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公开(公告)号：US5024994A
公开(公告)日：1991-06-18
申请号：US233320
申请日：1988-08-17
申请人： Annette M. Doherty , James P. Hudspeth , James S. Kaltenbronn , Joseph T. Repine , William H. Roark , Ila Sircar , Francis J. Tinney
发明人： Annette M. Doherty , James P. Hudspeth , James S. Kaltenbronn , Joseph T. Repine , William H. Roark , Ila Sircar , Francis J. Tinney
IPC分类号： C07K5/02
CPC分类号： C07K5/0227 , C07K5/0205
摘要： The invention concerns novel renin-inhibitory peptides which are useful for treating renin-assocated hypertension, hyperaldosteronism, and congestive heart failure. Processes for preparing the peptides, compositions containing them and methods of using them are included. Also included is a diagnostic method which uses the compounds to determine the presence of renin-associated hypertension or hyperaldosteronism.
摘要翻译： 本发明涉及可用于治疗肾素合成的高血压，醛固酮增多症和充血性心力衰竭的新型肾素抑制肽。 包括肽的制备方法，含有它们的组合物和使用它们的方法。 还包括使用该化合物来确定肾素相关性高血压或醛固酮增多症的存在的诊断方法。
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公开(公告)号：US4743585A
公开(公告)日：1988-05-10
申请号：US920330
申请日：1986-11-21
申请人： James P. Hudspeth , James S. Kaltenbronn , Elizabeth A. Lunney , Joseph T. Repine , W. Howard Roark , Michael A. Stier , Francis J. Tinney , Peter W. K. Woo , Ernest D. Nicolaides
发明人： James P. Hudspeth , James S. Kaltenbronn , Elizabeth A. Lunney , Joseph T. Repine , W. Howard Roark , Michael A. Stier , Francis J. Tinney , Peter W. K. Woo , Ernest D. Nicolaides
CPC分类号： C07K5/0227 , C07K5/0205 , C07K5/0207 , Y10S530/86 , Y10S930/27
摘要： The invention concerns novel renin-inhibitory peptides which are useful for treating renin associated hypertension and for treating hyperaldosteronism. Novel intermediates, processes for preparing both the intermediates and the novel peptides, pharmaceutical compositions, and methods of treatment are included.
摘要翻译： 本发明涉及可用于治疗肾素相关性高血压和治疗醛固酮增多症的新型肾素抑制肽。 包括新的中间体，制备中间体和新型肽的方法，药物组合物和治疗方法。
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公开(公告)号：US5034512A
公开(公告)日：1991-07-23
申请号：US226873
申请日：1988-08-03
IPC分类号： C07D233/54 , C07K5/02
CPC分类号： C07D233/64 , C07K5/0205 , C07K5/0227
摘要： The invention concerns a novel series of renin-inhibitory branched-backbone peptides which are useful for treating renin associated hypertension, congestive heart failure, and hyperaldosteronism. Processes for preparing the peptides, compositions containing them and methods of using them are included. Also included is a diagnostic test using the compounds to determine the presence of renin-associated hypertension, congestive heart failure, or hyperaldosteronism.
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公开(公告)号：US4895834A
公开(公告)日：1990-01-23
申请号：US113277
申请日：1987-11-02
申请人： James P. Hudspeth , James S. Kaltenbronn , Joseph T. Repine , William H. Roark , Michael A. Stier
发明人： James P. Hudspeth , James S. Kaltenbronn , Joseph T. Repine , William H. Roark , Michael A. Stier
IPC分类号： C07D213/56 , C07D233/54 , C07D233/64 , C07D401/12 , C07K5/08
CPC分类号： C07D233/64 , C07D213/56 , C07D401/12 , Y10S530/86
摘要： The invention concerns novel renin-inhibitory peptides which are useful for treating renin associated hypertension, hyperaldosternoism, and congestive heart failure. Processes for preparing the peptides, compositions containing them and methods of using them are included. Also included is a diagnostic test using the compounds to determine the presence of renin-associated hypertension or hyperaldosteronism.
