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公开(公告)号：US09757443B2
公开(公告)日：2017-09-12
申请号：US13295030
申请日：2011-11-11
申请人： Annaliesa Sybil Anderson , Kathrin Ute Jansen , Mark E. Ruppen , Justin Keith Moran , Susan Kay Hoiseth
发明人： Annaliesa Sybil Anderson , Kathrin Ute Jansen , Mark E. Ruppen , Justin Keith Moran , Susan Kay Hoiseth
IPC分类号： A61K39/095 , C07K14/22 , A61K39/00
CPC分类号： A61K39/095 , A61K2039/55505 , A61K2039/55577 , C07K14/22
摘要： The present invention relates to compositions including an isolated non-pyruvylated non-lipidated ORF2086 polypeptide, and methods thereof. In an exemplary embodiment, the compositions described herein are immunogenic. The present invention further relates to compositions that elicit a bactericidal immune response in a mammal against an ORF2086 subfamily B polypeptide from serogroup B Neisseria meningitidis, and methods related thereto.
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2.发明申请NON-LIPIDATED VARIANTS OF NEISSERIA MENINGITIDIS ORF2086 ANTIGENS 审中-公开NEISSERIA MENINGITIDIS ORF2086抗体的非脂肪变异公开(公告)号：US20120093852A1
公开(公告)日：2012-04-19
申请号：US13295030
申请日：2011-11-11
申请人： Annaliesa Sybil Anderson , Kathrin Ute Jansen , Mark E. Ruppen , Justin Keith Moran , Susan Kay Hoiseth
发明人： Annaliesa Sybil Anderson , Kathrin Ute Jansen , Mark E. Ruppen , Justin Keith Moran , Susan Kay Hoiseth
IPC分类号： A61K39/095 , A61P37/04 , C07K14/22
CPC分类号： A61K39/095 , A61K2039/55505 , A61K2039/55577 , C07K14/22
摘要： The present invention relates to compositions including an isolated non-pyruvylated non-lipidated ORF2086 polypeptide, and methods thereof. In an exemplary embodiment, the compositions described herein are immunogenic. The present invention further relates to compositions that elicit a bactericidal immune response in a mammal against an ORF2086 subfamily B polypeptide from serogroup B Neisseria meningitidis, and methods related thereto.
摘要翻译： 本发明涉及包含分离的非丙酮酸化的非脂化的非脂化ORF2086多肽的组合物及其方法。 在一个示例性实施方案中，本文所述的组合物是免疫原性的。 本发明还涉及在哺乳动物中引起来自血清组B脑膜炎奈瑟氏球菌的ORF2086亚家族B多肽的杀细菌免疫应答的组合物及其相关方法。
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公开(公告)号：US08481692B2
公开(公告)日：2013-07-09
申请号：US13451631
申请日：2012-04-20
申请人： Maninder K. Sidhu , Annaliesa Sybil Anderson , Robert G. K. Donald , Kathrin Ute Jansen , Narender K. Kalyan , Justin Keith Moran , Mark E. Ruppen , Michael James Flint
发明人： Maninder K. Sidhu , Annaliesa Sybil Anderson , Robert G. K. Donald , Kathrin Ute Jansen , Narender K. Kalyan , Justin Keith Moran , Mark E. Ruppen , Michael James Flint
CPC分类号： C07K14/33 , A61K39/08 , C07K16/1282 , C07K2317/33 , C07K2317/76 , C07K2317/92 , C12N9/1051 , C12N9/99 , C12N15/74
摘要： In one aspect, the invention relates to an immunogenic composition that includes a mutant Clostridium difficile toxin A and/or a mutant Clostridium difficile toxin B. Each mutant toxin includes a glucosyltransferase domain having at least one mutation and a cysteine protease domain having at least one mutation, relative to the corresponding wild-type C. difficile toxin. The mutant toxins may further include at least one amino acid that is chemically crosslinked. In another aspect, the invention relates to antibodies or binding fragments thereof that binds to said immunogenic compositions. In further aspects, the invention relates to isolated nucleotide sequences that encode any of the foregoing, and methods of use of any of the foregoing compositions.
