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公开(公告)号：US08471054B2
公开(公告)日：2013-06-25
申请号：US13414090
申请日：2012-03-07
申请人： Arikha Moses , Satish Pulapura , Arthur Schwartz , Qing Ge , Irene Shatova
发明人： Arikha Moses , Satish Pulapura , Arthur Schwartz , Qing Ge , Irene Shatova
CPC分类号： C08G69/48 , C07C235/34 , C07C235/52 , C08G63/6856 , C08G64/12 , C08G73/028
摘要： The invention provides biocompatible resorbable polymers, comprising monomer units having formula (I), formula (II), formula (III) or formula (IV). The polymers degrade over time when implanted in the body, and are useful as components of implantable medical devices.
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公开(公告)号：US20120165495A1
公开(公告)日：2012-06-28
申请号：US13414090
申请日：2012-03-07
申请人： Arikha Moses , Satish Pulapura , Arthur Schwartz , Qing Ge , Irene Shatova
发明人： Arikha Moses , Satish Pulapura , Arthur Schwartz , Qing Ge , Irene Shatova
IPC分类号： C08G63/193 , C07H15/18 , C07C69/716 , C07C235/52 , C07C237/52
CPC分类号： C08G69/48 , C07C235/34 , C07C235/52 , C08G63/6856 , C08G64/12 , C08G73/028
摘要： The invention provides biocompatible resorbable polymers, comprising monomer units having formula (I), formula (II), formula (III) or formula (IV). The polymers degrade over time when implanted in the body, and are useful as components of implantable medical devices.
摘要翻译： 本发明提供具有式（I），式（II），式（III）或式（IV））的单体单元的生物相容性可再吸收聚合物。 当植入体内时，聚合物随时间降解，并且可用作可植入医疗装置的组件。
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公开(公告)号：US08153837B2
公开(公告)日：2012-04-10
申请号：US12279539
申请日：2006-11-03
申请人： Arikha Moses , Satish Pulapura , Arthur Schwartz , Qing Ge , Irene Shatova
发明人： Arikha Moses , Satish Pulapura , Arthur Schwartz , Qing Ge , Irene Shatova
CPC分类号： C08G69/48 , C07C235/34 , C07C235/52 , C08G63/6856 , C08G64/12 , C08G73/028
摘要： The invention provides biocompatible resorbable polymers, comprising monomer units having formula (I), formula (II), formula (III) or formula (IV). The polymers degrade over time when implanted in the body, and are useful as components of implantable medical devices.
摘要翻译： 本发明提供具有式（I），式（II），式（III）或式（IV））的单体单元的生物相容性可再吸收聚合物。 当植入体内时，聚合物随时间降解，并且可用作可植入医疗装置的组件。
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公开(公告)号：US20090088548A1
公开(公告)日：2009-04-02
申请号：US12279539
申请日：2006-11-03
申请人： Arikha Moses , Satish Pulapura , Arthur Schwartz , Qing Ge , Irene Shatova
发明人： Arikha Moses , Satish Pulapura , Arthur Schwartz , Qing Ge , Irene Shatova
IPC分类号： C08G63/193 , C07C229/36
CPC分类号： C08G69/48 , C07C235/34 , C07C235/52 , C08G63/6856 , C08G64/12 , C08G73/028
摘要： The invention provides biocompatible resorbable polymers, comprising monomer units having formula (I), formula (II), formula (III) or formula (IV). The polymers degrade over time when implanted in the body, and are useful as components of implantable medical devices.
摘要翻译： 本发明提供具有式（I），式（II），式（III）或式（IV））的单体单元的生物相容性可再吸收聚合物。 当植入体内时，聚合物随时间降解，并且可用作可植入医疗装置的组件。
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公开(公告)号：US20080241212A1
公开(公告)日：2008-10-02
申请号：US12058060
申请日：2008-03-28
申请人： Arikha Moses , Satish Pulapura , Qing Ge , Sarita Nethula , Irene Shatova , Archana Rajaram
发明人： Arikha Moses , Satish Pulapura , Qing Ge , Sarita Nethula , Irene Shatova , Archana Rajaram
IPC分类号： A61F2/12 , A61K31/496 , A61K31/65 , A61K31/7036 , A61K38/00 , A61K31/7048 , A61K31/545 , A61K31/47 , A61K31/41 , A61K31/404 , A61K31/381 , A61K31/167 , A61K31/445 , A61P29/00 , A61P17/00
CPC分类号： A61F2/12 , A61K31/167 , A61K31/381 , A61K31/404 , A61K31/41 , A61K31/445 , A61K31/47 , A61K31/496 , A61K31/545 , A61K31/65 , A61K31/7036 , A61K31/7048 , A61K38/13 , B29C41/14 , A61K2300/00
摘要： A biodegradable, flexible covering for a breast implant is provided which comprises one or more biodegradable polymer layers dimensioned and shaped to cover at least a portion of the breast implant. The implant can be inserted into an opening of the covering immediately prior to surgery, but alternate configurations and times of insertion are contemplated as well as open or sheet type devices. The coverings can optionally contain one or more drugs for delivery at the surgical site, particularly for treating or preventing infection, pain, inflammation, capsular contracture, scarring or other complications associated with breast augmentation or breast reconstruction.