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公开(公告)号：US5260278A
公开(公告)日：1993-11-09
申请号：US678469
申请日：1991-04-01
申请人： Richard Himmelsbach , John C. Hodges , James S. Kaltenbronn , William C. Patt , Joseph T. Repine , Ila Sircar
发明人： Richard Himmelsbach , John C. Hodges , James S. Kaltenbronn , William C. Patt , Joseph T. Repine , Ila Sircar
IPC分类号： A61K38/00 , C07D233/54 , C07K5/065 , A61K37/02 , C07D265/30 , C07D295/26 , C07K5/06
CPC分类号： C07D233/64 , C07K5/06078 , A61K38/00 , Y10S530/86
摘要： The invention concerns novel renin-inhibitory peptides which are useful for treating renin-associated hypertension, congestive heart failure, hyperaldosteronism, and diseases caused by retroviruses including HTLV-I and -III. Processes for preparing the peptides, compositions containing them, and methods of using them are included. Also included is a diagnostic method which uses the compounds to determine the presence of renin-associated hypertension, or hyperaldosteronism.
摘要翻译： 本发明涉及可用于治疗肾素相关性高血压，充血性心力衰竭，醛固酮增多症和由逆转录病毒（包括HTLV-1和-III）引起的疾病的新型肾素抑制肽。 包括肽的制备方法，含有它们的组合物和使用它们的方法。 还包括使用该化合物来确定肾素相关性高血压或醛固酮增多症的存在的诊断方法。
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公开(公告)号：US4596819A
公开(公告)日：1986-06-24
申请号：US573233
申请日：1984-01-23
申请人： Ernest D. Nicolaides , Francis J. Tinney , James S. Kaltenbronn , Dana E. DeJohn , Elizabeth A. Lunney , W. Howard Roark , Joseph T. Repine
发明人： Ernest D. Nicolaides , Francis J. Tinney , James S. Kaltenbronn , Dana E. DeJohn , Elizabeth A. Lunney , W. Howard Roark , Joseph T. Repine
IPC分类号： C07D203/20 , C07D207/08 , C07D207/09 , C07D207/16 , C07D207/26 , C07D207/277 , C07D207/28 , C07D207/48 , C07D213/81 , C07D241/08 , C07D265/32 , C07D333/38 , C07D403/12 , C07D498/04 , C07K5/06 , C07K5/068 , A61K31/34 , C07D207/12
CPC分类号： C07D207/08 , C07D203/20 , C07D207/09 , C07D207/16 , C07D207/277 , C07D207/28 , C07D207/48 , C07D213/81 , C07D241/08 , C07D265/32 , C07D333/38 , C07D403/12 , C07K5/06043 , C07K5/06086 , Y10S930/15
摘要： Modified oxytocin-vasopressin di- or tri-peptides wherein an amide group is replaced by a group selected from ##STR1## --CH.sub.2 NH--, --CH.sub.2 O--, --CH.sub.2 S--, --CH.sub.2 SO--, --CH.sub.2 SO.sub.2 --, --CH.sub.2 CH.sub.2 -- and --CH.dbd.CH-- are described as well as methods for their manufacture, pharmaceutical compositions and methods for treatment, especially of cognitive disorders, depression, morphine dependency and parkinsonism by adjunctive therapy.
摘要翻译： 改性催产素 - 加压素二或三肽，其中酰胺基被选自下组的基团替代：-CH 2 NH - ， - CH 2 O - ， - CH 2 S - ， - CH 2 SO - ， - CH 2 SO 2 - ， - CH 2 CH 2 - 和-CH 描述了它们的制备方法，药物组合物和治疗方法，特别是认知障碍，抑郁症，吗啡依赖性和帕金森综合征的辅助治疗方法。
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公开(公告)号：US5036053A
公开(公告)日：1991-07-30
申请号：US321638
申请日：1989-03-15
申请人： Richard Himmelsbach , John C. Hodges , James S. Kaltenbronn , William C. Patt , Joseph T. Repine , Ila Sircar
发明人： Richard Himmelsbach , John C. Hodges , James S. Kaltenbronn , William C. Patt , Joseph T. Repine , Ila Sircar
IPC分类号： A61K31/16 , A61K31/18 , A61K31/27 , A61K31/40 , A61K31/445 , A61K31/495 , A61K31/535 , A61K31/5375 , A61K38/00 , A61K38/55 , A61P5/38 , A61P9/00 , A61P9/12 , A61P43/00 , C07D207/16 , C07D233/54 , C07D295/18 , C07D295/22 , C07D333/34 , C07K1/02 , C07K1/113 , C07K5/06 , C07K5/065 , C07K5/08 , C07K14/81
CPC分类号： C07D233/64 , C07K5/06078 , A61K38/00
摘要： The invention concerns novel renin-inhibitory peptides which are useful for treating renin-associated hypertension, congestive heart failure, hyperaldosteronism, and diseases caused by retroviruses including HTLV-I and -III. Processes for preparing the peptides, composition containing them, and methods of using them are included. Also included is a diagnostic method which uses the compounds to determine the presence of renin-associated hypertensions, or hyperaldosteronism.