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4.发明申请COMPOSITIONS RELATING TO A MUTANT CLOSTRIDIUM DIFFICILE TOXIN AND METHODS THEREOF 有权关于一种突变型脱落孢子虫毒素的组合物及其方法公开(公告)号：US20120269841A1
公开(公告)日：2012-10-25
申请号：US13451631
申请日：2012-04-20
申请人： Maninder K. Sidhu , Annaliesa Sybil Anderson , Robert G. K. Donald , Kathrin Ute Jansen , Narender K. Kalyan , Terri L. Mininni , Justin Keith Moran , Mark E. Ruppen , Michael James Flint
发明人： Maninder K. Sidhu , Annaliesa Sybil Anderson , Robert G. K. Donald , Kathrin Ute Jansen , Narender K. Kalyan , Terri L. Mininni , Justin Keith Moran , Mark E. Ruppen , Michael James Flint
CPC分类号： C07K14/33 , A61K39/08 , C07K16/1282 , C07K2317/33 , C07K2317/76 , C07K2317/92 , C12N9/1051 , C12N9/99 , C12N15/74
摘要： In one aspect, the invention relates to an immunogenic composition that includes a mutant Clostridium difficile toxin A and/or a mutant Clostridium difficile toxin B. Each mutant toxin includes a glucosyltransferase domain having at least one mutation and a cysteine protease domain having at least one mutation, relative to the corresponding wild-type C. difficile toxin. The mutant toxins may further include at least one amino acid that is chemically crosslinked. In another aspect, the invention relates to antibodies or binding fragments thereof that binds to said immunogenic compositions. In further aspects, the invention relates to isolated nucleotide sequences that encode any of the foregoing, and methods of use of any of the foregoing compositions.
摘要翻译： 一方面，本发明涉及包含突变型艰难梭菌毒素A和/或突变型艰难梭菌毒素B的免疫原性组合物。每种突变毒素包括具有至少一个突变的葡糖基转移酶结构域和具有至少一个突变的半胱氨酸蛋白酶结构域 突变，相对于相应的野生型艰难梭菌毒素。 突变毒素还可以包括至少一个化学交联的氨基酸。 在另一方面，本发明涉及结合所述免疫原性组合物的抗体或其结合片段。 在另外的方面，本发明涉及编码前述任何一种的分离的核苷酸序列，以及任何上述组合物的使用方法。
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5.发明申请COMPOSITIONS AND METHODS OF USE OF ORF 554 FROM BETA HEMOLYTIC STREPTOCOCCAL STRAINS 失效ORF 554从BETA HEMOLYTIC STREPTOCOCCAL STRAINS使用的组合物和方法公开(公告)号：US20090318358A1
公开(公告)日：2009-12-24
申请号：US12487765
申请日：2009-06-19
申请人： Ellen Murphy , Emily Mara Braunstein , Dorys Garcia-Hand , Annaliesa Sybil Anderson , Ingrid Lea Dodge , Eduardo Arturo Rojas
发明人： Ellen Murphy , Emily Mara Braunstein , Dorys Garcia-Hand , Annaliesa Sybil Anderson , Ingrid Lea Dodge , Eduardo Arturo Rojas
IPC分类号： A61K38/16 , C07K14/315 , C07H21/04 , C12N15/63 , C12N1/21 , C12N1/19 , C12N5/10 , C12P21/02 , A61P31/00
CPC分类号： A61K39/092 , A61K39/00 , A61K2039/53 , C07K14/315 , Y10S435/975
摘要： The present invention relates to compositions and methods of use comprising peptidyl-prolyl isomerase (PPI) polypeptides of group C and G streptococci and polynucleotides encoding same. The invention also relates to immunogenic compositions comprising the PPI polypeptides and polynucleotides, as well as antibodies and antibody fragments that bind the PPI polypeptides. In addition, the invention relates to methods of inducing an immune response in a subject against beta hemolytic streptococci using the immunogenic compositions, as well as conferring passive immunity by administering a therapeutic antibody or antibody fragment.
