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33 条记录 (耗时 0.026 秒)

    Morphogenic protein
    3.
    发明授权
    Morphogenic protein 有权
    形态发生蛋白

    公开(公告)号：US07241739B2

    公开(公告)日：2007-07-10

    申请号：US10465474

    申请日：2003-06-19

    申请人： David M. Valenzuela ,  Eduardo A. Rojas ,  Aris N. Economides ,  Neil Stahl

    发明人： David M. Valenzuela ,  Eduardo A. Rojas ,  Aris N. Economides ,  Neil Stahl

    IPC分类号： A61K38/18 ,  C07K14/475

    CPC分类号： C07K14/475 ,  A61K38/00 ,  C07K2319/00

    摘要： Human Cerberus proteins and related nucleic acids are provided. Included are proteins comprising a human cerberus domain having specific activity, particularly the ability to antagonize a bone morphogenic protein. The proteins may be produced recombinantly from transformed host cells with the subject nucleic acids. Also provided are isolated hybridization probes and primers capable of specifically hybridizing with the disclosed genes, specific binding agents and methods of making and using the subject compositions.

    摘要翻译： 提供人Cerberus蛋白和相关核酸。 包括包含具有比活性的人类cerberus结​​构域的蛋白质，特别是拮抗骨形态发生蛋白的能力。 蛋白质可以用受试核酸从转化的宿主细胞重组产生。 还提供了能够与所公开的基因，特异性结合剂和制备和使用本发明组合物的方法特异性杂交的分离的杂交探针和引物。

    Morphogenic proteins
    4.
    发明授权
    Morphogenic proteins 有权
    形态发生蛋白

    公开(公告)号：US06610510B1

    公开(公告)日：2003-08-26

    申请号：US09423029

    申请日：1999-11-16

    申请人： David M. Valenzuela ,  Eduardo A. Rojas ,  Aris N. Economides ,  Neil Stahl

    发明人： David M. Valenzuela ,  Eduardo A. Rojas ,  Aris N. Economides ,  Neil Stahl

    IPC分类号： C12P2100

    CPC分类号： C07K14/475 ,  A61K38/00 ,  C07K2319/00

    摘要： Human Cerberus proteins and related nucleic acids are provided. Included are proteins comprising a human cerberus domain having specific activity, particularly the ability to antagonize a bone morphogenic protein. The proteins may be produced recombinantly from transformed host cells with the subject nucleic acids. Also provided are isolated hybridization probes and primers capable of specifically hybridizing with the disclosed genes, specific binding agents and methods of making and using the subject compositions.

    摘要翻译： 提供人Cerberus蛋白和相关核酸。 包括包含具有比活性的人类cerberus结​​构域的蛋白质，特别是拮抗骨形态发生蛋白的能力。 蛋白质可以用受试核酸从转化的宿主细胞重组产生。 还提供了能够与所公开的基因，特异性结合剂和制备和使用本发明组合物的方法特异性杂交的分离的杂交探针和引物。

    DCR5, a BMP-binding protein, and applications thereof
    5.
    发明授权
    DCR5, a BMP-binding protein, and applications thereof 有权
    DCR5，BMP结合蛋白及其应用

    公开(公告)号：US06660499B1

    公开(公告)日：2003-12-09

    申请号：US09762960

    申请日：2001-02-14

    申请人： Aris N. Economides ,  Neil Stahl

    发明人： Aris N. Economides ,  Neil Stahl

    IPC分类号： C12P2106

    CPC分类号： C07K14/475 ,  A61K38/00 ,  C07K2319/02

    摘要： DCR5, a protein related to DAN (Differential-screening-selected gene Aberrative in Neuroblastoma) and related nucleic acids are provided. Included are natural DCR5 homologs from several species and proteins comprising a DCR5 domain having specific activity, particularly the ability to antagonize a bone morphogenetic protein. The proteins may be produced recombinantly from transformed host cells with the subject nucleic acids. Also provided are isolated hybridization probes and primers capable of specifically hybridizing with the disclosed genes, specific binding agents and methods of making and using the subject compositions.

