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公开(公告)号：US20070201736A1
公开(公告)日：2007-08-30
申请号：US11786599
申请日：2007-04-12
申请人： Jon Klingensmith , Anuja Nair , Barry Kuban , D. Vince
发明人： Jon Klingensmith , Anuja Nair , Barry Kuban , D. Vince
IPC分类号： G06K9/00
CPC分类号： A61B8/12 , A61B5/02007 , A61B8/0858
摘要： The present invention uses a radio frequency (RF) signal backscattered from vascular tissue to identify a border on a vascular image. Embodiments of the invention operate in accordance with a data gathering device connected to a computing device and a transducer via a catheter. The transducer is used to gather RF data backscattered from vascular tissue. The RF data is provided to the computing device via the data-gathering device. In one embodiment of the present invention, the computing device includes (i) a data storage device for storing tissue types and related parameters and (ii) an application. The application is used to convert the RF data into the frequency domain and to identify associated parameters. The parameters are compared to the parameters stored in the data storage device to identify the corresponding tissue type. This information is used, possibly with other border-related information, to determine a border on a vascular image.
摘要翻译： 本发明使用从血管组织反向散射的射频（RF）信号来识别血管图像上的边界。 本发明的实施例根据经由导管连接到计算设备和换能器的数据采集设备进行操作。 传感器用于收集从血管组织反向散射的RF数据。 RF数据经由数据收集装置提供给计算装置。 在本发明的一个实施例中，计算设备包括（i）用于存储组织类型和相关参数的数据存储设备，以及（ii）应用。 该应用程序用于将RF数据转换为频域并识别相关参数。 将参数与存储在数据存储设备中的参数进行比较，以识别相应的组织类型。 该信息可能与其他与边界有关的信息用于确定血管图像上的边界。
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公开(公告)号：US20050154315A1
公开(公告)日：2005-07-14
申请号：US10758477
申请日：2004-01-14
申请人： Anuja Nair , D. Vince , Jon Klingensmith , Barry Kuban
发明人： Anuja Nair , D. Vince , Jon Klingensmith , Barry Kuban
CPC分类号： A61B5/02007 , A61B5/726 , A61B8/12
摘要： A system and method is provided for using ultrasound data backscattered from vascular tissue to estimate the transfer function of a catheter (including components attached thereto—e.g., IVUS console, transducer, etc.). Specifically, in accordance with a first embodiment of the present invention, a computing device is electrically connected to a catheter and used to acquire RF backscattered data from a vascular structure (e.g., a blood vessel, etc.). The backscattered ultrasound data is then used, together with an algorithm, to estimate the transfer function. The transfer function can then be used (at least in a preferred embodiment) to calculate response data for the vascular tissue (i.e., the tissue component of the backscattered ultrasound data). In a second embodiment of the present invention, an IVUS console is electrically connected to a catheter and a computing device and is used to acquire RF backscattered data from a vascular structure. The backscattered data is then transmitted to the computing device, where it is used to estimate the catheter's transfer function and to calculate response data for the vascular tissue. The response data and histology data are then used to characterize at least a portion of the vascular tissue (e.g., identify tissue type, etc.).
摘要翻译： 提供了一种系统和方法，用于使用从血管组织反向散射的超声数据来估计导管（包括与其连接的部件，例如，IVUS控制台，换能器等）的传递功能。 具体地，根据本发明的第一实施例，计算设备电连接到导管并用于从血管结构（例如，血管等）获取RF背散射数据。 然后将后向散射的超声数据与算法一起用于估计传递函数。 然后可以使用传递函数（至少在一个优选实施例中）来计算血管组织的反应数据（即背散射超声数据的组织分量）。 在本发明的第二实施例中，IVUS控制台电连接到导管和计算设备，并用于从血管结构获取RF背散射数据。 然后将背散射数据传输到计算设备，其中其用于估计导管的传递函数并计算血管组织的反应数据。 然后使用响应数据和组织学数据来表征血管组织的至少一部分（例如，识别组织类型等）。
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公开(公告)号：US20070071326A1
公开(公告)日：2007-03-29
申请号：US11449569
申请日：2006-06-08
申请人： Jon Klingensmith , Anuja Nair , Barry Kuban , D. Vince
发明人： Jon Klingensmith , Anuja Nair , Barry Kuban , D. Vince
CPC分类号： A61B8/12 , A61B5/02007 , A61B8/0858
摘要： A system and method is provided for using the frequency spectrum of a radio frequency (RF) signal backscattered from vascular tissue to identify at least one border (e.g., tissue interface, etc.) on a vascular image. Embodiments of the present invention operate in accordance with a data gathering device (e.g., an intra-vascular ultrasound (IVUS) device, etc.) electrically connected to a computing device and a transducer via a catheter. The transducer is used to gather radio frequency (RF) data backscattered from vascular tissue. The RF data is then provided to (or acquired by) the computing device via the data-gathering device. In one embodiment of the present invention, the computing device includes (i) at least one data storage device (e.g., database, memory, etc.) for storing a plurality of tissue types and parameters related thereto and (ii) at least one application (e.g., a characterization application, a gradient-border application, a frequency-border application and/or an active-contour application). The characterization application is used to convert (or transform) the RF data into the frequency domain and to identify a plurality of parameters associated therewith. The identified parameters are then compared to the parameters stored in the data storage device to identify the corresponding tissue type. This information (e.g., tissue type, corresponding RF data, etc.) is then used, either alone or together with other border-related information (e.g., gradient information, other-border information, etc.), to determine at least one border on a vascular image.