摘要翻译： 本发明涉及包含C组和G链球菌的肽基 - 脯氨酰异构酶（PPI）多肽和编码其的多核苷酸的组合物和使用方法。 本发明还涉及包含PPI多肽和多核苷酸以及结合PPI多肽的抗体和抗体片段的免疫原性组合物。 此外，本发明涉及使用免疫原性组合物诱导受试者针对β溶血性链球菌的免疫应答的方法，以及通过施用治疗性抗体或抗体片段赋予被动免疫。
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6.发明申请COMPOSITIONS AND METHODS OF USE OF ORF1358 FROM BETA-HEMOLYTIC STREPTOCOCCAL STRAINS 有权来自BETA-HEMOLYTIC STREPTOCOCCAL菌株的ORF1358的组合物和使用方法公开(公告)号：US20090318359A1
公开(公告)日：2009-12-24
申请号：US12487831
申请日：2009-06-19
申请人： Ellen Murphy , Emily Mara Braunstein , Dorys Garcia-Hand , Annaliesa Sybil Anderson , Ingrid Lea Dodge , Eduardo Arturo Rojas
发明人： Ellen Murphy , Emily Mara Braunstein , Dorys Garcia-Hand , Annaliesa Sybil Anderson , Ingrid Lea Dodge , Eduardo Arturo Rojas
IPC分类号： A61K38/16 , C07K14/00 , C07H21/04 , C12N15/63 , C12N5/10 , A61K31/7088 , C12P21/00 , A61P37/04
CPC分类号： A61K39/092 , A61K2039/53 , C07K14/315 , Y10S435/975
摘要： The present invention relates to polynucleotides encoding Streptococcus group C and G polypeptides and their use in immunogenic compositions. The invention also relates to immunogenic compositions comprising polypeptides encoded by those polynucleotides. In addition, the invention relates to methods of inducing an immune response in mammals against beta hemolytic Streptococcus or beta hemolytic Streptococcus infection using immunogenic compositions of the Streptococcus group C and G polypeptides and polynucleotides.
摘要翻译： 本发明涉及编码链球菌C和G多肽的多核苷酸及其在免疫原性组合物中的用途。 本发明还涉及包含由这些多核苷酸编码的多肽的免疫原性组合物。 此外，本发明涉及使用链球菌C组和G多肽和多核苷酸的免疫原性组合物在哺乳动物中诱导免疫应答的方法，所述免疫应答针对β溶血性链球菌或β-溶血性链球菌感染。
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7.发明授权Compositions and methods of use of ORF-1358 from beta-hemolytic streptococcal strains 有权来自β-溶血性链球菌菌株的ORF-1358的组合物和使用方法公开(公告)号：US08071112B2
公开(公告)日：2011-12-06
申请号：US13028734
申请日：2011-02-16
申请人： Ellen Murphy , Emily Mara Braunstein , Dorys Garcia-Hand , Annaliesa Sybil Anderson , Ingrid Lea Dodge , Eduardo Arturo Rojas
发明人： Ellen Murphy , Emily Mara Braunstein , Dorys Garcia-Hand , Annaliesa Sybil Anderson , Ingrid Lea Dodge , Eduardo Arturo Rojas
IPC分类号： A61K39/09
CPC分类号： A61K39/092 , A61K2039/53 , C07K14/315 , Y10S435/975
摘要： The present invention relates to polynucleotides encoding Streptococcus group C and G polypeptides and their use in immunogenic compositions. The invention also relates to immunogenic compositions comprising polypeptides encoded by those polynucleotides. In addition, the invention relates to methods of inducing an immune response in mammals against beta hemolytic Streptococcus or beta hemolytic Streptococcus infection using immunogenic compositions of the Streptococcus group C and G polypeptides and polynucleotides.