摘要翻译： 提供了一种用于乳房植入物的可生物降解的柔性覆盖物，其包括尺寸和形状以覆盖乳房植入物的至少一部分的一个或多个可生物降解的聚合物层。 植入物可以在手术之前立即插入覆盖物的开口中，但可以考虑插入的交替构型和时间以及开式或片式装置。 覆盖物可任选地含有一种或多种用于在手术部位递送的药物，特别是用于治疗或预防感染，疼痛，炎症，囊肿挛缩，瘢痕或与隆胸或乳房重建相关的其他并发症。
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公开(公告)号：US08911765B2
公开(公告)日：2014-12-16
申请号：US12058060
申请日：2008-03-28
申请人： Arikha Moses , Satish Pulapura , Qing Ge , Sarita Nethula , Irene Shatova , Archana Rajaram
发明人： Arikha Moses , Satish Pulapura , Qing Ge , Sarita Nethula , Irene Shatova , Archana Rajaram
IPC分类号： A61F2/12 , A61K31/496 , A61K31/65 , A61K31/7036 , A61K38/00 , A61K31/48 , A61K31/545 , A61K31/47 , A61K31/41 , A61K31/404 , A61K31/381 , A61K31/167 , A61K31/445 , A61K38/13 , A61K31/7048 , B29C41/14
CPC分类号： A61F2/12 , A61K31/167 , A61K31/381 , A61K31/404 , A61K31/41 , A61K31/445 , A61K31/47 , A61K31/496 , A61K31/545 , A61K31/65 , A61K31/7036 , A61K31/7048 , A61K38/13 , B29C41/14 , A61K2300/00
摘要： A biodegradable, flexible covering for a breast implant is provided which comprises one or more biodegradable polymer layers dimensioned and shaped to cover at least a portion of the breast implant. The implant can be inserted into an opening of the covering immediately prior to surgery, but alternate configurations and times of insertion are contemplated as well as open or sheet type devices. The coverings can optionally contain one or more drugs for delivery at the surgical site, particularly for treating or preventing infection, pain, inflammation, capsular contracture, scarring or other complications associated with breast augmentation or breast reconstruction.
摘要翻译： 提供了一种用于乳房植入物的可生物降解的柔性覆盖物，其包括尺寸和形状以覆盖乳房植入物的至少一部分的一个或多个可生物降解的聚合物层。 植入物可以在手术之前立即插入覆盖物的开口中，但可以考虑插入的交替构型和时间以及开式或片式装置。 覆盖物可任选地含有一种或多种用于在手术部位递送的药物，特别是用于治疗或预防感染，疼痛，炎症，囊肿挛缩，瘢痕或与隆胸或乳房重建相关的其他并发症。
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公开(公告)号：US20100129417A1
公开(公告)日：2010-05-27
申请号：US12598559
申请日：2008-05-02
申请人： Arikha Moses , Satish Pulapura , Qing Ge , Sarita Nethula , Archana Rajaram
发明人： Arikha Moses , Satish Pulapura , Qing Ge , Sarita Nethula , Archana Rajaram
IPC分类号： A61K31/65 , A61F2/00 , A61K31/496 , C08L67/02 , C08G63/133 , A61P27/02 , A61P9/00 , A61P25/00
CPC分类号： A23L3/3481 , A61K31/765 , A61K45/06 , A61K2300/00
摘要： The present invention is directed to polyphenolic polymers formed from dihydroxybenzoic acid (DHB) derivatives or from resorcinol derivatives, monomers which form such polymers, blends of the polymers with drugs and/or additional polymers, as well as medical devices formed from, coated with, impregnated by or coverings made with any of the foregoing polymers (with or without drugs) or blends (with or without drugs).
