利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

28 条记录 (耗时 0.036 秒)

    Method and apparatus of pulsed infrared light for central nervous system neurons
    1.
    发明授权
    Method and apparatus of pulsed infrared light for central nervous system neurons 有权
    用于中枢神经系统神经元的脉冲红外光的方法和装置

    公开(公告)号：US09044596B2

    公开(公告)日：2015-06-02

    申请号：US13480012

    申请日：2012-05-24

    申请人： Anita Mahadevan-Jansen ,  Jonathan Cayce ,  Robert Friedman ,  Anna Roe ,  E. Duco Jansen ,  Mykyta Chernov ,  Peter E. Konrad

    发明人： Anita Mahadevan-Jansen ,  Jonathan Cayce ,  Robert Friedman ,  Anna Roe ,  E. Duco Jansen ,  Mykyta Chernov ,  Peter E. Konrad

    IPC分类号： A61N5/067 ,  A61N5/06

    CPC分类号： A61N5/0622 ,  A61N2005/063 ,  A61N2005/0659 ,  A61N2005/067

    摘要： Certain aspects of the present disclosure are directed to a method of applying infrared neural stimulation (INS) to the central nervous system (CNS) of a target. The methods includes applying a pulsed infrared laser at a stimulation site in the CNS; and evoking responses from a region of interest of the CNS that is at or adjacent to the stimulation site by the pulsed infrared laser. In the method, the pulsed infrared laser penetrates a predetermined penetration depth of the stimulation site. Certain aspects of the present disclosure are directed to an apparatus for applying INS to the CNS of a target. The apparatus includes a generator generating a pulsed infrared laser, which penetrates a predetermined penetration depth of a stimulation site to evoke a response from the CNS, and an optical medium adapted for delivering the pulsed infrared laser at the stimulation site of the CNS.

    摘要翻译： 本公开的某些方面涉及将红外神经刺激（INS）应用于靶的中枢神经系统（CNS）的方法。 所述方法包括在CNS的刺激部位应用脉冲红外激光; 并通过脉冲红外激光引起来自刺激部位处于或相邻的CNS的感兴趣区域的反应。 在该方法中，脉冲红外激光穿透刺激部位的预定穿透深度。 本公开的某些方面涉及用于将INS应用于目标的CNS的装置。 该装置包括产生脉冲红外激光器的发生器，其穿透刺激部位的预定穿透深度以引起来自CNS的响应，以及光学介质，其适于在CNS的刺激部位处递送脉冲红外激光。

    METHOD AND APPARATUS OF PULSED INFRARED LIGHT FOR THE INHIBITION OF CENTRAL NERVOUS SYSTEM NEURONS
    2.
    发明申请
    METHOD AND APPARATUS OF PULSED INFRARED LIGHT FOR THE INHIBITION OF CENTRAL NERVOUS SYSTEM NEURONS 有权
    用于抑制中枢神经系统神经元的脉冲红外光的方法和装置

    公开(公告)号：US20130013030A1

    公开(公告)日：2013-01-10

    申请号：US13480012

    申请日：2012-05-24

    申请人： Anita Mahadevan-Jansen ,  Jonathan Cayce ,  Robert Friedman ,  Anna Roe ,  E. Duco Jansen ,  Mykyta Chernov ,  Peter E. Konrad

    发明人： Anita Mahadevan-Jansen ,  Jonathan Cayce ,  Robert Friedman ,  Anna Roe ,  E. Duco Jansen ,  Mykyta Chernov ,  Peter E. Konrad

    IPC分类号： A61N5/067

    CPC分类号： A61N5/0622 ,  A61N2005/063 ,  A61N2005/0659 ,  A61N2005/067

    摘要： Certain aspects of the present disclosure are directed to a method of applying infrared neural stimulation (INS) to the central nervous system (CNS) of a target. The methods includes applying a pulsed infrared laser at a stimulation site in the CNS; and evoking responses from a region of interest of the CNS that is at or adjacent to the stimulation site by the pulsed infrared laser. In the method, the pulsed infrared laser penetrates a predetermined penetration depth of the stimulation site. Certain aspects of the present disclosure are directed to an apparatus for applying INS to the CNS of a target. The apparatus includes a generator generating a pulsed infrared laser, which penetrates a predetermined penetration depth of a stimulation site to evoke a response from the CNS, and an optical medium adapted for delivering the pulsed infrared laser at the stimulation site of the CNS.

