公开(公告)号：US06192945B1

公开(公告)日：2001-02-27

申请号：US09483606

申请日：2000-01-14

申请人： Anthony Ford ,  Darin McDaniel ,  Stephen Mead ,  William Richards ,  Wayne Showalter ,  Bobbi Druyor-Sanchez ,  Bronwen Heilman ,  Brian McGraw

发明人： Anthony Ford ,  Darin McDaniel ,  Stephen Mead ,  William Richards ,  Wayne Showalter ,  Bobbi Druyor-Sanchez ,  Bronwen Heilman ,  Brian McGraw

IPC分类号： B67D506

CPC分类号： G01N1/312 ,  G01N35/1016 ,  G01N2001/317 ,  G01N2035/1034

摘要： A method and apparatus for an automated biological reaction system is provided. In the processing of a biological reaction system, there is a need for consistently placing an amount of fluid on a slide. In order to accomplish this, several methods are used including a consistency pulse and a volume adjust means. Moreover, in order to reliably operate an automated biological reaction system, the dispenser must be reliable, easy to assemble and accurate. Among other things, in order to accomplish this, the dispense chamber is substantially in line with the reservoir chamber, the reservoir chamber piston is removed, and the flow of fluid through the dispenser is simplified. Further, in order to operate the automated biological reaction system more reliably, the system is designed in modular pieces with higher functions performed by a host device and the execution of the staining operations performed by remote devices. Also, to reliably catalog data which is used by the automated biological reaction system, data is loaded to a memory device, which in turn is used by the operator to update the operator's databases. The generation of the sequence of steps for the automated biological reaction device based on data loaded by the operator, including checks to determine the ability to complete the run, is provided.

摘要翻译： 提供了一种用于自动生物反应系统的方法和装置。 在生物反应系统的处理中，需要将一定量的流体一直放置在载玻片上。 为了实现这一点，使用了几种方法，包括一致性脉冲和音量调节装置。 此外，为了可靠地操作自动生物反应系统，分配器必须可靠，易于组装和准确。 除此之外，为了实现这一点，分配室基本上与储存室一致，储存室活塞被去除，并且通过分配器的流体流被简化。 此外，为了更可靠地操作自动化生物反应系统，该系统被设计成具有由主机设备执行的更高功能和由远程设备执行的染色操作的模块化部件。 此外，为了可靠地编制由自动生物反应系统使用的数据，将数据加载到存储器装置，存储器装置又由操作者用来更新操作者的数据库。 提供了基于由操作者加载的数据的自动生物反应装置的步骤序列的生成，包括确定完成运行的能力的检查。

公开(公告)号：US08609023B1

公开(公告)日：2013-12-17

申请号：US09571989

申请日：2000-05-16

申请人： Bobbi Druyor-Sanchez ,  Anthony Ford ,  Bronwen Heilman ,  Darin McDaniel ,  Brian McGraw ,  Stephen Mead ,  William Richards ,  Wayne Showalter

发明人： Bobbi Druyor-Sanchez ,  Anthony Ford ,  Bronwen Heilman ,  Darin McDaniel ,  Brian McGraw ,  Stephen Mead ,  William Richards ,  Wayne Showalter

IPC分类号： G01N21/00

CPC分类号： G01N35/1002 ,  G01N1/312 ,  G01N35/1016 ,  Y10T436/11 ,  Y10T436/112499 ,  Y10T436/115831 ,  Y10T436/25 ,  Y10T436/2575

摘要： A method and apparatus for an automated biological reaction system is provided. In the processing of a biological reaction system, there is a need for consistently placing an amount of liquid on a slide. In order to accomplish this, several methods are used including a consistency pulse and a volume adjust means. Moreover, in order to reliably operate an automated biological reaction system, the dispenser must be reliable, easy to assemble and accurate. Among other things, in order to accomplish this, the dispense chamber is substantially in line with the reservoir chamber, the reservoir chamber piston is removed, and the flow of liquid through the dispenser is simplified. Further, in order to operate the automated biological reaction system more reliably, the system is designed in modular pieces with higher functions performed by a host device and the execution of the staining operations performed by remote devices. Also, to reliably catalog data which is used by the automated biological reaction system, data is loaded to a memory device, which in turn is used by the operator to update the operator's databases. The generation of the sequence of steps for the automated biological reaction device based on data loaded by the operator, including checks to determine the ability to complete the run, is provided.

