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1.发明申请METHODS FOR GENETIC CONTROL OF PLANT PEST INFESTATION AND COMPOSITIONS THEREOF 有权植物病虫害感染的遗传控制方法及其组合物公开(公告)号：US20090188005A1
公开(公告)日：2009-07-23
申请号：US12101830
申请日：2008-04-11
申请人： Andrey A. Boukharov , Zijin Du , Liang Guo , David K. Kovalic , Maolong Lu , James P. McCarter , Nancy M. Miller , Mark Vaudin , Deryck Jeremy Williams , Wei Wu
发明人： Andrey A. Boukharov , Zijin Du , Liang Guo , David K. Kovalic , Maolong Lu , James P. McCarter , Nancy M. Miller , Mark Vaudin , Deryck Jeremy Williams , Wei Wu
CPC分类号： C12N15/8285 , C07K14/4354 , C12N15/8241 , C12N15/8245 , C12N15/8247 , C12N15/8274 , C12N15/8279 , Y02A40/164
摘要： The present invention is directed to controlling plant pest infestation, and particularly plant nematode infestation, by inhibiting one or more biological functions in the plant pest. The invention discloses methods and compositions for use in controlling plant pest infestation by providing one or more different recombinant double stranded RNA molecules in the diet of the pest in order to achieve a reduction in pest infestation through suppression of pest gene expression. The invention is also directed to methods for making transgenic plants that express the double stranded RNA molecules, to methods for detecting cells comprising the disclosed sequences, and to methods for detecting the disclosed sequences in biological samples.
摘要翻译： 本发明涉及通过抑制植物有害生物中的一种或多种生物功能来控制植物害虫侵染，特别是植物线虫侵染。 本发明公开了通过在害虫的饮食中提供一种或多种不同的重组双链RNA分子来控制植物害虫侵袭的方法和组合物，以通过抑制害虫基因表达来实现害虫侵染的减少。 本发明还涉及用于制备表达双链RNA分子的转基因植物的方法，用于检测包含所公开序列的细胞的方法，以及用于检测生物样品中所公开序列的方法。
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2.发明授权公开(公告)号：US08088976B2
公开(公告)日：2012-01-03
申请号：US11360355
申请日：2006-02-23
申请人： Andrey A. Boukharov , Zijin Du , Liang Guo , David K. Kovalic , Maolong Lu , James P. McCarter , Nancy M. Miller , Mark Vaudin , Deryck Jeremy Williams , Wei Wu
发明人： Andrey A. Boukharov , Zijin Du , Liang Guo , David K. Kovalic , Maolong Lu , James P. McCarter , Nancy M. Miller , Mark Vaudin , Deryck Jeremy Williams , Wei Wu
CPC分类号： C12N15/8285 , C07K14/4354 , C12N15/8241 , C12N15/8245 , C12N15/8247 , C12N15/8274 , C12N15/8279 , Y02A40/164
摘要： The present invention is directed to controlling plant pest infestation, and particularly plant nematode infestation, by inhibiting one or more biological functions in the plant pest. The invention discloses methods and compositions for use in controlling plant pest infestation by providing one or more different recombinant double stranded RNA molecules in the diet of the pest in order to achieve a reduction in pest infestation through suppression of pest gene expression. The invention is also directed to methods for making transgenic plants that express the double stranded RNA molecules, to methods for detecting cells comprising the disclosed sequences, and to methods for detecting the disclosed sequences in biological samples.