摘要翻译： 提供了一种用于使用从血管组织反向散射的射频（RF）信号的频谱来识别血管图像上的至少一个边界（例如，组织界面等）的系统和方法。 本发明的实施例根据通过导管电连接到计算设备和换能器的数据采集装置（例如，血管内超声（IVUS）装置等）进行操作。 传感器用于收集从血管组织反向散射的射频（RF）数据。 然后，RF数据经由数据收集装置提供给计算装置（或者由其获取）。 在本发明的一个实施例中，计算设备包括：（i）至少一个数据存储设备（例如，数据库，存储器等），用于存储与之相关的多个组织类型和参数，以及（ii）至少一个应用 （例如，表征应用，梯度边界应用，频率边界应用和/或主动轮廓应用）。 表征应用用于将RF数据转换（或变换）到频域中并且识别与其相关联的多个参数。 然后将识别的参数与存储在数据存储设备中的参数进行比较，以识别相应的组织类型。 然后，单独或与其他边界相关信息（例如，梯度信息，其他边界信息等）一起使用该信息（例如，组织类型，对应的RF数据等）以确定至少一个边界 在血管图像上。
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公开(公告)号：US20050196026A1
公开(公告)日：2005-09-08
申请号：US10837352
申请日：2004-04-29
申请人： Jon Klingensmith , Anuja Nair , Barry Kuban , D. Vince
发明人： Jon Klingensmith , Anuja Nair , Barry Kuban , D. Vince
CPC分类号： A61B8/12 , A61B5/02007 , A61B8/0858
摘要： A system and method is provided for using the frequency spectrum of a radio frequency (RF) signal backscattered from vascular tissue to identify at least one border (e.g., tissue interface, etc.) on a vascular image. Embodiments of the present invention operate in accordance with a data gathering device (e.g., an intra-vascular ultrasound (IVUS) device, etc.) electrically connected to a computing device and a transducer via a catheter. The transducer is used to gather radio frequency (RF) data backscattered from vascular tissue. The RF data is then provided to (or acquired by) the computing device via the data-gathering device. In one embodiment of the present invention, the computing device includes (i) at least one data storage device (e.g., database, memory, etc.) for storing a plurality of tissue types and parameters related thereto and (ii) at least one application (e.g., a characterization application, a gradient-border application, a frequency-border application and/or an active-contour application). The characterization application is used to convert (or transform) the RF data into the frequency domain and to identify a plurality of parameters associated therewith. The identified parameters are then compared to the parameters stored in the data storage device to identify the corresponding tissue type. This information (e.g., tissue type, corresponding RF data, etc.) is then used, either alone or together with other border-related information (e.g., gradient information, other-border information, etc.), to determine at least one border on a vascular image.