摘要翻译： 提供了一种用于自动生物反应系统的方法和装置。 在生物反应系统的处理中，需要将一定量的液体一直放置在载玻片上。 为了实现这一点，使用了几种方法，包括一致性脉冲和音量调节装置。 此外，为了可靠地操作自动生物反应系统，分配器必须可靠，易于组装和准确。 除此之外，为了实现这一点，分配室基本上与储存室一致，储存室活塞被移除，并且通过分配器的液体流被简化。 此外，为了更可靠地操作自动化生物反应系统，该系统被设计成具有由主机设备执行的更高功能和由远程设备执行的染色操作的模块化部件。 此外，为了可靠地编制由自动生物反应系统使用的数据，将数据加载到存储器装置，存储器装置又由操作者用来更新操作者的数据库。 提供了基于由操作者加载的数据的自动生物反应装置的步骤序列的生成，包括确定完成运行的能力的检查。

公开(公告)号：US20110168744A1

公开(公告)日：2011-07-14

申请号：US13050707

申请日：2011-03-17

申请人： Charles D. Lemme ,  Vincent R. Rizzo, JR. ,  Bobbi Druyor-Sanchez ,  Anthony Ford ,  Bronwen Heilman ,  Darin McDaniel ,  Brian McGraw ,  Stephen Mead ,  William Richards ,  Wayne Showalter

发明人： Charles D. Lemme ,  Vincent R. Rizzo, JR. ,  Bobbi Druyor-Sanchez ,  Anthony Ford ,  Bronwen Heilman ,  Darin McDaniel ,  Brian McGraw ,  Stephen Mead ,  William Richards ,  Wayne Showalter

IPC分类号： B67D7/06

CPC分类号： G01N1/312 ,  G01N35/1002 ,  G01N35/1016 ,  G01N2001/317 ,  G01N2035/1034

摘要： A fluid dispenser comprising a barrel having a reservoir chamber, the barrel having an upper portion, a cap connected to the reservoir chamber, the cap having a surface with at least one hole therethrough, a valve comprising a biasing member and a hole sealer, the valve being adjacent to the reservoir chamber, a coupler having a dispense chamber, and a vent located between the cap and the reservoir chamber, the vent including a vent opening and a vent material composed of oliophobic material.

摘要翻译： 一种流体分配器，包括具有储存室的桶，所述桶具有上部，连接到储存室的盖，所述盖具有带有至少一个孔的表面，包括偏置构件和孔封闭器的阀， 阀邻近储存室，具有分配室的联接器和位于盖和储存室之间的通风口，排气口包括通气口和由矾土材料构成的排气材料。

公开(公告)号：US06945128B2

公开(公告)日：2005-09-20

申请号：US09896649

申请日：2001-06-29

申请人： Anthony Ford ,  Darin McDaniel ,  Stephen Mead ,  William Richards ,  Wayne Showalter ,  Bobbi Druyor-Sanchez ,  Bronwen Heilman ,  Brian McGraw

发明人： Anthony Ford ,  Darin McDaniel ,  Stephen Mead ,  William Richards ,  Wayne Showalter ,  Bobbi Druyor-Sanchez ,  Bronwen Heilman ,  Brian McGraw

IPC分类号： G01N1/00 ,  A47K5/12 ,  B67D7/06 ,  G01N1/30 ,  G01N1/31 ,  G01N35/00 ,  G01N35/10 ,  B01L3/02

CPC分类号： G01N35/1016 ,  G01N1/312 ,  G01N35/00871 ,  G01N35/1002 ,  G01N2001/317 ,  G01N2035/00881 ,  G01N2035/1034 ,  Y10T137/7873 ,  Y10T436/11 ,  Y10T436/112499 ,  Y10T436/2575

摘要： A method and apparatus for an automated biological reaction system is provided. In the processing of a biological reaction system, there is a need for consistently placing an amount of fluid on a slide. In order to accomplish this, several methods are used including a consistency pulse and a volume adjust means. Moreover, in order to reliably operate an automated biological reaction system, the dispenser must be reliable, easy to assemble and accurate. Among other things, in order to accomplish this, the dispense chamber is substantially in line with the reservoir chamber, the reservoir chamber piston is removed, and the flow of fluid through the dispenser is simplified. Further, in order to operate the automated biological reaction system more reliably, the system is designed in modular pieces with higher functions performed by a host device and the execution of the staining operations performed by remote devices. Also, to reliably catalog data which is used by the automated biological reaction system, data is loaded to a memory device, which in turn is used by the operator to update the operator's databases. The generation of the sequence of steps for the automated biological reaction device based on data loaded by the operator, including checks to determine the ability to complete the run, is provided.