摘要翻译： 本发明涉及通过抑制植物有害生物中的一种或多种生物功能来控制植物害虫侵染，特别是植物线虫侵染。 本发明公开了通过在害虫的饮食中提供一种或多种不同的重组双链RNA分子来控制植物害虫侵袭的方法和组合物，以通过抑制害虫基因表达来实现害虫侵染的减少。 本发明还涉及用于制备表达双链RNA分子的转基因植物的方法，用于检测包含所公开序列的细胞的方法，以及用于检测生物样品中所公开序列的方法。
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3.发明授权公开(公告)号：US08067671B2
公开(公告)日：2011-11-29
申请号：US12101830
申请日：2008-04-11
申请人： Andrey A. Boukharov , Zijin Du , Liang Guo , David K. Kovalic , Maolong Lu , James P. McCarter , Nancy M. Miller , Mark Vaudin , Deryck Jeremy Williams , Wei Wu
发明人： Andrey A. Boukharov , Zijin Du , Liang Guo , David K. Kovalic , Maolong Lu , James P. McCarter , Nancy M. Miller , Mark Vaudin , Deryck Jeremy Williams , Wei Wu
CPC分类号： C12N15/8285 , C07K14/4354 , C12N15/8241 , C12N15/8245 , C12N15/8247 , C12N15/8274 , C12N15/8279 , Y02A40/164
摘要： The present invention is directed to controlling plant pest infestation, and particularly plant nematode infestation, by inhibiting one or more biological functions in the plant pest. The invention discloses methods and compositions for use in controlling plant pest infestation by providing one or more different recombinant double stranded RNA molecules in the diet of the pest in order to achieve a reduction in pest infestation through suppression of pest gene expression. The invention is also directed to methods for making transgenic plants that express the double stranded RNA molecules, to methods for detecting cells comprising the disclosed sequences, and to methods for detecting the disclosed sequences in biological samples.
摘要翻译： 本发明涉及通过抑制植物有害生物中的一种或多种生物功能来控制植物害虫侵染，特别是植物线虫侵染。 本发明公开了通过在害虫的饮食中提供一种或多种不同的重组双链RNA分子来控制植物害虫侵袭的方法和组合物，以通过抑制害虫基因表达来实现害虫侵染的减少。 本发明还涉及用于制备表达双链RNA分子的转基因植物的方法，用于检测包含所公开序列的细胞的方法，以及用于检测生物样品中所公开序列的方法。
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4.发明申请Methods for genetic control of plant pest infestation and compositions thereof 审中-公开植物害虫侵染遗传控制方法及其组成公开(公告)号：US20140325702A1
公开(公告)日：2014-10-30
申请号：US13374480
申请日：2011-12-29
申请人： Andrey A. Boukharov , Zijin Du , Liang Guo , David K. Kovalic , Maolong Lu , James P. McCarter , Nancy M. Miller , Mark Vaudin , Deryck Jeremy Williams , Wei Wu
发明人： Andrey A. Boukharov , Zijin Du , Liang Guo , David K. Kovalic , Maolong Lu , James P. McCarter , Nancy M. Miller , Mark Vaudin , Deryck Jeremy Williams , Wei Wu
IPC分类号： C12N15/82
CPC分类号： C12N15/8285 , C07K14/4354 , C12N15/8241 , C12N15/8245 , C12N15/8247 , C12N15/8274 , C12N15/8279 , Y02A40/164
摘要： The present invention is directed to controlling plant pest infestation, and particularly plant nematode infestation, by inhibiting one or more biological functions in the plant pest. The invention discloses methods and compositions for use in controlling plant pest infestation by providing one or more different recombinant double stranded RNA molecules in the diet of the pest in order to achieve a reduction in pest infestation through suppression of pest gene expression. The invention is also directed to methods for making transgenic plants that express the double stranded RNA molecules, to methods for detecting cells comprising the disclosed sequences, and to methods for detecting the disclosed sequences in biological samples.
