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    Methods for identification, diagnosis, and treatment of breast cancer
    6.
    发明申请
    Methods for identification, diagnosis, and treatment of breast cancer 审中-公开
    乳腺癌鉴别，诊断和治疗方法

    公开(公告)号：US20070218056A1

    公开(公告)日：2007-09-20

    申请号：US11705277

    申请日：2007-02-12

    申请人： Susan Love ,  Julian Nikolchev ,  David Hung

    发明人： Susan Love ,  Julian Nikolchev ,  David Hung

    IPC分类号： A61K39/395

    CPC分类号： A61K49/1812

    摘要： The invention provides methods of identifying premalignant and malignant breast cancer, determining lymph node involvement in patients diagnosed with premalignant and malignant breast cancer growths, and methods of treating premalignant and malignant breast cancer. The diagnostic and methods comprise intraductal administration of a targeting molecule either alone acting as an identifying agent, or coupled to an identifying agent; the therapeutic methods comprise intraductal administration of a targeting molecule coupled to a therapeutic agent or administration of a targeting molecule having therapeutic activity in and of itself.

    摘要翻译： 本发明提供了鉴定癌前期和恶性乳腺癌的方法，确定诊断为恶变前和恶性乳腺癌生长的患者的淋巴结受累，以及治疗癌前期和恶性乳腺癌的方法。 诊断和方法包括单独用作鉴定试剂或偶联至鉴定试剂的靶向分子的导管内施用; 治疗方法包括与治疗剂偶联的靶向分子的管内施用或其本身具有治疗活性的靶向分子的给药。

    Methods and systems for treating breast tissue
    7.
    发明授权
    Methods and systems for treating breast tissue 有权
    用于治疗乳腺组织的方法和系统

    公开(公告)号：US06712816B2

    公开(公告)日：2004-03-30

    申请号：US10144853

    申请日：2002-05-15

    申请人： David Hung ,  Chris Ken ,  Julian Nikolchev ,  Susan Love ,  Shawn O'Leary

    发明人： David Hung ,  Chris Ken ,  Julian Nikolchev ,  Susan Love ,  Shawn O'Leary

    IPC分类号： A61B1818

    CPC分类号： A61B18/00 ,  A61B18/02 ,  A61B18/1485 ,  A61B2018/0212 ,  A61N5/0601 ,  A61N5/062

    摘要： Methods, systems, and kits for treating breast tissue rely on transferring energy to or from cells lining an individual breast duct. Energy can be introduced into the breast duct, e.g., by filling the duct with an electrically conductive medium and applying radiofrequency energy to the medium. Other energy forms could also be used, such as light, ultrasound, radiation, microwave energy, heat, cold, direct current, and the like. By treating individual breast ducts, cancerous and pre-cancerous conditions originating in the duct can be effectively treated.

    摘要翻译： 用于治疗乳腺组织的方法，系统和试剂盒依赖于将能量转移到单独的乳房导管衬里的细胞或从细胞内移出能量。 可以将能量引入到乳房管道中，例如通过用导电介质填充管道并且向介质施加射频能量。 也可以使用其他能量形式，例如光，超声，辐射，微波能量，热，冷，直流电等。 通过治疗个体乳腺导管，可以有效地治疗起源于管道的癌性和癌前病症。

    Devices, methods and systems for collecting material from a breast duct
    8.
    发明申请
    Devices, methods and systems for collecting material from a breast duct 审中-公开
    用于从乳房管收集材料的装置，方法和系统

    公开(公告)号：US20070270708A1

    公开(公告)日：2007-11-22

    申请号：US11880811

    申请日：2007-07-24

    申请人： David Hung ,  Christopher Ken ,  Xuanmin He ,  Phillip Olsen ,  Julian Nikolchev ,  Shawn O'Leary ,  Pam Sayavong

    发明人： David Hung ,  Christopher Ken ,  Xuanmin He ,  Phillip Olsen ,  Julian Nikolchev ,  Shawn O'Leary ,  Pam Sayavong

    IPC分类号： A61B10/02

    CPC分类号： A61B10/02 ,  A61B10/0041 ,  A61B10/0045 ,  A61B10/0283

    摘要： The invention provides methods, devices and systems for collecting breast ductal fluid comprising cellular material and other useful markers for analysis. The methods typically comprise access of at least one breast duct and collecting materials from that duct separate from all other ducts in the breast. The devices comprise ductal access devices that provide the opportunity to collect fluid from a single duct separate from all the other ducts in the breast. The systems employ the methods and devices that used together provide systems for analysis of a breast condition in a patient specific to accessed breast ducts. The methods, devices and systems are particularly useful for indentification of breast precancer or cancer in patient.

