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    Method and nerve stimulator using simultaneous electrical and optical signals
    4.
    发明授权
    Method and nerve stimulator using simultaneous electrical and optical signals 有权
    方法和神经刺激器使用同时的电和光信号

    公开(公告)号：US08498699B2

    公开(公告)日：2013-07-30

    申请号：US13013816

    申请日：2011-01-26

    申请人： Jonathon D. Wells ,  Mark P. Bendett ,  James S. Webb ,  Charles A. Lemaire ,  Austin R. Duke ,  E. Duco Jansen ,  Peter E. Konrad ,  Anita Mahadevan-Jansen

    发明人： Jonathon D. Wells ,  Mark P. Bendett ,  James S. Webb ,  Charles A. Lemaire ,  Austin R. Duke ,  E. Duco Jansen ,  Peter E. Konrad ,  Anita Mahadevan-Jansen

    IPC分类号： A61N1/00

    CPC分类号： A61N1/36017 ,  A61B2018/2025 ,  A61N1/36082 ,  A61N1/378 ,  A61N5/0601 ,  A61N5/0613 ,  A61N5/0622 ,  A61N2005/063 ,  A61N2005/0659

    摘要： An apparatus and method for stimulating animal tissue (for example to trigger a nerve action potential (NAP) signal in a human patient) by application of both electrical and optical signals for treatment and diagnosis purposes. The application of an electrical signal before or simultaneously to the application of a NAP-triggering optical signal allows the use of a lower amount of optical power or energy than would otherwise be needed if an optical signal alone was used for the same purpose and effectiveness. The application of the electrical signal may precondition the nerve tissue such that a lower-power optical signal can be used to trigger the desired NAP, which otherwise would take a higher-power optical signal were the electric signal not applied. Some embodiments include an implanted nerve interface having a plurality of closely spaced electrodes placed transversely and/or longitudinally to the nerve and a plurality of optical emitters.

    摘要翻译： 一种用于刺激动物组织（例如在人类患者中触发神经动作电位（NAP）信号）的装置和方法）通过应用电信号和光信号用于治疗和诊断目的。 在应用NAP触发光信号之前或同时应用电信号允许使用比如果单独使用光信号用于相同目的和有效性时所需要的更少量的光功率或能量。 电信号的应用可以预处理神经组织，使得可以使用较低功率的光信号来触发所需的NAP，否则将在不施加电信号的情况下采取更高功率的光信号。 一些实施例包括植入的神经界面，其具有横向和/或纵向设置于神经的多个紧密间隔的电极以及多个光发射器。

    Method and apparatus of pulsed infrared light for central nervous system neurons
    6.
    发明授权
    Method and apparatus of pulsed infrared light for central nervous system neurons 有权
    用于中枢神经系统神经元的脉冲红外光的方法和装置

    公开(公告)号：US09044596B2

    公开(公告)日：2015-06-02

    申请号：US13480012

    申请日：2012-05-24

    申请人： Anita Mahadevan-Jansen ,  Jonathan Cayce ,  Robert Friedman ,  Anna Roe ,  E. Duco Jansen ,  Mykyta Chernov ,  Peter E. Konrad

    发明人： Anita Mahadevan-Jansen ,  Jonathan Cayce ,  Robert Friedman ,  Anna Roe ,  E. Duco Jansen ,  Mykyta Chernov ,  Peter E. Konrad

    IPC分类号： A61N5/067 ,  A61N5/06

    CPC分类号： A61N5/0622 ,  A61N2005/063 ,  A61N2005/0659 ,  A61N2005/067

    摘要： Certain aspects of the present disclosure are directed to a method of applying infrared neural stimulation (INS) to the central nervous system (CNS) of a target. The methods includes applying a pulsed infrared laser at a stimulation site in the CNS; and evoking responses from a region of interest of the CNS that is at or adjacent to the stimulation site by the pulsed infrared laser. In the method, the pulsed infrared laser penetrates a predetermined penetration depth of the stimulation site. Certain aspects of the present disclosure are directed to an apparatus for applying INS to the CNS of a target. The apparatus includes a generator generating a pulsed infrared laser, which penetrates a predetermined penetration depth of a stimulation site to evoke a response from the CNS, and an optical medium adapted for delivering the pulsed infrared laser at the stimulation site of the CNS.