摘要翻译： 本发明涉及通过抑制植物有害生物中的一种或多种生物功能来控制植物害虫侵染，特别是植物线虫侵染。 本发明公开了通过在害虫的饮食中提供一种或多种不同的重组双链RNA分子来控制植物害虫侵袭的方法和组合物，以通过抑制害虫基因表达来实现害虫侵染的减少。 本发明还涉及用于制备表达双链RNA分子的转基因植物的方法，用于检测包含所公开序列的细胞的方法，以及用于检测生物样品中所公开序列的方法。
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5.发明授权公开(公告)号：US08519225B2
公开(公告)日：2013-08-27
申请号：US11673351
申请日：2007-02-09
申请人： Andrey A. Boukharov , Zijin Du , Liang Guo , Michelle C. Hresko , David K. Kovalic , Zhaolong Li , Maolong Lu , James P. McCarter , Nancy M. Miller , Mark Vaudin , Deryck J. Williams , Wei Wu
发明人： Andrey A. Boukharov , Zijin Du , Liang Guo , Michelle C. Hresko , David K. Kovalic , Zhaolong Li , Maolong Lu , James P. McCarter , Nancy M. Miller , Mark Vaudin , Deryck J. Williams , Wei Wu
CPC分类号： C12N15/8285 , A01N57/16 , A23L33/105 , A23V2002/00 , A61K31/713 , C07K14/435 , C07K14/4354 , C12N15/113 , C12N15/1137 , C12N15/8261 , C12N15/8273 , C12N2310/11 , C12Q1/6888 , Y02A40/164
摘要： The invention relates to identifying and evaluating target coding sequences for control of plant parasitic nematodes by inhibiting one or more biological functions, and their use. The invention provides methods and compositions for identification of such sequences and for the control of a plant-parasitic nematode population. By feeding one or more recombinant double stranded RNA molecules provided by the invention to the nematode, a reduction in disease may be obtained through suppression of nematode gene expression. The invention is also directed to methods for making transgenic plants that express the double stranded RNA molecules, and the plant cells and plants obtained thereby.
摘要翻译： 本发明涉及鉴定和评估通过抑制一种或多种生物学功能及其用途来控制植物寄生线虫的靶编码序列。 本发明提供用于鉴定这种序列并控制植物寄生线虫种群的方法和组合物。 通过将本发明提供的一种或多种重组双链RNA分子送入线虫，通过抑制线虫基因表达可以获得疾病的减少。 本发明还涉及用于制备表达双链RNA分子的转基因植物以及由此获得的植物细胞和植物的方法。
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6.发明申请公开(公告)号：US20070250947A1
公开(公告)日：2007-10-25
申请号：US11673351
申请日：2007-02-09
申请人： Andrey Boukharov , Zijin Du , Liang Guo , Michelle Hresko , David Kovalic , Zhaolong Li , Maolong Lu , James McCarter , Nancy Miller , Mark Vaudin , Deryck Williams , Wei Wu
发明人： Andrey Boukharov , Zijin Du , Liang Guo , Michelle Hresko , David Kovalic , Zhaolong Li , Maolong Lu , James McCarter , Nancy Miller , Mark Vaudin , Deryck Williams , Wei Wu
CPC分类号： C12N15/8285 , A01N57/16 , A23L33/105 , A23V2002/00 , A61K31/713 , C07K14/435 , C07K14/4354 , C12N15/113 , C12N15/1137 , C12N15/8261 , C12N15/8273 , C12N2310/11 , C12Q1/6888 , Y02A40/164
摘要： The invention relates to identifying and evaluating target coding sequences for control of plant parasitic nematodes by inhibiting one or more biological functions, and their use. The invention provides methods and compositions for identification of such sequences and for the control of a plant-parasitic nematode population. By feeding one or more recombinant double stranded RNA molecules provided by the invention to the nematode, a reduction in disease may be obtained through suppression of nematode gene expression. The invention is also directed to methods for making transgenic plants that express the double stranded RNA molecules, and the plant cells and plants obtained thereby.
