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114 条记录 (耗时 0.032 秒)

    DIRECTED STEM CELL RECRUITMENT
    2.
    发明申请
    DIRECTED STEM CELL RECRUITMENT 有权
    指导性干细胞募集

    公开(公告)号：US20110097379A1

    公开(公告)日：2011-04-28

    申请号：US12991811

    申请日：2009-05-11

    申请人： James Yoo ,  Sang Jin Lee ,  Mark Van Dyke ,  Anthony Atala

    发明人： James Yoo ,  Sang Jin Lee ,  Mark Van Dyke ,  Anthony Atala

    IPC分类号： A61K9/00 ,  A61K38/39 ,  A61K38/43 ,  A61K38/18 ,  A61K38/48 ,  A61P13/12 ,  A61K47/30 ,  A61K31/573

    CPC分类号： A61K38/39 ,  A61K9/0024 ,  A61K38/4886 ,  A61L27/24 ,  A61L27/52 ,  A61L27/54 ,  A61L2300/41 ,  A61L2300/434 ,  A61L2400/06 ,  A61L2430/26 ,  A61K2300/00

    摘要： The invention is directed to methods of inducing cell recruitment and tissue regeneration at a target site in a subject. It is also based, in part, on the discovery that a subject's own biologic resources and environmental conditions can be used for in situ tissue regeneration and thereby reduce or eliminate the need for donor cell procurement and ex vivo manipulation of such donor cells. Methods are disclosed for recruitment of a subject's own stem cells to a target region by inducing a sustained positive pressure at a target site, such as the kidney, thereby increasing the number of pluripotent cells capable of differentiating to regenerate the target tissue.

    摘要翻译： 本发明涉及在受试者的靶位点诱导细胞募集和组织再生的方法。 它也部分地基于发现一个受试者自己的生物资源和环境条件可用于原位组织再生，从而减少或消除对供体细胞采购和离体操作这种供体细胞的需要。 公开了通过在目标部位（例如肾）处诱导持续的正压来将受试者自己的干细胞募集到靶区域的方法，从而增加能够分化以再生靶组织的多能细胞的数量。

    TISSUE EXPANDER
    4.
    发明申请
    TISSUE EXPANDER 有权
    组织膨胀机

    公开(公告)号：US20110172683A1

    公开(公告)日：2011-07-14

    申请号：US12986771

    申请日：2011-01-07

    申请人： James J. Yoo ,  Anthony Atala ,  Paul Scarpinato ,  Sang Jin Lee ,  Mitchell Ladd

    发明人： James J. Yoo ,  Anthony Atala ,  Paul Scarpinato ,  Sang Jin Lee ,  Mitchell Ladd

    IPC分类号： A61B17/00

    CPC分类号： A61B17/322 ,  A61B90/02 ,  A61B2017/00969 ,  A61B2017/3225

    摘要： Provided herein is a tissue stretching device including a tissue clamping member defining an area in a Z plane, wherein the tissue clamping member is configured to hold tissue parallel to the Z plane. Methods of use of the tissue stretching device to stretch a tissue as well as for culturing organized tissues are also provided. Stretched and/or cultured tissues produced by these processes are also provided, as well as methods of treatment making use of the same.

    摘要翻译： 本文提供了一种组织拉伸装置，其包括限定Z平面中的区域的组织夹持构件，其中组织夹持构件被构造成保持平行于Z平面的组织。 还提供了使用组织拉伸装置拉伸组织以及培养有组织的组织的方法。 还提供了通过这些方法生产的拉伸和/或培养的组织，以及使用它们的治疗方法。

    Metabolic Downregulation for Cell Survival
    5.
    发明申请
    Metabolic Downregulation for Cell Survival 审中-公开
    细胞存活的代谢下调

    公开(公告)号：US20130281400A1

    公开(公告)日：2013-10-24

    申请号：US13882433

    申请日：2011-11-10

    申请人： James J. Yoo ,  Sang Jin Lee ,  Jaehyun Kim ,  Anthony Atala

    发明人： James J. Yoo ,  Sang Jin Lee ,  Jaehyun Kim ,  Anthony Atala

    IPC分类号： C12N5/071

    CPC分类号： C12N5/0658 ,  C12N2500/02

    摘要： The present provides a system and method of maintaining and/or increasing cell viability by downregulating cellular metabolic rate under hypoxic conditions. The present invention also relates to a system and method of prolonging the survival of implanted cells that are under hypoxic condition until host neovascularization is achieved.