摘要翻译： 本发明涉及编码链球菌C和G多肽的多核苷酸及其在免疫原性组合物中的用途。 本发明还涉及包含由这些多核苷酸编码的多肽的免疫原性组合物。 此外，本发明涉及使用链球菌C组和G多肽和多核苷酸的免疫原性组合物在哺乳动物中诱导免疫应答的方法，所述免疫应答针对β溶血性链球菌或β-溶血性链球菌感染。
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8.发明授权Compositions and methods of use of ORF1358 from beta-hemolytic streptococcal strains 有权来自β-溶血性链球菌菌株的ORF1358的组合物和使用方法公开(公告)号：US07914798B2
公开(公告)日：2011-03-29
申请号：US12487831
申请日：2009-06-19
申请人： Ellen Murphy , Emily Mara Braunstein , Dorys Garcia-Hand , Annaliesa Sybil Anderson , Ingrid Lea Dodge , Eduardo Arturo Rojas
发明人： Ellen Murphy , Emily Mara Braunstein , Dorys Garcia-Hand , Annaliesa Sybil Anderson , Ingrid Lea Dodge , Eduardo Arturo Rojas
IPC分类号： A61K39/09
CPC分类号： A61K39/092 , A61K2039/53 , C07K14/315 , Y10S435/975
摘要： The present invention relates to polynucleotides encoding Streptococcus group C and G polypeptides and their use in immunogenic compositions. The invention also relates to immunogenic compositions comprising polypeptides encoded by those polynucleotides. In addition, the invention relates to methods of inducing an immune response in mammals against beta hemolytic Streptococcus or beta hemolytic Streptococcus infection using immunogenic compositions of the Streptococcus group C and G polypeptides and polynucleotides.
摘要翻译： 本发明涉及编码链球菌C和G多肽的多核苷酸及其在免疫原性组合物中的用途。 本发明还涉及包含由这些多核苷酸编码的多肽的免疫原性组合物。 此外，本发明涉及使用链球菌C组和G多肽和多核苷酸的免疫原性组合物在哺乳动物中诱导免疫应答的方法，所述免疫应答针对β溶血性链球菌或β-溶血性链球菌感染。
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9.发明申请MULTICOMPONENT IMMUNOGENIC COMPOSITION FOR THE PREVENTION OF BETA-HEMOLYTIC STREPTOCOCCAL (BHS) DISEASE 有权多发性免疫组织化学防治抗胆碱酯酶（BHS）疾病公开(公告)号：US20100119534A1
公开(公告)日：2010-05-13
申请号：US12612399
申请日：2009-11-04
申请人： Ingrid Lea Dodge , Eduardo Arturo Rojas , Annaliesa Sybil Anderson , Michael Hagen , Guyanand Singh
发明人： Ingrid Lea Dodge , Eduardo Arturo Rojas , Annaliesa Sybil Anderson , Michael Hagen , Guyanand Singh
CPC分类号： C07K16/1275 , A61K39/00 , A61K39/092 , A61K2039/505 , C07K14/315
摘要： A number of β-hemolytic streptococci polynucleotides and polypeptides, particularly Streptococcus pyogenes polypeptides and polynucleotides, are described. Two or more of the polypeptides of the invention can be formulated for use as immunogenic compositions. Also disclosed are methods for immunizing against and reducing infection caused by β-hemolytic streptococci.
摘要翻译： 描述了许多＆bgr-溶血性链球菌多核苷酸和多肽，特别是化脓性链球菌多肽和多核苷酸。 本发明的多肽中的两种或更多种可配制成用作免疫原性组合物。 还公开了用于免疫抗原并减少由＆amp;溶血性链球菌引起的感染的方法。
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10.发明授权Multicomponent immunogenic composition for the prevention of beta-hemolytic streptococcal (BHS) disease 有权用于预防β-溶血性链球菌（BHS）疾病的多组分免疫原性组合物公开(公告)号：US08563001B2
公开(公告)日：2013-10-22
申请号：US12612399
申请日：2009-11-04
CPC分类号： C07K16/1275 , A61K39/00 , A61K39/092 , A61K2039/505 , C07K14/315
摘要： A number of β-hemolytic streptococci polynucleotides and polypeptides, particularly Streptococcus pyogenes polypeptides and polynucleotides, are described. Two or more of the polypeptides of the invention can be formulated for use as immunogenic compositions. Also disclosed are methods for immunizing against and reducing infection caused by β-hemolytic streptococci.
摘要翻译： 描述了许多β-溶血性链球菌多核苷酸和多肽，特别是化脓性链球菌多肽和多核苷酸。 本发明的多肽中的两种或更多种可配制成用作免疫原性组合物。 还公开了用于免疫抗原并减少由β-溶血性链球菌引起的感染的方法。
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