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公开(公告)号：US08728463B2
公开(公告)日：2014-05-20
申请号：US11373046
申请日：2006-03-10
申请人： Anthony Atala , James Yoo , Grace Lim , Sang Jin Lee
发明人： Anthony Atala , James Yoo , Grace Lim , Sang Jin Lee
IPC分类号： A01N63/00
CPC分类号： A61F2/28 , A61K35/32 , A61K35/34 , A61K38/18 , A61L27/3604 , A61L27/3817 , A61L27/3821 , A61L27/3826 , A61L27/383 , A61L27/3891 , A61L27/48 , A61L27/56 , A61L27/58 , A61L2430/02
摘要： The invention pertains to methods of producing artificial composite tissue constructs that permit coordinated motion. Biocompatable structural matrices having sufficient rigidity to provide structural support for cartilage-forming cells and bone-forming cells are used. Biocompatable flexible matrices seeded with muscle cells are joined to the structural matrices to produce artificial composite tissue constructs that are capable of coordinated motion.
摘要翻译： 本发明涉及生产允许协调运动的人造复合组织结构的方法。 使用具有足够刚性以提供软骨形成细胞和骨形成细胞的结构支持的生物相容性结构基质。 用肌肉细胞接种的生物相容的柔性基质连接到结构基质上以产生能够协调运动的人造复合组织构建体。
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公开(公告)号：US09694055B2
公开(公告)日：2017-07-04
申请号：US12991811
申请日：2009-05-11
申请人： James Yoo , Sang Jin Lee , Mark Van Dyke , Anthony Atala
发明人： James Yoo , Sang Jin Lee , Mark Van Dyke , Anthony Atala
CPC分类号： A61K38/39 , A61K9/0024 , A61K38/4886 , A61L27/24 , A61L27/52 , A61L27/54 , A61L2300/41 , A61L2300/434 , A61L2400/06 , A61L2430/26 , A61K2300/00
摘要： The invention is directed to methods of inducing cell recruitment and tissue regeneration at a target site in a subject. It is also based, in part, on the discovery that a subject's own biologic resources and environmental conditions can be used for in situ tissue regeneration and thereby reduce or eliminate the need for donor cell procurement and ex vivo manipulation of such donor cells. Methods are disclosed for recruitment of a subject's own stem cells to a target region by inducing a sustained positive pressure at a target site, such as the kidney, thereby increasing the number of pluripotent cells capable of differentiating to regenerate the target tissue.
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公开(公告)号：US20110097379A1
公开(公告)日：2011-04-28
申请号：US12991811
申请日：2009-05-11
申请人： James Yoo , Sang Jin Lee , Mark Van Dyke , Anthony Atala
发明人： James Yoo , Sang Jin Lee , Mark Van Dyke , Anthony Atala
IPC分类号： A61K9/00 , A61K38/39 , A61K38/43 , A61K38/18 , A61K38/48 , A61P13/12 , A61K47/30 , A61K31/573
CPC分类号： A61K38/39 , A61K9/0024 , A61K38/4886 , A61L27/24 , A61L27/52 , A61L27/54 , A61L2300/41 , A61L2300/434 , A61L2400/06 , A61L2430/26 , A61K2300/00
摘要： The invention is directed to methods of inducing cell recruitment and tissue regeneration at a target site in a subject. It is also based, in part, on the discovery that a subject's own biologic resources and environmental conditions can be used for in situ tissue regeneration and thereby reduce or eliminate the need for donor cell procurement and ex vivo manipulation of such donor cells. Methods are disclosed for recruitment of a subject's own stem cells to a target region by inducing a sustained positive pressure at a target site, such as the kidney, thereby increasing the number of pluripotent cells capable of differentiating to regenerate the target tissue.
