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37 条记录 (耗时 0.049 秒)

    Renin inhibitors, method for using them, and compositions containing them
    1.
    发明授权
    Renin inhibitors, method for using them, and compositions containing them 失效
    肾素抑制剂，使用它们的方法和含有它们的组合物

    公开(公告)号：US5063207A

    公开(公告)日：1991-11-05

    申请号：US384236

    申请日：1989-07-24

    申请人： Annette M. Doherty ,  Harriet W. Hamilton ,  John C. Hodges ,  Joseph T. Repine ,  Ila Sircar

    发明人： Annette M. Doherty ,  Harriet W. Hamilton ,  John C. Hodges ,  Joseph T. Repine ,  Ila Sircar

    IPC分类号： C07K5/02

    CPC分类号： C07K5/0227

    摘要： The invention concerns novel renin-inhibitory peptides which are useful for treating renin-associated hypertension, congestive heart failure, hyperaldosteronism and diseases caused by retroviruses including HTLV-I and -III. Processes for preparing the peptides, novel intermediates useful in the preparation thereof, compositions containing them, and methods of using them are included. Also included is a diagnostic method which uses the compounds to determine the presence of renin-associated hypertension, congestive heart failure, or hyperaldosteronism.

    摘要翻译： 本发明涉及可用于治疗肾素相关性高血压，充血性心力衰竭，醛固酮增多症和由逆转录病毒（包括HTLV-1和-III）引起的疾病的新型肾素抑制肽。 制备肽的方法，可用于其制备的新型中间体，含有它们的组合物及其使用方法。 还包括使用该化合物来确定肾素相关性高血压，充血性心力衰竭或醛固酮增多症的存在的诊断方法。

    Renin inhibitors, processes for preparing them, methods for using them, and compositions containing them
    2.
    发明授权
    Renin inhibitors, processes for preparing them, methods for using them, and compositions containing them 失效
    肾素抑制剂，其制备方法，使用方法和含有它们的组合物

    公开(公告)号：US5288851A

    公开(公告)日：1994-02-22

    申请号：US925702

    申请日：1992-08-04

    申请人： Annette M. Doherty ,  Harriet W. Hamilton ,  John C. Hodges ,  Joseph T. Repine ,  Ila Sircar

    发明人： Annette M. Doherty ,  Harriet W. Hamilton ,  John C. Hodges ,  Joseph T. Repine ,  Ila Sircar

    IPC分类号： C07K5/02 ,  A61K37/02 ,  C07K5/00

    CPC分类号： C07K5/0227

    摘要： The invention concerns novel renin-inhibitory peptides which are useful for treating renin-associated hypertension, congestive heart failure, hyperaldosteronism and diseases caused by retroviruses including HTLV-I and -III. Processes for preparing the peptides, novel intermediates useful in the preparation thereof, compositions containing them, and methods of using them are included. Also included is a diagnostic method which uses the compounds to determine the presence of renin-associated hypertension, congestive heart failure, or hyperaldosteronism.

    摘要翻译： 本发明涉及可用于治疗肾素相关性高血压，充血性心力衰竭，醛固酮增多症和由逆转录病毒（包括HTLV-1和-III）引起的疾病的新型肾素抑制肽。 制备肽的方法，可用于其制备的新型中间体，含有它们的组合物及其使用方法。 还包括使用该化合物来确定肾素相关性高血压，充血性心力衰竭或醛固酮增多症的存在的诊断方法。

    Renin inhibitors, processes for preparing them, methods for using them, and compositions containing them
    3.
    发明授权
    Renin inhibitors, processes for preparing them, methods for using them, and compositions containing them 失效
    肾素抑制剂，其制备方法，使用方法和含有它们的组合物

    公开(公告)号：US5162527A

    公开(公告)日：1992-11-10

    申请号：US676047

    申请日：1991-03-27

    申请人： Annette M. Doherty ,  Harriet W. Hamilton ,  John C. Hodges ,  Joseph T. Repine ,  Ila Sircar

    发明人： Annette M. Doherty ,  Harriet W. Hamilton ,  John C. Hodges ,  Joseph T. Repine ,  Ila Sircar

    IPC分类号： C07K5/02

    CPC分类号： C07K5/0227

    摘要： The invention concerns novel renin-inhibitory peptides which are useful for treating renin-associated hypertension, congestive heart failure, hyperaldosteronism and diseases caused by retroviruses including HTLV-I and -III. Processes for preparing the peptides, novel intermediates useful in the preparation thereof, compositions containing them, and methods of using them are included. Also included is a diagnostic method which uses the compounds to determine the presence of renin-associated hypertension, congestive heart failure, or hyperaldosteronism.