摘要翻译： 提供了一种用于使用从血管组织反向散射的射频（RF）信号的频谱来识别血管图像上的至少一个边界（例如，组织界面等）的系统和方法。 本发明的实施例根据通过导管电连接到计算设备和换能器的数据采集装置（例如，血管内超声（IVUS）装置等）进行操作。 传感器用于收集从血管组织反向散射的射频（RF）数据。 然后，RF数据经由数据收集装置提供给计算装置（或者由其获取）。 在本发明的一个实施例中，计算设备包括（i）至少一个数据存储设备（例如，数据库，存储器等），用于存储与之相关的多个组织类型和参数，以及（ii）至少一个应用 （例如，表征应用，梯度边界应用，频率边界应用和/或主动轮廓应用）。 特征应用用于将RF数据转换（或变换）到频域中并且识别与其相关联的多个参数。 然后将识别的参数与存储在数据存储设备中的参数进行比较，以识别相应的组织类型。 然后，单独或与其他边界相关信息（例如，梯度信息，其他边界信息等）一起使用该信息（例如，组织类型，对应的RF数据等）以确定至少一个边界 在血管图像上。
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公开(公告)号：US20070100239A1
公开(公告)日：2007-05-03
申请号：US11580342
申请日：2006-10-14
申请人： Anuja Nair , Barry Kuban , D. Vince , Jon Klingensmith
发明人： Anuja Nair , Barry Kuban , D. Vince , Jon Klingensmith
IPC分类号： A61B8/00
CPC分类号： A61B8/0891 , A61B5/02007 , A61B5/7203 , A61B5/726 , A61B8/0833 , A61B8/12 , A61B8/4461 , A61B8/4488 , A61B8/461 , A61B8/467 , A61B8/52 , A61B8/5238 , G01S7/5205 , G01S7/52087 , G01S15/8977 , G06F19/00
摘要： A system and method is provided for using ultrasound data backscattered from vascular tissue to estimate the transfer function of a catheter and/or substantially synchronizing the acquisition of blood-vessel data to an identifiable portion of heartbeat data. Specifically, in accordance with a first embodiment of the present invention, a computing device is electrically connected to a catheter and used to acquire RF backscattered data from a vascular structure (e.g., a blood vessel, etc.). The backscattered ultrasound data is then used, together with an algorithm, to estimate at least one transfer function. The transfer function(s) can then be used (at least in a preferred embodiment) to calculate response data for the vascular tissue (i.e., the tissue component of the backscattered ultrasound data). In a second embodiment of the present invention, an IVUS console is electrically connected to a catheter and a computing device and is used to acquire RF backscattered data from a vascular structure. The backscattered data is then transmitted to the computing device, where it is used to estimate the catheter's transfer function and to calculate response data for the vascular tissue. The response data and histology data are then used to characterize at least a portion of the vascular tissue (e.g., identify tissue type, etc.). In a third embodiment of the present invention, a data-gathering device (e.g., an IVUS device, etc.) is electrically connected to a heart-monitoring device (e.g., an EKG device, etc.), which is used to gather heartbeat data from a patient. In accordance with this embodiment of the present invention, the backscattered data is acquired during a cyclical portion of the heartbeat data so that the blood vessel can be analyzed or imaged as if it were standing still, or not expanding and relaxing.
摘要翻译： 提供了一种用于使用从血管组织反向散射的超声数据来估计导管的传递功能和/或使血管数据的获取基本上同步到心跳数据的可识别部分的系统和方法。 具体地，根据本发明的第一实施例，计算设备电连接到导管并用于从血管结构（例如，血管等）获取RF背散射数据。 然后将后向散射超声数据与算法一起用于估计至少一个传递函数。 然后可以使用传递函数（至少在一个优选实施例中）来计算血管组织的反应数据（即反向散射超声数据的组织分量）。 在本发明的第二实施例中，IVUS控制台电连接到导管和计算设备，并用于从血管结构获取RF背散射数据。 然后将背散射数据传输到计算设备，其中其用于估计导管的传递函数并计算血管组织的反应数据。 然后使用响应数据和组织学数据来表征血管组织的至少一部分（例如，识别组织类型等）。 在本发明的第三实施例中，数据收集装置（例如，IVUS装置等）电连接到用于收集心跳的心脏监测装置（例如，EKG装置等） 来自病人的资料 根据本发明的该实施例，在心跳数据的循环部分期间获取背散射数据，使得血管可以被分析或成像，就好像静止不动，或者不扩张和放松。
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公开(公告)号：US20060253033A1
公开(公告)日：2006-11-09
申请号：US11445591
申请日：2006-06-01
申请人： Anuja Nair , D. Vince , Jon Klingensmith , Barry Kuban
发明人： Anuja Nair , D. Vince , Jon Klingensmith , Barry Kuban
IPC分类号： A61B8/14
CPC分类号： A61B8/12 , A61B5/02007 , A61B5/7257 , A61B5/726 , A61B8/0833 , G06T7/0012 , G06T2207/30101
摘要： A system and method is provided for using backscattered data and known parameters to characterize vascular tissue. Specifically, in one embodiment of the present invention, an ultrasonic device is used to acquire RF backscattered data (i.e., IVUS data) from a blood vessel. The IVUS data is then transmitted to a computing device and used to create an IVUS image. The blood vessel is then cross-sectioned and used to identify its tissue type and to create a corresponding image (i.e., histology image). A region of interest (ROI), preferably corresponding to the identified tissue type, is then identified on the histology image. The computing device, or more particularly, a characterization application operating thereon, is then adapted to identify a corresponding region on the IVUS image. To accurately match the ROI, however, it may be necessary to warp or morph the histology image to substantially fit the contour of the IVUS image. After the corresponding region is identified, the IVUS data that corresponds to this region is identified. Signal processing is then performed and at least one parameter is identified. The identified parameter and the tissue type (e.g., characterization data) is stored in a database. In another embodiment of the present invention, the characterization application is adapted to receive IVUS data, determine parameters related thereto (either directly or indirectly), and use the parameters stored in the database to identify a tissue type or a characterization thereof.