摘要翻译： 本发明涉及在受试者的靶位点诱导细胞募集和组织再生的方法。 它也部分地基于发现一个受试者自己的生物资源和环境条件可用于原位组织再生，从而减少或消除对供体细胞采购和离体操作这种供体细胞的需要。 公开了通过在目标部位（例如肾）处诱导持续的正压来将受试者自己的干细胞募集到靶区域的方法，从而增加能够分化以再生靶组织的多能细胞的数量。
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公开(公告)号：US07531503B2
公开(公告)日：2009-05-12
申请号：US11084350
申请日：2005-03-18
申请人： Anthony Atala , James Yoo , Grace Lim , Richard Czerw , Shay Soker , Joel Stitzel
发明人： Anthony Atala , James Yoo , Grace Lim , Richard Czerw , Shay Soker , Joel Stitzel
CPC分类号： A61K49/18 , A61K38/00 , A61K41/0042 , A61K47/6923 , A61L27/26 , A61L27/507 , A61L27/54 , A61L2400/12 , B82Y5/00 , B82Y10/00 , Y10S977/906 , C08L67/04
摘要： The invention is directed to methods and compositions for preparing matrices for controlled delivery of at least one therapeutic or biological agent to a target site in a subject. This is accomplished using nanoparticles coupled to the therapeutic or biological agent that are incorporated within the matrix or reacted on the surface of the matrix.
摘要翻译： 本发明涉及用于制备用于受控递送至少一种治疗或生物剂到受试者的靶位点的基质的方法和组合物。 这是使用与治疗或生物试剂偶联的纳米颗粒完成的，所述纳米颗粒结合到基质中或在基质的表面上反应。
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公开(公告)号：US20060204539A1
公开(公告)日：2006-09-14
申请号：US11083853
申请日：2005-03-18
申请人： Anthony Atala , James Yoo , Grace Lim , Richard Czerw , Shay Soker , Joel Stitzel
发明人： Anthony Atala , James Yoo , Grace Lim , Richard Czerw , Shay Soker , Joel Stitzel
IPC分类号： A61F2/02
CPC分类号： D01D5/0007 , C12N5/0691 , C12N2533/40 , C12N2533/54 , D01F4/00 , D01F6/92
摘要： The invention is directed to compositions and methods for preparing electrospun matrices comprising at least one natural biological material component and at least one synthetic polymer material. The natural component makes the matrices highly biocompatible while the molecular weight polymer component can impart additional strength mechanical strength to the scaffold and/or improve ease of manufacture by increasing viscosity and spinning characteristics of the solution during electrospining.
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公开(公告)号：US20060204445A1
公开(公告)日：2006-09-14
申请号：US11083602
申请日：2005-03-18
申请人： Anthony Atala , Shay Soker , James Yoo , Joel Stitzel , Richard Czerw , Grace Lim
发明人： Anthony Atala , Shay Soker , James Yoo , Joel Stitzel , Richard Czerw , Grace Lim
CPC分类号： A61L27/54 , A61K41/0042 , A61K47/6923 , A61K49/18 , A61L27/047 , A61L27/26 , A61L27/50 , A61L27/507 , A61L2300/44 , C08L89/06
摘要： The invention is directed to methods and compositions for monitoring remodeling of an artificial tissue construct using image or contrast enhancing agents. The invention allows the growth, development, and remodeling of the artificial tissue to be monitored.
摘要翻译： 本发明涉及使用图像或对比度增强剂监测人造组织构建体的重塑的方法和组合物。 本发明允许监测人造组织的生长，发育和重塑。
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公开(公告)号：US20060204441A1
公开(公告)日：2006-09-14
申请号：US11084350
申请日：2005-03-18
申请人： Anthony Atala , James Yoo , Grace Lim , Richard Czerw , Shay Soker , Joel Stitzel
发明人： Anthony Atala , James Yoo , Grace Lim , Richard Czerw , Shay Soker , Joel Stitzel
IPC分类号： A61K49/00 , A61K38/19 , A61K38/18 , A61K31/727
CPC分类号： A61K49/18 , A61K38/00 , A61K41/0042 , A61K47/6923 , A61L27/26 , A61L27/507 , A61L27/54 , A61L2400/12 , B82Y5/00 , B82Y10/00 , Y10S977/906 , C08L67/04
摘要： The invention is directed to methods and compositions for preparing matrices for controlled delivery of at least one therapeutic or biological agent to a target site in a subject. This is accomplished using nanoparticles coupled to the therapeutic or biological agent that are incorporated within the matrix or reacted on the surface of the matrix.
