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公开(公告)号：US20110168744A1
公开(公告)日：2011-07-14
申请号：US13050707
申请日：2011-03-17
申请人： Charles D. Lemme , Vincent R. Rizzo, JR. , Bobbi Druyor-Sanchez , Anthony Ford , Bronwen Heilman , Darin McDaniel , Brian McGraw , Stephen Mead , William Richards , Wayne Showalter
发明人： Charles D. Lemme , Vincent R. Rizzo, JR. , Bobbi Druyor-Sanchez , Anthony Ford , Bronwen Heilman , Darin McDaniel , Brian McGraw , Stephen Mead , William Richards , Wayne Showalter
IPC分类号： B67D7/06
CPC分类号： G01N1/312 , G01N35/1002 , G01N35/1016 , G01N2001/317 , G01N2035/1034
摘要： A fluid dispenser comprising a barrel having a reservoir chamber, the barrel having an upper portion, a cap connected to the reservoir chamber, the cap having a surface with at least one hole therethrough, a valve comprising a biasing member and a hole sealer, the valve being adjacent to the reservoir chamber, a coupler having a dispense chamber, and a vent located between the cap and the reservoir chamber, the vent including a vent opening and a vent material composed of oliophobic material.
摘要翻译： 一种流体分配器，包括具有储存室的桶，所述桶具有上部，连接到储存室的盖，所述盖具有带有至少一个孔的表面，包括偏置构件和孔封闭器的阀， 阀邻近储存室，具有分配室的联接器和位于盖和储存室之间的通风口，排气口包括通气口和由矾土材料构成的排气材料。
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公开(公告)号：US08147773B2
公开(公告)日：2012-04-03
申请号：US13050707
申请日：2011-03-17
申请人： Charles D. Lemme , Vincent R. Rizzo, Jr. , Bobbi Druyor-Sanchez , Anthony Ford , Bronwen Heilman , Darin McDaniel , Brian McGraw , Stephen Mead , William Richards , Wayne Showalter
发明人： Charles D. Lemme , Vincent R. Rizzo, Jr. , Bobbi Druyor-Sanchez , Anthony Ford , Bronwen Heilman , Darin McDaniel , Brian McGraw , Stephen Mead , William Richards , Wayne Showalter
IPC分类号： B01L3/02
CPC分类号： G01N1/312 , G01N35/1002 , G01N35/1016 , G01N2001/317 , G01N2035/1034
摘要： A fluid dispenser useful in automated biological reaction systems comprising a barrel having a reservoir chamber, the barrel having an upper portion and a lower portion, a cap located on top of the upper portion of the barrel and connected to the reservoir chamber, the cap having an external surface with at least one hole therethrough, a valve comprising a biasing member and a hole sealer, the valve being located in the hole in the cap at the point where a downward force is applied against the cap, a coupler having a dispense chamber, the coupler being coaxial with the barrel and wherein the barrel lower portion moves into the dispense chamber during dispensing of fluid, and a vent located between the cap and the reservoir chamber, the vent including a vent opening and a vent material composed of oliophobic material.
摘要翻译： 一种用于自动生物反应系统的流体分配器，包括具有储存室的桶，所述桶具有上部和下部，盖位于桶的上部的顶部并连接到储存室，盖具有 具有穿过其中的至少一个孔的外表面，包括偏置构件和孔封闭器的阀，所述阀位于所述盖中的向下施加在所述盖上的点处的孔中;耦合器，具有分配室 耦合器与筒同轴，并且其中筒子下部在分配流体期间移动到分配室中，并且位于盖和储存室之间的通风口，排气口包括通气口和由矾土材料构成的排气材料 。
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公开(公告)号：US07303725B2
公开(公告)日：2007-12-04
申请号：US10414804
申请日：2003-04-15
CPC分类号： B01L9/52 , B01L2300/0822 , G01N1/312 , G01N1/36 , Y10T436/11 , Y10T436/112499 , Y10T436/25
摘要： An automated slide processing apparatus includes a plurality of work stations arranged in a stack, and a transport/elevator for transporting slides between the various work stations.
