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    Immunogenic Complexes, Preparation Method Thereof And Use Of Same In Pharmaceutical Compositions
    5.
    发明申请
    Immunogenic Complexes, Preparation Method Thereof And Use Of Same In Pharmaceutical Compositions 审中-公开
    免疫原性复合物及其制备方法及其在药物组合物中的应用

    公开(公告)号：US20080300382A1

    公开(公告)日：2008-12-04

    申请号：US11658173

    申请日：2005-07-25

    申请人： Christine Libon ,  Thien Nguyen

    发明人： Christine Libon ,  Thien Nguyen

    IPC分类号： C07K2/00 ,  C07K1/107 ,  C07K14/135 ,  C07H21/04 ,  C07K5/083

    CPC分类号： C07K14/005 ,  A61K39/00 ,  A61K39/385 ,  A61K2039/6031 ,  C12N2760/18522

    摘要： The invention relates to a method of improving the immunogenicity of an immunogen, antigen or hapten, by means of coupling with a small support peptide. More specifically, the invention relates to a method of preparing an immunogenic complex, as well as the complexes that can be obtained using one such method, and to the use of said complexes as a medicament in order to increase the immunogenicity of an immunogen. The invention comprises, for example, a support peptide which is coupled with a peptide from protein G of the respiratory syncytial virus (RSV) and to the use thereof as a vaccine for the treatment of respiratory infections linked to RSV.

    摘要翻译： 本发明涉及通过与小支持肽偶联来提高免疫原，抗原或半抗原的免疫原性的方法。 更具体地，本发明涉及制备免疫原性复合物的方法，以及可以使用一种这样的方法获得的复合物，以及为了增加免疫原的免疫原性而使用所述复合物作为药物。 本发明包括例如与来自呼吸道合胞病毒（RSV）的蛋白G的肽偶联的支持肽以及作为用于治疗与RSV相关的呼吸道感染的疫苗的用途。

    Immunogenic complexes, preparation method thereof and use of same in pharmaceutical compositions
    7.
    发明申请
    Immunogenic complexes, preparation method thereof and use of same in pharmaceutical compositions 审中-公开
    免疫原性复合物及其制备方法及其在药物组合物中的应用

    公开(公告)号：US20080131450A1

    公开(公告)日：2008-06-05

    申请号：US11976085

    申请日：2007-10-19

    申请人： Christine Libon ,  Thien Nguyen

    发明人： Christine Libon ,  Thien Nguyen

    IPC分类号： A61K39/12 ,  A61K39/00

    CPC分类号： C07K14/005 ,  A61K39/00 ,  A61K39/385 ,  A61K2039/6068 ,  A61K2039/6075 ,  C12N2760/18522

    摘要： The present invention relates to a method of improving the immunogenicity of an immunogen, by means of coupling with a small support peptide. More specifically, the present invention relates to a method of preparing an immunogenic complex, as well as the complexes that can be obtained by one such method, and the use of said complexes as a drug in order to increase the immunogenicity of an immunogen. The invention comprises, for example, a support peptide which is coupled with a peptide from the respiratory syncytial virus (RSV) G protein and the use thereof, alone or comprising as a combination product a RSV F protein or subunit thereof, as a vaccine for the treatment of RSV-related respiratory infections.

    摘要翻译： 本发明涉及通过与小支持肽偶联来提高免疫原的免疫原性的方法。 更具体地，本发明涉及制备免疫原性复合物的方法，以及可以通过一种这样的方法获得的复合物以及所述复合物作为药物的用途，以增加免疫原的免疫原性。 本发明包括例如与来自呼吸道合胞病毒（RSV）G蛋白的肽偶联的支持肽及其单独的或作为RSV F蛋白或其亚基的组合产物包含的用途作为疫苗的疫苗 治疗RSV相关呼吸道感染。