    摘要翻译： 本公开的某些方面涉及将红外神经刺激（INS）应用于靶的中枢神经系统（CNS）的方法。 所述方法包括在CNS的刺激部位应用脉冲红外激光; 并通过脉冲红外激光引起来自刺激部位处于或相邻的CNS的感兴趣区域的反应。 在该方法中，脉冲红外激光穿透刺激部位的预定穿透深度。 本公开的某些方面涉及用于将INS应用于目标的CNS的装置。 该装置包括产生脉冲红外激光器的发生器，其穿透刺激部位的预定穿透深度以引起来自CNS的响应，以及光学介质，其适于在CNS的刺激部位处递送脉冲红外激光。

    METHOD AND APPARATUS OF PULSED INFRARED LIGHT FOR THE INHIBITION OF CENTRAL NERVOUS SYSTEM NEURONS
    7.
    发明申请
    METHOD AND APPARATUS OF PULSED INFRARED LIGHT FOR THE INHIBITION OF CENTRAL NERVOUS SYSTEM NEURONS 有权
    用于抑制中枢神经系统神经元的脉冲红外光的方法和装置

    公开(公告)号：US20130013030A1

    公开(公告)日：2013-01-10

    申请号：US13480012

    申请日：2012-05-24

    申请人： Anita Mahadevan-Jansen ,  Jonathan Cayce ,  Robert Friedman ,  Anna Roe ,  E. Duco Jansen ,  Mykyta Chernov ,  Peter E. Konrad

    发明人： Anita Mahadevan-Jansen ,  Jonathan Cayce ,  Robert Friedman ,  Anna Roe ,  E. Duco Jansen ,  Mykyta Chernov ,  Peter E. Konrad

    IPC分类号： A61N5/067

    CPC分类号： A61N5/0622 ,  A61N2005/063 ,  A61N2005/0659 ,  A61N2005/067

    摘要： Certain aspects of the present disclosure are directed to a method of applying infrared neural stimulation (INS) to the central nervous system (CNS) of a target. The methods includes applying a pulsed infrared laser at a stimulation site in the CNS; and evoking responses from a region of interest of the CNS that is at or adjacent to the stimulation site by the pulsed infrared laser. In the method, the pulsed infrared laser penetrates a predetermined penetration depth of the stimulation site. Certain aspects of the present disclosure are directed to an apparatus for applying INS to the CNS of a target. The apparatus includes a generator generating a pulsed infrared laser, which penetrates a predetermined penetration depth of a stimulation site to evoke a response from the CNS, and an optical medium adapted for delivering the pulsed infrared laser at the stimulation site of the CNS.

    摘要翻译： 本公开的某些方面涉及将红外神经刺激（INS）应用于靶的中枢神经系统（CNS）的方法。 所述方法包括在CNS的刺激部位应用脉冲红外激光; 并通过脉冲红外激光引起来自刺激部位处于或相邻的CNS的感兴趣区域的反应。 在该方法中，脉冲红外激光穿透刺激部位的预定穿透深度。 本公开的某些方面涉及用于将INS应用于目标的CNS的装置。 该装置包括产生脉冲红外激光器的发生器，其穿透刺激部位的预定穿透深度以引起来自CNS的响应，以及适于在CNS的刺激部位处递送脉冲红外激光的光学介质。

    Apparatus for supporting an adjustable surgical platform
    10.
    发明授权
    Apparatus for supporting an adjustable surgical platform 有权
    用于支撑可调节手术平台的装置

    公开(公告)号：US08414597B2

    公开(公告)日：2013-04-09

    申请号：US13161383

    申请日：2011-06-15

    申请人： Changquing C. Kao ,  J. Michael Fitzpatrick ,  Robert F. Labadie ,  Peter E. Konrad

    发明人： Changquing C. Kao ,  J. Michael Fitzpatrick ,  Robert F. Labadie ,  Peter E. Konrad

    IPC分类号： A61B19/00

    CPC分类号： A61B19/26 ,  A61B90/11 ,  A61B90/39 ,  A61B90/50 ,  A61B2017/3407 ,  A61B2090/363

    摘要： In one aspect, an apparatus for supporting an adjustable surgical platform is disclosed. In one embodiment, the apparatus includes a supporting platform portion with a body portion that defines bore along a central axis. Arm portions with engaging means extend radially from the supporting platform portion. The apparatus also includes a shaft portion extending from the supporting platform portion in a first direction, with a shaft body portion that defines a bore along a longitudinal axis B. The bore of the shaft body portion is in communication with the bore of the supporting platform portion. The apparatus further includes a base portion connected to the shaft portion, and that defines a bore in communication with the bore of the shaft portion and the bore of the supporting platform portion. Mounting means are configured to secure the base portion to a region of interest of a living subject.

    摘要翻译： 一方面，公开了一种用于支撑可调节手术平台的装置。 在一个实施例中，该装置包括具有主体部分的支撑平台部分，该主体部分沿着中心轴线限定孔。 具有接合装置的臂部分从支撑平台部分径向延伸。 该装置还包括从支撑平台部分沿第一方向延伸的轴部，轴体部分沿纵向轴线B限定孔。轴体部分的孔与支撑平台的孔连通 一部分。 该装置还包括连接到轴部分的基部，并且限定与轴部分的孔和支撑平台部分的孔连通的孔。 安装装置构造成将基部固定到活体的感兴趣区域。