    摘要翻译： 本公开的某些方面涉及将红外神经刺激（INS）应用于靶的中枢神经系统（CNS）的方法。 所述方法包括在CNS的刺激部位应用脉冲红外激光; 并通过脉冲红外激光引起来自刺激部位处于或相邻的CNS的感兴趣区域的反应。 在该方法中，脉冲红外激光穿透刺激部位的预定穿透深度。 本公开的某些方面涉及用于将INS应用于目标的CNS的装置。 该装置包括产生脉冲红外激光器的发生器，其穿透刺激部位的预定穿透深度以引起来自CNS的响应，以及适于在CNS的刺激部位处递送脉冲红外激光的光学介质。

    Method and nerve stimulator using simultaneous electrical and optical signals
    3.
    发明授权
    Method and nerve stimulator using simultaneous electrical and optical signals 有权
    方法和神经刺激器使用同时的电和光信号

    公开(公告)号：US08498699B2

    公开(公告)日：2013-07-30

    申请号：US13013816

    申请日：2011-01-26

    申请人： Jonathon D. Wells ,  Mark P. Bendett ,  James S. Webb ,  Charles A. Lemaire ,  Austin R. Duke ,  E. Duco Jansen ,  Peter E. Konrad ,  Anita Mahadevan-Jansen

    发明人： Jonathon D. Wells ,  Mark P. Bendett ,  James S. Webb ,  Charles A. Lemaire ,  Austin R. Duke ,  E. Duco Jansen ,  Peter E. Konrad ,  Anita Mahadevan-Jansen

    IPC分类号： A61N1/00

    CPC分类号： A61N1/36017 ,  A61B2018/2025 ,  A61N1/36082 ,  A61N1/378 ,  A61N5/0601 ,  A61N5/0613 ,  A61N5/0622 ,  A61N2005/063 ,  A61N2005/0659

    摘要： An apparatus and method for stimulating animal tissue (for example to trigger a nerve action potential (NAP) signal in a human patient) by application of both electrical and optical signals for treatment and diagnosis purposes. The application of an electrical signal before or simultaneously to the application of a NAP-triggering optical signal allows the use of a lower amount of optical power or energy than would otherwise be needed if an optical signal alone was used for the same purpose and effectiveness. The application of the electrical signal may precondition the nerve tissue such that a lower-power optical signal can be used to trigger the desired NAP, which otherwise would take a higher-power optical signal were the electric signal not applied. Some embodiments include an implanted nerve interface having a plurality of closely spaced electrodes placed transversely and/or longitudinally to the nerve and a plurality of optical emitters.

    摘要翻译： 一种用于刺激动物组织（例如在人类患者中触发神经动作电位（NAP）信号）的装置和方法）通过应用电信号和光信号用于治疗和诊断目的。 在应用NAP触发光信号之前或同时应用电信号允许使用比如果单独使用光信号用于相同目的和有效性时所需要的更少量的光功率或能量。 电信号的应用可以预处理神经组织，使得可以使用较低功率的光信号来触发所需的NAP，否则将在不施加电信号的情况下采取更高功率的光信号。 一些实施例包括植入的神经界面，其具有横向和/或纵向设置于神经的多个紧密间隔的电极以及多个光发射器。

    Tumor demarcation using optical spectroscopy
    8.
    发明授权
    Tumor demarcation using optical spectroscopy 失效
    使用光谱法进行肿瘤分界

    公开(公告)号：US06377841B1

    公开(公告)日：2002-04-23

    申请号：US09545425

    申请日：2000-04-07

    申请人： Wei-Chiang Lin ,  Anita Mahadevan-Jansen ,  E. Duco Jansen ,  Steven A. Toms

    发明人： Wei-Chiang Lin ,  Anita Mahadevan-Jansen ,  E. Duco Jansen ,  Steven A. Toms

    IPC分类号： A61B600

    CPC分类号： G01N21/6486 ,  A61B5/0059 ,  A61B5/4064 ,  G01N2021/6484

    摘要： Optical spectroscopy for brain tumor demarcation was investigated in this study. Fluorescence and diffuse reflectance spectra were measured from normal and tumorous human brain tissues in vitro. A fluorescence peak was consistently observed around 460 nm (±10 nm) emission from both normal and tumorous brain tissues using 337 nm excitation. Intensity of this fluorescence peak (F460) from normal brain tissues was greater than that from primary brain tumorous tissues. In addition, diffuse reflectance (Rd) between 650 nm and 800 nm from white matter was significantly stronger than that from primary and secondary brain tumors. A good separation between gray matter and brain tumors was found using the ratio of F460 and Rd at 400 nm-600 nm. Two empirical discrimination algorithms based on F (400 nm-600 nm), Rd (600 nm-800 nm), and F (400 nm-600 nm)/Rd (400 nm-600 nm) were developed. These algorithms yielded an average sensitivity and specificity of 96% and 93%, respectively.