    摘要翻译： 提供了与DAN相关的蛋白质（神经母细胞瘤中的差异筛选选择基因Aberrative）和相关核酸的DCR5。 包括来自几种物种的天然DCR5同源物和包含具有比活性的DCR5结构域的蛋白质，特别是拮抗骨形态发生蛋白的能力。 蛋白质可以用受试核酸从转化的宿主细胞重组产生。 还提供了能够与所公开的基因，特异性结合剂和制备和使用本发明组合物的方法特异性杂交的分离的杂交探针和引物。

    Methods of treating diseases with a VEGF antagonist
    8.
    发明授权
    Methods of treating diseases with a VEGF antagonist 有权
    用VEGF拮抗剂治疗疾病的方法

    公开(公告)号：US07531172B2

    公开(公告)日：2009-05-12

    申请号：US11502736

    申请日：2006-08-11

    申请人： Neil Stahl ,  George D. Yancopoulos ,  Eric Furfine ,  Jesse M. Cedarbaum

    发明人： Neil Stahl ,  George D. Yancopoulos ,  Eric Furfine ,  Jesse M. Cedarbaum

    IPC分类号： A61K38/18 ,  C07K14/71 ,  C12N15/62

    CPC分类号： A61K38/179

    摘要： A method of reducing or preventing hypertension associated with administration of a vascular endothelial growth factor (VEGF) antagonist in a human subjects suffering from a disease or condition treatable with a VEGF antagonist in which is it desirable to reduce or prevent hypertension. The method is particularly useful for treatment of patients unresponsive to treatment with a VEGF inhibitor administered intravenously.

    摘要翻译： 在患有可用VEGF拮抗剂治疗的疾病或病症的人类受试者中降低或预防与血管内皮生长因子（VEGF）拮抗剂的给药相关的高血压的方法，其中希望减少或预防高血压。 该方法对于治疗对用静脉内施用的VEGF抑制剂治疗无反应的患者特别有用。

    Isolating cells expressing secreted proteins
    9.
    发明授权
    Isolating cells expressing secreted proteins 有权
    分离表达分泌蛋白的细胞

    公开(公告)号：US07435553B2

    公开(公告)日：2008-10-14

    申请号：US11434403

    申请日：2006-05-15

    申请人： James P Fandl ,  Neil Stahl ,  Gang Chen ,  George D. Yancopoulos

    发明人： James P Fandl ,  Neil Stahl ,  Gang Chen ,  George D. Yancopoulos

    IPC分类号： G01N33/53 ,  C12N15/09

    CPC分类号： C40B30/04 ,  A01K2217/05 ,  A01K2267/01 ,  C07K14/315 ,  C07K14/52 ,  C07K16/2863 ,  C07K2317/77 ,  C07K2319/00 ,  C12N15/1051 ,  G01N33/56966 ,  G01N33/6845 ,  G01N2500/10

    摘要： A method of detecting and isolating cells that produce any secreted protein of interest (POI), comprising: a) constructing a cell line transiently or stably expressing a cell surface capture molecule, which binds the POI, by transfecting the cell line with a nucleic acid that encodes such cell surface capture molecule; b) transfecting said cell simultaneously or subsequently with a second nucleic acid that encodes a POI wherein such POI is secreted; c) detecting the surface-displayed POI by contacting the cells with a detection molecule, which binds the POI; and d) isolating cells based on the detection molecule.

    摘要翻译： 一种检测和分离产生任何分泌的感兴趣蛋白质（POI）的细胞的方法，包括：a）通过用核酸转染细胞系来构建瞬时或稳定表达结合POI的细胞表面捕获分子的细胞系 编码这种细胞表面捕获分子; b）同时或随后用编码POI的第二核酸同时转染所述细胞，其中所述POI被分泌; c）通过使细胞与结合POI的检测分子接触来检测表面显示的POI; 和d）基于检测分子分离细胞。