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9 条记录 (耗时 0.058 秒)

    Methods of controlling crop pests using aromatic amide insect repellents, methods of making aromatic amide insect repellents, and novel aromatic amide insect repellents
    7.
    发明授权
    Methods of controlling crop pests using aromatic amide insect repellents, methods of making aromatic amide insect repellents, and novel aromatic amide insect repellents 有权

    公开(公告)号：US12108762B2

    公开(公告)日：2024-10-08

    申请号：US17377022

    申请日：2021-07-15

    申请人： Santanu Maitra ,  David Lent ,  Jacob Guerra ,  Peter Robles

    发明人： Santanu Maitra ,  David Lent ,  Jacob Guerra ,  Peter Robles

    IPC分类号： A01N43/60 ,  A01N25/04

    CPC分类号： A01N43/60 ,  A01N25/04

    摘要： Methods of protecting fruit crops from flying insect pests and of repelling flying insects using aromatic amide compounds are disclosed. The methods apply the compounds to various surfaces, such as the fruit crops, the ground or structures adjacent to the fruit crops, or an object, article, human skin or animal. The compounds have the formula RxC6Hy—C(═O)—N(Cy), where RxC6Hy is a substituted phenyl group, each R group is independently C1-C6 alkyl, substituted C1-C4 alkyl, (substituted) C6-C10 aryl, C1-C4 alkoxy, C6-C10 aryloxy, halogen, nitro, cyano, cyanate, isocyanate, nitroso, C1-C4 alkylthio, phenylthio, (halogen-substituted) C1-C4 alkylsulfonyl, phenylsulfonyl, tolylsulfonyl, amino, mono- or di-C1-C4 alkylamino, diphenylamino, di-C1-C4 alkylamido, formyl, C2-C7 acyl, or C1-C6 alkoxycarbonyl; x is an integer of 1 to 5; x+y=5; Cy is a C2-C8 (substituted) alkadiyl, a C4-C6 (substituted) alkenediyl, or a (substituted) diyl of the formula —(CH2CH2)—O—(CH2CH2)—, —(CH2CH2)—NR′—(CH2CH2)— or —(CH2CH2)—S—(CH2CH2)— that, along with the amide N atom, forms a non-aromatic cyclic group; and R′ is C1-C6 alkyl, substituted C1-C4 alkyl, (substituted) C6-C10 aryl, or (substituted) benzyl.

    Method of inhibiting apolipoprotein-E expression comprising administering a triarylmethyl amine compound
    8.
    发明授权
    Method of inhibiting apolipoprotein-E expression comprising administering a triarylmethyl amine compound 有权
    抑制载脂蛋白-E表达的方法，包括施用三芳基甲基胺化合物

    公开(公告)号：US08633195B1

    公开(公告)日：2014-01-21

    申请号：US13536738

    申请日：2012-06-28

    申请人： Santanu Maitra ,  Nilay Patel

    发明人： Santanu Maitra ,  Nilay Patel

    IPC分类号： A61K31/495 ,  A61K31/445 ,  A61K31/40

    CPC分类号： C12N5/0693 ,  A61K31/135 ,  A61K31/40 ,  A61K31/4453 ,  A61K31/495 ,  A61K31/5375 ,  C12N5/0622 ,  C12N5/067

    摘要： This invention offers an effective method of inhibiting the expression of apolipoprotein E by mammalian cells. Apolipoprotein E is a protein that plays a significant role in the development of Alzheimer's Disease in humans. The method comprises administering an effective amount of a triarylmethyl amine compound having the general formula: wherein the R1 group may comprise acyclic amines and aliphatic amines. The R2 group may comprise one of three aryl varieties: aryl, substituted aryl, or heterocycle. Triarylamine compounds inhibit apolipoprotein E expression in mammalian cells. In one aspect of the invention the mammalian cells may be human cells, and more specifically may be human brain cells.

    摘要翻译： 本发明提供了抑制哺乳动物细胞载脂蛋白E表达的有效方法。 载脂蛋白E是一种在人类发展阿尔茨海默病中发挥重要作用的蛋白质。 该方法包括施用有效量的具有以下通式的三芳基甲基胺化合物：其中R 1基团可以包含无环胺和脂族胺。 R2基团可以包括三个芳基品种之一：芳基，取代的芳基或杂环。 三芳胺化合物抑制哺乳动物细胞中的载脂蛋白E表达。 在本发明的一个方面，哺乳动物细胞可以是人细胞，更具体地可以是人脑细胞。