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1.发明申请Novel benzylamine derivatives and their utility as cholesterol ester-transfer protein inhibitors 有权新型苄胺衍生物及其作为胆固醇酯转移蛋白抑制剂的作用公开(公告)号：US20070015758A1
公开(公告)日：2007-01-18
申请号：US11478547
申请日：2006-06-28
申请人： Anima Baruah , Dibyendu De , Ish Khanna , Sivaram Pillarisetti , Santanu Maitra , Christopher Alexander , Jennepalli Sreenu , Indu Dager
发明人： Anima Baruah , Dibyendu De , Ish Khanna , Sivaram Pillarisetti , Santanu Maitra , Christopher Alexander , Jennepalli Sreenu , Indu Dager
IPC分类号： A61K31/55 , A61K31/4709 , A61K31/506 , A61K31/4706 , C07D403/02
CPC分类号： C07D215/14 , C07D213/73 , C07D213/74 , C07D215/38 , C07D241/20 , C07D401/04 , C07D401/12 , C07D403/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D498/04
摘要： The present invention provides, among other things, new benzylamine compounds, compositions comprising benzylamine compounds, methods of making benzylamine compounds, and methods of using benzylamine compounds for treating or preventing a variety of conditions or diseases associated with lipoprotein metabolism.
摘要翻译： 本发明尤其提供了新的苄胺化合物，包含苄胺化合物的组合物，制备苄胺化合物的方法，以及使用苄胺化合物治疗或预防与脂蛋白代谢相关的各种病症或疾病的方法。
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公开(公告)号：US20060178514A1
公开(公告)日：2006-08-10
申请号：US11320120
申请日：2005-12-28
申请人： Anima Baruah , Dibyendu De , Ish Khanna , Sivaram Pillarisetti , Santanu Maitra , Christopher Alexander , Jennepalli Sreenu
发明人： Anima Baruah , Dibyendu De , Ish Khanna , Sivaram Pillarisetti , Santanu Maitra , Christopher Alexander , Jennepalli Sreenu
IPC分类号： A61K31/4965 , A61K31/4745 , A61K31/4706 , C07D491/02 , C07D471/02 , C07D215/38
CPC分类号： A61K31/506 , A61K31/437 , A61K31/438 , A61K31/47 , A61K31/4709 , A61K31/496 , C07D213/73 , C07D213/74 , C07D215/38 , C07D221/04 , C07D239/78 , C07D241/20 , C07D401/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D498/04
摘要： The present invention provides, among other things, new benzylamine compounds, compositions comprising benzylamine compounds, methods of making benzylamine compounds, and methods of using benzylamine compounds for treating or preventing a variety of conditions or diseases associated with lipoprotein metabolism.
摘要翻译： 本发明尤其提供了新的苄胺化合物，包含苄胺化合物的组合物，制备苄胺化合物的方法，以及使用苄胺化合物治疗或预防与脂蛋白代谢相关的各种病症或疾病的方法。
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3.发明申请Novel pyridine compounds, process for their preparation and compositions containing them 失效新型吡啶化合物，其制备方法和含有它们的组合物公开(公告)号：US20060084644A1
公开(公告)日：2006-04-20
申请号：US11234257
申请日：2005-09-23
申请人： Manojit Pal , Christopher Alexander , Ish Khanna , Javed Iqbal , Ram Pillarisetti , Santanu Maitra , Gayla Roberts , Lavanya Sagi , Chintakunta Krishna , Jennepalli Sreenu
发明人： Manojit Pal , Christopher Alexander , Ish Khanna , Javed Iqbal , Ram Pillarisetti , Santanu Maitra , Gayla Roberts , Lavanya Sagi , Chintakunta Krishna , Jennepalli Sreenu
IPC分类号： A61K31/541 , A61K31/5377 , A61K31/496 , A61K31/4545 , A61K31/4439 , A61K31/44 , C07D417/02 , C07D403/02 , C07D413/02 , C07D401/02
CPC分类号： C07D405/14 , C07D239/30 , C07D239/40 , C07D239/42 , C07D239/46 , C07D239/47 , C07D239/48 , C07D239/50 , C07D239/54 , C07D401/04 , C07D403/12 , C07D405/12
摘要： The present invention provides new heterocyclic compounds, particularly substituted pyridines, methods and compositions for making and using these heterocyclic compounds, and methods for treating a variety of diseases and disease states, including atherosclerosis, arthritis, restenosis, diabetic nephropathy, or dyslipidemia, or disease states mediated by the low expression of Perlecan.