    摘要翻译： 本发明提供通过在低氧条件下下调细胞代谢速率来维持和/或增加细胞存活力的系统和方法。 本发明还涉及延长在缺氧条件下进行宿主新生血管形成的植入细胞的存活的系统和方法。

    Tissue expander
    6.
    发明授权
    Tissue expander 有权
    组织扩张器

    公开(公告)号：US09585688B2

    公开(公告)日：2017-03-07

    申请号：US12986771

    申请日：2011-01-07

    申请人： James J. Yoo ,  Anthony Atala ,  Paul Scarpinato ,  Sang Jin Lee ,  Mitchell Ladd

    发明人： James J. Yoo ,  Anthony Atala ,  Paul Scarpinato ,  Sang Jin Lee ,  Mitchell Ladd

    IPC分类号： A61B17/322 ,  A61B17/00

    CPC分类号： A61B17/322 ,  A61B90/02 ,  A61B2017/00969 ,  A61B2017/3225

    摘要： Provided herein is a tissue stretching device including a tissue clamping member defining an area in a Z plane, wherein the tissue clamping member is configured to hold tissue parallel to the Z plane. Methods of use of the tissue stretching device to stretch a tissue as well as for culturing organized tissues are also provided. Stretched and/or cultured tissues produced by these processes are also provided, as well as methods of treatment making use of the same.

    摘要翻译： 本文提供了一种组织拉伸装置，其包括限定Z平面中的区域的组织夹持构件，其中组织夹持构件被构造成保持平行于Z平面的组织。 还提供了使用组织拉伸装置拉伸组织以及培养有组织的组织的方法。 还提供了通过这些方法生产的拉伸和/或培养的组织，以及使用它们的治疗方法。

    INTEGRATED ORGAN AND TISSUE PRINTING METHODS, SYSTEM AND APPARATUS
    7.
    发明申请
    INTEGRATED ORGAN AND TISSUE PRINTING METHODS, SYSTEM AND APPARATUS 审中-公开
    一体化组织和组织印刷方法，系统和装置

    公开(公告)号：US20120089238A1

    公开(公告)日：2012-04-12

    申请号：US13267448

    申请日：2011-10-06

    申请人： Hyun-Wook Kang ,  Sang Jin Lee ,  Anthony Atala ,  James J. Yoo

    发明人： Hyun-Wook Kang ,  Sang Jin Lee ,  Anthony Atala ,  James J. Yoo

    IPC分类号： A61F2/02 ,  B05C11/00 ,  B05D1/00

    CPC分类号： B29C64/112 ,  A61K35/12 ,  A61L27/20 ,  A61L27/222 ,  A61L27/225 ,  A61L27/26 ,  A61L27/38 ,  A61L27/52 ,  B29C64/124 ,  B29C64/386 ,  B29C64/393 ,  B29K2105/0005 ,  B29K2267/04 ,  B29L2031/7532 ,  B33Y10/00 ,  B33Y30/00 ,  B33Y70/00 ,  B33Y80/00 ,  C12M21/08 ,  C12M23/50 ,  C12M33/00 ,  C08L5/08

    摘要： A method of making an organ or tissue comprises: (a) providing a first dispenser containing a structural support polymer and a second dispenser containing a live cell-containing composition; (b) depositing a layer on said support from said first and second dispenser, said layer comprising a structural support polymer and said cell-containing composition; and then (c) iteratively repeating said depositing step a plurality of times to form a plurality of layers one on another, with separate and discrete regions in each of said layers comprising one or the other of said support polymer or said cell-containing composition, to thereby produce provide a composite three dimensional structure containing both structural support regions and cell-containing regions. Apparatus for carrying out the method and composite products produced by the method are also described.

    摘要翻译： 一种制造器官或组织的方法包括：（a）提供含有结构支持聚合物的第一分配器和包含含活细胞组合物的第二分配器; （b）从所述第一和第二分配器在所述支撑件上沉积一层，所述层包括结构支撑聚合物和所述含细胞的组合物; 然后（c）重复地重复所述沉积步骤多次以形成多个层，其中每个所述层中的单独和离散区域包括所述支撑聚合物或所述含细胞组合物中的一种或另一种， 从而产生提供包含结构支持区域和含细胞区域的复合三维结构。 还描述了用于实施由该方法生产的方法和复合产品的装置。