    摘要翻译： 本发明涉及可用于治疗肾素相关性高血压，充血性心力衰竭，醛固酮增多症和由逆转录病毒（包括HTLV-1和-III）引起的疾病的新型肾素抑制肽。 制备肽的方法，可用于其制备的新型中间体，含有它们的组合物及其使用方法。 还包括使用该化合物来确定肾素相关性高血压，充血性心力衰竭或醛固酮增多症的存在的诊断方法。

    Amino acid derivatives with angiotensin II antagonist properties
    6.
    发明授权
    Amino acid derivatives with angiotensin II antagonist properties 失效
    具有血管紧张素II拮抗剂性质的氨基酸衍生物

    公开(公告)号：US5041552A

    公开(公告)日：1991-08-20

    申请号：US529071

    申请日：1990-05-25

    申请人： John C. Hodges ,  Ila Sircar

    发明人： John C. Hodges ,  Ila Sircar

    IPC分类号： C07D233/68 ,  C07D249/08 ,  C07D249/12

    CPC分类号： C07D233/68 ,  C07D249/12

    摘要： This invention relates to novel amino acid derivatives which antagonize the binding of angiotensin II to its receptors. The compounds are useful in the treatment of hypertension, heart failure, glaucoma, and hyperaldosteronism. Methods of making the compounds, novel intermediates useful in the separation of the compounds, compositions containing the compounds and methods of using them are also covered.

    摘要翻译： 本发明涉及拮抗血管紧张素II与其受体结合的新型氨基酸衍生物。 该化合物可用于治疗高血压，心力衰竭，青光眼和醛固酮增多症。 制备化合物的方法，可用于分离化合物的新中间体，含有该化合物的组合物和使用它们的方法也被覆盖。

    Combined application of full color patterns to square paper napkins, that once folded, create napkins in 3D color images resembling the entity the napkin or origami fold is named for.
    9.
    发明申请
    Combined application of full color patterns to square paper napkins, that once folded, create napkins in 3D color images resembling the entity the napkin or origami fold is named for. 审中-公开
    将全彩色图案组合应用于方形餐巾纸，一旦折叠，就可以在类似于餐巾纸或折纸折叠的实体的3D彩色图像中创建餐巾。

    公开(公告)号：US20140072713A1

    公开(公告)日：2014-03-13

    申请号：US14015761

    申请日：2013-08-30

    申请人： John C. Hodges

    发明人： John C. Hodges

    IPC分类号： G09B19/00

    CPC分类号： B32B9/06 ,  B05D3/12 ,  B05D5/06 ,  B05D2203/22 ,  B31D1/04 ,  B31D5/00 ,  B31D5/04 ,  B32B1/00 ,  B32B29/00 ,  G09B19/00

    摘要： A method for creating new educational, and theme party products in the form of full color 3D paper napkin entities that resemble the color image likeness the entity that the napkin fold or origami fold is named for. By combining color napkin or origami patterns applied to the art or industry medium of square paper napkins or serviettes with the intention of matching the pattern to the like named fold or origami fold, creates a fun challenge to the individual folder to achieve the correct folded outcome. The paper napkins are both functional for everyday use, and are folding fun for seasonal & theme parties, birthdays, and are educational as they stimulate conversation and the creative mind while folding.

    摘要翻译： 创造新的教育和主题派对产品，以全彩3D纸巾实体的形式，类似于餐巾折叠或折纸折叠的实体的颜色图像。 通过将应用于方形餐巾纸或餐巾的艺术品或工业介质的彩色餐巾或折纸图案与将图案匹配为折叠或折纸折叠的方式相结合，为个人文件夹创造有趣的挑战，以实现正确的折叠结果 。 餐巾纸既可以日常使用，也可以为季节性和主题派对，生日而折腾，也可以在教育时激发对话和创意，同时折叠。

    METHOXATIN DERIVATIVES
    10.
    发明申请
    METHOXATIN DERIVATIVES 失效
    甲氧基衍生物

    公开(公告)号：US20110152526A1

    公开(公告)日：2011-06-23

    申请号：US12646234

    申请日：2009-12-23

    申请人： John C. Hodges

    发明人： John C. Hodges

    IPC分类号： C07D491/20 ,  C07D471/04

    CPC分类号： C07D471/04 ,  C07D491/20

    摘要： The present invention provides for compounds of Formula I and II: wherein y, X, Y, Z, R1, and R2 have any of the values defined there for in the specification. The compounds of formula I are useful as reagents in the isolation and the assay of PQQ dependent enzymes. Also provided are compositions comprising compounds of Formula I and II.

    摘要翻译： 本发明提供式I和II的化合物：其中y，X，Y，Z，R 1和R 2具有说明书中定义的任何值。 式I的化合物可用作PQQ依赖性酶的分离和测定中的试剂。 还提供了包含式I和II化合物的组合物。