摘要翻译： 一种自动滑块处理装置，包括以堆叠方式布置的多个工作站，以及用于在各个工作站之间运送滑块的运输/升降机。
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公开(公告)号：US08883509B2
公开(公告)日：2014-11-11
申请号：US12167459
申请日：2008-07-03
申请人： Charles D. Lemme , William Richards , Glen Ward , Austin Ashby , Andrew Ghusson , Lisa Jensen-Long , Kevin Knapp , Rodney Kugizaki , Alain Larson , Paul Richards , Wayne Showalter , Chad Wilkinson
发明人： Charles D. Lemme , William Richards , Glen Ward , Austin Ashby , Andrew Ghusson , Lisa Jensen-Long , Kevin Knapp , Rodney Kugizaki , Alain Larson , Paul Richards , Wayne Showalter , Chad Wilkinson
CPC分类号： G01N1/312 , G01N1/06 , G01N35/00029 , G01N35/0092 , G01N35/1002 , G01N35/1011 , G01N35/1081 , G01N2035/00039 , G01N2035/00049 , G01N2035/00138 , G01N2035/00346 , G01N2035/00376 , G01N2035/0453 , Y10T436/112499 , Y10T436/25 , Y10T436/2575
摘要： An apparatus and method are described that achieve independent and simultaneous processing of a plurality of substrate-supported biological samples. In one embodiment, substrate holders arranged in a minor arc are independently moveable between a processing position and an access position, and reagents are delivered to substrates held in the substrate holders through a nozzle plate that moves along the arc of substrate holders. The disclosed apparatus and method are particularly suited for implementation of lean processing of biological samples.
摘要翻译： 描述了实现多个基板支持的生物样品的独立且同时处理的装置和方法。 在一个实施例中，布置成小弧的衬底保持器可以在处理位置和访问位置之间独立地移动，并且试剂通过沿着衬底保持器的弧移动的喷嘴板被传送到保持在衬底保持器中的衬底。 所公开的装置和方法特别适合于实施生物样品的精益加工。
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公开(公告)号：US07404927B2
公开(公告)日：2008-07-29
申请号：US11293489
申请日：2005-12-02
IPC分类号： G01N21/00
CPC分类号： G01N1/312 , Y10T436/112499 , Y10T436/2575
摘要： Apparatus and methods for automatically staining or treating multiple tissue samples mounted on slides are provided, in which the slides and reagent bottles are held in fixed position, and the reagent and wash solutions brought to the slides.
摘要翻译： 提供了用于自动染色或处理安装在载玻片上的多个组织样品的装置和方法，其中载玻片和试剂瓶保持在固定位置，并将试剂和洗涤液带到载玻片上。
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公开(公告)号：US07270785B1
公开(公告)日：2007-09-18
申请号：US10283639
申请日：2002-10-30
IPC分类号： B32B5/02
CPC分类号： G01N1/312 , Y10T436/112499 , Y10T436/2575
摘要： Apparatus and methods for automatically staining or treating multiple tissue samples mounted on slides are provided, in which the slides and reagent bottles are held in fixed position, and the reagent and wash solutions brought to the slides.
摘要翻译： 提供了用于自动染色或处理安装在载玻片上的多个组织样品的装置和方法，其中载玻片和试剂瓶保持在固定位置，并将试剂和洗涤溶液带到载玻片上。
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公开(公告)号：US08048373B2
公开(公告)日：2011-11-01
申请号：US11876059
申请日：2007-10-22
IPC分类号： G01N1/28
CPC分类号： B01L9/52 , B01L2300/0822 , G01N1/312 , G01N1/36 , Y10T436/11 , Y10T436/112499 , Y10T436/25
摘要： An automated slide processing apparatus includes a plurality of work stations arranged in a stack, and a transport/elevator for transporting slides between the various work stations.
摘要翻译： 一种自动滑块处理装置，包括以堆叠方式布置的多个工作站，以及用于在各个工作站之间运送滑块的运输/升降机。
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公开(公告)号：US20090017491A1
公开(公告)日：2009-01-15
申请号：US12167459
申请日：2008-07-03
申请人： Charles D. Lemme , William Richards , Glen Ward , Austin Ashby , Andrew Ghusson , Lisa Jensen-Long , Kevin Knapp , Rodney Kugizaki , Alain Larson , Paul Richards , Wayne Showalter , Chad Wilkinson
发明人： Charles D. Lemme , William Richards , Glen Ward , Austin Ashby , Andrew Ghusson , Lisa Jensen-Long , Kevin Knapp , Rodney Kugizaki , Alain Larson , Paul Richards , Wayne Showalter , Chad Wilkinson
CPC分类号： G01N1/312 , G01N1/06 , G01N35/00029 , G01N35/0092 , G01N35/1002 , G01N35/1011 , G01N35/1081 , G01N2035/00039 , G01N2035/00049 , G01N2035/00138 , G01N2035/00346 , G01N2035/00376 , G01N2035/0453 , Y10T436/112499 , Y10T436/25 , Y10T436/2575
摘要： An apparatus and method are described that achieve independent and simultaneous processing of a plurality of substrate-supported biological samples. In one embodiment, substrate holders arranged in a minor arc are independently moveable between a processing position and an access position, and reagents are delivered to substrates held in the substrate holders through a nozzle plate that moves along the arc of substrate holders. The disclosed apparatus and method are particularly suited for implementation of lean processing of biological samples.