摘要翻译： 提供了一种用于自动生物反应系统的方法和装置。 在生物反应系统的处理中，需要将一定量的流体一直放置在载玻片上。 为了实现这一点，使用了几种方法，包括一致性脉冲和音量调节装置。 此外，为了可靠地操作自动生物反应系统，分配器必须可靠，易于组装和准确。 除此之外，为了实现这一点，分配室基本上与储存室一致，储存室活塞被去除，并且通过分配器的流体流被简化。 此外，为了更可靠地操作自动化生物反应系统，该系统被设计成具有由主机设备执行的更高功能和由远程设备执行的染色操作的模块化部件。 此外，为了可靠地编制由自动生物反应系统使用的数据，将数据加载到存储器装置，存储器装置又由操作者用来更新操作者的数据库。 提供了基于由操作者加载的数据的自动生物反应装置的步骤序列的生成，包括确定完成运行的能力的检查。

公开(公告)号：US20050135972A1

公开(公告)日：2005-06-23

申请号：US10913932

申请日：2004-08-06

申请人： Charles Lemme ,  Vincent Rizzo ,  Bobbi Druyor-Sanchez ,  Anthony Ford ,  Bronwen Heilman ,  Darin McDaniel ,  Brian McGraw ,  Stephen Mead ,  William Richards ,  Wayne Showalter

发明人： Charles Lemme ,  Vincent Rizzo ,  Bobbi Druyor-Sanchez ,  Anthony Ford ,  Bronwen Heilman ,  Darin McDaniel ,  Brian McGraw ,  Stephen Mead ,  William Richards ,  Wayne Showalter

IPC分类号： G01N1/31 ,  G01N35/00 ,  G01N35/10 ,  B01L3/00

CPC分类号： G01N1/312 ,  G01N35/1002 ,  G01N35/1016 ,  G01N2001/317 ,  G01N2035/1034

摘要： A method and apparatus for an automated biological reaction system is provided. In the processing of a biological reaction system, there is a need for consistently placing an amount of fluid on a slide. In order to accomplish this, several methods are used including a consistency pulse and a volume adjust means. Moreover, in order to reliably operate an automated biological reaction system, the dispenser must be reliable, easy to assemble and accurate. Among other things, in order to accomplish this, the dispense chamber is substantially in line with the reservoir chamber, the reservoir chamber piston is removed, and the flow of fluid through the dispenser is simplified. Further, in order to operate the automated biological reaction system more reliably, the system is designed in modular pieces with higher functions performed by a host device and the execution of the staining operations performed by remote devices. Also, to reliably catalog data which is used by the automated biological reaction system, data is loaded to a memory device, which in turn is used by the operator to update the operator's databases. The generation of the sequence of steps for the automated biological reaction device based on data loaded by the operator, including checks to determine the ability to complete the run, is provided.

摘要翻译： 提供了一种用于自动生物反应系统的方法和装置。 在生物反应系统的处理中，需要将一定量的流体一直放置在载玻片上。 为了实现这一点，使用了几种方法，包括一致性脉冲和音量调节装置。 此外，为了可靠地操作自动生物反应系统，分配器必须可靠，易于组装和准确。 除此之外，为了实现这一点，分配室基本上与储存室一致，储存室活塞被去除，并且通过分配器的流体流被简化。 此外，为了更可靠地操作自动化生物反应系统，该系统被设计成具有由主机设备执行的更高功能和由远程设备执行的染色操作的模块化部件。 此外，为了可靠地编制由自动生物反应系统使用的数据，将数据加载到存储器装置，存储器装置又由操作者用来更新操作者的数据库。 提供了基于由操作者加载的数据的自动生物反应装置的步骤序列的生成，包括确定完成运行的能力的检查。

公开(公告)号：US08147773B2

公开(公告)日：2012-04-03

申请号：US13050707

申请日：2011-03-17

申请人： Charles D. Lemme ,  Vincent R. Rizzo, Jr. ,  Bobbi Druyor-Sanchez ,  Anthony Ford ,  Bronwen Heilman ,  Darin McDaniel ,  Brian McGraw ,  Stephen Mead ,  William Richards ,  Wayne Showalter