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公开(公告)号：US09163331B2
公开(公告)日：2015-10-20
申请号：US12621052
申请日：2009-11-18
申请人： Anthony Atala , James Yoo , Grace Lim , Richard Czerw , Shay Soker , Joel Stitzel
发明人： Anthony Atala , James Yoo , Grace Lim , Richard Czerw , Shay Soker , Joel Stitzel
CPC分类号： D01D5/0007 , C12N5/0691 , C12N2533/40 , C12N2533/54 , D01F4/00 , D01F6/92
摘要： The invention is directed to compositions and methods for preparing electrospun matrices comprising at least one natural biological material component and at least one synthetic polymer material. The natural component makes the matrices highly biocompatible while the molecular weight polymer component can impart additional strength mechanical strength to the scaffold and/or improve ease of manufacture by increasing viscosity and spinning characteristics of the solution during electrospining.
摘要翻译： 本发明涉及用于制备包含至少一种天然生物材料组分和至少一种合成聚合物材料的电纺丝基质的组合物和方法。 天然组分使得基质高度生物相容，而分子量聚合物组分可以赋予支架额外的强度机械强度和/或通过在电纺丝期间增加溶液的粘度和纺丝特性来改善制造的容易性。
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公开(公告)号：US20100129450A1
公开(公告)日：2010-05-27
申请号：US12621052
申请日：2009-11-18
申请人： Anthony Atala , James Yoo , Grace Lim , Richard Czerw , Shay Soker , Joel Stitzel
发明人： Anthony Atala , James Yoo , Grace Lim , Richard Czerw , Shay Soker , Joel Stitzel
CPC分类号： D01D5/0007 , C12N5/0691 , C12N2533/40 , C12N2533/54 , D01F4/00 , D01F6/92
摘要： The invention is directed to compositions and methods for preparing electrospun matrices comprising at least one natural biological material component and at least one synthetic polymer material. The natural component makes the matrices highly biocompatible while the molecular weight polymer component can impart additional strength mechanical strength to the scaffold and/or improve ease of manufacture by increasing viscosity and spinning characteristics of the solution during electrospining.
摘要翻译： 本发明涉及用于制备包含至少一种天然生物材料组分和至少一种合成聚合物材料的电纺丝基质的组合物和方法。 天然组分使得基质高度生物相容，而分子量聚合物组分可以赋予支架额外的强度机械强度和/或通过在电纺丝期间增加溶液的粘度和纺丝特性来改善制造的容易性。
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公开(公告)号：US20060257377A1
公开(公告)日：2006-11-16
申请号：US11373046
申请日：2006-03-10
申请人： Anthony Atala , James Yoo , Grace Lim , Sang Lee
发明人： Anthony Atala , James Yoo , Grace Lim , Sang Lee
IPC分类号： A61K35/12
CPC分类号： A61F2/28 , A61K35/32 , A61K35/34 , A61K38/18 , A61L27/3604 , A61L27/3817 , A61L27/3821 , A61L27/3826 , A61L27/383 , A61L27/3891 , A61L27/48 , A61L27/56 , A61L27/58 , A61L2430/02
摘要： The invention pertains to methods of producing artificial composite tissue constructs that permit coordinated motion. Biocompatable structural matrices having sufficient rigidity to provide structural support for cartilage-forming cells and bone-forming cells are used. Biocompatable flexible matrices seeded with muscle cells are joined to the structural matrices to produce artificial composite tissue constructs that are capable of coordinated motion.
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