摘要翻译： 本发明提供新的杂环化合物，特别是取代的吡啶，制备和使用这些杂环化合物的方法和组合物，以及用于治疗各种疾病和疾病状态的方法，包括动脉粥样硬化，关节炎，再狭窄，糖尿病性肾病或血脂异常或疾病 由Perlecan低表达介导的状态。
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4.发明授权Pyridine compounds, process for their preparation and compositions containing them 失效吡啶化合物，其制备方法和含有它们的组合物公开(公告)号：US07622486B2
公开(公告)日：2009-11-24
申请号：US11234257
申请日：2005-09-23
申请人： Manojit Pal , Christopher W. Alexander , Ish Khanna , Javed Iqbal , Ram Pillarisetti , Santanu Maitra , Gayla W. Roberts , Lavanya Sagi , Chintakunta Vamsee Krishna , Jennepalli Sreenu
发明人： Manojit Pal , Christopher W. Alexander , Ish Khanna , Javed Iqbal , Ram Pillarisetti , Santanu Maitra , Gayla W. Roberts , Lavanya Sagi , Chintakunta Vamsee Krishna , Jennepalli Sreenu
IPC分类号： A61K31/445 , A61K31/44 , C07D401/02
CPC分类号： C07D405/14 , C07D239/30 , C07D239/40 , C07D239/42 , C07D239/46 , C07D239/47 , C07D239/48 , C07D239/50 , C07D239/54 , C07D401/04 , C07D403/12 , C07D405/12
摘要： The present invention provides new heterocyclic compounds, particularly substituted pyridines, methods and compositions for making and using these heterocyclic compounds, and methods for treating a variety of diseases and disease states, including atherosclerosis, arthritis, restenosis, diabetic nephropathy, or dyslipidemia, or disease states mediated by the low expression of Perlecan.
摘要翻译： 本发明提供新的杂环化合物，特别是取代的吡啶，制备和使用这些杂环化合物的方法和组合物，以及用于治疗各种疾病和疾病状态的方法，包括动脉粥样硬化，关节炎，再狭窄，糖尿病性肾病或血脂异常或疾病 由Perlecan低表达介导的状态。
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公开(公告)号：US07700774B2
公开(公告)日：2010-04-20
申请号：US11314299
申请日：2005-12-20
申请人： Anima Baruah , Ish Khanna , Sivaram Pillarisetti
发明人： Anima Baruah , Ish Khanna , Sivaram Pillarisetti
IPC分类号： C07D215/38
CPC分类号： C07D471/04
摘要： The present invention provides, among other things, new bicyclic heterocyclic compounds, compositions comprising these heterocyclic compounds, methods of making the heterocyclic compounds, and methods of using these heterocyclic compounds for treating or preventing a variety of conditions or diseases associated with lipoprotein metabolism.
摘要翻译： 本发明尤其提供了新的双环杂环化合物，包含这些杂环化合物的组合物，制备杂环化合物的方法，以及使用这些杂环化合物治疗或预防与脂蛋白代谢相关的多种病症或疾病的方法。
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公开(公告)号：US20060135551A1
公开(公告)日：2006-06-22
申请号：US11314299
申请日：2005-12-20
申请人： Anima Baruah , Ish Khanna , Sivaram Pillarisetti
发明人： Anima Baruah , Ish Khanna , Sivaram Pillarisetti
IPC分类号： A61K31/4745 , C07D471/02
CPC分类号： C07D471/04
摘要： The present invention provides, among other things, new bicyclic heterocyclic compounds, compositions comprising these heterocyclic compounds, methods of making the heterocyclic compounds, and methods of using these heterocyclic compounds for treating or preventing a variety of conditions or diseases associated with lipoprotein metabolism.
摘要翻译： 本发明尤其提供了新的双环杂环化合物，包含这些杂环化合物的组合物，制备杂环化合物的方法，以及使用这些杂环化合物治疗或预防与脂蛋白代谢相关的多种病症或疾病的方法。
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7.发明申请Novel pyrimidine compounds, process for their preparation and compositions containing them 失效新型嘧啶化合物，其制备方法和含有它们的组合物公开(公告)号：US20060084645A1
公开(公告)日：2006-04-20
申请号：US11234695
申请日：2005-09-23
申请人： Manojit Pal , Srinivas Kalleda , Srinivas Padakanti , Nalivela Swamy , Koteswar Yeleswarapu , Christopher Alexander , Ish Khanna , Javed Iqbal , Sivaram Pillarisetti , Deepak Barange
发明人： Manojit Pal , Srinivas Kalleda , Srinivas Padakanti , Nalivela Swamy , Koteswar Yeleswarapu , Christopher Alexander , Ish Khanna , Javed Iqbal , Sivaram Pillarisetti , Deepak Barange
IPC分类号： A61K31/541 , A61K31/5377 , A61K31/506 , C07D417/02 , C07D413/02 , C07D403/02
CPC分类号： C07D405/14 , C07D239/30 , C07D239/40 , C07D239/42 , C07D239/46 , C07D239/47 , C07D239/48 , C07D239/50 , C07D239/54 , C07D401/04 , C07D403/12 , C07D405/12
摘要： The present invention provides new heterocyclic compounds, particularly substituted pyrimidines, methods and compositions for making and using these heterocyclic compounds, and methods for treating a variety of diseases and disease states, including atherosclerosis, arthritis, restenosis, diabetic nephropathy, or dyslipidemia, or disease states mediated by the low expression of Perlecan.