摘要翻译： 本发明涉及由二羟基苯甲酸（DHB）衍生物或间苯二酚衍生物形成的多酚聚合物，形成这种聚合物的单体，聚合物与药物和/或另外的聚合物的共混物，以及由涂覆， 用任何前述聚合物（含或不含药物）或共混物（含或不含药物）制成的浸渍或覆盖物。
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公开(公告)号：US09491966B2
公开(公告)日：2016-11-15
申请号：US12598559
申请日：2008-05-02
申请人： Arikha Moses , Satish Pulapura , Qing Ge , Sarita Nethula , Archana Rajaram
发明人： Arikha Moses , Satish Pulapura , Qing Ge , Sarita Nethula , Archana Rajaram
IPC分类号： A61K31/65 , A61F2/00 , A61K31/496 , A61P25/00 , A61P27/02 , A61P9/00 , C08G63/133 , C08L67/02 , A23L3/3481 , A61K31/765 , A61K45/06
CPC分类号： A23L3/3481 , A61K31/765 , A61K45/06 , A61K2300/00
摘要： The present invention is directed to polyphenolic polymers formed from dihydroxybenzoic acid (DHB) derivatives or from resorcinol derivatives, monomers which form such polymers, blends of the polymers with drugs and/or additional polymers, as well as medical devices formed from, coated with, impregnated by or coverings made with any of the foregoing polymers (with or without drugs) or blends (with or without drugs).
摘要翻译： 本发明涉及由二羟基苯甲酸（DHB）衍生物或间苯二酚衍生物形成的多酚聚合物，形成这种聚合物的单体，聚合物与药物和/或另外的聚合物的共混物，以及由涂覆， 用任何前述聚合物（含或不含药物）或共混物（含或不含药物）制成的浸渍或覆盖物。
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公开(公告)号：US20120052292A1
公开(公告)日：2012-03-01
申请号：US13218096
申请日：2011-08-25
申请人： Satish Pulapura , Qing Ge
发明人： Satish Pulapura , Qing Ge
IPC分类号： B32B3/00 , A61K31/65 , A61K31/496 , A61K9/00 , A61K31/155 , A61K33/38 , A61P31/00 , A61P23/00 , A61P29/00 , A61P17/02 , A61P43/00 , A61P9/00 , A61P25/00 , A61P27/02 , A61P7/02 , A61P1/02 , A61P7/04 , A61P35/00 , A61P31/04 , A61L27/34 , A61L15/26 , A61L29/08 , A61L31/10 , B32B15/04 , A61K47/34
CPC分类号： A61L31/10 , A61K31/155 , A61K31/496 , A61K31/65 , A61K33/38 , A61L31/16 , A61L2300/204 , A61L2300/216 , A61L2300/404 , A61L2300/606 , A61L2420/06 , C09D5/14 , C09D171/02 , Y02A50/406 , Y10T428/265 , Y10T428/31678 , C08L71/02 , C08L67/02
摘要： The present invention relates to coatings comprising polyethylene glycol and at least one polyphenolic polymer. In particular, the polyphenolic polymer could be selected from the group consisting of tyrosine-derived polyarylates, linear polyesteramides, dihydroxybenzoate polymers, and resorcinol-derived polymers. The coating of the present invention may also include a drug, such as an antibiotic. The coatings of the present invention are suitable for use as coatings for medical devices, such as orthopedic pins or stents.
摘要翻译： 本发明涉及包含聚乙二醇和至少一种多酚聚合物的涂料。 特别地，多酚聚合物可以选自酪氨酸衍生的多芳基化合物，线性聚酯酰胺，二羟基苯甲酸酯聚合物和间苯二酚衍生的聚合物。 本发明的涂层还可以包括药物，例如抗生素。 本发明的涂层适用于医疗装置如矫形针或支架的涂层。
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公开(公告)号：US09585988B2
公开(公告)日：2017-03-07
申请号：US13293816
申请日：2011-11-10
申请人： William McJames , Frank Do , Satish Pulapura , Qing Ge
发明人： William McJames , Frank Do , Satish Pulapura , Qing Ge
CPC分类号： A61L31/08 , A61L31/10 , A61L31/16 , A61L2300/602 , A61N1/059
摘要： An anchorage device comprising a mesh substrate coupled to an implantable medical device is disclosed, where the mesh substrate has a coating comprising a polymer, and the mesh further comprises at least one active pharmaceutical ingredient. The active pharmaceutical agent is designed to elute from the mesh over time. The mesh substrate can be configured to reduce the mass of the anchorage device such that tissue in-growth and/or scar tissue formation at the treatment site is reduced. In some embodiments, the mesh substrate can be formed with a mesh having a low areal density. In some embodiments, the mesh substrate can include one or more apertures or pores to reduce the mass of the substrate.
摘要翻译： 公开了一种锚固装置，其包括联接到可植入医疗装置的网状基底，其中网状基底具有包含聚合物的涂层，并且网状物还包含至少一种活性药物成分。 活性药剂被设计成随时间从网筛中洗脱。 网状基底可以被配置为减小锚固装置的质量，使得在治疗部位的组织生长和/或瘢痕组织形成减少。 在一些实施例中，网状基底可以形成有具有低面密度的网。 在一些实施例中，网状基底可以包括一个或多个孔或孔以减小基底的质量。
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