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公开(公告)号：US4863905A
公开(公告)日：1989-09-05
申请号：US11990
申请日：1987-02-04
IPC分类号： C07K5/02
CPC分类号： C07K5/0227 , C07K5/0207 , Y10S530/86
摘要： The invention concerns novel renin-inhibiting peptides which are modified as isosteres. These peptides are useful for treating renin-associated hypertension and hyperaldosteronism. Processes for preparing the peptides, compositions containing them and methods for using them are included. Also included is a diagnostic test using the peptides to determine the presence of renin-associated hypertension or hyperaldosteronism.
摘要翻译： 本发明涉及被修饰为等位基因的新型肾素抑制肽。 这些肽可用于治疗肾素相关性高血压和醛固酮增多症。 包括肽的制备方法，含有它们的组合物和使用它们的方法。 还包括使用肽来确定肾素相关性高血压或醛固酮增多症的存在的诊断测试。
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公开(公告)号：US4735933A
公开(公告)日：1988-04-05
申请号：US941966
申请日：1986-12-15
申请人： James P. Hudspeth , James S. Kaltenbronn , Joseph T. Repine , W. Howard Roark , Michael A. Stier
发明人： James P. Hudspeth , James S. Kaltenbronn , Joseph T. Repine , W. Howard Roark , Michael A. Stier
IPC分类号： A61K38/51 , A61K31/165 , A61K31/215 , A61K31/415 , A61P5/38 , A61P9/00 , A61P9/12 , A61P43/00 , C07C67/00 , C07C231/00 , C07C237/12 , C07C237/14 , C07C237/20 , C07C237/22 , C07C239/00 , C07C269/00 , C07C279/28 , C07C279/32 , C07C313/00 , C07C315/02 , C07C317/28 , C07C323/41 , C07C323/60 , C07D213/56 , C07D233/54 , C07D401/12 , C07K1/06 , C07K1/113 , C07K5/06 , C07K14/81 , A61K37/43 , C07K5/08
CPC分类号： C07D233/64 , C07D213/56 , C07D401/12 , Y10S530/86
摘要： The invention concerns novel renin-inhibitory peptides which are useful for treating renin associated hypertension and hyperaldosteronism. Processes for preparing the peptides, compositions containing them and methods of using them are included. Also included is a diagnostic test using the compounds to determine the presence of renin-associated hypertension or hyperaldosteronism.
摘要翻译： 本发明涉及可用于治疗肾素相关性高血压和醛固酮增多症的新型肾素抑制肽。 包括肽的制备方法，含有它们的组合物和使用它们的方法。 还包括使用化合物来确定肾素相关性高血压或醛固酮增多症的存在的诊断测试。
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公开(公告)号：US5036054A
公开(公告)日：1991-07-30
申请号：US200444
申请日：1988-06-06
IPC分类号： C07C233/51 , C07C237/22 , C07C271/22 , C07C317/50 , C07C323/59 , C07C323/60 , C07C335/08 , C07D295/26 , C07K5/02
CPC分类号： C07D295/26 , C07C233/51 , C07C237/22 , C07C271/22 , C07C317/50 , C07C323/59 , C07C323/60 , C07C335/08 , C07K5/0205 , C07K5/0227
摘要： The invention concerns novel renin-inhibitory peptides which contain novel amino acids having an .alpha.-heteroatom attached to the backbone of the amino acid. These novel amino acids are positioned at the P.sub.2 position of the peptide. These are useful for treating renin-associated hypertension, hyperaldosteronism, and congestive heart failure. Processes for preparing the peptides, compositions containing them and methods of using them are included. Novel intermediates are also disclosed. Also included is a diagnostic method which uses the compounds to determine the presence of renin-associated hypertension or hyperaldosteronism.
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