K14/705
CPC分类号： C07D209/08 , C07D209/26 , C07D211/96 , C07D213/74 , C07D241/04 , C07D257/04 , C07D295/26 , C07D317/66 , C07D333/60 , C07D401/04 , C07D401/12 , C07D405/04 , C07D409/12 , C07D487/08
摘要： Compounds as modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.
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