摘要翻译： 本发明提供新的杂环化合物，特别是取代的嘧啶，用于制备和使用这些杂环化合物的方法和组合物，以及用于治疗各种疾病和疾病状态的方法，包括动脉粥样硬化，关节炎，再狭窄，糖尿病性肾病或血脂异常或疾病 由Perlecan低表达介导的状态。
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8.发明申请Novel bicyclic heterocyclic compounds, process for their preparation and compositions containing them 审中-公开新型双环杂环化合物，其制备方法和含有它们的组合物公开(公告)号：US20060128729A1
公开(公告)日：2006-06-15
申请号：US11285982
申请日：2005-11-23
申请人： Manojit Pal , Yeleswarapu Rao , Ish Khanna , Nalivela Swamy , Venkataraman Subramanian , Venkateswara Batchu , Javed Iqbal , Sivaram Pillarisetti
发明人： Manojit Pal , Yeleswarapu Rao , Ish Khanna , Nalivela Swamy , Venkataraman Subramanian , Venkateswara Batchu , Javed Iqbal , Sivaram Pillarisetti
IPC分类号： A61K31/519 , C07D487/02
CPC分类号： C07D471/04 , C07D487/04
摘要： The present invention provides, among other things, new bicyclo heterocyclic compounds, compositions comprising these heterocyclic compounds, methods of making the heterocyclic compounds, and methods of using these heterocyclic compounds for treating a variety of conditions and disease states associated with, for example, cellular proliferation, inflammation, glycosidase expression, or the low expression of Perlecan.
摘要翻译： 本发明尤其提供了新的双环杂环化合物，包含这些杂环化合物的组合物，制备杂环化合物的方法，以及使用这些杂环化合物治疗与例如细胞相关的多种病症和疾病状态的方法 增殖，炎症，糖苷酶表达或Perlecan的低表达。
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9.发明授权Pyrimidine compounds, process for their preparation and compositions containing them 失效嘧啶化合物，其制备方法和含有它们的组合物公开(公告)号：US07820654B2
公开(公告)日：2010-10-26
申请号：US11234695
申请日：2005-09-23
申请人： Manojit Pal , Srinivas Kalleda , Srinivas Padakanti , Nalivela Kumara Swamy , Koteswar Rao Yeleswarapu , Christopher W. Alexander , Ish Khanna , Javed Iqbal , Sivaram Pillarisetti , Deepak Barange
发明人： Manojit Pal , Srinivas Kalleda , Srinivas Padakanti , Nalivela Kumara Swamy , Koteswar Rao Yeleswarapu , Christopher W. Alexander , Ish Khanna , Javed Iqbal , Sivaram Pillarisetti , Deepak Barange
IPC分类号： A61K31/54 , A61K31/535 , A61K31/497 , A61K31/505 , C07D417/00 , C07D413/00 , C07D403/00 , C07D239/02
CPC分类号： C07D405/14 , C07D239/30 , C07D239/40 , C07D239/42 , C07D239/46 , C07D239/47 , C07D239/48 , C07D239/50 , C07D239/54 , C07D401/04 , C07D403/12 , C07D405/12
摘要： The present invention is directed to a compounds, methods and compositions for making the compounds and methods of treating a variety of diseases and disease states including atherosclerosis, arthritis, restenosis, diabetic nephropathy, or dyslipidemia, or disease states mediated by the low expression of Perlecan, comprising the administration of new heterocyclic compounds, particularly substituted pyrimidines. The present invention is directed to novel compounds represented by the general formula:
摘要翻译： 本发明涉及用于制备化合物的化合物，方法和组合物以及治疗各种疾病和疾病状态的方法，包括动脉粥样硬化，关节炎，再狭窄，糖尿病性肾病或血脂异常或由Perlecan低表达介导的疾病 包括施用新的杂环化合物，特别是取代的嘧啶。 本发明涉及由以下通式表示的新化合物：
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公开(公告)号：US20060128702A1
公开(公告)日：2006-06-15
申请号：US11286006
申请日：2005-11-23
申请人： Manojit Pal , Ish Khanna , Venkataraman Subramanian , Srinivas Padakanti , Sivaram Pillarisetti
发明人： Manojit Pal , Ish Khanna , Venkataraman Subramanian , Srinivas Padakanti , Sivaram Pillarisetti
IPC分类号： A61K31/5377 , A61K31/4709 , A61K31/4706 , C07D413/02 , C07D401/02 , C07D215/38
CPC分类号： C07D215/38 , C07D215/44 , C07D401/02 , C07D401/04 , C07D403/04 , C07D409/04 , C07D413/02
摘要： The present invention provides, among other things, new bicyclo heterocyclic compounds, compositions comprising these heterocyclic compounds, methods of making the heterocyclic compounds, and methods of using these heterocyclic compounds for treating a variety of conditions and disease states associated with, for example, cellular proliferation, inflammation, glycosidase expression, or the low expression of Perlecan.
摘要翻译： 本发明尤其提供了新的双环杂环化合物，包含这些杂环化合物的组合物，制备杂环化合物的方法，以及使用这些杂环化合物治疗与例如细胞相关的多种病症和疾病状态的方法 增殖，炎症，糖苷酶表达或Perlecan的低表达。
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