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33 条记录 (耗时 0.023 秒)

    Methods of treating diseases with a VEGF antagonist
    2.
    发明授权
    Methods of treating diseases with a VEGF antagonist 有权
    用VEGF拮抗剂治疗疾病的方法

    公开(公告)号：US07531172B2

    公开(公告)日：2009-05-12

    申请号：US11502736

    申请日：2006-08-11

    申请人： Neil Stahl ,  George D. Yancopoulos ,  Eric Furfine ,  Jesse M. Cedarbaum

    发明人： Neil Stahl ,  George D. Yancopoulos ,  Eric Furfine ,  Jesse M. Cedarbaum

    IPC分类号： A61K38/18 ,  C07K14/71 ,  C12N15/62

    CPC分类号： A61K38/179

    摘要： A method of reducing or preventing hypertension associated with administration of a vascular endothelial growth factor (VEGF) antagonist in a human subjects suffering from a disease or condition treatable with a VEGF antagonist in which is it desirable to reduce or prevent hypertension. The method is particularly useful for treatment of patients unresponsive to treatment with a VEGF inhibitor administered intravenously.

    摘要翻译： 在患有可用VEGF拮抗剂治疗的疾病或病症的人类受试者中降低或预防与血管内皮生长因子（VEGF）拮抗剂的给药相关的高血压的方法，其中希望减少或预防高血压。 该方法对于治疗对用静脉内施用的VEGF抑制剂治疗无反应的患者特别有用。

    Isolating cells expressing secreted proteins
    3.
    发明授权
    Isolating cells expressing secreted proteins 有权
    分离表达分泌蛋白的细胞

    公开(公告)号：US07435553B2

    公开(公告)日：2008-10-14

    申请号：US11434403

    申请日：2006-05-15

    申请人： James P Fandl ,  Neil Stahl ,  Gang Chen ,  George D. Yancopoulos

    发明人： James P Fandl ,  Neil Stahl ,  Gang Chen ,  George D. Yancopoulos

    IPC分类号： G01N33/53 ,  C12N15/09

    CPC分类号： C40B30/04 ,  A01K2217/05 ,  A01K2267/01 ,  C07K14/315 ,  C07K14/52 ,  C07K16/2863 ,  C07K2317/77 ,  C07K2319/00 ,  C12N15/1051 ,  G01N33/56966 ,  G01N33/6845 ,  G01N2500/10

    摘要： A method of detecting and isolating cells that produce any secreted protein of interest (POI), comprising: a) constructing a cell line transiently or stably expressing a cell surface capture molecule, which binds the POI, by transfecting the cell line with a nucleic acid that encodes such cell surface capture molecule; b) transfecting said cell simultaneously or subsequently with a second nucleic acid that encodes a POI wherein such POI is secreted; c) detecting the surface-displayed POI by contacting the cells with a detection molecule, which binds the POI; and d) isolating cells based on the detection molecule.

    摘要翻译： 一种检测和分离产生任何分泌的感兴趣蛋白质（POI）的细胞的方法，包括：a）通过用核酸转染细胞系来构建瞬时或稳定表达结合POI的细胞表面捕获分子的细胞系 编码这种细胞表面捕获分子; b）同时或随后用编码POI的第二核酸同时转染所述细胞，其中所述POI被分泌; c）通过使细胞与结合POI的检测分子接触来检测表面显示的POI; 和d）基于检测分子分离细胞。

    Receptor based antagonists and methods of making and using
    6.
    发明授权
    Receptor based antagonists and methods of making and using 失效
    基于受体的拮抗剂及其制备和使用方法

    公开(公告)号：US06472179B2

    公开(公告)日：2002-10-29

    申请号：US09313942

    申请日：1999-05-19

    申请人： Neil Stahl ,  George D. Yancopoulos

    发明人： Neil Stahl ,  George D. Yancopoulos

    IPC分类号： C12P2104

    CPC分类号： C07K14/715 ,  C07K2319/02

    摘要： The present invention provides a fusion polypeptide capable of binding a cytokine to form a nonfunctional complex. It also provides a nucleic acid sequence encoding the fusion polypeptide and methods of making and uses for the fusion polypeptide.

    摘要翻译： 本发明提供能够结合细胞因子以形成非功能性复合物的融合多肽。 它还提供编码融合多肽的核酸序列以及制备和用于融合多肽的方法。

    Methods of screening competitors of OB-R binding to SHP-2-SH2 peptides
    7.
    发明授权
    Methods of screening competitors of OB-R binding to SHP-2-SH2 peptides 失效
    筛选OB-R与SHP-2-SH2肽结合的竞争者的方法

    公开(公告)号：US06270981B1

    公开(公告)日：2001-08-07

    申请号：US09093814

    申请日：1998-06-09

    申请人： Laura R. Carpenter ,  Neil Stahl ,  George D. Yancopoulos

    发明人： Laura R. Carpenter ,  Neil Stahl ,  George D. Yancopoulos

    IPC分类号： G01N33567

    CPC分类号： G01N33/6842 ,  G01N33/68 ,  G01N33/74 ,  G01N2500/00

    摘要： The present invention relates to methods for identifying therapeutic agents that enhance the effect of leptin, an adipocyte-derived cytokine that regulates food intake and body weight. The invention further provides for use of agents identified using this assay system to enhance the interaction between leptin and its receptor, OB-R, thereby boosting leptin's weight-reducing effects in obese individuals.

    摘要翻译： 本发明涉及用于鉴定增强瘦素效应的治疗剂的方法，该瘦素是调节食物摄入和体重的脂肪细胞来源的细胞因子。 本发明进一步提供了使用该测定系统鉴定的试剂来增强瘦素与其受体OB-R之间的相互作用，从而提高瘦素在肥胖个体中的减肥作用。

    Isolating Cells Expressing Secreted Proteins
    9.
    发明申请
    Isolating Cells Expressing Secreted Proteins 审中-公开
    分离表达分泌蛋白的细胞

    公开(公告)号：US20090137416A1

    公开(公告)日：2009-05-28

    申请号：US12240541

    申请日：2008-09-29

    申请人： James P. Fandl ,  Gang Chen ,  Neil Stahl ,  George D. Yancopoulos

    发明人： James P. Fandl ,  Gang Chen ,  Neil Stahl ,  George D. Yancopoulos

    IPC分类号： C40B30/04 ,  G01N33/53

    CPC分类号： G01N33/6854 ,  C12N15/65 ,  G01N33/566 ,  G01N33/56966 ,  G01N2333/7051

    摘要： A method of detecting and isolating cells that produce a secreted protein of interest (POI) that has a T cell receptor variable domain, comprising: a) constructing a cell line transiently or stably expressing a cell surface capture molecule, which binds the POI, by transfecting the cell line with a nucleic acid that encodes such cell surface capture molecule; b) transfecting said cell simultaneously or subsequently with a second nucleic acid that encodes a POI wherein such POI is secreted; c) detecting the surface-displayed POI by contacting the cells with a detection molecule, which binds the POI; and d) isolating cells based on the detection molecule.

    摘要翻译： 一种检测和分离产生具有T细胞受体可变区的目标分泌蛋白质（POI）的细胞的方法，包括：a）通过以下步骤构建细胞系：瞬时或稳定表达结合POI的细胞表面捕获分子，通过 用编码这种细胞表面捕获分子的核酸转染细胞系; b）同时或随后用编码POI的第二核酸同时转染所述细胞，其中所述POI被分泌; c）通过使细胞与结合POI的检测分子接触来检测表面显示的POI; 和d）基于检测分子分离细胞。