发明人： Charles D. Lemme ,  Vincent R. Rizzo, Jr. ,  Bobbi Druyor-Sanchez ,  Anthony Ford ,  Bronwen Heilman ,  Darin McDaniel ,  Brian McGraw ,  Stephen Mead ,  William Richards ,  Wayne Showalter

IPC分类号： B01L3/02

CPC分类号： G01N1/312 ,  G01N35/1002 ,  G01N35/1016 ,  G01N2001/317 ,  G01N2035/1034

摘要： A fluid dispenser useful in automated biological reaction systems comprising a barrel having a reservoir chamber, the barrel having an upper portion and a lower portion, a cap located on top of the upper portion of the barrel and connected to the reservoir chamber, the cap having an external surface with at least one hole therethrough, a valve comprising a biasing member and a hole sealer, the valve being located in the hole in the cap at the point where a downward force is applied against the cap, a coupler having a dispense chamber, the coupler being coaxial with the barrel and wherein the barrel lower portion moves into the dispense chamber during dispensing of fluid, and a vent located between the cap and the reservoir chamber, the vent including a vent opening and a vent material composed of oliophobic material.

摘要翻译： 一种用于自动生物反应系统的流体分配器，包括具有储存室的桶，所述桶具有上部和下部，盖位于桶的上部的顶部并连接到储存室，盖具有 具有穿过其中的至少一个孔的外表面，包括偏置构件和孔封闭器的阀，所述阀位于所述盖中的向下施加在所述盖上的点处的孔中;耦合器，具有分配室 耦合器与筒同轴，并且其中筒子下部在分配流体期间移动到分配室中，并且位于盖和储存室之间的通风口，排气口包括通气口和由矾土材料构成的排气材料 。

公开(公告)号：US06416713B1

公开(公告)日：2002-07-09

申请号：US09483218

申请日：2000-01-14

申请人： Anthony Ford ,  Darin McDaniel ,  Stephen Mead ,  William Richards ,  Wayne Showalter ,  Bobbi Druyor-Sanchez ,  Bronwen Heilman ,  Brian McGraw

发明人： Anthony Ford ,  Darin McDaniel ,  Stephen Mead ,  William Richards ,  Wayne Showalter ,  Bobbi Druyor-Sanchez ,  Bronwen Heilman ,  Brian McGraw

IPC分类号： C01H3510

CPC分类号： G01N35/1016 ,  G01N1/312 ,  G01N35/00871 ,  G01N35/1002 ,  G01N2001/317 ,  G01N2035/00881 ,  G01N2035/1034 ,  Y10T137/7873 ,  Y10T436/11 ,  Y10T436/112499 ,  Y10T436/2575

摘要： A method of assembly of a fluid dispenser of an apparatus for an automated biological reaction system is provided. In the processing of a biological reaction system, there is a need for consistently placing an amount of fluid on a slide. In order to accomplish this, several methods are used including a consistency pulse and a volume adjust means. Moreover, in order to reliably operate an automated biological reaction system, the dispenser must be reliable, easy to assemble and accurate. Among other things, in order to accomplish this, the dispense chamber is substantially in line with the reservoir chamber, the reservoir chamber piston is removed, and the flow of fluid through the dispenser is simplified. Further, in order to operate the automated biological reaction system more reliably, the system is designed in modular pieces with higher functions performed by a host device and the execution of the staining operations performed by remote devices. Also, to reliably catalog data which is used by the automated biological reaction system, data is loaded to a memory device, which in turn is used by the operator to update the operator's databases. The generation of the sequence of steps for the automated biological reaction device based on data loaded by the operator, including checks to determine the ability to complete the run, is provided.

摘要翻译： 提供了一种组装用于自动生物反应系统的装置的流体分配器的方法。 在生物反应系统的处理中，需要将一定量的流体一直放置在载玻片上。 为了实现这一点，使用了几种方法，包括一致性脉冲和音量调节装置。 此外，为了可靠地操作自动生物反应系统，分配器必须可靠，易于组装和准确。 除此之外，为了实现这一点，分配室基本上与储存室一致，储存室活塞被去除，并且通过分配器的流体流被简化。 此外，为了更可靠地操作自动化生物反应系统，该系统被设计成具有由主机设备执行的更高功能和由远程设备执行的染色操作的模块化部件。 此外，为了可靠地编制由自动生物反应系统使用的数据，将数据加载到存储器装置，存储器装置又由操作者用来更新操作者的数据库。 提供了基于由操作者加载的数据的自动生物反应装置的步骤序列的生成，包括确定完成运行的能力的检查。