摘要翻译： 本发明涉及鉴定和评估通过抑制一种或多种生物学功能及其用途来控制植物寄生线虫的靶编码序列。 本发明提供用于鉴定这种序列并控制植物寄生线虫种群的方法和组合物。 通过将本发明提供的一种或多种重组双链RNA分子送入线虫，通过抑制线虫基因表达可以获得疾病的减少。 本发明还涉及用于制备表达双链RNA分子的转基因植物以及由此获得的植物细胞和植物的方法。
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7.发明申请公开(公告)号：US20070271630A1
公开(公告)日：2007-11-22
申请号：US11360355
申请日：2006-02-23
申请人： Andrey Boukharov , Zijin Du , Liang Guo , David Kovalic , Maolong Lu , James McCarter , Nancy Miller , Mark Vaudin , Deryck Williams , Wei Wu
发明人： Andrey Boukharov , Zijin Du , Liang Guo , David Kovalic , Maolong Lu , James McCarter , Nancy Miller , Mark Vaudin , Deryck Williams , Wei Wu
IPC分类号： A01H5/00
CPC分类号： C12N15/8285 , C07K14/4354 , C12N15/8241 , C12N15/8245 , C12N15/8247 , C12N15/8274 , C12N15/8279 , Y02A40/164
摘要： The present invention is directed to controlling plant pest infestation, and particularly plant nematode infestation, by inhibiting one or more biological functions in the plant pest. The invention discloses methods and compositions for use in controlling plant pest infestation by providing one or more different recombinant double stranded RNA molecules in the diet of the pest in order to achieve a reduction in pest infestation through suppression of pest gene expression. The invention is also directed to methods for making transgenic plants that express the double stranded RNA molecules, to methods for detecting cells comprising the disclosed sequences, and to methods for detecting the disclosed sequences in biological samples.
摘要翻译： 本发明涉及通过抑制植物有害生物中的一种或多种生物功能来控制植物害虫侵染，特别是植物线虫侵染。 本发明公开了通过在害虫的饮食中提供一种或多种不同的重组双链RNA分子来控制植物害虫侵袭的方法和组合物，以通过抑制害虫基因表达来实现害虫侵染的减少。 本发明还涉及用于制备表达双链RNA分子的转基因植物的方法，用于检测包含所公开的序列的细胞的方法，以及用于检测生物样品中公开的序列的方法。
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8.发明申请公开(公告)号：US20100168211A1
公开(公告)日：2010-07-01
申请号：US12294655
申请日：2007-03-29
IPC分类号： A61K31/7088 , C12Q1/68
CPC分类号： C12Q1/6876 , C12Q2600/156 , C12Q2600/172 , G01N2800/166
摘要： The invention provides methods for assessing the Hereditary cataract (HC) status of a canine mammal, which methods comprise use of an HSF4 marker to assess the status. Preferred canine mammals are dogs selected from the following breeds: Staffordshire bull terrier, Boston terrier, French bulldog, Mastiff, Bulldog, Boxer, Bullmastiff, Miniature bull terrier.
摘要翻译： 本发明提供了用于评估犬哺乳动物的遗传性白内障（HC）状态的方法，该方法包括使用HSF4标记来评估状态。 优选的犬哺乳动物是选自以下品种的狗：斯塔福郡郡斗牛犬，波士顿梗犬，法国斗牛犬，獒犬，牛头犬，拳击手，獒犬，小型斗牛犬。
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公开(公告)号：US08124337B2
公开(公告)日：2012-02-28
申请号：US12294655
申请日：2007-03-29
CPC分类号： C12Q1/6876 , C12Q2600/156 , C12Q2600/172 , G01N2800/166
摘要： The invention provides methods for assessing the Hereditary cataract (HC) status of a canine mammal, which methods comprise use of an HSF4 marker to assess the status. Preferred canine mammals are dogs selected from the following breeds: Staffordshire bull terrier, Boston terrier, French bulldog, Mastiff, Bulldog, Boxer, Bullmastiff, Miniature bull terrier.
摘要翻译： 本发明提供了用于评估犬哺乳动物的遗传性白内障（HC）状态的方法，该方法包括使用HSF4标记来评估状态。 优选的犬哺乳动物是选自以下品种的狗：斯塔福郡郡斗牛犬，波士顿梗犬，法国斗牛犬，獒犬，牛头犬，拳击手，獒犬，小型斗牛犬。
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