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    DIRECTED STEM CELL RECRUITMENT
    2.
    发明申请
    DIRECTED STEM CELL RECRUITMENT 有权
    指导性干细胞募集

    公开(公告)号：US20110097379A1

    公开(公告)日：2011-04-28

    申请号：US12991811

    申请日：2009-05-11

    申请人： James Yoo ,  Sang Jin Lee ,  Mark Van Dyke ,  Anthony Atala

    发明人： James Yoo ,  Sang Jin Lee ,  Mark Van Dyke ,  Anthony Atala

    IPC分类号： A61K9/00 ,  A61K38/39 ,  A61K38/43 ,  A61K38/18 ,  A61K38/48 ,  A61P13/12 ,  A61K47/30 ,  A61K31/573

    CPC分类号： A61K38/39 ,  A61K9/0024 ,  A61K38/4886 ,  A61L27/24 ,  A61L27/52 ,  A61L27/54 ,  A61L2300/41 ,  A61L2300/434 ,  A61L2400/06 ,  A61L2430/26 ,  A61K2300/00

    摘要： The invention is directed to methods of inducing cell recruitment and tissue regeneration at a target site in a subject. It is also based, in part, on the discovery that a subject's own biologic resources and environmental conditions can be used for in situ tissue regeneration and thereby reduce or eliminate the need for donor cell procurement and ex vivo manipulation of such donor cells. Methods are disclosed for recruitment of a subject's own stem cells to a target region by inducing a sustained positive pressure at a target site, such as the kidney, thereby increasing the number of pluripotent cells capable of differentiating to regenerate the target tissue.

    摘要翻译： 本发明涉及在受试者的靶位点诱导细胞募集和组织再生的方法。 它也部分地基于发现一个受试者自己的生物资源和环境条件可用于原位组织再生，从而减少或消除对供体细胞采购和离体操作这种供体细胞的需要。 公开了通过在目标部位（例如肾）处诱导持续的正压来将受试者自己的干细胞募集到靶区域的方法，从而增加能够分化以再生靶组织的多能细胞的数量。

    Engineered oral tissue structural constructs
    5.
    发明申请
    Engineered oral tissue structural constructs 审中-公开
    工程口腔组织结构构造

    公开(公告)号：US20060171902A1

    公开(公告)日：2006-08-03

    申请号：US11048097

    申请日：2005-02-01

    申请人： Anthony Atala ,  Akira Joraku ,  Christopher Sullivan ,  James Yoo

    发明人： Anthony Atala ,  Akira Joraku ,  Christopher Sullivan ,  James Yoo

    IPC分类号： A61K8/96 ,  A61K35/12

    CPC分类号： A61L27/3839 ,  A61L27/3804 ,  C12N5/0633 ,  C12N2500/84 ,  C12N2501/11 ,  C12N2533/40

    摘要： The invention is directed to compositions and methods for preparing an artificial oral tissue. The artificial oral tissue is prepared using a biocompatible substrate seeded with salivary gland cells that develop to produce a salivary gland tissue layer with a prototypal salivary system and a prototypal secretory system. The salivary gland cells proliferate, mature and differentiate into a salivary gland structure that are analogous to its in vivo counterpart.

    摘要翻译： 本发明涉及用于制备人造口腔组织的组合物和方法。 人造口腔组织使用种植有唾液腺细胞的生物相容性底物制备，所述唾液腺细胞通过原型唾液系统和原型分泌系统开发产生唾液腺组织层。 唾液腺细胞增殖，成熟并分化成类似于其体内对应物的唾液腺结构。

    Penile reconstruction
    6.
    发明申请
    Penile reconstruction 失效
    阴茎重建

    公开(公告)号：US20050054893A1

    公开(公告)日：2005-03-10

    申请号：US10396202

    申请日：2003-03-25

    申请人： Anthony Atala ,  James Yoo

    发明人： Anthony Atala ,  James Yoo

    IPC分类号： A61F2/26 ,  A61L27/18 ,  A61L27/38 ,  A61F5/00

    CPC分类号： A61L27/3817 ,  A61F2/26 ,  A61L27/18 ,  A61L27/3852 ,  C08L67/04

    摘要： A cartilaginous structural member (CSM) for use in penile reconstruction, for the correction of developmental defects, postoperative reconstruction, and for reconstructive preprosthetic surgery. The cartilaginous structural member (CSM) comprise of live cells seeded onto pre-formed shaped structure which may be biodegradable. The live cells may comprise chondrocyte and the cartilaginous structural member (CSM) for use in reconstructive surgery may be constructed of polyglycolic acid. The implant structure is applicable to use for the regeneration and reconstruction or augmentation of semirigid members of the body such as the penis, nose, ear and locations which naturally has cartilage. Further, the cartilaginous structural member (CSM) may be used in plastic surgery such as, for example, breast augmentation or pectoral augmentation. The cartilaginous structural member (CSM) may be a composite cartilaginous structural member (CSM) comprising additional anchoring and strengthening elements for anchoring or changing the structural strength of said composite cartilaginous structural member (CSM).

    摘要翻译： 用于阴茎重建的软骨结构构件（CSM），用于矫正发育缺陷，术后重建和重建假体外科手术。 软骨结构构件（CSM）包括接种到预先形成的成形结构上的活细胞，其可生物降解。 活细胞可以包括软骨细胞，并且用于重建手术的软骨结构构件（CSM）可以由聚乙醇酸构成。 植入物结构适用于再生和重建或增加身体的半刚性成分，例如阴茎，鼻子，耳朵和自然具有软骨的位置。 此外，软骨结构构件（CSM）可以用于整形手术，例如隆胸或胸部增大。 软骨结构构件（CSM）可以是复合软骨结构构件（CSM），其包括用于锚固或改变所述复合软骨结构构件（CSM）的结构强度的附加锚定和加固元件。