摘要翻译： 提供了一种使用背散射数据和已知参数来表征血管组织的系统和方法。 具体地，在本发明的一个实施例中，使用超声波装置从血管获取RF背散射数据（即，IVUS数据）。 然后将IVUS数据传输到计算设备并用于创建IVUS图像。 然后将血管切片并用于识别其组织类型并产生相应的图像（即，组织学图像）。 然后在组织学图像上识别优选对应于所识别的组织类型的感兴趣区域（ROI）。 然后，计算设备，或更具体地，在其上操作的表征应用程序适用于识别IVUS图像上的对应区域。 然而，为了精确地匹配ROI，可能需要使组织学图像变形或变形以基本上适合IVUS图像的轮廓。 识别对应区域后，识别与该区域对应的IVUS数据。 然后执行信号处理，并且识别至少一个参数。 所识别的参数和组织类型（例如表征数据）被存储在数据库中。 在本发明的另一个实施例中，表征应用适于接收IVUS数据，确定与其相关的参数（直接或间接），并且使用存储在数据库中的参数来识别组织类型或其表征。
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公开(公告)号：US10292676B2
公开(公告)日：2019-05-21
申请号：US14367543
申请日：2012-12-20
申请人： Volcano Corporation , Nikhil Rajguru , Vladimir Zagrodsky , David Goodwin , Jon Klingensmith , Wolf-Ekkehard Blanz , Bernhard Sturm
发明人： Nikhil Rajguru , Vladimir Zagrodsky , David Goodwin , Jon Klingensmith , Wolf-Ekkehard Blanz , Bernhard Sturm
摘要： Computer-implemented methods for use in improving the diagnostic quality of images, including intravascular ultrasound (IVUS) images, are disclosed. The methods include using a non-linear, probabilistic classifier algorithm to analyze a plurality of spatiotemporal features of RF backscatter and to produce a blood likelihood map or blood probability map that corresponds to the original IVUS image. The methods disclosed herein allow for visualizing both static and dynamic characteristic of a vessel either by producing a transparency modulated color overlay of the blood likelihood map without altering the underlying IVUS image or by processing the IVUS image based upon the blood likelihood map to better distinguish between static and dynamic components of the vessel.
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8.发明申请公开(公告)号：US20070038061A1
公开(公告)日：2007-02-15
申请号：US11473974
申请日：2006-06-23
申请人： Richard Huennekens , Vincent Burgess , Marja Margolis , Blair Walker , Jon Klingensmith , Nancy Pool , Randall Hanson
发明人： Richard Huennekens , Vincent Burgess , Marja Margolis , Blair Walker , Jon Klingensmith , Nancy Pool , Randall Hanson
IPC分类号： A61B5/05
CPC分类号： A61B6/504 , A61B6/5247 , A61B8/12 , A61B8/5238
摘要： A method and system are disclosed for creating, in a coordinated manner, graphical images of a body including vascular features from a combination of image data sources. The method includes initially creating an angiographic image of a vessel segment. The angiographic image is, for example, either a two or three dimensional image representation. Next, a vessel image data set is acquired that is distinct from the angiographic image data. The vessel image data set comprises information acquired at a series of positions along the vessel segment. An example of such vessel image data is a set of intravascular ultrasound frames corresponding to circumferential cross-section slices taken at various positions along the vessel segment. The angiographic image and the vessel image data set are correlated by comparing a characteristic rendered independently from both the angiographic image and the vessel image data at positions along the vessel segment.