公开(公告)号：US06093574A

公开(公告)日：2000-07-25

申请号：US909335

申请日：1997-08-11

申请人： Bobbi Druyor-Sanchez ,  Anthony Ford ,  Bronwen Heilman ,  Darin McDaniel ,  Brian McGraw ,  Stephen Mead ,  William Richards ,  Wayne Showalter

发明人： Bobbi Druyor-Sanchez ,  Anthony Ford ,  Bronwen Heilman ,  Darin McDaniel ,  Brian McGraw ,  Stephen Mead ,  William Richards ,  Wayne Showalter

IPC分类号： G01N1/31 ,  G01N35/00 ,  G01N35/10 ,  G01N1/30

CPC分类号： G01N35/1002 ,  G01N1/312 ,  G01N35/1016 ,  Y10T436/11 ,  Y10T436/112499 ,  Y10T436/115831 ,  Y10T436/25 ,  Y10T436/2575

摘要： A method and apparatus for an automated biological reaction system is provided. In the processing of a biological reaction system, there is a need for consistently placing an amount of liquid on a slide. In order to accomplish this, several methods are used including a consistency pulse and a volume adjust means. Moreover, in order to reliably operate an automated biological reaction system, the dispenser must be reliable, easy to assemble and accurate. Among other things, in order to accomplish this, the dispense chamber is substantially in line with the reservoir chamber, the reservoir chamber piston is removed, and the flow of liquid through the dispenser is simplified. Further, in order to operate the automated biological reaction system more reliably, the system is designed in modular pieces with higher functions performed by a host device and the execution of the staining operations performed by remote devices. Also, to reliably catalog data which is used by the automated biological reaction system, data is loaded to a memory device, which in turn is used by the operator to update the operator's databases. The generation of the sequence of steps for the automated biological reaction device based on data loaded by the operator, including checks to determine the ability to complete the run, is provided.

摘要翻译： 提供了一种用于自动生物反应系统的方法和装置。 在生物反应系统的处理中，需要将一定量的液体一直放置在载玻片上。 为了实现这一点，使用了几种方法，包括一致性脉冲和音量调节装置。 此外，为了可靠地操作自动生物反应系统，分配器必须可靠，易于组装和准确。 除此之外，为了实现这一点，分配室基本上与储存室一致，储存室活塞被移除，并且通过分配器的液体流被简化。 此外，为了更可靠地操作自动化生物反应系统，该系统被设计成具有由主机设备执行的更高功能和由远程设备执行的染色操作的模块化部件。 此外，为了可靠地编制由自动生物反应系统使用的数据，将数据加载到存储器装置，存储器装置又由操作者用来更新操作者的数据库。 提供了基于由操作者加载的数据的自动生物反应装置的步骤序列的生成，包括确定完成运行的能力的检查。

公开(公告)号：US07516749B2

公开(公告)日：2009-04-14

申请号：US10408108

申请日：2003-04-08

申请人： Stephen Felder ,  Richard Kris ,  Brian McGraw

发明人： Stephen Felder ,  Richard Kris ,  Brian McGraw

IPC分类号： B08B6/00

CPC分类号： B08B9/093 ,  B01L3/5085 ,  B01L99/00 ,  B01L2300/0829 ,  B08B3/02 ,  B08B9/00 ,  B08B9/0826 ,  Y10T436/11 ,  Y10T436/114998

摘要： Methods of and apparatus for washing an array of sites in high-density microplates or similar assay plates wherein the microplates or assay plates are washed in an inverted or nearly inverted position, rather than in an upright position. Preferably, the wash liquid is dispensed upwardly in the form of a sheet from a nozzle mounted on a spray bar as the spray bar moves relative to the microplate or assay plate. After washing, the microplate or assay plate is dried with a stream of gas such as air, also preferably blown upwardly in the form of a sheet.

摘要翻译： 在高密度微孔板或类似测定板中洗涤位点阵列的方法和装置，其中微孔板或测定板以颠倒或接近倒置的位置而不是直立位置洗涤。 优选地，当喷雾杆相对于微板或测定板移动时，洗涤液体以安装在喷雾杆上的喷嘴从片材的形式向上分配。 洗涤后，用气流例如空气干燥微板或测定板，最好以片状向上吹。