    摘要翻译： 在本研究中研究了脑肿瘤分界的光学光谱。 从正常和肿瘤的人脑组织体外测量荧光和漫反射光谱。 使用337 nm激发，从正常和肿瘤的脑组织发现约460nm（±10nm）的荧光峰。 来自正常脑组织的这种荧光峰（F460）的强度大于原发性脑肿瘤组织的强度。 另外，白色物质在650 nm到800 nm之间的漫反射率（Rd）明显强于初级和次级脑肿瘤。 使用F460和Rd在400nm-600nm的比例，发现灰质和脑肿瘤之间的良好分离。 开发了基于F（400nm-600nm），Rd（600nm-800nm）和F（400nm-600nm）/ Rd（400nm-600nm）的两种经验辨别算法。 这些算法的平均灵敏度和特异度分别为96％和93％。

    Apparatus and methods for optical stimulation of neural tissues
    9.
    发明授权
    Apparatus and methods for optical stimulation of neural tissues 有权
    用于光学刺激神经组织的装置和方法

    公开(公告)号：US08444683B2

    公开(公告)日：2013-05-21

    申请号：US11945649

    申请日：2007-11-27

    申请人： Anita Mahadevan-Jansen ,  Jonathon D. Wells ,  E. Duco Jansen

    发明人： Anita Mahadevan-Jansen ,  Jonathon D. Wells ,  E. Duco Jansen

    IPC分类号： A61N5/06

    CPC分类号： A61N5/0622 ,  A61N5/0618

    摘要： The present invention, in one aspect, relates to a method for stimulating neural tissue of a living subject. In one embodiment, the method has the steps of generating at least one beam of radiation; introducing at least one of one or more chromophores and one or more optical agents to a target neural tissue; and delivering the at least one beam of radiation to the target neural tissue, wherein the at least one beam of radiation is delivered with a radiant exposure that causes a thermal gradient in the target neural tissue, thereby stimulating the target neural tissue.

    摘要翻译： 本发明在一个方面涉及一种用于刺激活体的神经组织的方法。 在一个实施例中，该方法具有产生至少一个辐射束的步骤; 将一种或多种发色团和一种或多种光学剂中的至少一种引入靶神经组织; 以及将所述至少一束辐射递送到所述靶神经组织，其中所述至少一束辐射以辐射暴露递送，所述辐射暴露导致所述靶神经组织中的热梯度，从而刺激所述靶神经组织。

    OPTICAL PROJECTION OVERLAY DEVICE
    10.
    发明申请
    OPTICAL PROJECTION OVERLAY DEVICE 审中-公开
    光学投影覆盖设备

    公开(公告)号：US20170046586A1

    公开(公告)日：2017-02-16

    申请号：US14822447

    申请日：2015-08-10

    申请人： Adnan Abbas ,  Melanie McWade ,  Anita Mahadevan-Jansen

    发明人： Adnan Abbas ,  Melanie McWade ,  Anita Mahadevan-Jansen

    IPC分类号： G06K9/32 ,  A61B5/00 ,  H04N9/31 ,  G06K9/20 ,  G06T7/00 ,  H04N5/33

    CPC分类号： G06K9/3233 ,  A61B5/0071 ,  A61B5/0075 ,  A61B90/30 ,  A61B2090/366 ,  A61B2090/373 ,  A61B2505/05 ,  G06K9/2027 ,  G06K9/2054 ,  G06T7/0014 ,  G06T2207/30004 ,  H04N9/3185 ,  H04N9/3194

    摘要： Devices and methods for producing a highlighted overlay of a region, including an illumination source configured to illuminate the region at a bandwidth containing a first wavelength at a working distance, an imager at a working distance configured to image the illuminated region at a bandwidth containing a second wavelength, where the first and second bandwidths and wavelengths are not visible, a visible light projector configured to illuminate the region and registered to the imager to produce alignment of imaged feature with projected features at the same location on the region, and a controller executing a program configured to filter acquired images from the imager to identify areas of the region of a predetermined light intensity, and control the projector to visibly highlight those areas on the region.

    摘要翻译： 用于产生区域的突出覆盖的装置和方法，包括被配置为在工作距离处以包含第一波长的带宽照亮区域的照明源，工作距离处的成像器被配置成以包含 第二波长，其中第一和第二带宽和波长不可见，可见光投影器被配置为照亮该区域并被注册到成像器以产生成像特征与区域上相同位置处的投影特征的对准，以及控制器执行 程序，被配置为从所述成像器过滤所获取的图像，以识别所述区域的预定光强度的区域，并且控制所述投影仪以可视地突出显示所述区域上的那些区域。