摘要翻译： 描述了实现多个基板支持的生物样品的独立且同时处理的装置和方法。 在一个实施例中，布置成小弧的衬底保持器可以在处理位置和访问位置之间独立地移动，并且试剂通过沿着衬底保持器的弧移动的喷嘴板被传送到保持在衬底保持器中的衬底。 所公开的装置和方法特别适合于实施生物样品的精益加工。
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公开(公告)号：US07468161B2
公开(公告)日：2008-12-23
申请号：US11116676
申请日：2005-04-27
申请人： Kurt Reinhardt , Charles D. Lemme , Glen Ward , William L. Richards , Wayne Showalter , Brandon Ambler , Austin Ashby , Chris Borchert , Devon C. Campbell , Kimberly Christensen , Matthew Freeman , Andrew Ghusson , Rick Griebel , Kendall B. Hendrick , Miroslav Holubec , Parula Mehta , Vince Rizzo
发明人： Kurt Reinhardt , Charles D. Lemme , Glen Ward , William L. Richards , Wayne Showalter , Brandon Ambler , Austin Ashby , Chris Borchert , Devon C. Campbell , Kimberly Christensen , Matthew Freeman , Andrew Ghusson , Rick Griebel , Kendall B. Hendrick , Miroslav Holubec , Parula Mehta , Vince Rizzo
CPC分类号： G01N35/00029 , B01L9/52 , B01L2300/0822 , G01N1/30 , G01N1/312 , G01N1/36 , G01N35/00732 , G01N35/0099 , G01N2035/00039 , G01N2035/00138 , Y10T436/11 , Y10T436/112499 , Y10T436/25 , Y10T436/2575
摘要： An automated system is provided for performing slide processing operations on slides bearing biological samples. In one embodiment, the disclosed system includes a slide tray holding a plurality of slides in a substantially horizontal position and a workstation that receives the slide tray. In a particular embodiment, a workstation delivers a reagent to slide surfaces without substantial transfer of reagent (and reagent borne contaminants such as dislodged cells) from one slide to another. A method for automated processing of slides also is provided.
摘要翻译： 提供了一种自动化系统，用于对载有生物样品的载玻片进行滑动加工操作。 在一个实施例中，所公开的系统包括容纳大致水平位置的多个滑块的滑动盘和接收滑动盘的工作站。 在一个具体实施方案中，工作站递送试剂以滑动表面，而不会将试剂（和试剂携带的污染物，例如脱落的细胞）基本上从一个载玻片转移到另一个载体。 还提供了一种用于自动处理幻灯片的方法。
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公开(公告)号：US08663991B2
公开(公告)日：2014-03-04
申请号：US11181625
申请日：2005-07-13
申请人： Kurt Reinhardt , Charles D. Lemme , Glen Ward , William L. Richards , Wayne Showalter , Brandon Ambler , Austin Ashby , Chris Borchert , Devon C. Campbell , Kimberly Christensen , Matthew Freeman , Andrew Ghusson , Rick Griebel , Kendall B. Hendrick , Miroslav Holubec , Parula Mehta , Vince Rizzo
发明人： Kurt Reinhardt , Charles D. Lemme , Glen Ward , William L. Richards , Wayne Showalter , Brandon Ambler , Austin Ashby , Chris Borchert , Devon C. Campbell , Kimberly Christensen , Matthew Freeman , Andrew Ghusson , Rick Griebel , Kendall B. Hendrick , Miroslav Holubec , Parula Mehta , Vince Rizzo
IPC分类号： G01N35/00
CPC分类号： G01N35/00029 , B01L9/52 , B01L2300/0822 , G01N1/30 , G01N1/312 , G01N1/36 , G01N35/00732 , G01N35/0099 , G01N2035/00039 , G01N2035/00138 , Y10T436/11 , Y10T436/112499 , Y10T436/25 , Y10T436/2575
摘要： An automated system is provided for performing slide processing operations on slides bearing biological samples. In one embodiment, the disclosed system includes a slide tray holding a plurality of slides in a substantially horizontal position and a workstation that receives the slide tray. In a particular embodiment, a workstation delivers a reagent to slide surfaces without substantial transfer of reagent (and reagent borne contaminants such as dislodged cells) from one slide to another. A method for automated processing of slides also is provided.
摘要翻译： 提供了一种自动化系统，用于对载有生物样品的载玻片进行滑动加工操作。 在一个实施例中，所公开的系统包括容纳大致水平位置的多个滑块的滑动盘和接收滑动盘的工作站。 在一个具体实施方案中，工作站递送试剂以滑动表面，而不会将试剂（和试剂携带的污染物，例如脱落的细胞）基本上从一个载玻片转移到另一个载体。 还提供了一种用于自动处理幻灯片的方法。
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