摘要翻译： 公开了用于以协调的方式从图像数据源的组合创建包括血管特征的身体的图形图像的方法和系统。 该方法包括最初创建血管段的血管造影图像。 血管造影图像例如是二维或三维图像表示。 接下来，获取与血管造影图像数据不同的血管图像数据集。 容器图像数据集包括沿着血管段的一系列位置获取的信息。 这种血管图像数据的一个例子是一组血管内超声波帧，对应于沿着血管段的不同位置处的圆周横截面切片。 血管造影图像和血管图像数据集通过比较沿着血管段的位置独立地从血管造影图像和血管图像数据两者呈现的特征相关联。
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公开(公告)号：US20070083111A1
公开(公告)日：2007-04-12
申请号：US11250159
申请日：2005-10-12
申请人： Norman Hugh Hossack , Stephen Davies , Donald Mamayek , Richard Scott Huennekens , Stephen Fry , Eric Mott , Peter Smith , Scott Brownlie , Jon Klingensmith , Richard Klosinski , Edward Oliver , Masood Ahmed , Gerald Litzza
发明人： Norman Hugh Hossack , Stephen Davies , Donald Mamayek , Richard Scott Huennekens , Stephen Fry , Eric Mott , Peter Smith , Scott Brownlie , Jon Klingensmith , Richard Klosinski , Edward Oliver , Masood Ahmed , Gerald Litzza
CPC分类号： A61B8/12 , A61B1/00059 , A61B8/4438 , A61B8/4472 , A61B2090/0803 , G06K19/07749
摘要： A method and system is provided for using backscattered data and known parameters to characterize vascular tissue. Specifically, methods and devices for identifying information about the imaging element used to gather the backscattered data are provided in order to permit an operation console having a plurality of Virtual Histology classification trees to select the appropriate VH classification tree for analyzing data gathered using that imaging element. In order to select the appropriate VH database for analyzing data from a specific imaging catheter, it is advantageous to know information regarding the function and performance of the catheter, such as the operating frequency of the catheter and whether it is a rotational or phased-array catheter. The present invention provides a device and method for storing this information on the imaging catheter and communicating the information to the operation console. In addition, information related to additional functions of the catheter may also be stored on the catheter and used to further optimize catheter performance and/or select the appropriate Virtual Histology classification tree for analyzing data from the catheter imaging element.
摘要翻译： 提供了一种使用反向散射数据和已知参数来表征血管组织的方法和系统。 具体地，提供了用于识别关于用于收集背散射数据的成像元件的信息的方法和装置，以便允许具有多个虚拟组织学分类树的操作控制台选择适当的VH分类树，以分析使用该成像元件收集的数据 。 为了选择用于分析来自特定成像导管的数据的适当的VH数据库，有利的是知道关于导管的功能和性能的信息，例如导管的操作频率以及它是旋转的还是相控阵的 导管。 本发明提供了一种用于将该信息存储在成像导管上并将信息传送到操作台的装置和方法。 此外，与导管的附加功能相关的信息也可以存储在导管上并且用于进一步优化导管性能和/或选择适当的虚拟组织学分类树来分析来自导管成像元件的数据。
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公开(公告)号：US20060241465A1
公开(公告)日：2006-10-26
申请号：US11329609
申请日：2006-01-11
申请人： R. Huennekens , Stephen Fry , Blair Walker , Jon Klingensmith , Nancy Pool , Vincent Burgess , William Kanz
发明人： R. Huennekens , Stephen Fry , Blair Walker , Jon Klingensmith , Nancy Pool , Vincent Burgess , William Kanz
IPC分类号： A61B8/14
CPC分类号： A61B5/06 , A61B5/0215 , A61B6/12 , A61B6/4441 , A61B6/4494 , A61B6/463 , A61B6/487 , A61B6/504 , A61B6/5247 , A61B8/12 , A61B8/4494 , A61B8/463 , A61B8/543
摘要： A system and method for providing a vascular image are disclosed wherein a single composite display simultaneously provides a first view of a patient including an angiogram image and a second view including an intravascular image rendered from information provided by an imaging probe mounted on a distal end of a flexible elongate member. A cursor, having a position derived from image information provided by a radiopaque marker proximate the imaging probe, is displayed within the angiogram image to correlate the position of the imaging probe to a presently displayed intravascular image and thus provide an easily discernable identification of a position within a patient corresponding to a currently displayed intravascular image. The resulting composite display simultaneously provides: an intravascular image that includes information about a vessel that is not available from an angiogram and a current location within a vessel of a source of intravascular image data from which the intravascular image is rendered.
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