    摘要翻译： 本发明提供了用于收集乳腺导管液的方法，装置和系统，包括细胞材料和用于分析的其它有用标记物。 所述方法通常包括进入至少一个乳房导管并从该管道收集与乳房中所有其他导管分开的材料。 这些装置包括导管进入装置，其提供从与乳房中的所有其他导管分开的单个管道收集流体的机会。 系统采用一起使用的方法和装置，其提供用于分析特定于被访问的乳房导管的患者的乳房状况的系统。 方法，装置和系统对于患者中乳腺癌前病变或癌症的鉴别特别有用。

    Devices, methods and systems for collecting material from a breast duct
    9.
    发明授权
    Devices, methods and systems for collecting material from a breast duct 有权
    用于从乳房管收集材料的装置，方法和系统

    公开(公告)号：US06413228B1

    公开(公告)日：2002-07-02

    申请号：US09473510

    申请日：1999-12-28

    申请人： David Hung ,  Christopher G. M. Ken ,  Xuanmin He ,  Phillip M. Olsen ,  Julian Nikolchev ,  Shawn O'Leary ,  Pam Sayavong

    发明人： David Hung ,  Christopher G. M. Ken ,  Xuanmin He ,  Phillip M. Olsen ,  Julian Nikolchev ,  Shawn O'Leary ,  Pam Sayavong

    IPC分类号： A61B1000

    CPC分类号： A61M3/0279 ,  A61B10/0041 ,  A61B10/0045 ,  A61M3/0262 ,  A61M2210/1007 ,  G01N33/57415

    摘要： The invention provides methods, devices and systems for collecting breast ductal fluid comprising cellular material and other useful markers for analysis. The methods typically comprise access of at least one breast duct and collecting materials from that duct separate from all other ducts in the breast. The devices comprise ductal access devices that provide the opportunity to collect fluid from a single duct separate from all the other ducts in the breast. The systems employ the methods and devices that used together provide systems for analysis of a breast condition in a patient specific to accessed breast ducts. The methods, devices and systems are particularly useful for indentification of breast precancer or cancer in patient.

    摘要翻译： 本发明提供了用于收集乳腺导管液的方法，装置和系统，包括细胞材料和用于分析的其它有用标记物。 所述方法通常包括进入至少一个乳房导管并从该管道收集与乳房中所有其他导管分开的材料。 这些装置包括导管进入装置，其提供从与乳房中的所有其他导管分开的单个管道收集流体的机会。 系统采用一起使用的方法和装置，其提供用于分析特定于被访问的乳房导管的患者的乳房状况的系统。 方法，装置和系统对于患者中乳腺癌前病变或癌症的鉴别特别有用。

    Devices and methods to identify ductal orifices during nipple aspiration
    10.
    发明授权
    Devices and methods to identify ductal orifices during nipple aspiration 有权
    在乳头抽吸期间识别导管孔的装置和方法

    公开(公告)号：US06328709B1

    公开(公告)日：2001-12-11

    申请号：US09438219

    申请日：1999-11-12

    申请人： David Hung ,  Susan M. Love ,  Julian Nikolchev ,  William R. George

    发明人： David Hung ,  Susan M. Love ,  Julian Nikolchev ,  William R. George

    IPC分类号： A61M106

    CPC分类号： A61B5/4312 ,  A61B5/0091 ,  A61B5/444 ,  A61B10/0041 ,  A61B2090/3616 ,  A61B2090/395 ,  A61M1/06 ,  A61M1/064 ,  A61M1/08 ,  A61M2205/583

    摘要： Devices, methods and kits for identifying a breast milk duct orifice capable of yielding fluid or releasing a keratin plug under a vacuum are described and claimed. The devices include a magnification lens integral to a nipple aspiration device or a nipple aspiration device having an attachment element for attaching a magnification tool to aid the practitioner to better observe a nipple surface under a vacuum. The devices also can include one or more access ports for such purposes as accessing the duct, marking the duct, or collecting fluid from the duct. The methods of nipple aspiration comprise identifying a duct that yields fluid or releases a keratin plug under a vacuum. The kits can comprise a device of the invention, a container for the kit contents, and instructions.

    摘要翻译： 描述并要求保护用于识别能够产生流体或在真空下释放角蛋白塞的母乳管孔的装置，方法和试剂盒。 这些装置包括与乳头抽吸装置成一体的放大透镜或具有用于附接放大工具的附接元件的乳头抽吸装置，以帮助从业者在真空下更好地观察乳头表面。 这些装置还可以包括一个或多个访问端口，用于诸如访问管道，标记管道或从管道收集流体的目的。 乳头抽吸的方法包括鉴定在真空下产生流体或释放角蛋白塞的管道。 试剂盒可以包括本发明的装置，用于试剂盒内容物的容器和说明书。